iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046316

Ensembl Protein ID

ENSP00000399903.1

UniProt Accession

Q6ZS30; A6NHD5; Q6Y876; Q6ZP36; Q6ZQY5; Q8N8R4; Q96Q30; Q96Q31; NBEL1_HUMAN

Genbank Protein ID

BAB69026.1; BAB69027.1; BAC87125.1; BAC87543.1; BAC85289.1; AAO45288.1

Protein Name

Neurobeachin-like protein 1; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein

Genbank Nucleotide ID

AC011737; AB053319; AK127772; AK128636; AK130065; AY172970

Gene Name

NBEAL1; ALS2CR16; ALS2CR17

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000144426.18	ENST00000449802.5	ENSP00000399903.1
ENSG00000144426.18	ENST00000414576.6	ENSP00000388466.2
ENSG00000144426.18	ENST00000434469.1	ENSP00000411142.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.00e-06	28.1	2440	2473

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtl.lvsGsdDgtikvWDlrtg 33
           H d vtcla    + + l+sGs+D t+++W ++++
   Q: 2440 HMDIVTCLATdyCG-IhLISGSRDTTCMIWQITQQ 2473
           88999**9874322.249************98765 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MASRERLFEL WMLYCTKKDP DYLKLWLDTF VSSYEQFLDV DFEKLPTRVD DMPPGISLLP 60
DNILQVLRIQ LLQCVQKMAD GLEEQQQALS ILLVKFFIIL CRNLSNVEEI GTCSYINYVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCGTCTGC CTGGCTGCGG GGTGACACGG GGCTTCGCCT TGGGAAGGGG TCGAGGGAAG 60
CAGTTAGACG GCTGCCGGGC GGCGGCTGCC GCGCGGCACA CAATGTGAGC CCGGTGATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000409--BEACH_dom
IPR013320--ConA-like_dom
IPR031570--DUF4704
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF02138--Beach
PF15787--DUF4704
PF14844--PH_BEACH
PF00400--WD40

SMART

SM01026--Beach
SM00320--WD40

KEGG

hsa:65065

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000339	Aegilops tauschii	33.43	2.00e-137	484.00
IUUC-Aml-001205	Ailuropoda melanoleuca	93.13	0.00e+00	5006.00
IUUC-Atr-002998	Amborella trichopoda	37.55	4.00e-139	491.00
IUUC-Apl-004130	Anas platyrhynchos	77.57	0.00e+00	4002.00
IUUC-Aca-005335	Anolis carolinensis	77.53	0.00e+00	4275.00
IUUC-Ath-006607	Arabidopsis thaliana	32.42	2.00e-126	448.00
IUUC-Ame-011863	Astyanax mexicanus	65.16	0.00e+00	2874.00
IUUC-Bta-013018	Bos taurus	92.80	0.00e+00	5046.00
IUUC-Bdi-014244	Brachypodium distachyon	33.81	2.00e-140	494.00
IUUC-Bol-016214	Brassica oleracea	32.14	3.00e-127	451.00
IUUC-Bra-017047	Brassica rapa	32.00	3.00e-133	471.00
IUUC-Cja-019409	Callithrix jacchus	91.57	0.00e+00	4469.00
IUUC-Cfa-021045	Canis familiaris	93.28	0.00e+00	4985.00
IUUC-Cpo-021291	Cavia porcellus	89.17	0.00e+00	2563.00
IUUC-Csa-023251	Chlorocebus sabaeus	97.10	0.00e+00	5289.00
IUUC-Cho-024721	Choloepus hoffmanni	83.70	0.00e+00	1245.00
IUUC-Csv-026337	Ciona savignyi	49.94	0.00e+00	852.00
IUUC-Dre-027616	Danio rerio	70.13	0.00e+00	1923.00
IUUC-Dno-029573	Dasypus novemcinctus	86.22	0.00e+00	4617.00
IUUC-Dme-031593	Drosophila melanogaster	42.22	0.00e+00	976.00
IUUC-Ete-032803	Echinops telfairi	84.32	0.00e+00	1451.00
IUUC-Eca-034151	Equus caballus	84.53	0.00e+00	4021.00
IUUC-Eeu-034829	Erinaceus europaeus	63.82	0.00e+00	638.00
IUUC-Fca-036558	Felis catus	86.79	0.00e+00	4704.00
IUUC-Fal-037518	Ficedula albicollis	79.18	0.00e+00	4202.00
IUUC-Gga-041228	Gallus gallus	79.45	0.00e+00	4263.00
IUUC-Gac-042518	Gasterosteus aculeatus	65.50	0.00e+00	3467.00
IUUC-Gma-042772	Glycine max	32.63	3.00e-138	488.00
IUUC-Ggo-045255	Gorilla gorilla	99.39	0.00e+00	1989.00
IUUC-Hvu-047772	Hordeum vulgare	37.55	5.00e-136	479.00
IUUC-Lch-049963	Latimeria chalumnae	72.34	0.00e+00	3966.00
IUUC-Lpe-050958	Leersia perrieri	34.68	5.00e-143	503.00
IUUC-Mcc-054720	Macaca mulatta	98.29	0.00e+00	5283.00
IUUC-Mtr-058372	Medicago truncatula	36.96	6.00e-134	473.00
IUUC-Mga-060173	Meleagris gallopavo	71.00	0.00e+00	3632.00
IUUC-Mmr-061257	Microcebus murinus	92.81	0.00e+00	4982.00
IUUC-Mdo-062583	Monodelphis domestica	83.01	0.00e+00	4460.00
IUUC-Mmu-063641	Mus musculus	90.20	0.00e+00	4934.00
IUUC-Mac-064991	Musa acuminata	33.63	1.00e-137	486.00
IUUC-Mpu-066823	Mustela putorius furo	91.88	0.00e+00	4966.00
IUUC-Mlu-067759	Myotis lucifugus	88.38	0.00e+00	4726.00
IUUC-Nle-069582	Nomascus leucogenys	98.52	0.00e+00	5315.00
IUUC-Ont-071396	Oreochromis niloticus	64.98	0.00e+00	3407.00
IUUC-Oan-073440	Ornithorhynchus anatinus	77.32	1.00e-142	499.00
IUUC-Ocu-074036	Oryctolagus cuniculus	91.54	0.00e+00	2701.00
IUUC-Oba-075426	Oryza barthii	34.52	2.00e-141	498.00
IUUC-Obr-076907	Oryza brachyantha	34.59	8.00e-142	499.00
IUUC-Ogl-077620	Oryza glaberrima	37.23	3.00e-130	459.00
IUUC-Ogu-078751	Oryza glumaepatula	34.29	4.00e-141	496.00
IUUC-Oin-079673	Oryza indica	37.23	7.00e-131	463.00
IUUC-Olo-080417	Oryza longistaminata	37.10	2.00e-130	461.00
IUUC-Ome-081931	Oryza meridionalis	34.42	1.00e-141	499.00
IUUC-Oni-082349	Oryza nivara	34.49	1.00e-141	498.00
IUUC-Oru-085197	Oryza rufipogon	34.49	7.00e-142	499.00
IUUC-Osa-085645	Oryza sativa	31.84	8.00e-33	133.00
IUUC-Oga-088899	Otolemur garnettii	88.75	0.00e+00	4764.00
IUUC-Oar-090283	Ovis aries	92.29	0.00e+00	5062.00
IUUC-Psi-093570	Pelodiscus sinensis	74.73	0.00e+00	2953.00
IUUC-Ppa-095295	Physcomitrella patens	34.23	2.00e-144	508.00
IUUC-Pfo-096377	Poecilia formosa	64.55	0.00e+00	3490.00
IUUC-Pab-098101	Pongo abelii	98.55	0.00e+00	3435.00
IUUC-Pop-099604	Populus trichocarpa	37.82	4.00e-136	481.00
IUUC-Ppe-101836	Prunus persica	37.47	3.00e-137	484.00
IUUC-Pva-102558	Pteropus vampyrus	93.42	0.00e+00	1529.00
IUUC-Rno-104903	Rattus norvegicus	85.29	0.00e+00	4627.00
IUUC-Smo-109504	Selaginella moellendorffii	38.90	2.00e-140	493.00
IUUC-Sit-110075	Setaria italica	33.46	2.00e-134	475.00
IUUC-Sly-111033	Solanum lycopersicum	37.29	6.00e-135	476.00
IUUC-Sar-113411	Sorex araneus	88.26	0.00e+00	1753.00
IUUC-Sbi-113954	Sorghum bicolor	36.48	2.00e-119	423.00
IUUC-Tru-118125	Takifugu rubripes	64.63	0.00e+00	3475.00
IUUC-Tsy-119218	Tarsius syrichta	92.21	0.00e+00	1921.00
IUUC-Tca-121572	Theobroma cacao	38.94	3.00e-139	491.00
IUUC-Tur-126212	Triticum urartu	33.33	2.00e-137	485.00
IUUC-Tbe-127556	Tupaia belangeri	84.00	0.00e+00	1486.00
IUUC-Ttr-128941	Tursiops truncatus	90.95	0.00e+00	2661.00
IUUC-Vpa-130417	Vicugna pacos	87.13	0.00e+00	1813.00
IUUC-Vvi-130860	Vitis vinifera	32.89	3.00e-133	471.00
IUUC-Xma-133712	Xiphophorus maculatus	65.04	0.00e+00	3523.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence