iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048070

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01050539

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000006174.2	ENSSTOT00000006179.2	ENSSTOP00000005527.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-67	218.6	197	240
UBD/Beta-Prp	1.30e-86	290.4	106	326

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 197  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRVWDTTAGRCER 240
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+s+sp+g+kl+sG +   i +wd +tg+ +  t
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRT 194
           5899************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlvsgs...sDgsiriWdlrsgdllkt 259
           tl+gh  +v+ +++s  d  l +g+   ++ +++  dl+ + +l t
   Q: 282  TLQGHGHWVNTMALS-TDYALRTGAfepAEATVNAQDLQGSWYLDT 326
           ***************.555566665777777777777666655555 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MAAAVVDETA APDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDKLQLVCNA LLAQEDPLPL 60
AFFVHDAEIT SSLGKTLESQ AVETEKILDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCCG CAGTGGTGGT GGGTGTGCTC AGATGGGGCG GGGGCTCCGT GGCTCGGCGC 60
CGGGCGGGGT CCCCGAGGCC GGTGGGAGGC AAAGCCGGGG CCAGCGATCG GGCTGCGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	57.54	3.00e-169	587.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.23	0.00e+00	943.00
IUUC-Atr-002507	Amborella trichopoda	57.73	2.00e-168	585.00
IUUC-Apl-003964	Anas platyrhynchos	83.22	0.00e+00	805.00
IUUC-Aly-006396	Arabidopsis lyrata	54.32	2.00e-160	558.00
IUUC-Ath-007278	Arabidopsis thaliana	54.53	2.00e-160	558.00
IUUC-Ago-007951	Ashbya gossypii	47.26	4.00e-127	447.00
IUUC-Acl-008298	Aspergillus clavatus	45.97	4.00e-119	421.00
IUUC-Afl-008581	Aspergillus flavus	52.21	5.00e-109	387.00
IUUC-Afu-008906	Aspergillus fumigatus	45.47	3.00e-119	421.00
IUUC-Ani-009189	Aspergillus nidulans	44.78	5.00e-116	410.00
IUUC-Ang-009630	Aspergillus niger	50.49	2.00e-121	428.00
IUUC-Aor-010038	Aspergillus oryzae	46.48	2.00e-126	445.00
IUUC-Ate-010278	Aspergillus terreus	46.23	4.00e-121	427.00
IUUC-Ame-011890	Astyanax mexicanus	79.71	0.00e+00	816.00
IUUC-Bgr-012011	Blumeria graminis	45.62	2.00e-128	451.00
IUUC-Bta-012964	Bos taurus	95.19	0.00e+00	937.00
IUUC-Bci-013592	Botrytis cinerea	44.64	9.00e-119	420.00
IUUC-Bdi-015035	Brachypodium distachyon	57.63	1.00e-170	592.00
IUUC-Bol-015501	Brassica oleracea	55.39	8.00e-161	559.00
IUUC-Bra-017642	Brassica rapa	55.18	3.00e-160	557.00
IUUC-Cel-018430	Caenorhabditis elegans	57.32	1.00e-168	585.00
IUUC-Cja-019125	Callithrix jacchus	95.61	0.00e+00	938.00
IUUC-Cfa-021013	Canis familiaris	94.75	0.00e+00	857.00
IUUC-Cpo-021743	Cavia porcellus	94.77	0.00e+00	936.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	45.51	2.00e-117	415.00
IUUC-Csa-024270	Chlorocebus sabaeus	95.87	0.00e+00	951.00
IUUC-Cin-025795	Ciona intestinalis	64.61	0.00e+00	681.00
IUUC-Csv-025953	Ciona savignyi	66.67	0.00e+00	680.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	50.78	1.00e-106	379.00
IUUC-Cne-026901	Cryptococcus neoformans	48.44	9.00e-139	486.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.80	2.00e-114	405.00
IUUC-Dre-028515	Danio rerio	76.78	0.00e+00	795.00
IUUC-Dno-029596	Dasypus novemcinctus	94.90	0.00e+00	951.00
IUUC-Dor-030494	Dipodomys ordii	96.01	0.00e+00	933.00
IUUC-Dse-031538	Dothistroma septosporum	47.42	4.00e-128	451.00
IUUC-Dme-031974	Drosophila melanogaster	58.75	5.00e-168	583.00
IUUC-Ete-032948	Echinops telfairi	95.33	6.00e-117	414.00
IUUC-Eca-033399	Equus caballus	97.06	0.00e+00	946.00
IUUC-Eeu-035013	Erinaceus europaeus	92.99	3.00e-115	408.00
IUUC-Fca-035860	Felis catus	96.03	0.00e+00	939.00
IUUC-Fal-037069	Ficedula albicollis	85.49	9.00e-130	455.00
IUUC-Fox-038059	Fusarium oxysporum	45.68	1.00e-122	432.00
IUUC-Fso-038445	Fusarium solani	45.40	8.00e-124	436.00
IUUC-Gmo-039319	Gadus morhua	75.16	0.00e+00	734.00
IUUC-Ggr-040095	Gaeumannomyces graminis	46.39	4.00e-121	428.00
IUUC-Gga-040303	Gallus gallus	83.53	5.00e-128	449.00
IUUC-Gac-042267	Gasterosteus aculeatus	77.64	0.00e+00	767.00
IUUC-Gma-043974	Glycine max	57.05	4.00e-169	587.00
IUUC-Ggo-044637	Gorilla gorilla	96.22	0.00e+00	936.00
IUUC-Hsa-046128	Homo sapiens	95.92	0.00e+00	960.00
IUUC-Hvu-047373	Hordeum vulgare	56.99	1.00e-168	585.00
IUUC-Kpa-049274	Komagataella pastoris	44.33	4.00e-126	444.00
IUUC-Lch-049907	Latimeria chalumnae	81.08	0.00e+00	813.00
IUUC-Lpe-050778	Leersia perrieri	53.60	4.00e-152	530.00
IUUC-Loc-051889	Lepisosteus oculatus	79.08	0.00e+00	817.00
IUUC-Lma-053041	Leptosphaeria maculans	48.49	7.00e-116	410.00
IUUC-Laf-053598	Loxodonta africana	95.28	0.00e+00	952.00
IUUC-Mcc-055660	Macaca mulatta	95.66	0.00e+00	949.00
IUUC-Meu-056197	Macropus eugenii	78.26	0.00e+00	770.00
IUUC-Mor-056949	Magnaporthe oryzae	45.29	4.00e-118	417.00
IUUC-Mpo-057571	Magnaporthe poae	44.88	1.00e-62	233.00
IUUC-Mtr-058530	Medicago truncatula	56.79	6.00e-166	576.00
IUUC-Mla-059133	Melampsora laricipopulina	45.82	8.00e-124	437.00
IUUC-Mga-059252	Meleagris gallopavo	82.97	0.00e+00	652.00
IUUC-Mvi-060522	Microbotryum violaceum	49.70	1.00e-135	476.00
IUUC-Mmr-061117	Microcebus murinus	95.05	0.00e+00	939.00
IUUC-Mdo-062892	Monodelphis domestica	86.73	0.00e+00	888.00
IUUC-Mmu-064108	Mus musculus	96.03	0.00e+00	914.00
IUUC-Mac-064430	Musa acuminata	58.26	5.00e-172	597.00
IUUC-Mpu-065882	Mustela putorius furo	95.61	0.00e+00	935.00
IUUC-Mlu-068123	Myotis lucifugus	95.40	0.00e+00	941.00
IUUC-Nfi-068484	Neosartorya fischeri	45.66	4.00e-119	421.00
IUUC-Ncr-068649	Neurospora crassa	42.91	6.00e-116	410.00
IUUC-Nle-069140	Nomascus leucogenys	96.22	0.00e+00	938.00
IUUC-Opr-070220	Ochotona princeps	87.16	0.00e+00	818.00
IUUC-Ont-072643	Oreochromis niloticus	78.84	0.00e+00	812.00
IUUC-Ocu-074007	Oryctolagus cuniculus	95.61	0.00e+00	911.00
IUUC-Oba-075904	Oryza barthii	58.26	4.00e-172	597.00
IUUC-Obr-076280	Oryza brachyantha	58.05	9.00e-172	596.00
IUUC-Ogl-077425	Oryza glaberrima	58.26	5.00e-172	597.00
IUUC-Ogu-078586	Oryza glumaepatula	57.86	3.00e-172	597.00
IUUC-Oin-079489	Oryza indica	56.14	6.00e-163	566.00
IUUC-Olo-080766	Oryza longistaminata	58.14	7.00e-172	596.00
IUUC-Ome-081905	Oryza meridionalis	58.26	4.00e-172	597.00
IUUC-Oni-083022	Oryza nivara	58.26	2.00e-172	598.00
IUUC-Opu-083615	Oryza punctata	58.26	3.00e-172	597.00
IUUC-Oru-085076	Oryza rufipogon	58.26	2.00e-172	598.00
IUUC-Osa-085744	Oryza sativa	58.69	2.00e-173	601.00
IUUC-Ola-087290	Oryzias latipes	77.24	0.00e+00	796.00
IUUC-Olu-087898	Ostreococcus lucimarinus	52.80	1.00e-143	502.00
IUUC-Oga-088980	Otolemur garnettii	95.17	0.00e+00	932.00
IUUC-Oar-089580	Ovis aries	94.93	0.00e+00	813.00
IUUC-Ptr-090845	Pan troglodytes	95.80	0.00e+00	932.00
IUUC-Pan-092836	Papio anubis	95.31	0.00e+00	957.00
IUUC-Psi-093965	Pelodiscus sinensis	81.58	8.00e-56	207.00
IUUC-Pno-095052	Phaeosphaeria nodorum	46.41	1.00e-121	429.00
IUUC-Ppa-095432	Physcomitrella patens	57.59	3.00e-169	587.00
IUUC-Pfo-096963	Poecilia formosa	70.77	0.00e+00	694.00
IUUC-Pab-097716	Pongo abelii	92.65	0.00e+00	892.00
IUUC-Pop-099224	Populus trichocarpa	57.47	4.00e-170	590.00
IUUC-Pca-100682	Procavia capensis	91.11	0.00e+00	672.00
IUUC-Ppe-101819	Prunus persica	57.02	2.00e-168	585.00
IUUC-Pva-102338	Pteropus vampyrus	94.59	0.00e+00	719.00
IUUC-Pgr-103583	Puccinia graminis	54.33	2.00e-131	462.00
IUUC-Ptt-103737	Puccinia triticina	43.61	1.00e-94	340.00
IUUC-Pte-104150	Pyrenophora teres	48.87	6.00e-120	424.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	48.99	3.00e-120	425.00
IUUC-Rno-105987	Rattus norvegicus	95.60	0.00e+00	936.00
IUUC-Sce-106315	Saccharomyces cerevisiae	46.88	3.00e-129	455.00
IUUC-Sha-107273	Sarcophilus harrisii	87.76	0.00e+00	898.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	45.64	8.00e-118	417.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.42	1.00e-122	432.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	43.83	1.00e-115	409.00
IUUC-Smo-108855	Selaginella moellendorffii	55.49	1.00e-163	569.00
IUUC-Sit-110329	Setaria italica	59.32	1.00e-172	599.00
IUUC-Sly-111830	Solanum lycopersicum	58.05	9.00e-173	599.00
IUUC-Stu-112603	Solanum tuberosum	58.05	1.00e-172	598.00
IUUC-Sar-113504	Sorex araneus	89.58	6.00e-73	267.00
IUUC-Sbi-114560	Sorghum bicolor	56.79	1.00e-169	588.00
IUUC-Sre-115133	Sporisorium reilianum	42.09	2.00e-125	442.00
IUUC-Ssc-115903	Sus scrofa	95.82	0.00e+00	939.00
IUUC-Tgu-116798	Taeniopygia guttata	83.89	0.00e+00	848.00
IUUC-Tru-118361	Takifugu rubripes	78.08	0.00e+00	799.00
IUUC-Tsy-118849	Tarsius syrichta	96.25	0.00e+00	944.00
IUUC-Tni-120094	Tetraodon nigroviridis	78.08	0.00e+00	797.00
IUUC-Tca-121634	Theobroma cacao	57.89	1.00e-167	582.00
IUUC-Tre-122051	Trichoderma reesei	45.98	1.00e-118	419.00
IUUC-Tvi-122322	Trichoderma virens	46.29	1.00e-121	429.00
IUUC-Tae-125822	Triticum aestivum	57.42	2.00e-169	588.00
IUUC-Tur-126766	Triticum urartu	51.32	6.00e-161	560.00
IUUC-Tme-127175	Tuber melanosporum	51.46	3.00e-131	461.00
IUUC-Tbe-127779	Tupaia belangeri	94.44	0.00e+00	828.00
IUUC-Ttr-128224	Tursiops truncatus	90.99	0.00e+00	807.00
IUUC-Uma-129537	Ustilago maydis	41.14	4.00e-123	434.00
IUUC-Vda-129927	Verticillium dahliae	44.86	2.00e-109	389.00
IUUC-Vpa-130658	Vicugna pacos	95.56	1.00e-154	538.00
IUUC-Vvi-131659	Vitis vinifera	57.59	5.00e-170	590.00
IUUC-Xtr-132918	Xenopus tropicalis	76.36	0.00e+00	786.00
IUUC-Xma-133700	Xiphophorus maculatus	79.12	0.00e+00	807.00
IUUC-Yli-134478	Yarrowia lipolytica	50.10	7.00e-138	483.00
IUUC-Zma-135835	Zea mays	55.42	1.00e-166	578.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence