iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027701

UUCD1 version

UUC-DaR-01356

Ensembl Protein ID

ENSDARP00000052745.4

UniProt Accession

Q9DDJ0; UBC9B_DANRE

Genbank Protein ID

AAG48365.1; AAH66609.1; AAH58302.1

Protein Name

SUMO-conjugating enzyme UBC9-B; RING-type E3 SUMO transferase UBC9-B; SUMO-protein ligase B; Ubiquitin carrier protein 9-B; Ubiquitin carrier protein I-B; Ubiquitin-conjugating enzyme E2 I-B; Ubiquitin-protein ligase I-B

Genbank Nucleotide ID

AF332623; BC066609; BC058302

Gene Name

ube2ia; ube2ib; ubc9b; ube2i2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000052649.5	ENSDART00000052746.6	ENSDARP00000052745.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.30e-49	168.5	8	149

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd....ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsi 85
           Rl++e k+++kd+p g++a p+++ d    l++we++i G+++tp+egg+Fkl++ f++dYP++PPk+kf+ ++fhPnvy++G+vClsi
   Q: 8    RLAQERKAWRKDHPFGFVAVPTKNPDgtmnLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSI 96
           99*****************99998877777*********************************************************** PP
   S: 86   lkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           l+e+++W+pa++++++ll+iq+ll+epn+++p+++ea++++++nr ey+k+vr
   Q: 97   LEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVR 149
           ***************************************************98 PP

Organism

Danio rerio

Functional Description
(View)

Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis.

Protein Sequence
(Fasta)

MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG TPWEGGLFKL 60
RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED KDWRPAITIK QILLGIQELL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTTATTCC ACTAATTACA ACATATAAAC GAGTATGGTT TGAATTATTT CATTAATCAG 60
TTAATTGTAC GTGGTTAACC TTAAATTCAA GGTTCAGGTG AAATCCATCA GCTTGTGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR027230--Ubc9
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0019789--F:SUMO transferase activity
GO:0051301--P:cell division
GO:0007059--P:chromosome segregation
GO:0060216--P:definitive hemopoiesis
GO:0007067--P:mitotic nuclear division

KEGG

dre:114445

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002383	Ailuropoda melanoleuca	99.36	1.00e-91	328.00
IUUC-Apl-003840	Anas platyrhynchos	99.36	1.00e-91	328.00
IUUC-Aca-004772	Anolis carolinensis	99.36	1.00e-91	328.00
IUUC-Ago-007998	Ashbya gossypii	57.05	7.00e-53	199.00
IUUC-Acl-008040	Aspergillus clavatus	63.16	7.00e-50	189.00
IUUC-Ani-009222	Aspergillus nidulans	64.47	1.00e-50	192.00
IUUC-Ame-011711	Astyanax mexicanus	94.27	3.00e-88	316.00
IUUC-Bgr-012012	Blumeria graminis	55.92	2.00e-48	184.00
IUUC-Bta-013269	Bos taurus	99.36	1.00e-91	328.00
IUUC-Cja-019349	Callithrix jacchus	99.36	1.00e-91	328.00
IUUC-Cfa-021008	Canis familiaris	99.11	8.00e-65	238.00
IUUC-Cpo-021324	Cavia porcellus	99.36	1.00e-91	328.00
IUUC-Cre-022836	Chlamydomonas reinhardtii	61.15	6.00e-57	213.00
IUUC-Csa-024207	Chlorocebus sabaeus	99.36	1.00e-91	328.00
IUUC-Cin-025734	Ciona intestinalis	83.33	5.00e-79	286.00
IUUC-Csv-026049	Ciona savignyi	82.05	9.00e-78	282.00
IUUC-Cgl-026699	Colletotrichum gloeosporioides	63.70	3.00e-54	204.00
IUUC-Cne-027034	Cryptococcus neoformans	61.78	6.00e-60	223.00
IUUC-Dno-030037	Dasypus novemcinctus	99.36	1.00e-91	328.00
IUUC-Dor-030622	Dipodomys ordii	98.54	3.00e-78	283.00
IUUC-Dme-031818	Drosophila melanogaster	85.90	1.00e-81	294.00
IUUC-Ete-032517	Echinops telfairi	100.00	2.00e-79	287.00
IUUC-Eca-033789	Equus caballus	99.36	1.00e-91	328.00
IUUC-Fca-035851	Felis catus	99.36	1.00e-91	328.00
IUUC-Fal-037177	Ficedula albicollis	99.36	1.00e-91	328.00
IUUC-Fox-037789	Fusarium oxysporum	62.50	2.00e-57	214.00
IUUC-Gmo-039482	Gadus morhua	100.00	5.00e-92	329.00
IUUC-Gga-041199	Gallus gallus	99.36	1.00e-91	328.00
IUUC-Gac-042250	Gasterosteus aculeatus	100.00	5.00e-92	329.00
IUUC-Ggo-045530	Gorilla gorilla	99.36	1.00e-91	328.00
IUUC-Hsa-046248	Homo sapiens	99.36	1.00e-91	328.00
IUUC-Itr-048429	Ictidomys tridecemlineatus	99.36	1.00e-91	328.00
IUUC-Kpa-049362	Komagataella pastoris	58.97	3.00e-53	200.00
IUUC-Lch-050644	Latimeria chalumnae	96.82	4.00e-90	323.00
IUUC-Loc-052357	Lepisosteus oculatus	100.00	7.00e-92	328.00
IUUC-Laf-053577	Loxodonta africana	99.36	1.00e-91	328.00
IUUC-Mcc-054925	Macaca mulatta	99.36	1.00e-91	328.00
IUUC-Meu-056094	Macropus eugenii	81.75	3.00e-60	223.00
IUUC-Mor-057141	Magnaporthe oryzae	61.22	7.00e-56	209.00
IUUC-Mpo-057613	Magnaporthe poae	65.19	5.00e-52	196.00
IUUC-Mtr-058465	Medicago truncatula	67.10	2.00e-62	231.00
IUUC-Mga-059384	Meleagris gallopavo	99.36	1.00e-91	328.00
IUUC-Mmr-061541	Microcebus murinus	99.36	1.00e-91	328.00
IUUC-Mdo-062540	Monodelphis domestica	99.36	1.00e-91	328.00
IUUC-Mmu-063818	Mus musculus	99.36	1.00e-91	328.00
IUUC-Mpu-065734	Mustela putorius furo	99.36	1.00e-91	328.00
IUUC-Mlu-067619	Myotis lucifugus	99.36	1.00e-91	328.00
IUUC-Ncr-068897	Neurospora crassa	65.31	9.00e-57	212.00
IUUC-Nle-069541	Nomascus leucogenys	99.36	6.00e-91	325.00
IUUC-Ont-071585	Oreochromis niloticus	100.00	5.00e-92	329.00
IUUC-Oan-073178	Ornithorhynchus anatinus	100.00	3.00e-42	162.00
IUUC-Ocu-074588	Oryctolagus cuniculus	91.72	2.00e-81	293.00
IUUC-Obr-076199	Oryza brachyantha	64.74	4.00e-59	220.00
IUUC-Ola-086314	Oryzias latipes	95.54	6.00e-89	319.00
IUUC-Olu-087715	Ostreococcus lucimarinus	54.09	5.00e-48	183.00
IUUC-Oga-088729	Otolemur garnettii	100.00	1.00e-79	287.00
IUUC-Oar-090221	Ovis aries	99.36	2.00e-91	327.00
IUUC-Ptr-090528	Pan troglodytes	99.36	1.00e-91	328.00
IUUC-Pan-092834	Papio anubis	99.36	1.00e-91	328.00
IUUC-Psi-093001	Pelodiscus sinensis	99.36	1.00e-91	328.00
IUUC-Pma-094539	Petromyzon marinus	96.18	7.00e-90	322.00
IUUC-Pfo-097457	Poecilia formosa	99.36	1.00e-91	328.00
IUUC-Pab-098205	Pongo abelii	99.36	1.00e-91	328.00
IUUC-Pca-100603	Procavia capensis	100.00	4.00e-79	286.00
IUUC-Pva-103251	Pteropus vampyrus	78.10	7.00e-56	209.00
IUUC-Rno-105794	Rattus norvegicus	99.36	1.00e-91	328.00
IUUC-Sha-106997	Sarcophilus harrisii	89.94	1.00e-81	295.00
IUUC-Sja-108000	Schizosaccharomyces japonicus	67.53	1.00e-55	208.00
IUUC-Spo-108311	Schizosaccharomyces pombe	65.61	1.00e-54	205.00
IUUC-Ssc-116173	Sus scrofa	99.36	1.00e-91	328.00
IUUC-Tgu-116668	Taeniopygia guttata	99.36	1.00e-91	328.00
IUUC-Tru-118365	Takifugu rubripes	98.09	2.00e-90	324.00
IUUC-Tni-120455	Tetraodon nigroviridis	95.54	9.00e-89	318.00
IUUC-Tca-120956	Theobroma cacao	65.38	8.00e-59	219.00
IUUC-Tre-121927	Trichoderma reesei	63.95	1.00e-57	215.00
IUUC-Tvi-122363	Trichoderma virens	63.95	3.00e-57	213.00
IUUC-Tme-126981	Tuber melanosporum	55.10	2.00e-37	147.00
IUUC-Ttr-128280	Tursiops truncatus	100.00	2.00e-48	183.00
IUUC-Vda-129845	Verticillium dahliae	65.99	6.00e-58	216.00
IUUC-Vpa-130242	Vicugna pacos	100.00	2.00e-79	287.00
IUUC-Xtr-132540	Xenopus tropicalis	99.36	2.00e-91	327.00
IUUC-Xma-133010	Xiphophorus maculatus	99.36	1.00e-91	328.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence