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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046678
UUCD1 version UUC-HoS-00389
Ensembl Protein ID ENSP00000294173.3
UniProt Accession Q9NSE2; B2R9N1; G5E9R1; Q9NS38; Q9Y5R1; CISH_HUMAN
Genbank Protein ID BAA92328.1; AAF97410.1; AAD28471.2; BAG36578.1; EAW65128.1; EAW65129.1; AAH31590.1; AAH64354.1
Protein Name Cytokine-inducible SH2-containing protein; CIS-1; Protein G18; Suppressor of cytokine signaling
Genbank Nucleotide ID D83532; AF035947; AF132297; AK313850; AC096920; CH471055; BC031590; BC064354
Gene Name CISH; G18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114737.15 ENST00000443053.6 ENSP00000409346.2
ENSG00000114737.15 ENST00000348721.3 ENSP00000294173.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitemiRTarBasemicroRNA
TRANSFACmiRWalkRepTarmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 19622774
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.10e-14 55.7 210 257
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           l++++++rs+ rSLqhLCRl+I+r++ +     +d+LPLP+++ dYL+++++q
   Q: 210  LVQPFVRRSSARSLQHLCRLVINRLVAD-----VDCLPLPRRMADYLRQYPFQ 257
           57999***********************.....8****************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Protein Sequence
(Fasta)
MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV 60
LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046678|E3,SOCS|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCCGCTCGTC TGGCCCGCCC CCCTCGCCCT CGCAGGCGGT CCGCGCCACT GCCTCTCAGT 60
CCCTGTCCTG CGCCCGCGCG CCCCGGGAGC CTACCCAGCA CGCGCTCCGC GCCCACTGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046678|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF07525--SOCS_box
PRINTS

PR00401--SH2DOMAIN
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
KEGG hsa:1154
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001189 Ailuropoda melanoleuca 90.51 3.00e-113 400.00
IUUC-Aca-004372 Anolis carolinensis 63.98 1.00e-87 316.00
IUUC-Ame-010787 Astyanax mexicanus 46.12 2.00e-51 194.00
IUUC-Bta-012826 Bos taurus 87.60 6.00e-120 422.00
IUUC-Cja-020004 Callithrix jacchus 94.82 7.00e-118 416.00
IUUC-Cfa-020150 Canis familiaris 89.24 1.00e-107 382.00
IUUC-Csa-023173 Chlorocebus sabaeus 96.02 9.00e-120 422.00
IUUC-Dre-028606 Danio rerio 37.66 7.00e-33 133.00
IUUC-Dno-028956 Dasypus novemcinctus 86.77 4.00e-114 403.00
IUUC-Dor-030148 Dipodomys ordii 73.64 2.00e-97 348.00
IUUC-Ete-032313 Echinops telfairi 83.20 2.00e-100 358.00
IUUC-Eca-033422 Equus caballus 90.31 6.00e-123 433.00
IUUC-Eeu-034806 Erinaceus europaeus 89.64 2.00e-110 392.00
IUUC-Fca-036374 Felis catus 89.92 3.00e-122 430.00
IUUC-Fal-036801 Ficedula albicollis 65.77 2.00e-87 315.00
IUUC-Gmo-038483 Gadus morhua 37.84 5.00e-36 144.00
IUUC-Gga-040891 Gallus gallus 66.15 2.00e-82 298.00
IUUC-Gac-042147 Gasterosteus aculeatus 39.62 3.00e-34 138.00
IUUC-Ggo-045511 Gorilla gorilla 98.80 2.00e-119 421.00
IUUC-Itr-048397 Ictidomys tridecemlineatus 83.39 2.00e-122 431.00
IUUC-Lch-050555 Latimeria chalumnae 55.73 2.00e-70 258.00
IUUC-Laf-054141 Loxodonta africana 86.87 5.00e-116 410.00
IUUC-Mcc-055401 Macaca mulatta 96.41 2.00e-119 421.00
IUUC-Meu-056592 Macropus eugenii 69.44 4.00e-93 333.00
IUUC-Mga-059515 Meleagris gallopavo 64.86 5.00e-78 283.00
IUUC-Mmr-060848 Microcebus murinus 91.24 7.00e-120 423.00
IUUC-Mdo-062720 Monodelphis domestica 67.83 5.00e-94 337.00
IUUC-Mmu-063348 Mus musculus 88.37 1.00e-126 445.00
IUUC-Mpu-065834 Mustela putorius furo 79.20 2.00e-115 407.00
IUUC-Mlu-067687 Myotis lucifugus 77.70 4.00e-97 347.00
IUUC-Nle-069277 Nomascus leucogenys 98.06 1.00e-125 442.00
IUUC-Ont-071890 Oreochromis niloticus 45.83 1.00e-35 142.00
IUUC-Oan-073672 Ornithorhynchus anatinus 65.38 3.00e-86 311.00
IUUC-Ocu-073875 Oryctolagus cuniculus 88.84 1.00e-112 399.00
IUUC-Ola-087140 Oryzias latipes 55.29 1.00e-23 102.00
IUUC-Oga-087943 Otolemur garnettii 89.15 4.00e-115 407.00
IUUC-Oar-090194 Ovis aries 87.75 3.00e-117 414.00
IUUC-Ptr-090934 Pan troglodytes 99.60 2.00e-120 424.00
IUUC-Pan-092121 Papio anubis 96.51 2.00e-124 437.00
IUUC-Psi-093733 Pelodiscus sinensis 62.45 1.00e-83 302.00
IUUC-Pfo-096313 Poecilia formosa 47.52 1.00e-42 166.00
IUUC-Pab-098439 Pongo abelii 98.84 9.00e-125 439.00
IUUC-Pca-101010 Procavia capensis 86.87 2.00e-114 404.00
IUUC-Pva-103112 Pteropus vampyrus 87.98 6.00e-125 439.00
IUUC-Rno-105917 Rattus norvegicus 82.66 5.00e-113 400.00
IUUC-Sha-106954 Sarcophilus harrisii 66.67 6.00e-93 333.00
IUUC-Smo-109292 Selaginella moellendorffii 31.15 2.30e-01 30.80
IUUC-Sar-113001 Sorex araneus 89.24 2.00e-109 388.00
IUUC-Ssc-115922 Sus scrofa 91.49 2.00e-65 241.00
IUUC-Tgu-117338 Taeniopygia guttata 65.22 1.00e-83 302.00
IUUC-Tru-118511 Takifugu rubripes 43.48 2.00e-31 129.00
IUUC-Tsy-119434 Tarsius syrichta 89.64 5.00e-115 406.00
IUUC-Tni-119837 Tetraodon nigroviridis 42.13 3.00e-28 118.00
IUUC-Tca-120923 Theobroma cacao 24.68 4.90e-02 30.40
IUUC-Ttr-128340 Tursiops truncatus 75.19 2.00e-78 284.00
IUUC-Vpa-130443 Vicugna pacos 89.53 1.00e-128 452.00
IUUC-Xtr-131784 Xenopus tropicalis 54.58 8.00e-68 249.00
Created Date 25-Jun-2017

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