iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133837

Ensembl Protein ID

ENSXMAP00000011107.1

UniProt Accession

M4A9G3; M4A9G3_XIPMA

Genbank Protein ID

ENSXMAP00000011107

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGAJ01006576

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000011056.1	ENSXMAT00000011121.1	ENSXMAP00000011107.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.90e-59	200.5	324	826
UBD/Alpha-Helix/UBA	6.70e-19	67.4	697	734

Active Site

Position(s)	Description	Evidence
333	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
789	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk....................avs 69
           tG+kNlgN+CY+NSv+Q+L+ +p++++ + + +  k+ +e+p++p++++ ++++kl   l++++ +                     ++
   Q: 324  TGMKNLGNSCYLNSVMQVLFTVPDFQSTYVS-NIDKIIDEAPSDPTQDFKTQVAKLGYGLLSGEYSkpapdpgdeigaseprgdqvGIA 411
           7******************************.888888999*******************63333333455666666666666666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ +++ ++efs+++qqDaqEfl ++++ +e+++                             ++    s+ F++ ++++i+c++
   Q: 412  PRMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNC-----------------------------RSGPNPSEAFRFLVEEKIVCQQ 471
           **************************************.............................556677999************* PP
   S: 159  cdnvssreepfldlslpvpgkeetkke.......................slqdcLesftkeeelegenkyycekckkkqeaekklklk 224
            ++ + ++   + ++lpvp+++  ++e                        ++ c+++ +++e+l++   ++++  ++k+ a+k++++ 
   Q: 472  SQKAKYTQRVDYIVQLPVPMDQAANTEelkeaerrreegdssaptvraqiPFSACMAALSEPEMLTD---FWSSAVQAKTSATKTTRFA 557
           **********************998889**************************************7...******************* PP
   S: 225  klPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.............................................. 267
           ++P+ L++++k+f+f  + ++++k++ ++++p++Ldls   ++                                              
   Q: 558  SFPDHLVIQIKKFTFGLD-WVPKKLDVSIDVPDTLDLSGLRATgqqpgeellpevappplmtpdvevkapvlddstvsqlcemgfplea 645
           ***************997.*******************877775566666666666666666666666666655555555555555555 PP
   S: 268  ..............peekqke.................................................................... 274
                                                                                                    
   Q: 646  crkavyytgntgidA-----Amnwimshmddpdfsaplvlpgsssgpgttpteslseehlativsmgfsrdqatkalratsnvleravd 729
           555555555555550.....055555555555555555555555555555555666666777777777777777777777777778888 PP
   S: 275  .......................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevl 323
                                                  + kYeL+a ++H+G s+ +GHYv+++k+ +++W+ f+D+kV ++  e+  
   Q: 730  wifshlddldsmdvseagrsaaeseggrdpppgprvrdgPGKYELFAFISHMGtSTMCGHYVCHIKK-DQQWVIFNDQKVCAS--EKPP 815
           888888888888888888888888999999999999999****************************.999*********999..7888 PP
   S: 324  eetgstaYvlfYkr 337
           +   + +Y++fY+r
   Q: 816  K---DLGYLYFYRR 826
           8...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ l+ +v+MGF+r++a +aLra++n le+Av++++++
   Q: 697  EEHLATIVSMGFSRDQATKALRATSNVLERAVDWIFSH 734
           7889********************************97 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MADVGEVLMS VLSTIRVPKP GDRVHKDECA LSFSSPESEG GIYVCMNTFL GFGSQYVGRH 60
HARTGQRAYL HITRTRKAKK EDENNSGSGH PPKKKPTRLA IGIEGGFDVE QELYEEDVKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG TTGGAGAGGT TTTGATGTCA GTTTTGTCCA CAATTCGCGT CCCAAAGCCT 60
GGGGACCGCG TCCACAAAGA CGAATGCGCC CTGTCATTTT CGTCACCGGT GAGCCTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	41.56	6.00e-176	611.00
IUUC-Aml-002104	Ailuropoda melanoleuca	67.02	0.00e+00	1166.00
IUUC-Atr-002580	Amborella trichopoda	44.48	0.00e+00	702.00
IUUC-Apl-003774	Anas platyrhynchos	66.34	0.00e+00	1129.00
IUUC-Aca-005368	Anolis carolinensis	68.10	0.00e+00	1199.00
IUUC-Aly-005727	Arabidopsis lyrata	45.69	0.00e+00	709.00
IUUC-Ath-006974	Arabidopsis thaliana	45.93	0.00e+00	711.00
IUUC-Ago-007890	Ashbya gossypii	27.45	1.00e-74	274.00
IUUC-Acl-008057	Aspergillus clavatus	34.95	8.00e-129	454.00
IUUC-Afl-008547	Aspergillus flavus	36.47	7.00e-116	411.00
IUUC-Afu-008805	Aspergillus fumigatus	34.23	3.00e-112	399.00
IUUC-Ani-009441	Aspergillus nidulans	33.51	2.00e-99	356.00
IUUC-Ang-009720	Aspergillus niger	33.65	6.00e-116	411.00
IUUC-Aor-010111	Aspergillus oryzae	34.17	5.00e-125	441.00
IUUC-Ate-010531	Aspergillus terreus	33.49	2.00e-110	393.00
IUUC-Ame-011893	Astyanax mexicanus	87.63	0.00e+00	1315.00
IUUC-Bgr-012183	Blumeria graminis	33.21	1.00e-117	417.00
IUUC-Bta-013179	Bos taurus	67.41	0.00e+00	1174.00
IUUC-Bci-013858	Botrytis cinerea	34.86	2.00e-128	452.00
IUUC-Bdi-014904	Brachypodium distachyon	44.17	0.00e+00	667.00
IUUC-Bol-015296	Brassica oleracea	46.23	0.00e+00	714.00
IUUC-Bra-017939	Brassica rapa	46.24	0.00e+00	723.00
IUUC-Cel-018625	Caenorhabditis elegans	33.57	2.00e-121	429.00
IUUC-Cja-019063	Callithrix jacchus	66.00	0.00e+00	1153.00
IUUC-Cfa-020976	Canis familiaris	69.57	0.00e+00	1190.00
IUUC-Cpo-022265	Cavia porcellus	69.20	0.00e+00	1190.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	42.45	3.00e-116	412.00
IUUC-Csa-024177	Chlorocebus sabaeus	67.92	0.00e+00	1067.00
IUUC-Cho-024702	Choloepus hoffmanni	61.82	0.00e+00	686.00
IUUC-Cin-025411	Ciona intestinalis	50.18	0.00e+00	807.00
IUUC-Csv-026347	Ciona savignyi	46.73	0.00e+00	782.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	35.16	1.00e-113	404.00
IUUC-Cne-026831	Cryptococcus neoformans	36.43	9.00e-127	447.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.60	1.00e-56	214.00
IUUC-Dre-027982	Danio rerio	86.87	0.00e+00	1377.00
IUUC-Dno-029034	Dasypus novemcinctus	67.53	0.00e+00	1172.00
IUUC-Dse-031467	Dothistroma septosporum	34.38	8.00e-123	434.00
IUUC-Dme-032075	Drosophila melanogaster	47.69	0.00e+00	773.00
IUUC-Ete-032865	Echinops telfairi	61.43	0.00e+00	1035.00
IUUC-Eca-034059	Equus caballus	66.90	0.00e+00	1169.00
IUUC-Eeu-035304	Erinaceus europaeus	63.29	0.00e+00	1060.00
IUUC-Fca-035515	Felis catus	67.29	0.00e+00	1174.00
IUUC-Fal-037271	Ficedula albicollis	68.60	0.00e+00	1122.00
IUUC-Fox-037745	Fusarium oxysporum	36.48	8.00e-130	457.00
IUUC-Fso-038158	Fusarium solani	35.19	5.00e-126	445.00
IUUC-Gmo-039071	Gadus morhua	88.74	0.00e+00	1407.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.69	1.00e-121	430.00
IUUC-Gga-040635	Gallus gallus	66.51	0.00e+00	1191.00
IUUC-Gac-042528	Gasterosteus aculeatus	91.40	0.00e+00	1481.00
IUUC-Gma-043614	Glycine max	44.93	0.00e+00	687.00
IUUC-Ggo-044602	Gorilla gorilla	67.18	0.00e+00	1171.00
IUUC-Hsa-045959	Homo sapiens	67.18	0.00e+00	1171.00
IUUC-Hvu-047563	Hordeum vulgare	46.17	6.00e-163	567.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	66.82	0.00e+00	1171.00
IUUC-Lch-049648	Latimeria chalumnae	69.84	0.00e+00	1173.00
IUUC-Lpe-051523	Leersia perrieri	44.50	0.00e+00	672.00
IUUC-Loc-052520	Lepisosteus oculatus	70.32	0.00e+00	1149.00
IUUC-Lma-053216	Leptosphaeria maculans	33.86	6.00e-108	386.00
IUUC-Laf-054327	Loxodonta africana	66.82	0.00e+00	1160.00
IUUC-Mcc-055443	Macaca mulatta	67.18	0.00e+00	1171.00
IUUC-Meu-056298	Macropus eugenii	67.88	0.00e+00	824.00
IUUC-Mor-057106	Magnaporthe oryzae	37.59	2.00e-134	473.00
IUUC-Mpo-057589	Magnaporthe poae	35.68	2.00e-127	449.00
IUUC-Mtr-058680	Medicago truncatula	46.71	0.00e+00	716.00
IUUC-Mla-058903	Melampsora laricipopulina	33.49	2.00e-116	413.00
IUUC-Mga-059669	Meleagris gallopavo	65.71	0.00e+00	1121.00
IUUC-Mvi-060476	Microbotryum violaceum	35.73	4.00e-121	429.00
IUUC-Mmr-060575	Microcebus murinus	67.06	0.00e+00	1168.00
IUUC-Mdo-062183	Monodelphis domestica	68.02	0.00e+00	1162.00
IUUC-Mmu-063592	Mus musculus	67.18	0.00e+00	1171.00
IUUC-Mpu-066082	Mustela putorius furo	69.08	0.00e+00	1182.00
IUUC-Mlu-067345	Myotis lucifugus	66.59	0.00e+00	1163.00
IUUC-Nfi-068558	Neosartorya fischeri	35.83	2.00e-123	436.00
IUUC-Ncr-068960	Neurospora crassa	34.64	3.00e-115	409.00
IUUC-Nle-070173	Nomascus leucogenys	69.32	0.00e+00	1186.00
IUUC-Opr-070556	Ochotona princeps	68.35	0.00e+00	1191.00
IUUC-Ont-071502	Oreochromis niloticus	95.42	0.00e+00	1504.00
IUUC-Ocu-074861	Oryctolagus cuniculus	69.57	0.00e+00	1195.00
IUUC-Oba-075109	Oryza barthii	44.35	0.00e+00	685.00
IUUC-Obr-076292	Oryza brachyantha	45.35	0.00e+00	669.00
IUUC-Ogl-077065	Oryza glaberrima	45.44	0.00e+00	709.00
IUUC-Ogu-078776	Oryza glumaepatula	43.87	0.00e+00	696.00
IUUC-Oin-080048	Oryza indica	45.08	0.00e+00	702.00
IUUC-Olo-080711	Oryza longistaminata	42.52	3.00e-180	625.00
IUUC-Ome-081506	Oryza meridionalis	43.43	0.00e+00	630.00
IUUC-Oni-082320	Oryza nivara	43.65	0.00e+00	681.00
IUUC-Opu-083801	Oryza punctata	44.66	0.00e+00	669.00
IUUC-Oru-085139	Oryza rufipogon	43.76	0.00e+00	681.00
IUUC-Osa-085713	Oryza sativa	45.56	0.00e+00	712.00
IUUC-Ola-086951	Oryzias latipes	90.85	0.00e+00	1422.00
IUUC-Olu-087822	Ostreococcus lucimarinus	42.10	3.00e-172	598.00
IUUC-Oga-088625	Otolemur garnettii	66.39	0.00e+00	1163.00
IUUC-Oar-089995	Ovis aries	66.35	0.00e+00	1157.00
IUUC-Ptr-090640	Pan troglodytes	66.67	0.00e+00	1170.00
IUUC-Pan-091974	Papio anubis	66.59	0.00e+00	1164.00
IUUC-Psi-093957	Pelodiscus sinensis	66.86	0.00e+00	1201.00
IUUC-Pma-094242	Petromyzon marinus	69.47	3.00e-157	547.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.11	9.00e-108	384.00
IUUC-Ppa-095901	Physcomitrella patens	47.28	0.00e+00	763.00
IUUC-Pfo-097148	Poecilia formosa	99.64	0.00e+00	1556.00
IUUC-Pab-098068	Pongo abelii	62.28	0.00e+00	1026.00
IUUC-Pop-098943	Populus trichocarpa	46.71	0.00e+00	704.00
IUUC-Pca-100738	Procavia capensis	67.16	0.00e+00	810.00
IUUC-Ppe-101315	Prunus persica	45.61	0.00e+00	701.00
IUUC-Pva-102154	Pteropus vampyrus	66.98	0.00e+00	1163.00
IUUC-Pgr-103343	Puccinia graminis	33.86	2.00e-102	366.00
IUUC-Ptt-103928	Puccinia triticina	30.63	7.00e-104	371.00
IUUC-Pte-104306	Pyrenophora teres	34.73	4.00e-106	379.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.66	5.00e-107	382.00
IUUC-Rno-105801	Rattus norvegicus	67.41	0.00e+00	1174.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.09	4.00e-68	253.00
IUUC-Sha-107635	Sarcophilus harrisii	68.80	0.00e+00	1179.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.93	4.00e-99	355.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.49	7.00e-112	398.00
IUUC-Smo-108848	Selaginella moellendorffii	47.27	0.00e+00	712.00
IUUC-Sit-110728	Setaria italica	44.93	0.00e+00	728.00
IUUC-Sly-111523	Solanum lycopersicum	45.23	0.00e+00	729.00
IUUC-Sbi-114419	Sorghum bicolor	45.36	0.00e+00	717.00
IUUC-Sre-115225	Sporisorium reilianum	34.16	1.00e-117	417.00
IUUC-Ssc-115686	Sus scrofa	66.63	0.00e+00	1168.00
IUUC-Tgu-117346	Taeniopygia guttata	66.55	0.00e+00	1174.00
IUUC-Tru-118350	Takifugu rubripes	87.30	0.00e+00	1429.00
IUUC-Tni-120658	Tetraodon nigroviridis	89.23	0.00e+00	1409.00
IUUC-Tca-121585	Theobroma cacao	46.71	0.00e+00	695.00
IUUC-Tre-122043	Trichoderma reesei	33.77	4.00e-119	422.00
IUUC-Tvi-122303	Trichoderma virens	34.06	1.00e-119	423.00
IUUC-Tae-125686	Triticum aestivum	44.36	0.00e+00	684.00
IUUC-Tur-126732	Triticum urartu	41.95	0.00e+00	649.00
IUUC-Tme-126909	Tuber melanosporum	34.80	6.00e-118	418.00
IUUC-Tbe-127261	Tupaia belangeri	61.69	0.00e+00	717.00
IUUC-Uma-129599	Ustilago maydis	35.28	4.00e-123	435.00
IUUC-Vda-129688	Verticillium dahliae	34.54	2.00e-119	422.00
IUUC-Vvi-131116	Vitis vinifera	45.20	0.00e+00	681.00
IUUC-Xtr-131953	Xenopus tropicalis	66.20	0.00e+00	1106.00
IUUC-Yli-134510	Yarrowia lipolytica	36.64	5.00e-125	442.00
IUUC-Zma-135786	Zea mays	44.05	0.00e+00	674.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence