iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133177

Ensembl Protein ID

ENSXMAP00000011695.1

UniProt Accession

M4AB51; M4AB51_XIPMA

Genbank Protein ID

ENSXMAP00000011695

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AGAJ01006704

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000011661.1	ENSXMAT00000011709.1	ENSXMAP00000011695.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.60e-19	67.9	529	917

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 529  NAYCNCMIQVLYFLEPIRCLVQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQASNFLRAFRTIPEASAlGLILADSDEQT 608
           56*********************...55654......57*******************************9999855655666666655 PP
   S: 97   a.flldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
               l +l ++ ++    + +++++e+e+ +  +    ++++  ++ +s i +lF+ +++++  c +c+++++r +  l ++++ p+++
   Q: 609  GkAKLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGVSSSSLGSSAESAIGKLFGCEVENSSLC-RCGKETVRSSLTLLFTMHYPEQN 694
           3133555555565544323333333333333..44555789999*********************.8*******************888 PP
   S: 181  etkke....slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           +++k+    ++ ++L+       le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e+     k++ +  +++ ++ + + 
   Q: 695  SQDKTvkeyDFAEILKRSIC---LEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSAKEA--EFWKVQAECAYNKAMQKEAME 778
           76555434455555554444...5666679****************************99976665..444888888888666655333 PP
   S: 266  ts.....peekqke.................................................................kkkYeLiavv 284
                  p                                                                          Y+L+  v
   Q: 779  PAkrtepP-----PmptewcldgeeicntegftfdtraedlrhvwipatlkmsisksqgleivswsesdeisaadeadgVSLYDLVVTV 862
           22333440.....14445555555555555555555555566666666666666666666666666666777777777799******** PP
   S: 285  vHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
            H      +G  va++k            ++++W+lf+D  +++++++e  ++  
   Q: 863  PHIQdARTGGNLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKTEAAQFDV 917
           ****99999*********999988877777888*************999888654 PP

Organism

Xiphophorus maculatus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MMNFEGLDPG MGEYPAGLHG TLEARLEPAL DPHLNPSLLQ GVELDPEGLA VTVPEPVHLM 60
EGVFSELHSV VSEVGIPVTA THFDLQEEML WMGNHRGHVT SYFGPTMGRH SSFQVHATDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGATGCAC CTGGAAGTTC TGCTGCTCTT GAACGCACCG CGGTTTGCTC CGGAAACGTT 60
TCCGTGTTAT TGTTGTTGTG AGCAGTTAGC ATGGGCAGCT ACATGTCAAA AAGTTTCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

KEGG

xma:102229846

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	75.78	0.00e+00	1826.00
IUUC-Apl-003500	Anas platyrhynchos	77.76	0.00e+00	1713.00
IUUC-Aca-004930	Anolis carolinensis	75.74	0.00e+00	1848.00
IUUC-Acl-008214	Aspergillus clavatus	31.58	1.00e-155	544.00
IUUC-Afu-009112	Aspergillus fumigatus	30.80	1.00e-144	507.00
IUUC-Ang-009531	Aspergillus niger	31.65	3.00e-149	523.00
IUUC-Ame-011259	Astyanax mexicanus	88.18	0.00e+00	2133.00
IUUC-Bta-012371	Bos taurus	75.62	0.00e+00	1812.00
IUUC-Bci-013684	Botrytis cinerea	30.82	3.00e-134	473.00
IUUC-Cja-019297	Callithrix jacchus	73.68	0.00e+00	1772.00
IUUC-Cfa-020489	Canis familiaris	75.62	0.00e+00	1812.00
IUUC-Cpo-022392	Cavia porcellus	75.95	0.00e+00	1852.00
IUUC-Csa-023220	Chlorocebus sabaeus	75.21	0.00e+00	1814.00
IUUC-Csv-025841	Ciona savignyi	48.29	1.00e-140	494.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	28.89	6.00e-88	319.00
IUUC-Cne-026932	Cryptococcus neoformans	43.02	3.00e-71	263.00
IUUC-Dre-028482	Danio rerio	85.83	0.00e+00	2086.00
IUUC-Dno-029398	Dasypus novemcinctus	75.66	0.00e+00	1816.00
IUUC-Dor-030307	Dipodomys ordii	70.67	0.00e+00	1020.00
IUUC-Dme-032111	Drosophila melanogaster	41.60	0.00e+00	885.00
IUUC-Eca-033985	Equus caballus	75.70	0.00e+00	1815.00
IUUC-Eeu-034928	Erinaceus europaeus	77.31	3.00e-177	616.00
IUUC-Fca-035587	Felis catus	75.70	0.00e+00	1842.00
IUUC-Fal-037587	Ficedula albicollis	76.95	0.00e+00	1829.00
IUUC-Fso-038133	Fusarium solani	32.19	3.00e-95	343.00
IUUC-Gmo-039076	Gadus morhua	86.31	0.00e+00	2077.00
IUUC-Ggr-039957	Gaeumannomyces graminis	28.94	1.00e-75	278.00
IUUC-Gga-040948	Gallus gallus	77.72	0.00e+00	1860.00
IUUC-Gac-042396	Gasterosteus aculeatus	90.29	0.00e+00	2192.00
IUUC-Ggo-045412	Gorilla gorilla	75.37	0.00e+00	1816.00
IUUC-Hsa-046076	Homo sapiens	75.37	0.00e+00	1817.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	70.56	0.00e+00	1638.00
IUUC-Kpa-049178	Komagataella pastoris	41.37	4.00e-67	250.00
IUUC-Lch-050279	Latimeria chalumnae	71.33	0.00e+00	870.00
IUUC-Loc-052872	Lepisosteus oculatus	85.35	0.00e+00	2043.00
IUUC-Lma-052986	Leptosphaeria maculans	30.41	3.00e-92	333.00
IUUC-Laf-054181	Loxodonta africana	73.20	0.00e+00	1776.00
IUUC-Mcc-054812	Macaca mulatta	75.29	0.00e+00	1806.00
IUUC-Meu-056325	Macropus eugenii	76.75	0.00e+00	1849.00
IUUC-Mor-057246	Magnaporthe oryzae	30.04	5.00e-121	429.00
IUUC-Mpo-057464	Magnaporthe poae	31.46	6.00e-138	485.00
IUUC-Mla-058911	Melampsora laricipopulina	33.33	1.00e-107	385.00
IUUC-Mga-059335	Meleagris gallopavo	78.47	0.00e+00	1820.00
IUUC-Mvi-060461	Microbotryum violaceum	34.05	2.00e-143	503.00
IUUC-Mmr-060636	Microcebus murinus	75.54	0.00e+00	1810.00
IUUC-Mmu-063503	Mus musculus	74.96	0.00e+00	1812.00
IUUC-Mpu-066670	Mustela putorius furo	75.86	0.00e+00	1819.00
IUUC-Mlu-068119	Myotis lucifugus	75.37	0.00e+00	1875.00
IUUC-Nfi-068398	Neosartorya fischeri	31.50	5.00e-154	538.00
IUUC-Ncr-068927	Neurospora crassa	28.44	4.00e-124	439.00
IUUC-Nle-069651	Nomascus leucogenys	72.43	0.00e+00	1732.00
IUUC-Opr-070614	Ochotona princeps	75.18	0.00e+00	1793.00
IUUC-Ont-072433	Oreochromis niloticus	90.45	0.00e+00	2228.00
IUUC-Oan-073283	Ornithorhynchus anatinus	67.40	0.00e+00	1278.00
IUUC-Ocu-074401	Oryctolagus cuniculus	75.04	0.00e+00	1812.00
IUUC-Ola-087522	Oryzias latipes	91.74	0.00e+00	2218.00
IUUC-Oga-088226	Otolemur garnettii	74.35	0.00e+00	1817.00
IUUC-Oar-089241	Ovis aries	75.45	0.00e+00	1840.00
IUUC-Pan-092297	Papio anubis	76.82	0.00e+00	1641.00
IUUC-Psi-094043	Pelodiscus sinensis	74.44	0.00e+00	1730.00
IUUC-Pma-094394	Petromyzon marinus	67.24	0.00e+00	1531.00
IUUC-Pno-095053	Phaeosphaeria nodorum	28.89	2.00e-75	277.00
IUUC-Ppa-095188	Physcomitrella patens	31.69	3.00e-161	562.00
IUUC-Pfo-097517	Poecilia formosa	98.92	0.00e+00	2427.00
IUUC-Pca-100471	Procavia capensis	76.55	0.00e+00	1736.00
IUUC-Pva-102805	Pteropus vampyrus	73.08	0.00e+00	1432.00
IUUC-Pte-104021	Pyrenophora teres	31.89	3.00e-159	556.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	29.64	2.00e-89	324.00
IUUC-Rno-105471	Rattus norvegicus	75.60	0.00e+00	1828.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.02	1.00e-59	225.00
IUUC-Sha-106883	Sarcophilus harrisii	76.42	0.00e+00	1715.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.58	3.00e-144	506.00
IUUC-Sar-113323	Sorex araneus	75.86	0.00e+00	1351.00
IUUC-Sre-115075	Sporisorium reilianum	32.56	2.00e-67	251.00
IUUC-Ssc-116363	Sus scrofa	74.63	0.00e+00	1820.00
IUUC-Tru-118427	Takifugu rubripes	91.37	0.00e+00	2262.00
IUUC-Tni-120218	Tetraodon nigroviridis	91.49	0.00e+00	2251.00
IUUC-Tre-122177	Trichoderma reesei	31.24	8.00e-157	548.00
IUUC-Tme-127176	Tuber melanosporum	32.20	6.00e-139	488.00
IUUC-Tbe-127641	Tupaia belangeri	66.73	3.00e-178	619.00
IUUC-Ttr-128888	Tursiops truncatus	74.57	0.00e+00	1129.00
IUUC-Uma-129361	Ustilago maydis	39.18	1.00e-62	235.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence