iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.10e-09	36.4	328	366
UBD/Alpha-Helix/CUE	1.10e-11	44.7	443	484

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 328  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 366
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 443  QLNAMAHQIQEMFPQVPYHLVLQDL-QMTRSVEITTDNILEGR 484
           5889*********************.***************95 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

LRTYTGLSGL ALLGTIVSAY RALSQPEDGS GEPEPLTAPL QPEALAPARL TPGGPRVRDV 60
AQYLLSDSLF VWVLVNTACC VLMLVAKLIQ CIVFGPLRVS ERQHLKDKFW NFIFYKFIFI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCGCACTT ACACGGGCCT CAGCGGCCTG GCCTTGCTGG GCACCATCGT CAGCGCCTAC 60
CGCGCCCTCA GCCAGCCCGA GGACGGGTCG GGCGAGCCGG AGCCGCTAAC GGCCCCACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030426--C:growth cone
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0007568--P:aging
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0007611--P:learning or memory
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	91.68	0.00e+00	991.00
IUUC-Apl-003404	Anas platyrhynchos	85.94	0.00e+00	910.00
IUUC-Aca-004559	Anolis carolinensis	83.40	0.00e+00	845.00
IUUC-Ame-011640	Astyanax mexicanus	68.29	0.00e+00	780.00
IUUC-Bta-012980	Bos taurus	86.93	0.00e+00	1023.00
IUUC-Cel-018598	Caenorhabditis elegans	24.26	2.00e-33	137.00
IUUC-Cja-019577	Callithrix jacchus	92.22	0.00e+00	1129.00
IUUC-Cfa-020793	Canis familiaris	92.32	0.00e+00	985.00
IUUC-Cpo-022387	Cavia porcellus	92.70	0.00e+00	1119.00
IUUC-Csa-023168	Chlorocebus sabaeus	92.70	0.00e+00	1141.00
IUUC-Cho-024433	Choloepus hoffmanni	93.62	0.00e+00	811.00
IUUC-Cin-025215	Ciona intestinalis	46.35	5.00e-140	491.00
IUUC-Csv-026133	Ciona savignyi	44.56	6.00e-127	447.00
IUUC-Dre-027594	Danio rerio	67.58	0.00e+00	742.00
IUUC-Dno-029407	Dasypus novemcinctus	94.09	0.00e+00	986.00
IUUC-Dor-030961	Dipodomys ordii	94.80	0.00e+00	1015.00
IUUC-Ete-032962	Echinops telfairi	85.13	0.00e+00	837.00
IUUC-Eca-033683	Equus caballus	87.32	0.00e+00	1015.00
IUUC-Eeu-034515	Erinaceus europaeus	97.04	8.00e-78	284.00
IUUC-Fca-035398	Felis catus	94.14	0.00e+00	955.00
IUUC-Fal-036758	Ficedula albicollis	79.68	0.00e+00	851.00
IUUC-Gmo-039014	Gadus morhua	67.73	0.00e+00	725.00
IUUC-Gga-040575	Gallus gallus	86.16	0.00e+00	961.00
IUUC-Gac-041414	Gasterosteus aculeatus	67.34	0.00e+00	708.00
IUUC-Hsa-046272	Homo sapiens	92.38	0.00e+00	1106.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	93.59	0.00e+00	1004.00
IUUC-Lch-050491	Latimeria chalumnae	75.39	0.00e+00	815.00
IUUC-Loc-052758	Lepisosteus oculatus	74.37	0.00e+00	800.00
IUUC-Laf-053452	Loxodonta africana	94.11	0.00e+00	1001.00
IUUC-Mcc-055820	Macaca mulatta	93.61	0.00e+00	997.00
IUUC-Meu-056726	Macropus eugenii	83.11	0.00e+00	802.00
IUUC-Mga-059937	Meleagris gallopavo	85.17	0.00e+00	919.00
IUUC-Mmr-060730	Microcebus murinus	89.84	0.00e+00	1072.00
IUUC-Mdo-062771	Monodelphis domestica	87.06	0.00e+00	1011.00
IUUC-Mmu-064219	Mus musculus	96.72	0.00e+00	1166.00
IUUC-Mpu-066796	Mustela putorius furo	93.07	0.00e+00	988.00
IUUC-Mlu-068189	Myotis lucifugus	91.43	0.00e+00	979.00
IUUC-Nle-069239	Nomascus leucogenys	91.92	0.00e+00	1108.00
IUUC-Opr-070702	Ochotona princeps	88.77	3.00e-139	488.00
IUUC-Ont-072033	Oreochromis niloticus	69.98	0.00e+00	780.00
IUUC-Oan-073717	Ornithorhynchus anatinus	83.20	0.00e+00	843.00
IUUC-Ocu-074145	Oryctolagus cuniculus	91.11	0.00e+00	1092.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	1.00e-11	62.40
IUUC-Ola-087152	Oryzias latipes	68.18	0.00e+00	751.00
IUUC-Oga-088486	Otolemur garnettii	94.32	0.00e+00	1010.00
IUUC-Oar-089310	Ovis aries	92.68	0.00e+00	1009.00
IUUC-Ptr-090649	Pan troglodytes	93.55	0.00e+00	1016.00
IUUC-Pan-091692	Papio anubis	88.41	0.00e+00	1042.00
IUUC-Psi-093064	Pelodiscus sinensis	92.21	0.00e+00	749.00
IUUC-Pma-094763	Petromyzon marinus	77.25	8.00e-91	326.00
IUUC-Ppa-095969	Physcomitrella patens	29.38	6.00e-35	142.00
IUUC-Pfo-096810	Poecilia formosa	68.35	0.00e+00	756.00
IUUC-Pab-097859	Pongo abelii	93.61	0.00e+00	999.00
IUUC-Pop-099576	Populus trichocarpa	27.06	1.00e-28	121.00
IUUC-Pca-100344	Procavia capensis	89.08	0.00e+00	1029.00
IUUC-Pva-103114	Pteropus vampyrus	65.77	0.00e+00	677.00
IUUC-Sha-107015	Sarcophilus harrisii	91.46	0.00e+00	961.00
IUUC-Smo-109664	Selaginella moellendorffii	31.21	5.00e-32	132.00
IUUC-Sar-113397	Sorex araneus	94.61	0.00e+00	735.00
IUUC-Ssc-115988	Sus scrofa	89.93	3.00e-140	491.00
IUUC-Tgu-116717	Taeniopygia guttata	87.04	0.00e+00	914.00
IUUC-Tru-117805	Takifugu rubripes	66.93	0.00e+00	776.00
IUUC-Tsy-119442	Tarsius syrichta	87.81	0.00e+00	912.00
IUUC-Tni-119777	Tetraodon nigroviridis	70.60	2.00e-165	575.00
IUUC-Tbe-127322	Tupaia belangeri	66.27	7.00e-109	387.00
IUUC-Ttr-128181	Tursiops truncatus	92.29	0.00e+00	1006.00
IUUC-Vpa-130483	Vicugna pacos	83.10	0.00e+00	638.00
IUUC-Xtr-132614	Xenopus tropicalis	77.37	0.00e+00	763.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence