iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059551

UUCD1 version

UUC-MeG-00849

Ensembl Protein ID

ENSMGAP00000015355.1

UniProt Accession

G1NNU7; G1NNU7_MELGA

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000014504.1	ENSMGAT00000016310.1	ENSMGAP00000015355.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-85	286.1	193	822

Active Site

Position(s)	Description	Evidence
202	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
758	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..........kepkgellkslqklfeelwkskkkavsprellkal 77
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e    + +++ e+p           ++ g+l+ +++++++e++++k+++v+p+el++++
   Q: 193  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEakIPNTTVKIESPelfmepqlvkLDQPGPLTLAMHQFLTEMQETKRGVVTPKELFAQV 281
           5******************************7533333333333677777777788899****************************** PP
   S: 78   kkeaeefsgyeqqDaqEflaflldqleeelkk.....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdn 161
           +k+a +f+gy+qqD+qE+l++lld+++ e  +       +  +++ ++++++ +++++e++kkk  ks+++++F+g+l+s i+c+ec++
   Q: 282  CKKAIRFKGYQQQDSQELLRYLLDGMRAEEIQrisvgILKALTDSNKQNEEELRKKIKEYEKKKGIKSFVDRIFGGELTSAIMCEECRT 370
           **************************9887555777655555666666666667778******************************** PP
   S: 162  vssreepfldlslpvpgkeetkke................................................................. 185
           vs  +e+fldlslpv +++ + k+                                                                 
   Q: 371  VSLVHESFLDLSLPVLDDQPETKNtnernvkknkgkeseeeeddknndyyikqrdeppgtskhlqkkakkqakkqaksqrrqqklqgkv 459
           ****************99976666999************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 460  lqltdicateesekdvvcdqegeaeinseipdvkqeeessndcrddyltqndlniqgnstdvqsmhestgkpeqecvekesivdppted 548
           ***************************************************************************************** PP
   S: 186  .....................................................................................slqd 189
                                                                                                s+++
   Q: 549  ldspvefvnglddlslkdedeeneddeglatdfsklhlgasaesdinvvddlqtvpaktceiltedaemafctlasredlnpeegSIHH 637
           ***************************************************************************************** PP
   S: 190  cLesftkeeelegenkyycekckkkqe...............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           cL +ft++e+l ++nk+ c+ c++++                a+k++ ++  P++L+lhLkRf  ++++ + +k+n++++fp+ +d++p
   Q: 638  CLYQFTRNEKLSENNKLLCDVCTQRRYgpkntktdekhvytnAKKQMLISLAPPILTLHLKRF--QQAGFNLRKVNRHIKFPEVIDMAP 724
           ***********************7777777888888888888*********************..9999******************** PP
   S: 264  fctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtevkeeevlee 325
           fct ++++++e   k+ Y+L++vv HsG+++sGHY+ay+k                          kg+W++++D++V++v+ ++vl+ 
   Q: 725  FCTVKCKNVAEgntKVLYSLYGVVEHSGTMRSGHYTAYAKIrnmnnhlsdlvlqghppqaletepIKGQWFHISDTHVQAVSTSKVLS- 812
           ****99999888889*************************99999999999999999988888888**********************. PP
   S: 326  tgstaYvlfYkr 337
             s+aY+lfY+r
   Q: 813  --SQAYLLFYER 822
           ..********98 PP

Organism

Meleagris gallopavo

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT AQADESLDIV EPVCKHIRKG LEQSHLKKAL LNVEWHVCQD CKADNKTREK 60
SEEETDESPP IWLCLKCGHR GCGRNSQEQH ALKHYTTPRS DPHCLVLSLD NWSVWCYICD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAAGA AACGCACCAA AGGCAAAACT GCACAGGCTG ATGAGTCTCT GGACATAGTG 60
GGTATGTTTC TTCTGAGAAG TCTCTGGTTT TGAAGAGGAA AACAGTAATT CTGTAGCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	27.19	2.00e-29	124.00
IUUC-Aml-001931	Ailuropoda melanoleuca	61.92	0.00e+00	913.00
IUUC-Atr-003015	Amborella trichopoda	30.36	1.00e-38	154.00
IUUC-Apl-004145	Anas platyrhynchos	84.24	0.00e+00	1253.00
IUUC-Aca-004314	Anolis carolinensis	62.91	0.00e+00	921.00
IUUC-Aly-006422	Arabidopsis lyrata	39.31	6.00e-25	109.00
IUUC-Ath-006732	Arabidopsis thaliana	30.89	9.00e-32	132.00
IUUC-Ame-011659	Astyanax mexicanus	49.89	7.00e-108	384.00
IUUC-Bta-013362	Bos taurus	62.72	0.00e+00	924.00
IUUC-Bdi-014624	Brachypodium distachyon	29.10	1.00e-28	121.00
IUUC-Bol-015941	Brassica oleracea	28.78	9.00e-33	135.00
IUUC-Bra-016751	Brassica rapa	28.05	3.00e-30	127.00
IUUC-Cja-019177	Callithrix jacchus	63.53	0.00e+00	939.00
IUUC-Cfa-020051	Canis familiaris	61.92	0.00e+00	927.00
IUUC-Cpo-021886	Cavia porcellus	59.45	0.00e+00	899.00
IUUC-Csa-024103	Chlorocebus sabaeus	62.63	0.00e+00	934.00
IUUC-Cho-024315	Choloepus hoffmanni	58.47	3.00e-77	282.00
IUUC-Cin-025775	Ciona intestinalis	48.23	8.00e-39	151.00
IUUC-Csv-026075	Ciona savignyi	48.73	5.00e-53	202.00
IUUC-Dre-028388	Danio rerio	54.59	2.00e-114	405.00
IUUC-Dno-029409	Dasypus novemcinctus	62.74	0.00e+00	944.00
IUUC-Dor-030443	Dipodomys ordii	55.26	2.00e-124	439.00
IUUC-Ete-032807	Echinops telfairi	62.20	3.00e-141	495.00
IUUC-Eca-033479	Equus caballus	63.16	0.00e+00	949.00
IUUC-Eeu-034835	Erinaceus europaeus	55.43	2.00e-104	373.00
IUUC-Fca-036320	Felis catus	62.62	0.00e+00	936.00
IUUC-Fal-037029	Ficedula albicollis	77.08	0.00e+00	1136.00
IUUC-Gmo-039480	Gadus morhua	50.63	2.00e-107	382.00
IUUC-Gga-040527	Gallus gallus	94.42	0.00e+00	1382.00
IUUC-Gac-042343	Gasterosteus aculeatus	51.89	2.00e-111	396.00
IUUC-Gma-044402	Glycine max	29.23	3.00e-36	146.00
IUUC-Ggo-045598	Gorilla gorilla	62.47	0.00e+00	931.00
IUUC-Hsa-046598	Homo sapiens	62.56	0.00e+00	932.00
IUUC-Hvu-047146	Hordeum vulgare	29.25	1.00e-29	124.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	62.51	0.00e+00	934.00
IUUC-Lch-050536	Latimeria chalumnae	49.88	0.00e+00	706.00
IUUC-Lpe-050703	Leersia perrieri	28.93	4.00e-29	123.00
IUUC-Loc-051814	Lepisosteus oculatus	55.15	1.00e-121	430.00
IUUC-Laf-053732	Loxodonta africana	62.01	0.00e+00	928.00
IUUC-Mcc-054661	Macaca mulatta	62.75	0.00e+00	934.00
IUUC-Meu-055967	Macropus eugenii	64.89	4.00e-136	478.00
IUUC-Mtr-057945	Medicago truncatula	30.86	2.00e-32	134.00
IUUC-Mvi-060391	Microbotryum violaceum	30.96	3.00e-18	87.40
IUUC-Mmr-061747	Microcebus murinus	62.73	0.00e+00	906.00
IUUC-Mdo-062220	Monodelphis domestica	60.88	0.00e+00	886.00
IUUC-Mmu-063582	Mus musculus	60.48	0.00e+00	885.00
IUUC-Mac-064941	Musa acuminata	34.73	1.00e-36	147.00
IUUC-Mpu-066339	Mustela putorius furo	61.80	0.00e+00	923.00
IUUC-Mlu-067511	Myotis lucifugus	60.87	0.00e+00	900.00
IUUC-Nle-069252	Nomascus leucogenys	62.75	0.00e+00	931.00
IUUC-Opr-070969	Ochotona princeps	61.66	0.00e+00	877.00
IUUC-Ont-071786	Oreochromis niloticus	51.64	3.00e-116	412.00
IUUC-Ocu-074704	Oryctolagus cuniculus	63.25	0.00e+00	922.00
IUUC-Oba-075094	Oryza barthii	29.81	2.00e-29	124.00
IUUC-Obr-076743	Oryza brachyantha	29.25	1.00e-28	122.00
IUUC-Ogl-077739	Oryza glaberrima	29.81	2.00e-29	124.00
IUUC-Ogu-078851	Oryza glumaepatula	29.81	3.00e-29	124.00
IUUC-Oin-079402	Oryza indica	29.81	3.00e-29	124.00
IUUC-Olo-080431	Oryza longistaminata	29.81	2.00e-29	124.00
IUUC-Ome-081580	Oryza meridionalis	29.81	2.00e-29	124.00
IUUC-Oni-082644	Oryza nivara	29.81	3.00e-29	124.00
IUUC-Opu-083452	Oryza punctata	29.56	3.00e-29	123.00
IUUC-Oru-084546	Oryza rufipogon	29.81	3.00e-29	124.00
IUUC-Osa-085858	Oryza sativa	29.81	3.00e-29	124.00
IUUC-Ola-086795	Oryzias latipes	49.76	6.00e-108	384.00
IUUC-Oga-088713	Otolemur garnettii	62.78	0.00e+00	934.00
IUUC-Oar-089887	Ovis aries	62.37	0.00e+00	928.00
IUUC-Ptr-091670	Pan troglodytes	62.89	0.00e+00	932.00
IUUC-Pan-092293	Papio anubis	62.75	0.00e+00	934.00
IUUC-Psi-093101	Pelodiscus sinensis	69.47	0.00e+00	1015.00
IUUC-Ppa-095622	Physcomitrella patens	30.51	6.00e-35	142.00
IUUC-Pfo-097202	Poecilia formosa	52.61	1.00e-117	416.00
IUUC-Pab-098773	Pongo abelii	63.31	0.00e+00	681.00
IUUC-Pop-099136	Populus trichocarpa	30.96	1.00e-42	167.00
IUUC-Pca-101069	Procavia capensis	53.57	4.00e-167	581.00
IUUC-Ppe-101794	Prunus persica	31.82	2.00e-34	140.00
IUUC-Pva-103092	Pteropus vampyrus	52.32	1.00e-104	373.00
IUUC-Rno-105237	Rattus norvegicus	59.86	0.00e+00	880.00
IUUC-Sha-106889	Sarcophilus harrisii	62.41	0.00e+00	899.00
IUUC-Sit-110283	Setaria italica	30.82	1.00e-30	128.00
IUUC-Sly-111491	Solanum lycopersicum	30.23	2.00e-36	147.00
IUUC-Stu-112820	Solanum tuberosum	31.51	1.00e-39	158.00
IUUC-Sar-113530	Sorex araneus	60.66	0.00e+00	908.00
IUUC-Sbi-113785	Sorghum bicolor	36.77	4.00e-24	107.00
IUUC-Ssc-116091	Sus scrofa	62.69	0.00e+00	931.00
IUUC-Tgu-117478	Taeniopygia guttata	75.57	0.00e+00	1104.00
IUUC-Tru-118640	Takifugu rubripes	53.49	2.00e-117	416.00
IUUC-Tsy-119042	Tarsius syrichta	51.96	4.00e-158	551.00
IUUC-Tni-120015	Tetraodon nigroviridis	51.98	1.00e-110	394.00
IUUC-Tca-121701	Theobroma cacao	30.47	5.00e-39	156.00
IUUC-Tae-125351	Triticum aestivum	27.99	4.00e-28	120.00
IUUC-Tur-126788	Triticum urartu	27.36	6.00e-28	119.00
IUUC-Tbe-127309	Tupaia belangeri	52.93	0.00e+00	670.00
IUUC-Ttr-128271	Tursiops truncatus	61.36	0.00e+00	907.00
IUUC-Vpa-130674	Vicugna pacos	61.05	0.00e+00	837.00
IUUC-Xtr-131869	Xenopus tropicalis	52.03	0.00e+00	761.00
IUUC-Xma-134195	Xiphophorus maculatus	52.97	1.00e-117	416.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence