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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-007160
UUCD1 version UUC-ArT-01458
Ensembl Protein ID AT1G70320.1
UniProt Accession Q8H0T4; O64604; O64605; Q0WL35; Q9M7K6; UPL2_ARATH
Genbank Protein ID AAF36455.1; AAC18812.1; AAC18813.1; AEE35045.1; BAF02172.1; AAN72076.1; AAP68269.1
Protein Name E3 ubiquitin-protein ligase UPL2; HECT-type E3 ubiquitin transferase UPL2
Genbank Nucleotide ID AF127565; AC003671; AC003671; CP002684; AK230373; BT002065; BT008830
Gene Name UPL2; At1g70320; F17O7.14/F17O7.15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G70320 AT1G70320.1 AT1G70320.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPPTdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 12969426
Classification
Family E-value Score Start End
E3 activity/HECT 3.30e-121 405.7 3318 3657
UBD/Alpha-Helix/UBA 7.20e-07 30.0 1274 1311
Active Site
Position(s) Description Evidence
3625 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfy 97
           ++dlk rl+v+f+gEeg+d+gG+tre+++lls+ ++++ + lf ++ ++++t+qpnp+s ++ +ehl++F+f+Gr+++kal+dg+lld+ +++sfy
   Q: 3318 PQDLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF-TTVGNDATFQPNPNSVYQ-TEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFY 3411
           689************************************9999.556678889******986.5******************************** PP
   S: 98   klllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.......lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           k++lg+k++++d+e+vdp++yk+lk+++en   d++++ ldltfs++ ++         e++++eLkpgG+ni+Vt+e k+eYv+lv++++l++ i
   Q: 3412 KHILGVKVTYHDIEAVDPDYYKNLKWLLEN---DVSDI-LDLTFSMDADEekhilyeKTEVTDYELKPGGRNIRVTEETKHEYVDLVADHILTSAI 3503
           ****************************99...88887.88888866666668895555566778******************************* PP
   S: 187  keqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfael 282
           + q++af eG+ne+ip el+s+F+ +elelli+G +eid++dlk++t+y++ yt  sp+i+wFwev+++fs+e+ ++fLqFvTg+s++Pl+Gf++l
   Q: 3504 RPQINAFLEGLNELIPRELVSIFNDKELELLISGLPEIDFDDLKANTEYTS-YTVGSPVIRWFWEVVKAFSKEDMARFLQFVTGTSKVPLEGFKAL 3598
           *************************************************99.******************************************** PP
   S: 283  k....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +    p++ +i+k ++s++rlPs++TCfn+L+LPeY+ske+++e+Ll+Ai+e+ +gF++
   Q: 3599 QgisgPQRLQIHKaYGSPERLPSAHTCFNQLDLPEYQSKEQVQERLLLAIHEAnEGFGF 3657
           *************999*************************************9***86 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraa.nnnleaAveyLld 40
           e ++  +veMGF+r++a  aLr+   n++e+A+++L++
   Q: 1274 EAIVGMIVEMGFSRSRAEDALRRVgTNSVEMAMDWLFT 1311
           55666789*****************************8 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MKLRRRRASE VPTKISLFIN SVTSVPLELI QEPLASFRWE FDKGDFHHWV DLFYHFDTFF 60
EKHVKVRKDL RIEEEFDESD PPFPKDAVLQ VLRVIRLVLE NCTNKQFYTS YEQHLSLLLA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-007160|E3,HECT;UBD,UBA|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTCTCTCTC ACACCGTCTT TCTCTCTCCC TATCAAATCC CTTCTCTCTA ATATGCGATC 60
TTCAAAACCC TAGTTTCTTC GGATCGCTTC CAAACTTGCG ATTATCTCCA AGATAGTCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-007160|E3,HECT;UBD,UBA|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom
PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM
Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
SMART

SM00119--HECTc
SM00165--UBA
Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
KEGG ath:AT1G70320
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000627 Aegilops tauschii 35.62 0.00e+00 1048.00
IUUC-Apl-003400 Anas platyrhynchos 42.53 2.00e-94 338.00
IUUC-Ago-008005 Ashbya gossypii 38.66 1.00e-123 438.00
IUUC-Ani-009412 Aspergillus nidulans 43.24 2.00e-139 491.00
IUUC-Aor-010186 Aspergillus oryzae 39.47 2.00e-129 456.00
IUUC-Bol-015228 Brassica oleracea 35.55 0.00e+00 939.00
IUUC-Cpo-021766 Cavia porcellus 42.99 1.00e-95 343.00
IUUC-Cgl-026647 Colletotrichum gloeosporioides 39.11 1.00e-135 478.00
IUUC-Cne-027095 Cryptococcus neoformans 40.35 5.00e-110 393.00
IUUC-Cme-027267 Cyanidioschyzon merolae 50.91 2.00e-125 444.00
IUUC-Ete-032966 Echinops telfairi 42.76 1.00e-95 344.00
IUUC-Fal-036687 Ficedula albicollis 41.86 6.00e-95 341.00
IUUC-Fox-037756 Fusarium oxysporum 31.21 2.00e-147 518.00
IUUC-Fso-038464 Fusarium solani 48.78 3.00e-135 477.00
IUUC-Ggr-039946 Gaeumannomyces graminis 39.84 1.00e-133 472.00
IUUC-Ggo-044465 Gorilla gorilla 42.66 5.00e-94 338.00
IUUC-Hvu-047697 Hordeum vulgare 56.25 0.00e+00 1069.00
IUUC-Kpa-049228 Komagataella pastoris 40.63 2.00e-127 451.00
IUUC-Meu-056436 Macropus eugenii 40.40 3.00e-77 282.00
IUUC-Mor-057201 Magnaporthe oryzae 36.60 2.00e-134 474.00
IUUC-Mpo-057597 Magnaporthe poae 38.35 3.00e-133 471.00
IUUC-Mga-059935 Meleagris gallopavo 42.53 1.00e-94 340.00
IUUC-Ncr-068813 Neurospora crassa 39.91 6.00e-143 503.00
IUUC-Ome-081289 Oryza meridionalis 65.54 0.00e+00 1058.00
IUUC-Osa-086200 Oryza sativa 63.52 0.00e+00 1221.00
IUUC-Ola-086777 Oryzias latipes 42.53 1.00e-96 347.00
IUUC-Ptr-090529 Pan troglodytes 42.76 2.00e-95 343.00
IUUC-Psi-093969 Pelodiscus sinensis 42.53 4.00e-95 342.00
IUUC-Rno-105153 Rattus norvegicus 42.76 9.00e-96 344.00
IUUC-Sce-106449 Saccharomyces cerevisiae 31.71 1.00e-126 448.00
IUUC-Sja-107814 Schizosaccharomyces japonicus 32.37 1.00e-130 462.00
IUUC-Spo-108024 Schizosaccharomyces pombe 34.01 2.00e-140 494.00
IUUC-Stu-112501 Solanum tuberosum 67.38 5.00e-132 463.00
IUUC-Tgu-117225 Taeniopygia guttata 41.63 1.00e-94 340.00
IUUC-Tvi-122370 Trichoderma virens 39.04 8.00e-139 489.00
IUUC-Tae-125214 Triticum aestivum 54.36 0.00e+00 1055.00
IUUC-Tme-127172 Tuber melanosporum 39.87 7.00e-132 466.00
IUUC-Vda-129886 Verticillium dahliae 47.75 1.00e-135 478.00
IUUC-Yli-134657 Yarrowia lipolytica 40.58 5.00e-134 473.00
Created Date 25-Jun-2017

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