iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069788

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01075609

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000000338.2	ENSNLET00000000439.2	ENSNLEP00000000414.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-58	191.6	407	441
UBD/Beta-Prp	6.40e-69	232.4	320	485

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 407  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 441
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 320  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 403
           4556679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 404  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 485
           ***************9..***********************************99.************..99**************7 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MEPDSVIEDK TIELMISNGT SSVIVSRKRP SEGNYQKEKD LCIKYFDQWS ESDQVEFVEH 60
LISRMCHYQH GHINSYLKPM LQRDFITALP EQGLDHIAEN ILSYLDARSL CAAELVCKEW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCCCG ACTCGGTGAT TGAGGACAAG ACCATCGAGC TCATGGTGAG TGCGGCCCGC 60
TGGACCGTCT GTGCTTCCGT CCGTCCGGCC CCGGGCGGGC CTGCCCACCT CAACGTCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045862--P:positive regulation of proteolysis
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

nle:100605260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	93.73	0.00e+00	1033.00
IUUC-Apl-003449	Anas platyrhynchos	95.94	0.00e+00	1013.00
IUUC-Aca-004341	Anolis carolinensis	99.10	0.00e+00	913.00
IUUC-Ang-009766	Aspergillus niger	31.41	3.00e-52	199.00
IUUC-Ame-011393	Astyanax mexicanus	88.24	0.00e+00	953.00
IUUC-Bta-012920	Bos taurus	97.27	0.00e+00	1021.00
IUUC-Cja-018879	Callithrix jacchus	93.73	0.00e+00	1033.00
IUUC-Cfa-020021	Canis familiaris	93.73	0.00e+00	1033.00
IUUC-Cpo-022151	Cavia porcellus	99.59	0.00e+00	1013.00
IUUC-Csa-024095	Chlorocebus sabaeus	100.00	0.00e+00	1020.00
IUUC-Cho-024658	Choloepus hoffmanni	86.69	1.00e-129	456.00
IUUC-Dre-028160	Danio rerio	90.87	0.00e+00	951.00
IUUC-Dno-029485	Dasypus novemcinctus	88.93	0.00e+00	889.00
IUUC-Dor-030498	Dipodomys ordii	99.39	0.00e+00	1016.00
IUUC-Eca-033804	Equus caballus	99.80	0.00e+00	1021.00
IUUC-Fca-035887	Felis catus	96.03	0.00e+00	1039.00
IUUC-Fal-036783	Ficedula albicollis	96.12	0.00e+00	1017.00
IUUC-Gmo-038590	Gadus morhua	91.28	0.00e+00	927.00
IUUC-Gga-040628	Gallus gallus	95.74	0.00e+00	1012.00
IUUC-Gac-041305	Gasterosteus aculeatus	90.87	0.00e+00	929.00
IUUC-Ggo-044604	Gorilla gorilla	93.73	0.00e+00	1033.00
IUUC-Hsa-046139	Homo sapiens	93.73	0.00e+00	1033.00
IUUC-Lch-050460	Latimeria chalumnae	97.16	0.00e+00	994.00
IUUC-Laf-053968	Loxodonta africana	96.51	0.00e+00	1021.00
IUUC-Mcc-055822	Macaca mulatta	100.00	0.00e+00	1018.00
IUUC-Mga-059225	Meleagris gallopavo	98.99	0.00e+00	1006.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	2.00e-69	257.00
IUUC-Mmr-060746	Microcebus murinus	93.73	0.00e+00	1033.00
IUUC-Mdo-062005	Monodelphis domestica	99.39	0.00e+00	1015.00
IUUC-Mmu-063851	Mus musculus	96.12	0.00e+00	1019.00
IUUC-Mpu-065716	Mustela putorius furo	100.00	0.00e+00	1022.00
IUUC-Mlu-067001	Myotis lucifugus	100.00	0.00e+00	1020.00
IUUC-Opr-071229	Ochotona princeps	93.54	0.00e+00	1031.00
IUUC-Ont-071792	Oreochromis niloticus	91.48	0.00e+00	938.00
IUUC-Oan-072782	Ornithorhynchus anatinus	96.12	0.00e+00	1017.00
IUUC-Ocu-074894	Oryctolagus cuniculus	96.51	0.00e+00	1021.00
IUUC-Ola-086985	Oryzias latipes	89.26	0.00e+00	943.00
IUUC-Oga-088604	Otolemur garnettii	100.00	0.00e+00	1019.00
IUUC-Oar-090412	Ovis aries	96.51	0.00e+00	1021.00
IUUC-Ptr-091039	Pan troglodytes	93.54	0.00e+00	1031.00
IUUC-Pan-092770	Papio anubis	96.36	0.00e+00	974.00
IUUC-Psi-093887	Pelodiscus sinensis	95.35	0.00e+00	1009.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	2.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	89.84	0.00e+00	950.00
IUUC-Pva-102547	Pteropus vampyrus	93.51	0.00e+00	1018.00
IUUC-Rno-105246	Rattus norvegicus	96.12	0.00e+00	1019.00
IUUC-Sha-107339	Sarcophilus harrisii	99.39	0.00e+00	1015.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	4.00e-74	271.00
IUUC-Tgu-116541	Taeniopygia guttata	95.93	0.00e+00	1013.00
IUUC-Tru-117671	Takifugu rubripes	88.48	0.00e+00	935.00
IUUC-Tni-120359	Tetraodon nigroviridis	86.96	0.00e+00	940.00
IUUC-Tbe-127418	Tupaia belangeri	93.13	0.00e+00	936.00
IUUC-Ttr-129131	Tursiops truncatus	93.73	0.00e+00	1032.00
IUUC-Vpa-130668	Vicugna pacos	93.51	0.00e+00	1021.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	6.00e-158	549.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence