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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045694
UUCD1 version UUC-HoS-01132
Ensembl Protein ID ENSP00000359829.1
UniProt Accession Q8TEY7; Q8TEY6; Q96AV6; Q9H9F0; Q9UPQ5; UBP33_HUMAN
Genbank Protein ID AAL78314.1; AAL78315.1; BAA83049.1; BAB14279.1; AAH16663.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme 33; Ubiquitin thioesterase 33; Ubiquitin-specific-processing protease 33; VHL-interacting deubiquitinating enzyme 1
Genbank Nucleotide ID AF383172; AF383173; AB029020; AK022864; AC114487
Gene Name USP33; KIAA1097; VDU1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000077254.14 ENST00000481579.5 ENSP00000432392.1
ENSG00000077254.14 ENST00000370793.5 ENSP00000359829.1
ENSG00000077254.14 ENST00000370792.7 ENSP00000359828.3
ENSG00000077254.14 ENST00000527390.1 ENSP00000432667.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 16325574; 15933713
Classification
Family E-value Score Start End
DUB/USP 3.90e-114 383.0 185 714
Active Site
Position(s) Description Evidence
194 Nucleophile
673 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeqqD 91
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +   +++++k +++ks+ kl++elw ks+ ++v p++l++ +k++++ f+gy+qqD
   Q: 185  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLARTDKKPAICKSYLKLMTELWhKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271
           7******************************.....999999*******************99***************************** PP
   S: 92   aqEflaflldqleeelkk........eknkpkeeeeeedkselsde.............................................. 129
           aqEfl++l+d l+eelk+         ++ ++ee++eedks+++ +                                              
   Q: 272  AQEFLRCLMDLLHEELKEqvmeveedPQTITTEETMEEDKSQSDVDfqscescsnsdraenengsrcfsednnettmliqddennsemskdw 363
           ****************8899998887777777788888877777779********************************************* PP
   S: 130  ............................................................................................ 129
                                                                                                       
   Q: 364  qkekmcnkinkvnsegefdkdrdsisetvdlnnqetvkvqihsraseyitdvhsndlstpqilpsnegvnprlsasppksgnlwpglapphk 455
           ******************************************************************************************** PP
   S: 130  .......aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke............................. 185
                  +++k++kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+                             
   Q: 456  kaqsaspKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshptsivkagscgeayapqgwiaffm 547
           *******9**************************************************99888***************************** PP
   S: 186  ....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
                               +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++++Pe+L++hLkRf  ++e ++++ki+++v+fpl
   Q: 548  eyvkrfvvscvpswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRF--RHELMFSTKISTHVSFPL 637
           ************************************************************************..9999************** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           e Ldl+pf+++++ +q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e++v++   ++aYvlfY++
   Q: 638  EgLDLQPFLAKDSPAQ--IVTYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEVSESTVQN---AEAYVLFYRK 714
           ***********88777..9**************************88889*******************...********98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MTGSNSHITI LTLKVLPHFE SLGKQEKIPN KMSAFRNHCP HLDSVGEITK EDLIQKSLGT 60
CQDCKVQGPN LWACLENRCS YVGCGESQVD HSTIHSQETK HYLTVNLTTL RVWCYACSKE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045694|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGACACCG GAAGGAGCCG CGGCTGCTGC GGGAAGTGGC CAGTTCAGGA GGCGGACCCC 60
CCGAGGGCAG CGCTGCGGGG CCGTTTTCCG GCCCTCCTGA CGCGACACTG CCCCTCTCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045694|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP
SMART

SM00695--DUSP
SM00290--ZnF_UBP
Gene Ontology

GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0030891--C:VCB complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0001664--F:G-protein coupled receptor binding
GO:0017160--F:Ral GTPase binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0006897--P:endocytosis
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:23032
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001742 Ailuropoda melanoleuca 96.06 0.00e+00 1800.00
IUUC-Apl-003987 Anas platyrhynchos 81.94 0.00e+00 1479.00
IUUC-Aca-004713 Anolis carolinensis 77.44 0.00e+00 1415.00
IUUC-Bta-013132 Bos taurus 96.60 0.00e+00 1770.00
IUUC-Cja-018811 Callithrix jacchus 97.53 0.00e+00 1834.00
IUUC-Cfa-021158 Canis familiaris 95.14 0.00e+00 1801.00
IUUC-Cpo-021910 Cavia porcellus 89.05 0.00e+00 1578.00
IUUC-Csa-023130 Chlorocebus sabaeus 98.57 0.00e+00 1803.00
IUUC-Cho-024383 Choloepus hoffmanni 78.59 0.00e+00 679.00
IUUC-Dre-028639 Danio rerio 70.08 0.00e+00 1240.00
IUUC-Dno-029416 Dasypus novemcinctus 94.19 0.00e+00 1712.00
IUUC-Ete-032994 Echinops telfairi 78.49 0.00e+00 856.00
IUUC-Eca-034248 Equus caballus 95.91 0.00e+00 1789.00
IUUC-Eeu-035357 Erinaceus europaeus 77.05 0.00e+00 1311.00
IUUC-Fca-036013 Felis catus 94.15 0.00e+00 1729.00
IUUC-Fal-037509 Ficedula albicollis 81.80 0.00e+00 1477.00
IUUC-Gmo-038944 Gadus morhua 65.77 0.00e+00 1178.00
IUUC-Gga-040647 Gallus gallus 80.94 0.00e+00 1451.00
IUUC-Gac-041752 Gasterosteus aculeatus 70.00 0.00e+00 1248.00
IUUC-Ggo-044689 Gorilla gorilla 93.05 0.00e+00 1084.00
IUUC-Itr-049041 Ictidomys tridecemlineatus 96.27 0.00e+00 1756.00
IUUC-Lch-050400 Latimeria chalumnae 70.18 0.00e+00 1259.00
IUUC-Loc-052616 Lepisosteus oculatus 70.03 0.00e+00 1325.00
IUUC-Laf-053493 Loxodonta africana 95.19 0.00e+00 1749.00
IUUC-Mcc-055542 Macaca mulatta 97.99 0.00e+00 1857.00
IUUC-Meu-056645 Macropus eugenii 73.52 0.00e+00 1298.00
IUUC-Mga-060019 Meleagris gallopavo 82.20 0.00e+00 1252.00
IUUC-Mmr-061241 Microcebus murinus 93.21 0.00e+00 1749.00
IUUC-Mmu-063786 Mus musculus 92.43 0.00e+00 1686.00
IUUC-Mpu-065772 Mustela putorius furo 96.93 0.00e+00 1472.00
IUUC-Mlu-067732 Myotis lucifugus 93.55 0.00e+00 1767.00
IUUC-Nle-069528 Nomascus leucogenys 97.37 0.00e+00 1811.00
IUUC-Opr-070606 Ochotona princeps 89.98 0.00e+00 1593.00
IUUC-Ont-071495 Oreochromis niloticus 71.24 0.00e+00 1260.00
IUUC-Oan-073695 Ornithorhynchus anatinus 85.02 0.00e+00 1035.00
IUUC-Ocu-074457 Oryctolagus cuniculus 92.93 0.00e+00 1710.00
IUUC-Ola-086739 Oryzias latipes 69.77 0.00e+00 1288.00
IUUC-Oga-088720 Otolemur garnettii 94.38 0.00e+00 1790.00
IUUC-Oar-089921 Ovis aries 95.33 0.00e+00 1804.00
IUUC-Ptr-090526 Pan troglodytes 99.25 0.00e+00 1850.00
IUUC-Pan-092396 Papio anubis 97.46 0.00e+00 1839.00
IUUC-Psi-092971 Pelodiscus sinensis 83.06 0.00e+00 1543.00
IUUC-Pfo-097415 Poecilia formosa 69.97 0.00e+00 1264.00
IUUC-Pab-098740 Pongo abelii 98.79 0.00e+00 1832.00
IUUC-Pca-100598 Procavia capensis 83.27 0.00e+00 900.00
IUUC-Pva-102820 Pteropus vampyrus 92.20 0.00e+00 1507.00
IUUC-Rno-104894 Rattus norvegicus 92.43 0.00e+00 1699.00
IUUC-Sha-107244 Sarcophilus harrisii 78.02 0.00e+00 1400.00
IUUC-Sar-113665 Sorex araneus 93.00 0.00e+00 1760.00
IUUC-Ssc-115793 Sus scrofa 93.43 0.00e+00 1682.00
IUUC-Tgu-117487 Taeniopygia guttata 82.81 0.00e+00 1449.00
IUUC-Tru-117694 Takifugu rubripes 68.94 0.00e+00 1273.00
IUUC-Tsy-119598 Tarsius syrichta 84.14 0.00e+00 1493.00
IUUC-Tni-120189 Tetraodon nigroviridis 67.35 0.00e+00 1199.00
IUUC-Tbe-128125 Tupaia belangeri 84.38 8.00e-119 421.00
IUUC-Ttr-128269 Tursiops truncatus 92.13 0.00e+00 1651.00
IUUC-Vpa-130598 Vicugna pacos 93.76 0.00e+00 1741.00
IUUC-Xtr-132044 Xenopus tropicalis 74.62 0.00e+00 1313.00
Created Date 25-Jun-2017

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