iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062532

UUCD1 version

UUC-MoD-01064

Ensembl Protein ID

ENSMODP00000028230.1

UniProt Accession

F7C8D9; F7C8D9_MONDO

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000006838.4	ENSMODT00000029811.1	ENSMODP00000028230.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	4.10e-131	438.1	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+g +t+vD+++v+ ++ +++F+++++++gk++A++a+e l+eln+dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGAFTIVDGNQVSGEDAGNNFFLQRSSIGKNRAQAAMELLQELNSDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ee++++l ++++ Ff++fdvVv+++ ++++ ++++++++na++pl+ ++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEENPEKLLDNDPsFFCRFDVVVATQLPESTLLHLAEILWNACIPLLVCRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke++++++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHIQsydldhmekKDHSHTPWIVIIAKYLAQWYSEKNGQIPKTYKEKEAFRELIRQGILKnengvpEDEENFEEAIKNVNTALSTT 279
           *****88888888888***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk+++ fw+                                                              
   Q: 280  QIPSsIEDIFNDDHCINITKQSPHFWIlaralkefvamegqgslpvrgtipdmiadsgkfiklqniyrekaktdaaavgnhaakllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +c+n++ l+v            ++v+kde+++++++p     lyl++ra++rf+k++gr+pg+ ++++++d+  +
   Q: 369  gqapesisqkelkLLCNNSAFLRVVrcrslaeeyglDTVNKDEITSSMDNPdseivLYLMIRAVDRFQKQYGRYPGVYNYQVEEDIgkL 457
           ************999999999997777777777888*************99**********************************9999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t+++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTSFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           99***999....********************************************************9776 PP

Organism

Monodelphis domestica

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

QSEVGKLPKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGAFTIV 60
DGNQVSGEDA GNNFFLQRSS IGKNRAQAAM ELLQELNSDV SGSFVEENPE KLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTCCGAGG TGGGGAAGCT GCCCAAGGAG CAGAAGTATG ACCGGCAGCT GAGGTGAGTG 60
AGGGGAGGAG GCAGCAGGTG CTTCCGCCGA GCCCCGGCCC AGGCCAGGCT GCTCAGGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	43.13	7.00e-126	444.00
IUUC-Aml-002333	Ailuropoda melanoleuca	91.03	0.00e+00	1025.00
IUUC-Atr-002644	Amborella trichopoda	41.14	8.00e-113	400.00
IUUC-Apl-003446	Anas platyrhynchos	84.97	0.00e+00	929.00
IUUC-Aca-004450	Anolis carolinensis	81.27	0.00e+00	926.00
IUUC-Aly-006187	Arabidopsis lyrata	40.46	1.00e-124	439.00
IUUC-Ath-007600	Arabidopsis thaliana	41.48	5.00e-127	447.00
IUUC-Ago-007900	Ashbya gossypii	26.69	7.00e-38	151.00
IUUC-Acl-008333	Aspergillus clavatus	35.00	7.00e-82	298.00
IUUC-Afl-008529	Aspergillus flavus	35.73	6.00e-87	314.00
IUUC-Afu-009071	Aspergillus fumigatus	33.69	2.00e-81	296.00
IUUC-Ani-009443	Aspergillus nidulans	33.94	2.00e-79	289.00
IUUC-Ang-009669	Aspergillus niger	33.87	9.00e-84	304.00
IUUC-Aor-009914	Aspergillus oryzae	35.05	9.00e-84	304.00
IUUC-Ate-010450	Aspergillus terreus	34.65	1.00e-84	307.00
IUUC-Ame-011183	Astyanax mexicanus	72.78	0.00e+00	833.00
IUUC-Bgr-012111	Blumeria graminis	32.79	2.00e-63	236.00
IUUC-Bta-012583	Bos taurus	91.37	0.00e+00	1027.00
IUUC-Bci-013892	Botrytis cinerea	33.39	7.00e-66	244.00
IUUC-Bdi-014592	Brachypodium distachyon	43.92	8.00e-128	450.00
IUUC-Bol-016399	Brassica oleracea	40.49	1.00e-125	443.00
IUUC-Bra-017506	Brassica rapa	39.32	5.00e-120	424.00
IUUC-Cel-018456	Caenorhabditis elegans	36.38	8.00e-94	337.00
IUUC-Cja-020007	Callithrix jacchus	90.86	0.00e+00	1021.00
IUUC-Cfa-020324	Canis familiaris	91.18	0.00e+00	1025.00
IUUC-Cpo-022248	Cavia porcellus	62.10	6.00e-172	597.00
IUUC-Csa-023149	Chlorocebus sabaeus	91.59	0.00e+00	872.00
IUUC-Cho-024537	Choloepus hoffmanni	79.83	0.00e+00	758.00
IUUC-Cin-025763	Ciona intestinalis	50.66	7.00e-157	546.00
IUUC-Csv-026113	Ciona savignyi	46.85	8.00e-147	513.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.10	3.00e-65	243.00
IUUC-Cne-026884	Cryptococcus neoformans	30.63	1.00e-71	264.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.22	2.00e-18	87.00
IUUC-Dre-028140	Danio rerio	74.29	0.00e+00	856.00
IUUC-Dno-030033	Dasypus novemcinctus	90.25	0.00e+00	902.00
IUUC-Dor-030513	Dipodomys ordii	65.50	3.00e-110	392.00
IUUC-Dse-031536	Dothistroma septosporum	35.12	4.00e-84	305.00
IUUC-Dme-031683	Drosophila melanogaster	45.22	7.00e-129	454.00
IUUC-Ete-032420	Echinops telfairi	78.49	0.00e+00	840.00
IUUC-Eca-033992	Equus caballus	91.69	0.00e+00	861.00
IUUC-Eeu-034713	Erinaceus europaeus	75.98	4.00e-111	394.00
IUUC-Fca-036548	Felis catus	89.87	0.00e+00	1010.00
IUUC-Fal-037600	Ficedula albicollis	81.23	0.00e+00	893.00
IUUC-Fox-038037	Fusarium oxysporum	33.69	3.00e-75	275.00
IUUC-Fso-038387	Fusarium solani	34.34	6.00e-78	285.00
IUUC-Gmo-038562	Gadus morhua	72.35	0.00e+00	832.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.71	1.00e-73	270.00
IUUC-Gga-041129	Gallus gallus	84.98	0.00e+00	938.00
IUUC-Gac-042558	Gasterosteus aculeatus	74.01	0.00e+00	842.00
IUUC-Gma-043610	Glycine max	41.44	3.00e-120	425.00
IUUC-Ggo-045611	Gorilla gorilla	91.04	0.00e+00	1024.00
IUUC-Hsa-046563	Homo sapiens	91.74	0.00e+00	1030.00
IUUC-Hvu-047790	Hordeum vulgare	39.14	2.00e-78	286.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	91.18	0.00e+00	1022.00
IUUC-Kpa-049309	Komagataella pastoris	34.35	3.00e-78	285.00
IUUC-Lch-050038	Latimeria chalumnae	76.49	0.00e+00	858.00
IUUC-Lpe-051535	Leersia perrieri	41.65	6.00e-111	394.00
IUUC-Loc-051917	Lepisosteus oculatus	70.30	0.00e+00	796.00
IUUC-Lma-053112	Leptosphaeria maculans	34.22	5.00e-84	305.00
IUUC-Laf-053690	Loxodonta africana	91.18	0.00e+00	1026.00
IUUC-Mcc-055117	Macaca mulatta	89.57	0.00e+00	1006.00
IUUC-Meu-056761	Macropus eugenii	80.82	0.00e+00	870.00
IUUC-Mor-057230	Magnaporthe oryzae	34.16	3.00e-77	282.00
IUUC-Mpo-057514	Magnaporthe poae	34.00	7.00e-73	268.00
IUUC-Mtr-058551	Medicago truncatula	40.77	2.00e-118	419.00
IUUC-Mla-059183	Melampsora laricipopulina	36.84	5.00e-96	345.00
IUUC-Mga-060144	Meleagris gallopavo	83.78	0.00e+00	919.00
IUUC-Mvi-060221	Microbotryum violaceum	34.88	2.00e-79	290.00
IUUC-Mmr-061325	Microcebus murinus	88.25	0.00e+00	993.00
IUUC-Mmu-063956	Mus musculus	90.62	0.00e+00	1019.00
IUUC-Mac-064521	Musa acuminata	40.45	7.00e-119	421.00
IUUC-Mpu-066716	Mustela putorius furo	89.82	0.00e+00	959.00
IUUC-Mlu-067459	Myotis lucifugus	89.87	0.00e+00	1004.00
IUUC-Nfi-068245	Neosartorya fischeri	34.05	1.00e-81	297.00
IUUC-Ncr-068910	Neurospora crassa	34.54	1.00e-77	284.00
IUUC-Nle-070034	Nomascus leucogenys	89.02	0.00e+00	986.00
IUUC-Opr-070552	Ochotona princeps	83.00	0.00e+00	840.00
IUUC-Ont-071426	Oreochromis niloticus	75.05	0.00e+00	863.00
IUUC-Oan-073389	Ornithorhynchus anatinus	85.62	0.00e+00	799.00
IUUC-Ocu-074911	Oryctolagus cuniculus	90.24	0.00e+00	1020.00
IUUC-Oba-075437	Oryza barthii	42.75	1.00e-117	416.00
IUUC-Obr-076684	Oryza brachyantha	42.97	6.00e-113	401.00
IUUC-Ogl-077170	Oryza glaberrima	42.75	1.00e-117	416.00
IUUC-Ogu-078844	Oryza glumaepatula	43.51	5.00e-111	394.00
IUUC-Oin-079105	Oryza indica	42.75	7.00e-117	414.00
IUUC-Olo-080943	Oryza longistaminata	40.24	2.00e-105	375.00
IUUC-Oni-082891	Oryza nivara	39.89	9.00e-111	394.00
IUUC-Opu-083457	Oryza punctata	42.75	8.00e-117	414.00
IUUC-Oru-084960	Oryza rufipogon	40.24	2.00e-105	375.00
IUUC-Osa-085358	Oryza sativa	42.94	8.00e-118	417.00
IUUC-Ola-086420	Oryzias latipes	72.39	2.00e-170	591.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.51	4.00e-61	229.00
IUUC-Oga-088810	Otolemur garnettii	89.49	0.00e+00	1009.00
IUUC-Oar-089196	Ovis aries	91.04	0.00e+00	1023.00
IUUC-Ptr-090617	Pan troglodytes	91.74	0.00e+00	1030.00
IUUC-Pan-092761	Papio anubis	91.74	0.00e+00	1031.00
IUUC-Psi-093191	Pelodiscus sinensis	87.23	0.00e+00	965.00
IUUC-Pma-094380	Petromyzon marinus	62.27	0.00e+00	664.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.95	2.00e-70	261.00
IUUC-Ppa-095875	Physcomitrella patens	40.61	1.00e-119	423.00
IUUC-Pfo-096467	Poecilia formosa	73.50	0.00e+00	838.00
IUUC-Pab-098255	Pongo abelii	90.07	0.00e+00	848.00
IUUC-Pop-099722	Populus trichocarpa	41.13	4.00e-124	438.00
IUUC-Pca-100807	Procavia capensis	74.34	2.00e-112	399.00
IUUC-Ppe-101280	Prunus persica	40.00	1.00e-121	429.00
IUUC-Pva-102333	Pteropus vampyrus	86.38	0.00e+00	963.00
IUUC-Pgr-103401	Puccinia graminis	32.30	2.00e-81	296.00
IUUC-Ptt-103889	Puccinia triticina	27.67	1.00e-58	220.00
IUUC-Pte-104355	Pyrenophora teres	35.05	1.00e-86	313.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.29	1.00e-87	317.00
IUUC-Rno-105810	Rattus norvegicus	90.57	0.00e+00	1012.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.75	1.00e-38	154.00
IUUC-Sha-106770	Sarcophilus harrisii	96.09	5.00e-165	573.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.14	1.00e-77	283.00
IUUC-Spo-108276	Schizosaccharomyces pombe	35.21	4.00e-83	301.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	33.27	5.00e-68	251.00
IUUC-Smo-109296	Selaginella moellendorffii	42.99	7.00e-124	437.00
IUUC-Sit-110157	Setaria italica	45.08	1.00e-134	473.00
IUUC-Sly-111105	Solanum lycopersicum	40.52	4.00e-122	431.00
IUUC-Stu-112469	Solanum tuberosum	40.33	1.00e-122	433.00
IUUC-Sar-113083	Sorex araneus	69.77	0.00e+00	721.00
IUUC-Sbi-113813	Sorghum bicolor	44.89	4.00e-133	468.00
IUUC-Sre-115058	Sporisorium reilianum	38.00	6.00e-82	298.00
IUUC-Tgu-116772	Taeniopygia guttata	81.02	0.00e+00	894.00
IUUC-Tru-118686	Takifugu rubripes	72.59	0.00e+00	847.00
IUUC-Tsy-119111	Tarsius syrichta	83.15	6.00e-138	484.00
IUUC-Tni-120231	Tetraodon nigroviridis	67.35	0.00e+00	766.00
IUUC-Tca-121491	Theobroma cacao	40.72	2.00e-116	412.00
IUUC-Tre-122103	Trichoderma reesei	36.50	3.00e-82	299.00
IUUC-Tvi-122672	Trichoderma virens	36.20	2.00e-75	276.00
IUUC-Tae-125679	Triticum aestivum	43.73	5.00e-128	451.00
IUUC-Tur-126487	Triticum urartu	42.02	3.00e-121	428.00
IUUC-Tme-127097	Tuber melanosporum	38.36	1.00e-93	337.00
IUUC-Ttr-128465	Tursiops truncatus	84.51	0.00e+00	938.00
IUUC-Uma-129645	Ustilago maydis	33.83	1.00e-88	320.00
IUUC-Vda-129989	Verticillium dahliae	31.07	2.00e-58	219.00
IUUC-Vpa-130529	Vicugna pacos	86.94	0.00e+00	971.00
IUUC-Vvi-131059	Vitis vinifera	41.25	3.00e-122	432.00
IUUC-Xtr-132002	Xenopus tropicalis	78.33	0.00e+00	898.00
IUUC-Xma-133930	Xiphophorus maculatus	74.10	0.00e+00	845.00
IUUC-Yli-134505	Yarrowia lipolytica	35.62	6.00e-87	314.00
IUUC-Zma-135895	Zea mays	44.66	4.00e-132	464.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence