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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046181
UUCD1 version UUC-HoS-00856
Ensembl Protein ID ENSP00000262450.3
UniProt Accession Q8TDI0; O75032; Q5TG89; Q7LGH2; Q9UFR9; CHD5_HUMAN
Genbank Protein ID AAL98962.1; CAI19450.1; CAI19450.1; CAI19891.1; CAI19891.1; CAB55959.1; BAA32289.1
Protein Name Chromodomain-helicase-DNA-binding protein 5; ATP-dependent helicase CHD5
Genbank Nucleotide ID AF425231; AL031847; AL035406; AL035406; AL031847; AL117491; AB007913
Gene Name CHD5; KIAA0444
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116254.17 ENST00000262450.7 ENSP00000262450.3
ENSG00000116254.17 ENST00000475121.1 ENSP00000466440.1
ENSG00000116254.17 ENST00000462991.5 ENSP00000466706.1
ENSG00000116254.17 ENST00000377999.5 ENSP00000367238.2
ENSG00000116254.17 ENST00000496404.1 ENSP00000433676.1
ENSG00000116254.17 ENST00000491020.1 ENSP00000468624.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.20e-16 61.4 344 389
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C vC++gge    ++ C+ C +++H  Cl ++  e+ p+ + w Cp C++
   Q: 344  DYCEVCQQGGE----IILCDTCPRAYHLVCLDPE-LEKAPEGK-WSCPHCEK 389
           79*********....9******************.*******7.******86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
 Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
Protein Sequence
(Fasta)
MRGPVGTEEE LPRLFAEEME NEDEMSEEED GGLEAFDDFF PVEPVSLPKK KKPKKLKENK 60
CKGKRKKKEG SNDELSENEE DLEEKSESEG SDYSPNKKKK KKLKDKKEKK AKRKKKDEDE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046181|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
TCGCCCGCCG CGCGCGCCGG TCCGGCAGCG CACGGGTTAA GGCTGGCACC GCGCCCGGCG 60
GGAGGGGGGG CGCCCACCTC CCCTCCTCCC CGCGCCGGGC ATGCGGGGCC CAGTGGGCAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046181|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR012957--CHD_C2
IPR012958--CHD_N
IPR000953--Chromo/chromo_shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR009462--DUF1086
IPR009463--DUF1087
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50013--CHROMO_2
PS00690--DEAH_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF08074--CHDCT2
PF08073--CHDNT
PF00385--Chromo
PF06461--DUF1086
PF06465--DUF1087
PF00271--Helicase_C
PF00628--PHD
PF00176--SNF2_N
SMART

SM00298--CHROMO
SM00487--DEXDc
SM01146--DUF1086
SM01147--DUF1087
SM00490--HELICc
SM00249--PHD
Gene Ontology

GO:0005829--C:cytosol
GO:0000792--C:heterochromatin
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0005524--F:ATP binding
GO:0008026--F:ATP-dependent helicase activity
GO:0003677--F:DNA binding
GO:0061628--F:H3K27me3 modified histone binding
GO:0008270--F:zinc ion binding
GO:0021895--P:cerebral cortex neuron differentiation
GO:0098532--P:histone H3-K27 trimethylation
GO:0043967--P:histone H4 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:1901798--P:positive regulation of signal transduction by p53 class mediator
GO:0060850--P:regulation of transcription involved in cell fate commitment
GO:0035093--P:spermatogenesis, exchange of chromosomal proteins
GO:0006351--P:transcription, DNA-templated
KEGG hsa:26038
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001701 Ailuropoda melanoleuca 96.15 0.00e+00 3034.00
IUUC-Apl-003406 Anas platyrhynchos 81.80 0.00e+00 2532.00
IUUC-Aca-004671 Anolis carolinensis 82.89 0.00e+00 2683.00
IUUC-Aly-005645 Arabidopsis lyrata 39.10 4.00e-152 533.00
IUUC-Ath-007406 Arabidopsis thaliana 40.11 8.00e-157 549.00
IUUC-Ame-011883 Astyanax mexicanus 80.85 0.00e+00 2131.00
IUUC-Bta-012951 Bos taurus 90.81 0.00e+00 2629.00
IUUC-Bol-016073 Brassica oleracea 40.79 1.00e-156 548.00
IUUC-Bra-016724 Brassica rapa 41.02 1.00e-157 552.00
IUUC-Cel-018108 Caenorhabditis elegans 57.15 0.00e+00 1311.00
IUUC-Cja-018871 Callithrix jacchus 91.89 0.00e+00 2869.00
IUUC-Cfa-021063 Canis familiaris 97.14 0.00e+00 2967.00
IUUC-Cpo-022083 Cavia porcellus 94.09 0.00e+00 2899.00
IUUC-Csa-023084 Chlorocebus sabaeus 99.23 0.00e+00 3204.00
IUUC-Dre-028226 Danio rerio 78.23 0.00e+00 2404.00
IUUC-Dno-029923 Dasypus novemcinctus 96.34 0.00e+00 1965.00
IUUC-Dme-032150 Drosophila melanogaster 61.75 0.00e+00 1424.00
IUUC-Eca-034372 Equus caballus 96.71 0.00e+00 2963.00
IUUC-Fca-036048 Felis catus 96.10 0.00e+00 2973.00
IUUC-Fal-037282 Ficedula albicollis 88.59 0.00e+00 2787.00
IUUC-Gga-040607 Gallus gallus 89.04 0.00e+00 2386.00
IUUC-Ggo-044514 Gorilla gorilla 99.74 0.00e+00 3220.00
IUUC-Loc-052795 Lepisosteus oculatus 80.79 0.00e+00 2684.00
IUUC-Laf-053749 Loxodonta africana 96.98 0.00e+00 3053.00
IUUC-Mcc-055856 Macaca mulatta 99.23 0.00e+00 3181.00
IUUC-Mga-059630 Meleagris gallopavo 89.22 0.00e+00 2822.00
IUUC-Mmr-060986 Microcebus murinus 95.14 0.00e+00 2963.00
IUUC-Mmu-063644 Mus musculus 93.61 0.00e+00 3034.00
IUUC-Mpu-066528 Mustela putorius furo 91.39 0.00e+00 2909.00
IUUC-Nle-069824 Nomascus leucogenys 96.48 0.00e+00 2915.00
IUUC-Ont-072647 Oreochromis niloticus 76.57 0.00e+00 2363.00
IUUC-Ola-086961 Oryzias latipes 74.29 0.00e+00 2415.00
IUUC-Oga-088775 Otolemur garnettii 96.99 0.00e+00 2986.00
IUUC-Oar-090301 Ovis aries 95.76 0.00e+00 2872.00
IUUC-Ptr-090586 Pan troglodytes 97.82 0.00e+00 3152.00
IUUC-Pan-092282 Papio anubis 99.22 0.00e+00 3156.00
IUUC-Psi-093007 Pelodiscus sinensis 86.97 0.00e+00 2340.00
IUUC-Pfo-096802 Poecilia formosa 76.15 0.00e+00 2247.00
IUUC-Pab-097677 Pongo abelii 99.67 0.00e+00 2534.00
IUUC-Pca-100559 Procavia capensis 93.09 0.00e+00 2878.00
IUUC-Rno-105378 Rattus norvegicus 94.74 0.00e+00 2974.00
IUUC-Sha-107350 Sarcophilus harrisii 86.27 0.00e+00 2776.00
IUUC-Smo-108946 Selaginella moellendorffii 36.88 3.00e-165 577.00
IUUC-Ssc-116303 Sus scrofa 97.37 0.00e+00 2515.00
IUUC-Tgu-116779 Taeniopygia guttata 82.20 0.00e+00 2529.00
IUUC-Tru-117597 Takifugu rubripes 78.69 0.00e+00 2374.00
IUUC-Ttr-128301 Tursiops truncatus 94.70 0.00e+00 2991.00
IUUC-Xtr-132668 Xenopus tropicalis 80.50 0.00e+00 2473.00
Created Date 25-Jun-2017

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