iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059243

UUCD1 version

UUC-MeG-00527

Ensembl Protein ID

ENSMGAP00000012149.1

UniProt Accession

G1NGE2; G1NGE2_MELGA

Protein Name

Apoptotic protease-activating factor 1

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000011573.1	ENSMGAT00000013036.1	ENSMGAP00000012149.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-62	203.0	741	779
UBD/Beta-Prp	9.50e-126	418.7	614	912

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           gH + v+ ++f  +d++++s+s Dgt+k+WD+r+ + lk
   Q: 741  GHVNAVSHCRFspNDDYIASCSTDGTVKLWDVRSANELK 779
           89999*******666******************998876 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h + ++  +fs+d++ +a+ ++d+t++v+++++g  l ++s h++e+ +++fs d+k+ +t+s D+ +k+w+ +tgkc++++++h+++v
   Q: 614  HRDAVYHACFSRDRQRIASCGADKTLQVFKAESGERLLEISAHDDEILCCTFSADDKYVATCSADKKVKIWNSRTGKCLYVYEEHTEQV 702
           44555669********************************************************************************* PP
   S: 98   lslsfsp..sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl......... 175
            +++f+   s++ l++ s+d  i++w+l+ ++c + t  gh  +v++ +++p++++++s+s+D+tv+lWd+++++ l+t          
   Q: 703  NCCQFNNsrSQYLLATCSDDTFIKLWNLKDKYCRN-TMFGHVNAVSHCRFSPNDDYIASCSTDGTVKLWDVRSANELKTIeikeffrna 790
           *******76669999********************.***********************************999999999999999986 PP
   S: 176  tgghtdsvysls....fdsng.........................................kelvsgsl.dgtvklwdlqtgecvrtl 218
            + ++d+v+ l     +++++                                          elv+++l   +v+lw++++ + v  +
   Q: 791  DE-QQDDVEVLVkccsWSRSSdtilvvaknklllfdvttcnlvtqviishhstiqycdfcagDELVAVALsHCSVELWNIKSLSKVADC 878
           33.55665555556668888844444444444444444455555555555555555555555444444431335555555555555555 PP
   S: 219  nghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           +gh ++v +v fs+++ ++++ s+D++iriW                                           + +
   Q: 879  RGHMSWVHCVTFSSDGSLFLTSSEDQTIRIW-------------------------------------------ETN 912
           5555555555555555555555555555555...........................................433 PP

Organism

Meleagris gallopavo

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

NMDAKSRTCL IRHRQALEKD IKTSYIMDCM VSDQVLTLQE EEKVKQQNTQ KERAAMLIDT 60
LLKKDNNAYR SFYNALLHEG YRDLAALLQD GIPVFFSGNG KNTMDEMTSY VKTTLCEGGV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATATGGATG CGAAGAGTAG AACGTGTTTA ATTAGGCATC GTCAGGCACT GGAGAAAGAC 60
ATCAAAACCT CTTACATTAT GGATTGTATG GTTTCTGACC AAGTCCTGAC ATTGCAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	70.06	0.00e+00	1833.00
IUUC-Apl-004201	Anas platyrhynchos	90.79	0.00e+00	2326.00
IUUC-Aca-004638	Anolis carolinensis	70.02	0.00e+00	1872.00
IUUC-Ani-009285	Aspergillus nidulans	25.84	2.00e-62	234.00
IUUC-Ang-009637	Aspergillus niger	24.50	1.00e-28	122.00
IUUC-Ame-011062	Astyanax mexicanus	53.92	0.00e+00	1366.00
IUUC-Bta-012865	Bos taurus	69.99	0.00e+00	1868.00
IUUC-Cel-018376	Caenorhabditis elegans	20.24	1.00e-25	112.00
IUUC-Cja-018815	Callithrix jacchus	65.05	0.00e+00	1677.00
IUUC-Cfa-020222	Canis familiaris	66.56	0.00e+00	1715.00
IUUC-Cpo-021524	Cavia porcellus	69.19	0.00e+00	1837.00
IUUC-Csa-023861	Chlorocebus sabaeus	70.31	0.00e+00	1847.00
IUUC-Cho-024484	Choloepus hoffmanni	59.31	0.00e+00	915.00
IUUC-Dre-028006	Danio rerio	52.31	0.00e+00	1268.00
IUUC-Dno-029591	Dasypus novemcinctus	71.03	0.00e+00	1875.00
IUUC-Dor-030237	Dipodomys ordii	57.46	0.00e+00	821.00
IUUC-Ete-032620	Echinops telfairi	66.77	0.00e+00	862.00
IUUC-Eca-033569	Equus caballus	70.79	0.00e+00	1854.00
IUUC-Eeu-035354	Erinaceus europaeus	49.79	7.00e-134	471.00
IUUC-Fca-036337	Felis catus	69.86	0.00e+00	1862.00
IUUC-Fal-037077	Ficedula albicollis	87.34	0.00e+00	2260.00
IUUC-Gmo-039687	Gadus morhua	48.27	0.00e+00	899.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.62	8.00e-38	152.00
IUUC-Gga-040299	Gallus gallus	95.43	0.00e+00	2471.00
IUUC-Gac-041762	Gasterosteus aculeatus	51.74	0.00e+00	1269.00
IUUC-Ggo-045563	Gorilla gorilla	70.55	0.00e+00	1858.00
IUUC-Hsa-046771	Homo sapiens	70.39	0.00e+00	1855.00
IUUC-Lch-050200	Latimeria chalumnae	65.31	0.00e+00	1652.00
IUUC-Loc-052090	Lepisosteus oculatus	58.25	0.00e+00	1520.00
IUUC-Laf-053861	Loxodonta africana	69.62	0.00e+00	1837.00
IUUC-Mcc-055543	Macaca mulatta	70.15	0.00e+00	1840.00
IUUC-Meu-056688	Macropus eugenii	69.59	0.00e+00	1797.00
IUUC-Mmr-061134	Microcebus murinus	66.99	0.00e+00	1580.00
IUUC-Mdo-062913	Monodelphis domestica	69.11	0.00e+00	1806.00
IUUC-Mmu-063811	Mus musculus	69.19	0.00e+00	1840.00
IUUC-Mpu-066780	Mustela putorius furo	70.26	0.00e+00	1822.00
IUUC-Mlu-067276	Myotis lucifugus	70.49	0.00e+00	1864.00
IUUC-Nle-069129	Nomascus leucogenys	70.15	0.00e+00	1845.00
IUUC-Opr-071007	Ochotona princeps	51.35	0.00e+00	841.00
IUUC-Ont-071348	Oreochromis niloticus	53.42	0.00e+00	1385.00
IUUC-Oan-072717	Ornithorhynchus anatinus	71.91	0.00e+00	1902.00
IUUC-Ocu-074286	Oryctolagus cuniculus	69.44	0.00e+00	1551.00
IUUC-Ola-086895	Oryzias latipes	49.01	0.00e+00	1182.00
IUUC-Oga-088678	Otolemur garnettii	69.27	0.00e+00	1828.00
IUUC-Oar-089359	Ovis aries	70.07	0.00e+00	1863.00
IUUC-Ptr-091062	Pan troglodytes	70.31	0.00e+00	1855.00
IUUC-Pan-092528	Papio anubis	74.36	0.00e+00	1152.00
IUUC-Psi-093430	Pelodiscus sinensis	77.59	0.00e+00	2022.00
IUUC-Pma-094690	Petromyzon marinus	37.21	2.00e-146	512.00
IUUC-Pfo-097204	Poecilia formosa	53.49	0.00e+00	1368.00
IUUC-Pab-097690	Pongo abelii	70.63	0.00e+00	1861.00
IUUC-Pca-100778	Procavia capensis	54.26	0.00e+00	899.00
IUUC-Pva-102870	Pteropus vampyrus	68.42	0.00e+00	1667.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	25.83	8.00e-60	225.00
IUUC-Rno-104889	Rattus norvegicus	69.35	0.00e+00	1815.00
IUUC-Sha-107465	Sarcophilus harrisii	69.35	0.00e+00	1843.00
IUUC-Sar-113268	Sorex araneus	66.95	6.00e-144	504.00
IUUC-Ssc-115654	Sus scrofa	69.75	0.00e+00	1858.00
IUUC-Tgu-117302	Taeniopygia guttata	88.78	0.00e+00	2302.00
IUUC-Tru-118363	Takifugu rubripes	53.34	0.00e+00	1360.00
IUUC-Tsy-119007	Tarsius syrichta	68.16	0.00e+00	1778.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.03	0.00e+00	1314.00
IUUC-Tbe-127413	Tupaia belangeri	59.87	0.00e+00	1099.00
IUUC-Ttr-129213	Tursiops truncatus	64.33	0.00e+00	1669.00
IUUC-Vpa-130146	Vicugna pacos	65.38	0.00e+00	1262.00
IUUC-Xtr-132559	Xenopus tropicalis	59.54	0.00e+00	1551.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence