• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064275
UUCD1 version UUC-MuM-00823
Ensembl Protein ID ENSMUSP00000133309.1
UniProt Accession Q91V17; Q8C5D7; ZNRF1_MOUSE
Genbank Protein ID AAK69754.1; BAC37410.1; BAC37612.1; AAH06765.1; AAH86770.1
Protein Name E3 ubiquitin-protein ligase ZNRF1; Nerve injury-induced gene 283 protein; RING-type E3 ubiquitin transferase ZNRF1; Zinc/RING finger protein 1
Genbank Nucleotide ID AF378525; AK078819; AK079338; BC006765; BC086770
Gene Name Znrf1; Nin283
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000033545.14 ENSMUST00000172856.7 ENSMUSP00000133309.1
ENSMUSG00000033545.14 ENSMUST00000173726.7 ENSMUSP00000133472.1
ENSMUSG00000033545.14 ENSMUST00000174376.7 ENSMUSP00000133455.1
ENSMUSG00000033545.14 ENSMUST00000174333.7 ENSMUSP00000134634.1
ENSMUSG00000033545.14 ENSMUST00000173922.1 ENSMUSP00000134369.1
ENSMUSG00000033545.14 ENSMUST00000173819.1 ENSMUSP00000133361.1
ENSMUSG00000033545.14 ENSMUST00000171182.7 ENSMUSP00000127956.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 99.12 7.00e-130 460.00 IUUC-Hsa-046894
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons.
 E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons.
Protein Sequence
(Fasta)
MGGKQSTAAR SRGPFPGVST DDSAVPPPGG APHFGHYRTG GGAMGLRSRS VSSVAGMGMD 60
PSTAGGVPFS LYTPASRGTG DSERAPGGGG STSDSTYAHG NGYQETGGGH HRDGMLYLGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064275|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGTGAGGGCA GGTCTGTGGC GGGAGGGGAG CTCCCCCAGT GACCCTTCAA ACCCAGGTAG 60
GCTTTATTAG TTGGTTTTTC TTTCTTCTCG GTGTTTCCTT CCTACCCGCT AAAACCGTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064275|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0005764--C:lysosome
GO:0016020--C:membrane
GO:0030672--C:synaptic vesicle membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007010--P:cytoskeleton organization
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
KEGG mmu:170737
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004093 Anas platyrhynchos 95.45 3.00e-60 222.00
IUUC-Bta-012934 Bos taurus 96.48 4.00e-128 450.00
IUUC-Cja-019419 Callithrix jacchus 99.12 3.00e-131 460.00
IUUC-Cfa-020388 Canis familiaris 98.91 6.00e-106 375.00
IUUC-Cpo-021584 Cavia porcellus 98.24 3.00e-130 456.00
IUUC-Cgl-026728 Colletotrichum gloeosporioides 54.00 3.00e-09 56.60
IUUC-Dre-027713 Danio rerio 75.77 3.00e-94 337.00
IUUC-Dse-031322 Dothistroma septosporum 46.81 7.00e-09 55.50
IUUC-Eca-033414 Equus caballus 100.00 8.00e-66 241.00
IUUC-Fca-036570 Felis catus 98.68 1.00e-130 458.00
IUUC-Fal-037096 Ficedula albicollis 96.30 2.00e-76 277.00
IUUC-Fox-038020 Fusarium oxysporum 33.04 3.00e-10 60.50
IUUC-Fso-038176 Fusarium solani 51.02 2.00e-08 55.10
IUUC-Ggr-039766 Gaeumannomyces graminis 46.77 9.00e-09 55.50
IUUC-Gga-041242 Gallus gallus 86.40 1.00e-94 338.00
IUUC-Hsa-046894 Homo sapiens 99.12 3.00e-131 460.00
IUUC-Itr-048339 Ictidomys tridecemlineatus 100.00 6.00e-49 184.00
IUUC-Kpa-049401 Komagataella pastoris 32.67 9.00e-09 53.50
IUUC-Lch-049749 Latimeria chalumnae 69.01 1.00e-39 155.00
IUUC-Loc-052268 Lepisosteus oculatus 79.30 4.00e-95 340.00
IUUC-Laf-054263 Loxodonta africana 97.80 2.00e-129 454.00
IUUC-Mpo-057355 Magnaporthe poae 46.77 8.00e-09 55.80
IUUC-Mla-059140 Melampsora laricipopulina 33.33 6.00e-05 42.00
IUUC-Mga-059226 Meleagris gallopavo 98.82 1.00e-48 183.00
IUUC-Mpu-066334 Mustela putorius furo 98.68 1.00e-130 458.00
IUUC-Mlu-067491 Myotis lucifugus 96.93 1.00e-123 435.00
IUUC-Ont-071907 Oreochromis niloticus 70.48 1.00e-81 295.00
IUUC-Oan-072941 Ornithorhynchus anatinus 88.10 5.00e-39 151.00
IUUC-Ocu-074256 Oryctolagus cuniculus 98.24 4.00e-126 443.00
IUUC-Ola-087551 Oryzias latipes 90.80 1.00e-46 176.00
IUUC-Pfo-097234 Poecilia formosa 73.25 6.00e-90 323.00
IUUC-Pab-098719 Pongo abelii 99.12 3.00e-131 460.00
IUUC-Rno-105985 Rattus norvegicus 99.56 7.00e-132 462.00
IUUC-Sja-107832 Schizosaccharomyces japonicus 34.26 1.00e-09 57.00
IUUC-Sre-115192 Sporisorium reilianum 38.78 2.00e-15 78.60
IUUC-Tgu-116682 Taeniopygia guttata 87.01 7.00e-82 295.00
IUUC-Tre-122233 Trichoderma reesei 32.32 1.00e-06 48.50
IUUC-Tvi-122664 Trichoderma virens 35.04 5.00e-09 56.20
IUUC-Tme-127002 Tuber melanosporum 56.25 1.00e-10 60.80
IUUC-Uma-129459 Ustilago maydis 37.62 5.00e-15 77.40
IUUC-Vda-129847 Verticillium dahliae 54.00 5.00e-10 59.30
IUUC-Xtr-132972 Xenopus tropicalis 63.44 8.00e-62 229.00
IUUC-Xma-134213 Xiphophorus maculatus 73.13 5.00e-89 320.00
IUUC-Yli-134502 Yarrowia lipolytica 29.48 1.00e-12 66.60
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved