iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054028

UUCD1 version

UUC-LoA-00297

Ensembl Protein ID

ENSLAFP00000007207.3

UniProt Accession

G3T240; G3T240_LOXAF

Protein Name

Uncharacterized protein

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000008582.3	ENSLAFT00000008583.3	ENSLAFP00000007207.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.10e-11	43.6	300	344

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC++gge    l++C+ C ++fH aCl ++  +e p+ + w C++C 
   Q: 300  DECAVCRDGGE----LICCDGCPRAFHLACLCPP-LREIPSGT-WRCSSCL 344
           57*********....*******************.*******6.******6 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

RPGGDAALRR LLRLYRTEIA VAVDSAFPLL HALADHDVVP EDKFQETMSL KDREGCPQAF 60
HALLSWLLTQ DTATILDFWR VLFKDYNLER YARLQPILDS FPKDVDLSQP RKGRKPPTGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACCCGGCG GGGACGCAGC GCTGCGCCGC CTCCTGAGGT TGTACCGCAC CGAGATAGCT 60
GTGGCCGTGG ACAGCGCCTT CCCGCTGCTG CACGCGCTGG CCGACCACGA CGTGGTCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	83.62	9.00e-138	483.00
IUUC-Atr-002978	Amborella trichopoda	34.41	1.00e-11	63.20
IUUC-Aca-004543	Anolis carolinensis	64.52	2.00e-23	100.00
IUUC-Bta-012988	Bos taurus	69.19	1.00e-177	615.00
IUUC-Bdi-014663	Brachypodium distachyon	61.70	3.00e-13	71.20
IUUC-Cja-019486	Callithrix jacchus	83.46	7.00e-49	187.00
IUUC-Cfa-021069	Canis familiaris	83.00	2.00e-135	475.00
IUUC-Cpo-021649	Cavia porcellus	63.24	8.00e-139	487.00
IUUC-Csa-023960	Chlorocebus sabaeus	84.50	2.00e-128	452.00
IUUC-Dre-028583	Danio rerio	40.88	2.00e-59	223.00
IUUC-Dno-029869	Dasypus novemcinctus	57.14	2.00e-120	425.00
IUUC-Dor-030263	Dipodomys ordii	81.91	3.00e-44	171.00
IUUC-Ete-032778	Echinops telfairi	92.73	4.00e-50	192.00
IUUC-Eca-034328	Equus caballus	84.86	9.00e-146	509.00
IUUC-Fca-035400	Felis catus	82.32	4.00e-138	484.00
IUUC-Fal-036644	Ficedula albicollis	51.16	3.00e-67	249.00
IUUC-Fox-038014	Fusarium oxysporum	38.00	6.00e-08	53.50
IUUC-Ggo-045250	Gorilla gorilla	83.28	7.00e-126	444.00
IUUC-Hsa-046603	Homo sapiens	84.16	3.00e-127	448.00
IUUC-Hvu-047073	Hordeum vulgare	46.97	2.00e-13	71.60
IUUC-Itr-048977	Ictidomys tridecemlineatus	78.71	1.00e-120	426.00
IUUC-Lch-050310	Latimeria chalumnae	42.65	2.00e-91	329.00
IUUC-Loc-052508	Lepisosteus oculatus	48.33	1.00e-78	286.00
IUUC-Lma-053053	Leptosphaeria maculans	27.66	2.00e-12	68.20
IUUC-Mcc-054935	Macaca mulatta	85.41	1.00e-133	469.00
IUUC-Mga-059318	Meleagris gallopavo	41.03	4.00e-48	184.00
IUUC-Mmr-061557	Microcebus murinus	65.65	8.00e-101	360.00
IUUC-Mdo-062475	Monodelphis domestica	47.10	4.00e-111	395.00
IUUC-Mmu-063994	Mus musculus	64.52	0.00e+00	627.00
IUUC-Mpu-066347	Mustela putorius furo	78.87	8.00e-141	493.00
IUUC-Mlu-068239	Myotis lucifugus	60.61	1.00e-88	319.00
IUUC-Nle-069544	Nomascus leucogenys	87.93	1.00e-24	105.00
IUUC-Opr-071199	Ochotona princeps	73.98	2.00e-72	266.00
IUUC-Ont-072571	Oreochromis niloticus	30.51	2.00e-34	140.00
IUUC-Oan-073739	Ornithorhynchus anatinus	51.31	1.00e-127	449.00
IUUC-Ogl-077865	Oryza glaberrima	45.45	1.00e-12	68.90
IUUC-Olo-080499	Oryza longistaminata	45.45	1.00e-12	69.70
IUUC-Opu-083209	Oryza punctata	45.45	1.00e-12	69.30
IUUC-Ola-086528	Oryzias latipes	32.23	1.00e-40	160.00
IUUC-Oga-088353	Otolemur garnettii	68.63	2.00e-173	601.00
IUUC-Oar-090065	Ovis aries	75.00	7.00e-144	503.00
IUUC-Ptr-091347	Pan troglodytes	83.89	2.00e-120	426.00
IUUC-Pan-092423	Papio anubis	81.79	5.00e-126	444.00
IUUC-Psi-093798	Pelodiscus sinensis	58.86	2.00e-96	346.00
IUUC-Pfo-096145	Poecilia formosa	66.10	1.00e-19	91.30
IUUC-Pab-098369	Pongo abelii	80.00	9.00e-122	429.00
IUUC-Pca-100537	Procavia capensis	72.40	1.00e-177	616.00
IUUC-Ppe-101215	Prunus persica	58.33	4.00e-13	70.10
IUUC-Pva-102639	Pteropus vampyrus	67.68	1.00e-153	536.00
IUUC-Rno-105285	Rattus norvegicus	63.78	7.00e-177	613.00
IUUC-Sha-107159	Sarcophilus harrisii	46.45	8.00e-105	374.00
IUUC-Sit-110355	Setaria italica	60.42	2.00e-12	68.60
IUUC-Sly-111378	Solanum lycopersicum	33.33	7.00e-14	73.20
IUUC-Stu-112427	Solanum tuberosum	33.33	1.00e-13	72.80
IUUC-Sbi-113930	Sorghum bicolor	47.76	2.00e-12	68.60
IUUC-Ssc-115773	Sus scrofa	65.11	2.00e-165	575.00
IUUC-Tgu-116922	Taeniopygia guttata	48.99	4.00e-70	257.00
IUUC-Tru-118263	Takifugu rubripes	29.96	1.00e-53	204.00
IUUC-Tsy-119270	Tarsius syrichta	69.58	3.00e-88	318.00
IUUC-Tni-120138	Tetraodon nigroviridis	30.52	4.00e-41	162.00
IUUC-Tca-121757	Theobroma cacao	54.72	4.00e-13	71.20
IUUC-Tae-124715	Triticum aestivum	46.97	3.00e-13	71.20
IUUC-Tme-127204	Tuber melanosporum	55.32	5.00e-13	70.10
IUUC-Tbe-128077	Tupaia belangeri	63.70	2.00e-165	575.00
IUUC-Ttr-128781	Tursiops truncatus	80.57	7.00e-75	274.00
IUUC-Xma-133054	Xiphophorus maculatus	32.85	3.00e-43	169.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence