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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063122
UUCD1 version UUC-MuM-00016
Ensembl Protein ID ENSMUSP00000051481.6
UniProt Accession Q0MW30; C9DQJ8; NEU1B_MOUSE
Genbank Protein ID ABH10575.1; ACV53566.1
Protein Name E3 ubiquitin-protein ligase NEURL1B; Neuralized-2; Neuralized-like protein 1B; Neuralized-like protein 2; Neuralized-like protein 3; RING-type E3 ubiquitin transferase NEURL1B
Genbank Nucleotide ID DQ839448; GQ414760
Gene Name Neurl1b; Neurl2; Neurl3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034413.14 ENSMUST00000182897.7 ENSMUSP00000138417.1
ENSMUSG00000034413.14 ENSMUST00000183077.7 ENSMUSP00000138178.1
ENSMUSG00000034413.14 ENSMUST00000053020.7 ENSMUSP00000051481.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20410139; 17003037
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.57 11.9 494 534
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgH.vfhadClqkwpglknssskefrCPlCr 46
           C +C+++  d +++  CgH + ++ C  ++       + ++ CP+Cr
   Q: 494  CTVCFDSEVD-TVIYTCGHmCLCHGCGLRL-----RRQARACCPICR 534
           9*****9999.88899***555****6555.....6999999****8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
 E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
Protein Sequence
(Fasta)
MGNTVHRTLP DSSPPARLLA TRPCYGPGPE RRAVLGEAPR FHAQAKGKNV RLDGHSRRAT 60
RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG FTAHDPSLMS AQDIPKYACP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063122|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTCCGCCTC CTCCCGCCGC CGCCCGCGCC GCCCATCTGC CGCCCGCCGG TCGCCGGTGC 60
AGCGGCAATG CCCCGCAGCC CGGCCGCGGC CCCCGGCCCG CCCAGCTAGC CCCGCGCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063122|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001370--BIR_rpt
IPR006573--NHR_dom
IPR001841--Znf_RING
PROSITE

PS51065--NHR
PS50089--ZF_RING_2
Pfam

PF07177--Neuralized
SMART

SM00588--NEUZ
Gene Ontology

GO:0005769--C:early endosome
GO:0016874--F:ligase activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination
GO:0070086--P:ubiquitin-dependent endocytosis
KEGG mmu:240055
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000891 Aegilops tauschii 47.27 5.00e-11 62.80
IUUC-Aml-002324 Ailuropoda melanoleuca 67.82 7.00e-156 543.00
IUUC-Atr-002944 Amborella trichopoda 50.91 3.00e-11 64.30
IUUC-Apl-003920 Anas platyrhynchos 67.82 0.00e+00 626.00
IUUC-Aca-005343 Anolis carolinensis 62.84 8.00e-159 553.00
IUUC-Aly-006153 Arabidopsis lyrata 49.06 2.00e-10 61.60
IUUC-Ath-006716 Arabidopsis thaliana 40.00 2.00e-08 55.10
IUUC-Ate-010322 Aspergillus terreus 42.31 4.00e-09 57.80
IUUC-Ame-010891 Astyanax mexicanus 41.94 6.00e-84 305.00
IUUC-Bta-013255 Bos taurus 83.81 0.00e+00 677.00
IUUC-Bdi-014456 Brachypodium distachyon 42.86 8.00e-12 65.90
IUUC-Bol-016142 Brassica oleracea 50.91 3.00e-12 67.40
IUUC-Bra-017746 Brassica rapa 50.91 3.00e-12 67.00
IUUC-Cja-019314 Callithrix jacchus 90.09 0.00e+00 818.00
IUUC-Cfa-021151 Canis familiaris 90.27 0.00e+00 782.00
IUUC-Cpo-022395 Cavia porcellus 72.54 5.00e-169 587.00
IUUC-Csa-024268 Chlorocebus sabaeus 90.99 0.00e+00 834.00
IUUC-Cho-025082 Choloepus hoffmanni 96.13 8.00e-93 334.00
IUUC-Cin-025529 Ciona intestinalis 30.59 6.00e-48 185.00
IUUC-Csv-026316 Ciona savignyi 27.72 3.00e-56 213.00
IUUC-Cgl-026591 Colletotrichum gloeosporioides 30.00 8.90e-02 32.30
IUUC-Dre-028687 Danio rerio 57.40 2.00e-169 588.00
IUUC-Dno-029754 Dasypus novemcinctus 88.29 0.00e+00 755.00
IUUC-Dor-030366 Dipodomys ordii 88.77 0.00e+00 812.00
IUUC-Dme-032154 Drosophila melanogaster 36.72 8.00e-33 135.00
IUUC-Eca-034278 Equus caballus 35.80 3.00e-18 85.10
IUUC-Fca-035976 Felis catus 98.71 3.00e-89 322.00
IUUC-Fal-036894 Ficedula albicollis 67.28 2.00e-176 612.00
IUUC-Gmo-038673 Gadus morhua 53.78 7.00e-71 261.00
IUUC-Gga-041040 Gallus gallus 67.32 0.00e+00 637.00
IUUC-Gac-042143 Gasterosteus aculeatus 55.30 6.00e-110 390.00
IUUC-Gma-043468 Glycine max 43.64 2.00e-11 65.10
IUUC-Ggo-045648 Gorilla gorilla 86.18 0.00e+00 785.00
IUUC-Hsa-046831 Homo sapiens 90.45 0.00e+00 830.00
IUUC-Hvu-047768 Hordeum vulgare 45.45 6.00e-11 62.80
IUUC-Itr-048936 Ictidomys tridecemlineatus 95.74 1.00e-131 461.00
IUUC-Lch-049591 Latimeria chalumnae 64.56 6.00e-172 597.00
IUUC-Lpe-051170 Leersia perrieri 42.86 2.00e-12 67.40
IUUC-Loc-052110 Lepisosteus oculatus 59.69 8.00e-158 550.00
IUUC-Laf-054262 Loxodonta africana 89.67 0.00e+00 765.00
IUUC-Mcc-055333 Macaca mulatta 90.61 0.00e+00 800.00
IUUC-Meu-056023 Macropus eugenii 64.51 5.00e-168 584.00
IUUC-Mtr-057749 Medicago truncatula 43.64 2.00e-10 61.60
IUUC-Mga-059732 Meleagris gallopavo 62.26 1.00e-166 579.00
IUUC-Mdo-061835 Monodelphis domestica 68.22 0.00e+00 649.00
IUUC-Mac-064976 Musa acuminata 49.09 1.00e-11 65.10
IUUC-Mpu-066450 Mustela putorius furo 90.99 0.00e+00 805.00
IUUC-Mlu-067385 Myotis lucifugus 57.35 9.00e-101 360.00
IUUC-Nle-069149 Nomascus leucogenys 74.68 2.00e-151 529.00
IUUC-Opr-070822 Ochotona princeps 89.53 0.00e+00 855.00
IUUC-Ont-072255 Oreochromis niloticus 62.08 2.00e-159 555.00
IUUC-Oan-073429 Ornithorhynchus anatinus 41.06 5.00e-85 308.00
IUUC-Ocu-074215 Oryctolagus cuniculus 70.04 8.00e-159 553.00
IUUC-Oba-075400 Oryza barthii 41.38 2.00e-11 64.30
IUUC-Obr-076257 Oryza brachyantha 42.86 1.00e-12 67.80
IUUC-Ogl-077249 Oryza glaberrima 41.38 2.00e-11 64.70
IUUC-Ogu-078361 Oryza glumaepatula 45.45 6.00e-11 62.80
IUUC-Oin-080213 Oryza indica 41.38 2.00e-11 64.70
IUUC-Olo-080683 Oryza longistaminata 41.38 2.00e-11 64.30
IUUC-Ome-081101 Oryza meridionalis 41.38 2.00e-11 65.10
IUUC-Oni-082539 Oryza nivara 41.38 2.00e-11 64.70
IUUC-Opu-083826 Oryza punctata 41.38 1.00e-11 65.10
IUUC-Oru-084786 Oryza rufipogon 41.38 1.00e-11 64.70
IUUC-Osa-085344 Oryza sativa 41.38 1.00e-11 65.10
IUUC-Ola-086439 Oryzias latipes 58.63 4.00e-115 408.00
IUUC-Oga-088419 Otolemur garnettii 89.51 0.00e+00 812.00
IUUC-Oar-090002 Ovis aries 69.30 2.00e-127 449.00
IUUC-Ptr-091650 Pan troglodytes 90.63 0.00e+00 831.00
IUUC-Pan-092859 Papio anubis 87.25 0.00e+00 645.00
IUUC-Psi-092984 Pelodiscus sinensis 66.85 0.00e+00 627.00
IUUC-Ppa-095704 Physcomitrella patens 35.19 8.00e-08 52.80
IUUC-Pfo-097341 Poecilia formosa 57.84 2.00e-149 522.00
IUUC-Pab-097779 Pongo abelii 90.63 0.00e+00 842.00
IUUC-Pop-099791 Populus trichocarpa 49.09 4.00e-11 63.50
IUUC-Pca-100160 Procavia capensis 50.32 1.00e-47 184.00
IUUC-Ppe-102105 Prunus persica 49.09 5.00e-11 63.50
IUUC-Pva-102531 Pteropus vampyrus 88.83 0.00e+00 766.00
IUUC-Pgr-103610 Puccinia graminis 29.23 4.10e+00 26.90
IUUC-Pte-104404 Pyrenophora teres 32.93 4.30e-02 33.50
IUUC-Rno-105206 Rattus norvegicus 98.53 0.00e+00 955.00
IUUC-Sha-107468 Sarcophilus harrisii 67.82 0.00e+00 627.00
IUUC-Sit-110065 Setaria italica 42.62 7.00e-12 66.20
IUUC-Sly-111517 Solanum lycopersicum 43.14 3.00e-08 54.70
IUUC-Stu-112627 Solanum tuberosum 47.27 1.00e-10 62.00
IUUC-Sbi-113922 Sorghum bicolor 40.98 1.00e-11 65.50
IUUC-Tgu-116692 Taeniopygia guttata 68.95 1.00e-175 609.00
IUUC-Tru-118732 Takifugu rubripes 58.19 8.00e-140 490.00
IUUC-Tni-120907 Tetraodon nigroviridis 56.37 2.00e-146 512.00
IUUC-Tca-121136 Theobroma cacao 49.09 6.00e-11 63.20
IUUC-Tae-124586 Triticum aestivum 47.27 4.00e-11 63.20
IUUC-Tur-126820 Triticum urartu 47.27 7.00e-13 65.50
IUUC-Tbe-127614 Tupaia belangeri 55.36 6.00e-33 135.00
IUUC-Ttr-128919 Tursiops truncatus 86.99 3.00e-97 348.00
IUUC-Vpa-130273 Vicugna pacos 98.34 5.00e-95 341.00
IUUC-Vvi-131176 Vitis vinifera 45.45 2.00e-08 54.70
IUUC-Xtr-132312 Xenopus tropicalis 62.27 9.00e-168 583.00
IUUC-Xma-134204 Xiphophorus maculatus 58.12 3.00e-148 518.00
Created Date 25-Jun-2017

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