iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098060

UUCD1 version

UUC-PoA-00999

Ensembl Protein ID

ENSPPYP00000015351.2

UniProt Accession

A0A0A0MXR2; A0A0A0MXR2_PONAB

Genbank Protein ID

ENSPPYP00000015351

Protein Name

NEDD8-activating enzyme E1 catalytic subunit

Genbank Nucleotide ID

ABGA01092740

Gene Name

UBA3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000013729.2	ENSPPYT00000015964.2	ENSPPYP00000015351.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.70e-99	333.3	87	277

Active Site

Position(s)	Description	Evidence
258	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 15   klksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesiteleee 103
            l+++kvl++GagglGcEllKnL+l+G+++i+v+Dmdt++vsnlnrqFLfr++d+g++KAevaae+l++++p++nv++h ++i++ +++
   Q: 87   LLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDT 175
           589***********************************************************************************999 PP
   S: 104  ivFfkkfdvVvlaldnrearrkvnrlclna............rvpliesgtlGllGqvrviikgltecyscsd..dppqktiPfctlke 178
             F+++f+++v++ld++ arr++n +++++             vpli++gt+G++G++rvi++g+t+c++c+   +ppq+++P+ct+++
   Q: 176  --FYRQFHIIVCGLDSIIARRWINGMLISLlnyedgvldpssIVPLIDGGTEGFKGNARVILPGMTACIECTLelYPPQVNFPMCTIAS 262
           ..***************************9*********************************************************** PP
   S: 179  tpnaaehtiewavlf 193
           +p+ +eh+ie+++++
   Q: 263  MPRLPEHCIEYVRML 277
           ***********9443 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MPVPLLPAPL REGTWEEAEN NMADGEEPEK KRRRIEELLA EKMAVDGGCG DTGDWEGRWN 60
HVKKFLERSG PFTHPDFEPS TESLQFLLDT CKVLVIGAGG LGCELLKNLA LSGFRQIHVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCTATGC CAGTCCCGCT CCTCCCCGCC CCGCTGCGCG AGGGCACCTG GGAAGAGGCG 60
GAGAACAATA TGGCGGATGG CGAGGAGCCG TAAGTACCGG GGCTCTGCAG ACGCGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014929--E2_binding
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR030468--Uba3
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF08825--E2_bind
PF00899--ThiF

SMART

SM01181--E2_bind

Gene Ontology

GO:0005634--C:nucleus
GO:0016881--F:acid-amino acid ligase activity
GO:0005524--F:ATP binding
GO:0019781--F:NEDD8 activating enzyme activity
GO:0007113--P:endomitotic cell cycle
GO:0045116--P:protein neddylation
GO:0051726--P:regulation of cell cycle

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001124	Aegilops tauschii	48.52	3.00e-81	295.00
IUUC-Aml-001578	Ailuropoda melanoleuca	98.25	0.00e+00	939.00
IUUC-Atr-002591	Amborella trichopoda	50.12	1.00e-91	329.00
IUUC-Apl-003671	Anas platyrhynchos	89.89	0.00e+00	860.00
IUUC-Aca-004749	Anolis carolinensis	90.40	0.00e+00	824.00
IUUC-Aly-005747	Arabidopsis lyrata	47.39	2.00e-97	349.00
IUUC-Ath-006623	Arabidopsis thaliana	47.64	3.00e-97	348.00
IUUC-Ago-007934	Ashbya gossypii	45.60	3.00e-73	268.00
IUUC-Acl-008047	Aspergillus clavatus	49.88	5.00e-122	431.00
IUUC-Afl-008615	Aspergillus flavus	43.57	4.00e-79	288.00
IUUC-Afu-008996	Aspergillus fumigatus	50.70	1.00e-115	409.00
IUUC-Ani-009281	Aspergillus nidulans	43.53	1.00e-84	306.00
IUUC-Ang-009539	Aspergillus niger	50.82	1.00e-112	399.00
IUUC-Aor-010151	Aspergillus oryzae	48.21	5.00e-110	390.00
IUUC-Ate-010502	Aspergillus terreus	51.06	4.00e-114	404.00
IUUC-Ame-011837	Astyanax mexicanus	86.10	0.00e+00	790.00
IUUC-Bgr-012068	Blumeria graminis	50.48	6.00e-114	404.00
IUUC-Bta-013003	Bos taurus	98.49	0.00e+00	915.00
IUUC-Bci-013983	Botrytis cinerea	53.29	5.00e-124	437.00
IUUC-Bdi-014429	Brachypodium distachyon	48.76	1.00e-88	320.00
IUUC-Bol-015813	Brassica oleracea	48.39	1.00e-89	323.00
IUUC-Bra-018023	Brassica rapa	47.64	1.00e-86	313.00
IUUC-Cel-018684	Caenorhabditis elegans	53.04	6.00e-128	450.00
IUUC-Cja-019200	Callithrix jacchus	98.49	0.00e+00	910.00
IUUC-Cfa-021038	Canis familiaris	98.87	0.00e+00	915.00
IUUC-Cre-022778	Chlamydomonas reinhardtii	49.02	3.00e-107	382.00
IUUC-Csa-024079	Chlorocebus sabaeus	99.14	0.00e+00	920.00
IUUC-Cho-025052	Choloepus hoffmanni	90.27	0.00e+00	820.00
IUUC-Cin-025113	Ciona intestinalis	68.33	0.00e+00	627.00
IUUC-Csv-026231	Ciona savignyi	67.44	0.00e+00	629.00
IUUC-Cgl-026535	Colletotrichum gloeosporioides	50.69	2.00e-124	439.00
IUUC-Cne-026850	Cryptococcus neoformans	48.00	6.00e-108	384.00
IUUC-Cme-027275	Cyanidioschyzon merolae	36.22	1.00e-68	253.00
IUUC-Dre-028751	Danio rerio	86.10	0.00e+00	801.00
IUUC-Dno-029571	Dasypus novemcinctus	97.74	0.00e+00	909.00
IUUC-Dor-030395	Dipodomys ordii	97.19	0.00e+00	886.00
IUUC-Dse-031329	Dothistroma septosporum	45.29	4.00e-104	371.00
IUUC-Dme-031776	Drosophila melanogaster	64.04	1.00e-161	562.00
IUUC-Ete-032894	Echinops telfairi	77.65	2.00e-70	259.00
IUUC-Eca-034389	Equus caballus	95.46	0.00e+00	917.00
IUUC-Eeu-035152	Erinaceus europaeus	85.57	0.00e+00	689.00
IUUC-Fca-036032	Felis catus	98.65	0.00e+00	922.00
IUUC-Fal-037506	Ficedula albicollis	89.20	0.00e+00	856.00
IUUC-Fox-037871	Fusarium oxysporum	53.58	2.00e-110	392.00
IUUC-Fso-038350	Fusarium solani	51.85	3.00e-122	431.00
IUUC-Gmo-039246	Gadus morhua	83.59	0.00e+00	790.00
IUUC-Ggr-039859	Gaeumannomyces graminis	52.90	9.00e-120	423.00
IUUC-Gga-040843	Gallus gallus	87.44	0.00e+00	822.00
IUUC-Gac-042601	Gasterosteus aculeatus	84.02	0.00e+00	806.00
IUUC-Gma-043031	Glycine max	49.51	2.00e-90	326.00
IUUC-Ggo-044788	Gorilla gorilla	99.14	0.00e+00	913.00
IUUC-Hsa-045849	Homo sapiens	99.57	0.00e+00	921.00
IUUC-Hvu-047819	Hordeum vulgare	50.71	1.00e-82	300.00
IUUC-Itr-047863	Ictidomys tridecemlineatus	98.19	0.00e+00	912.00
IUUC-Kpa-049393	Komagataella pastoris	54.41	1.00e-103	369.00
IUUC-Lch-049471	Latimeria chalumnae	90.13	0.00e+00	835.00
IUUC-Lpe-051297	Leersia perrieri	48.56	5.00e-98	351.00
IUUC-Loc-052910	Lepisosteus oculatus	87.64	0.00e+00	812.00
IUUC-Lma-053181	Leptosphaeria maculans	49.77	5.00e-121	427.00
IUUC-Laf-054314	Loxodonta africana	97.43	0.00e+00	907.00
IUUC-Mcc-054870	Macaca mulatta	99.55	0.00e+00	918.00
IUUC-Meu-056574	Macropus eugenii	78.03	3.00e-130	457.00
IUUC-Mor-056919	Magnaporthe oryzae	53.72	1.00e-123	436.00
IUUC-Mpo-057614	Magnaporthe poae	54.20	2.00e-114	405.00
IUUC-Mtr-058110	Medicago truncatula	49.87	2.00e-89	322.00
IUUC-Mla-058949	Melampsora laricipopulina	52.32	1.00e-116	413.00
IUUC-Mga-059455	Meleagris gallopavo	89.85	0.00e+00	856.00
IUUC-Mvi-060270	Microbotryum violaceum	50.90	4.00e-119	421.00
IUUC-Mmr-061155	Microcebus murinus	92.95	0.00e+00	883.00
IUUC-Mdo-062037	Monodelphis domestica	95.03	0.00e+00	858.00
IUUC-Mmu-063670	Mus musculus	98.92	0.00e+00	916.00
IUUC-Mac-064711	Musa acuminata	48.14	1.00e-87	316.00
IUUC-Mpu-066734	Mustela putorius furo	98.20	0.00e+00	910.00
IUUC-Mlu-067068	Myotis lucifugus	98.06	0.00e+00	878.00
IUUC-Nfi-068349	Neosartorya fischeri	50.47	6.00e-115	407.00
IUUC-Ncr-068626	Neurospora crassa	52.50	4.00e-107	381.00
IUUC-Nle-069366	Nomascus leucogenys	91.45	0.00e+00	827.00
IUUC-Opr-070993	Ochotona princeps	93.08	6.00e-69	254.00
IUUC-Ont-072196	Oreochromis niloticus	85.13	0.00e+00	800.00
IUUC-Oan-073511	Ornithorhynchus anatinus	92.87	0.00e+00	877.00
IUUC-Ocu-073773	Oryctolagus cuniculus	98.70	0.00e+00	917.00
IUUC-Oba-075726	Oryza barthii	44.79	1.00e-85	310.00
IUUC-Obr-076286	Oryza brachyantha	47.60	9.00e-95	340.00
IUUC-Ogu-078473	Oryza glumaepatula	44.79	1.00e-85	310.00
IUUC-Oin-079393	Oryza indica	49.75	4.00e-100	358.00
IUUC-Olo-080446	Oryza longistaminata	46.39	1.00e-89	323.00
IUUC-Ome-081737	Oryza meridionalis	47.01	4.00e-89	321.00
IUUC-Oni-082853	Oryza nivara	44.79	1.00e-85	310.00
IUUC-Opu-083590	Oryza punctata	48.80	8.00e-100	357.00
IUUC-Oru-084184	Oryza rufipogon	44.79	1.00e-85	310.00
IUUC-Osa-085402	Oryza sativa	49.75	4.00e-100	358.00
IUUC-Ola-086615	Oryzias latipes	77.97	0.00e+00	736.00
IUUC-Olu-087738	Ostreococcus lucimarinus	48.15	4.00e-93	334.00
IUUC-Oga-088101	Otolemur garnettii	98.49	0.00e+00	914.00
IUUC-Oar-090293	Ovis aries	97.10	0.00e+00	907.00
IUUC-Ptr-090503	Pan troglodytes	99.57	0.00e+00	921.00
IUUC-Pan-092477	Papio anubis	97.21	0.00e+00	890.00
IUUC-Psi-093442	Pelodiscus sinensis	90.70	0.00e+00	853.00
IUUC-Pma-094247	Petromyzon marinus	80.36	0.00e+00	766.00
IUUC-Pno-094780	Phaeosphaeria nodorum	49.37	2.00e-114	405.00
IUUC-Ppa-095338	Physcomitrella patens	50.12	3.00e-116	411.00
IUUC-Pfo-097137	Poecilia formosa	84.70	0.00e+00	803.00
IUUC-Pop-099470	Populus trichocarpa	47.18	3.00e-94	338.00
IUUC-Pca-100500	Procavia capensis	79.70	0.00e+00	735.00
IUUC-Ppe-102008	Prunus persica	48.16	5.00e-86	311.00
IUUC-Pva-103095	Pteropus vampyrus	99.57	1.00e-128	452.00
IUUC-Pgr-103666	Puccinia graminis	50.58	8.00e-115	407.00
IUUC-Ptt-103901	Puccinia triticina	51.06	3.00e-117	415.00
IUUC-Pte-104198	Pyrenophora teres	48.75	2.00e-119	422.00
IUUC-Pyt-104792	Pyrenophora triticirepentis	48.07	2.00e-117	415.00
IUUC-Rno-105446	Rattus norvegicus	98.92	0.00e+00	915.00
IUUC-Sce-106355	Saccharomyces cerevisiae	43.31	1.00e-71	263.00
IUUC-Sha-106664	Sarcophilus harrisii	94.82	0.00e+00	857.00
IUUC-Sja-107982	Schizosaccharomyces japonicus	42.79	7.00e-99	353.00
IUUC-Spo-108345	Schizosaccharomyces pombe	43.30	8.00e-98	350.00
IUUC-Ssl-108540	Sclerotinia sclerotiorum	47.91	1.00e-106	380.00
IUUC-Smo-109133	Selaginella moellendorffii	49.53	1.00e-115	410.00
IUUC-Sit-109724	Setaria italica	49.01	4.00e-91	328.00
IUUC-Sly-110916	Solanum lycopersicum	48.33	4.00e-95	341.00
IUUC-Stu-112236	Solanum tuberosum	48.07	6.00e-95	340.00
IUUC-Sar-113044	Sorex araneus	97.51	0.00e+00	816.00
IUUC-Sbi-114276	Sorghum bicolor	49.13	2.00e-91	329.00
IUUC-Sre-114963	Sporisorium reilianum	51.28	2.00e-117	416.00
IUUC-Ssc-116301	Sus scrofa	97.65	0.00e+00	909.00
IUUC-Tgu-117265	Taeniopygia guttata	88.98	0.00e+00	855.00
IUUC-Tru-117526	Takifugu rubripes	83.23	0.00e+00	785.00
IUUC-Tsy-119483	Tarsius syrichta	98.07	0.00e+00	847.00
IUUC-Tni-120363	Tetraodon nigroviridis	83.84	0.00e+00	780.00
IUUC-Tca-121731	Theobroma cacao	48.36	5.00e-88	318.00
IUUC-Tre-122221	Trichoderma reesei	53.05	3.00e-111	394.00
IUUC-Tvi-122352	Trichoderma virens	51.28	3.00e-123	435.00
IUUC-Tae-123864	Triticum aestivum	48.08	2.00e-90	326.00
IUUC-Tur-126070	Triticum urartu	45.51	4.00e-71	261.00
IUUC-Tme-127199	Tuber melanosporum	50.13	6.00e-109	387.00
IUUC-Tbe-128076	Tupaia belangeri	98.64	0.00e+00	914.00
IUUC-Ttr-128695	Tursiops truncatus	82.58	0.00e+00	744.00
IUUC-Uma-129638	Ustilago maydis	50.58	5.00e-117	414.00
IUUC-Vda-129963	Verticillium dahliae	51.73	1.00e-114	406.00
IUUC-Vpa-130637	Vicugna pacos	90.95	0.00e+00	822.00
IUUC-Vvi-131613	Vitis vinifera	48.21	1.00e-84	306.00
IUUC-Xtr-132924	Xenopus tropicalis	88.81	0.00e+00	816.00
IUUC-Xma-133356	Xiphophorus maculatus	84.70	0.00e+00	803.00
IUUC-Yli-134365	Yarrowia lipolytica	51.92	1.00e-110	393.00
IUUC-Zma-135941	Zea mays	44.67	4.00e-86	311.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence