iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093101

Ensembl Protein ID

ENSPSIP00000019304.1

UniProt Accession

K7GG93; K7GG93_PELSI

Genbank Protein ID

ENSPSIP00000019304

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AGCU01106421

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000017125.1	ENSPSIT00000019394.1	ENSPSIP00000019304.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-82	276.4	196	826

Active Site

Position(s)	Description	Evidence
205	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
763	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp..............kepkgellkslqklfeelwkskk 65
           +Gl+NlgNtC++N+v+Q Ls++p+lrell++          +         p               e+ g+l+ ++ ++++ ++++kk
   Q: 196  KGLSNLGNTCFFNAVMQNLSQTPDLRELLKKvkmpgatvniE--------PPefstlfkkeplvikLEQPGPLTLAMCQFLSDMQETKK 276
           5******************************86444444430........336666666666777788999****************** PP
   S: 66   kavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.......eknkpkeeeeeedkselsdeaeekkkkknkslisdlFq 147
           + v+p+el+++++k+a +f+gy+qqD+qE+l++lld+++ e  +       +  + +++ ++++++ +++++e++kk+  +++++++F+
   Q: 277  GTVTPKELFAQVCKKAIRFKGYQQQDSQELLRYLLDGMRAEEIQrvsvglfK--TLTDSDQKNEEELKKKIKEYEKKRAIPTFVDRIFG 363
           **************************************98775546665321..222222233333344559999999999******** PP
   S: 148  gqlksqikclecdnvssreepfldlslpvpgkeetkke................................................... 185
           g+l+s+++c+ec++vs  +e+fldlslpv ++++ kk+                                                   
   Q: 364  GELTSTVMCEECRTVSLVHESFLDLSLPVLDDQSVKKSsyeknvkknkekededdeedkdndsymkergdnpgaskhlqkkakkqakkq 452
           *********************************99888*************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 453  aknqrrqqkiqgkvlpitnvcsvelseenvkedketkgeitsevtdlkkkedssneceelslnqkdlnaqrnstdvdslhesienpdke 541
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 542  fednetsmdvamedfvsaeyirgfdnpcvkeddhgeeeelatnleelhldavtdsdmdilddhhvtelrtyevvnedpetafctlanre 630
           ***************************************************************************************** PP
   S: 186  .......slqdcLesftkeeelegenkyycekckkkqe................aekklklkklPevLilhLkRfsfseeqksrekink 251
                  s+ +cL +ft++e+l + nk+ c+ c+++                  a+k++ ++  P++L+lhLkRf  ++++ + +k+nk
   Q: 631  dlnveesSILHCLYQFTRNEKLSDVNKLLCDVCTQRHCgpkisgksakkfvytnAKKQMLISLAPPILTLHLKRF--QQAGFNLRKVNK 717
           **********************************77778888888888888888*********************..9999******** PP
   S: 252  kvefpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn.......................ekgkWllfdDskV 314
           +++fp+ +dl+pfc+ ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                        + g+W++++D++V
   Q: 718  HIKFPEVIDLAPFCAIKCKNVAEgntSVLYSLYGVVEHSGTMRSGHYTAYAKMrtmrnylsdlvfrgeipqtleteSAGQWFHISDTHV 806
           ****************999998888899*************************999999999999999999998877889********* PP
   S: 315  tevkeeevleetgstaYvlfYkr 337
           ++v+ ++vl+   s+aY+lfY+r
   Q: 807  QPVTVSKVLN---SQAYLLFYER 826
           **********...********98 PP

Organism

Pelodiscus sinensis

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKN IQVDESEDIS EPICKHIRKG LEQGHLKKAL LNVEWNICQD CKTDNKTQDK 60
SEEEADESPS IWLCLKCGHR GCGRNSQEQH ALKHYTTPRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAAGA AAAGAACAAA GGGAAAAAAC ATACAAGTTG ATGAGTCTGA GGATATTTCA 60
GGTATGTTTC ATAGCAAAAT TGTTTCAGAG ATGTCTATAG TACTGGGGAA GAAACATGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	28.27	3.00e-26	114.00
IUUC-Aml-001931	Ailuropoda melanoleuca	66.71	0.00e+00	961.00
IUUC-Atr-003015	Amborella trichopoda	29.24	8.00e-33	135.00
IUUC-Apl-004145	Anas platyrhynchos	69.07	0.00e+00	1014.00
IUUC-Aca-004314	Anolis carolinensis	65.29	0.00e+00	968.00
IUUC-Aly-006422	Arabidopsis lyrata	29.54	7.00e-31	129.00
IUUC-Ath-006732	Arabidopsis thaliana	32.33	2.00e-34	140.00
IUUC-Afl-008729	Aspergillus flavus	27.07	2.00e-12	67.40
IUUC-Aor-009965	Aspergillus oryzae	27.07	9.00e-13	68.60
IUUC-Ame-011659	Astyanax mexicanus	47.89	4.00e-105	375.00
IUUC-Bta-013362	Bos taurus	66.71	0.00e+00	956.00
IUUC-Bdi-014465	Brachypodium distachyon	30.09	5.00e-28	119.00
IUUC-Bol-015941	Brassica oleracea	29.40	1.00e-30	128.00
IUUC-Bra-016751	Brassica rapa	28.54	5.00e-28	120.00
IUUC-Cja-019177	Callithrix jacchus	67.50	0.00e+00	984.00
IUUC-Cfa-020051	Canis familiaris	66.43	0.00e+00	964.00
IUUC-Cpo-021886	Cavia porcellus	62.07	0.00e+00	950.00
IUUC-Csa-024103	Chlorocebus sabaeus	66.98	0.00e+00	986.00
IUUC-Cho-024315	Choloepus hoffmanni	59.07	8.00e-79	288.00
IUUC-Cin-025775	Ciona intestinalis	48.94	3.00e-37	146.00
IUUC-Csv-026075	Ciona savignyi	47.39	5.00e-52	198.00
IUUC-Dre-028388	Danio rerio	53.61	8.00e-112	397.00
IUUC-Dno-029409	Dasypus novemcinctus	66.47	0.00e+00	970.00
IUUC-Dor-030443	Dipodomys ordii	67.22	1.00e-127	450.00
IUUC-Dse-031252	Dothistroma septosporum	29.22	1.00e-12	67.80
IUUC-Ete-032807	Echinops telfairi	66.03	1.00e-145	510.00
IUUC-Eca-033479	Equus caballus	67.46	0.00e+00	975.00
IUUC-Eeu-034835	Erinaceus europaeus	57.83	6.00e-111	395.00
IUUC-Fca-036320	Felis catus	66.23	0.00e+00	971.00
IUUC-Fal-037029	Ficedula albicollis	66.87	0.00e+00	961.00
IUUC-Gmo-039480	Gadus morhua	51.72	2.00e-110	393.00
IUUC-Gga-040527	Gallus gallus	70.91	0.00e+00	1031.00
IUUC-Gac-042343	Gasterosteus aculeatus	50.12	2.00e-111	396.00
IUUC-Gma-044402	Glycine max	28.68	7.00e-32	132.00
IUUC-Ggo-045598	Gorilla gorilla	66.87	0.00e+00	979.00
IUUC-Hsa-046598	Homo sapiens	66.91	0.00e+00	979.00
IUUC-Hvu-047146	Hordeum vulgare	34.69	2.00e-25	110.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	67.50	0.00e+00	981.00
IUUC-Lch-050536	Latimeria chalumnae	58.07	8.00e-125	441.00
IUUC-Lpe-050703	Leersia perrieri	30.18	9.00e-28	119.00
IUUC-Loc-051814	Lepisosteus oculatus	55.12	1.00e-121	430.00
IUUC-Laf-053732	Loxodonta africana	63.81	0.00e+00	934.00
IUUC-Mcc-054661	Macaca mulatta	67.22	0.00e+00	987.00
IUUC-Meu-055967	Macropus eugenii	64.25	7.00e-145	507.00
IUUC-Mga-059551	Meleagris gallopavo	70.55	0.00e+00	1049.00
IUUC-Mvi-060391	Microbotryum violaceum	30.73	3.00e-17	84.00
IUUC-Mmr-061747	Microcebus murinus	68.04	0.00e+00	963.00
IUUC-Mdo-062220	Monodelphis domestica	61.10	0.00e+00	888.00
IUUC-Mmu-063582	Mus musculus	64.35	0.00e+00	934.00
IUUC-Mpu-066339	Mustela putorius furo	66.59	0.00e+00	966.00
IUUC-Mlu-067511	Myotis lucifugus	65.71	0.00e+00	932.00
IUUC-Nle-069252	Nomascus leucogenys	67.22	0.00e+00	986.00
IUUC-Opr-070969	Ochotona princeps	65.81	0.00e+00	916.00
IUUC-Ont-071786	Oreochromis niloticus	50.71	1.00e-108	387.00
IUUC-Ocu-074704	Oryctolagus cuniculus	66.42	0.00e+00	946.00
IUUC-Oba-075094	Oryza barthii	29.00	4.00e-28	120.00
IUUC-Obr-076743	Oryza brachyantha	29.39	7.00e-28	119.00
IUUC-Ogl-077739	Oryza glaberrima	29.00	5.00e-28	119.00
IUUC-Ogu-078851	Oryza glumaepatula	29.00	4.00e-28	120.00
IUUC-Oin-079402	Oryza indica	29.00	4.00e-28	120.00
IUUC-Olo-080431	Oryza longistaminata	29.00	4.00e-28	120.00
IUUC-Ome-081580	Oryza meridionalis	28.70	7.00e-28	119.00
IUUC-Oni-082644	Oryza nivara	29.00	4.00e-28	120.00
IUUC-Opu-083452	Oryza punctata	27.52	3.00e-27	117.00
IUUC-Oru-084546	Oryza rufipogon	29.00	5.00e-28	120.00
IUUC-Osa-085858	Oryza sativa	29.00	4.00e-28	120.00
IUUC-Ola-086795	Oryzias latipes	50.12	4.00e-108	385.00
IUUC-Oga-088713	Otolemur garnettii	66.67	0.00e+00	965.00
IUUC-Oar-089887	Ovis aries	66.98	0.00e+00	965.00
IUUC-Ptr-091670	Pan troglodytes	66.87	0.00e+00	981.00
IUUC-Pan-092293	Papio anubis	67.22	0.00e+00	987.00
IUUC-Ppa-095622	Physcomitrella patens	29.98	9.00e-34	139.00
IUUC-Pfo-097202	Poecilia formosa	51.29	7.00e-115	407.00
IUUC-Pab-098773	Pongo abelii	64.52	0.00e+00	697.00
IUUC-Pop-099136	Populus trichocarpa	30.48	3.00e-40	160.00
IUUC-Pca-101069	Procavia capensis	53.95	0.00e+00	834.00
IUUC-Ppe-101794	Prunus persica	32.84	4.00e-34	139.00
IUUC-Pva-103092	Pteropus vampyrus	57.51	2.00e-113	403.00
IUUC-Rno-105237	Rattus norvegicus	64.44	0.00e+00	925.00
IUUC-Sha-106889	Sarcophilus harrisii	64.12	0.00e+00	939.00
IUUC-Sit-110283	Setaria italica	31.00	2.00e-26	114.00
IUUC-Sly-111487	Solanum lycopersicum	30.93	4.00e-39	156.00
IUUC-Stu-112820	Solanum tuberosum	30.15	2.00e-38	154.00
IUUC-Sar-113530	Sorex araneus	64.10	0.00e+00	922.00
IUUC-Sbi-113785	Sorghum bicolor	36.49	7.00e-24	106.00
IUUC-Ssc-116091	Sus scrofa	64.18	0.00e+00	944.00
IUUC-Tgu-117478	Taeniopygia guttata	66.11	0.00e+00	956.00
IUUC-Tru-118640	Takifugu rubripes	52.05	9.00e-114	404.00
IUUC-Tsy-119042	Tarsius syrichta	54.95	1.00e-165	576.00
IUUC-Tni-120015	Tetraodon nigroviridis	45.38	6.00e-174	604.00
IUUC-Tca-121701	Theobroma cacao	30.23	2.00e-38	154.00
IUUC-Tae-125351	Triticum aestivum	28.44	3.00e-26	114.00
IUUC-Tur-126788	Triticum urartu	27.83	5.00e-26	113.00
IUUC-Tbe-127309	Tupaia belangeri	72.76	5.00e-107	381.00
IUUC-Ttr-128271	Tursiops truncatus	65.60	0.00e+00	938.00
IUUC-Vpa-130674	Vicugna pacos	65.99	0.00e+00	880.00
IUUC-Xtr-131869	Xenopus tropicalis	52.88	0.00e+00	763.00
IUUC-Xma-134195	Xiphophorus maculatus	51.42	1.00e-113	404.00
IUUC-Zma-135157	Zea mays	37.84	2.00e-24	108.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence