iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tur-126011

Ensembl Protein ID

TRIUR3_06068-P1

UniProt Accession

M8ADD7; M8ADD7_TRIUA

Genbank Protein ID

EMS58574.1

Protein Name

Ubiquitin-activating enzyme E1 3

Genbank Nucleotide ID

KD131344

Gene Name

TRIUR3_06068

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIUR3_06068	TRIUR3_06068-T1	TRIUR3_06068-P1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.70e-155	517.9	449	938

Active Site

Position(s)	Description	Evidence
630	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YD Q+ ++G++ q+k+++a+ ++vG g+lGcE+lKnL+l+Gv     g++t++D+d +e+snl+rqFLfr++++g+ K+ vaa a+  +np+ +
   Q: 449  YDAQVSVFGSKLQKKMEEANTFVVGSGALGCEFLKNLALMGVscsskGKLTITDDDIIEKSNLSRQFLFRDWNIGQAKSTVAATAASAINPSLH 542
           ********************************************************************************************** PP
   S: 90   veaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketp 180
           ++a +++ ++++e+++   F + +dvV++aldn+ ar++++ +cl+ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p
   Q: 543  IDALQNRACPDTENVFhdtFWEGLDVVINALDNVNARMYMDMRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFP 636
           **************8899999999********************************************************************** PP
   S: 181  naaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfec 262
            +++h+++wa              +n +l++ a+      k   ++ +e +++v++ l++ + ++f+++i++a+ +f+ +++n +kql+  f+ 
   Q: 637  HNIDHCLTWArsefegllektpNEVNSFLSNPAQYAAAMRKAGDAQARELLERVSECLNKDRCSTFDDCISWARLKFEDYFSNRVKQLTFTFPE 730
           *********************99999999999999999999***************************************************** PP
   S: 263  divtkskspfwv......................................................sfcsnaealqvpekvekdeevvkasap. 301
           d  t+ ++pfw+                                                       +++++ ++ v+  ++++  ++++++  
   Q: 731  DAATSMGAPFWSapkrfpralqfsaadqshlnfimsasilraesfgvaipewakdtskladvvnkiAVPTFEPKQGVNIVTDEKASNLSSTSVd 824
           ******************9999999999999999999999999999999999998887777777774444444444444444444444333335 PP
   S: 302  ....lylllralerfekk..kgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKv 387
               ++ ll++l++ +k   +g +++ ++fekddd   ++dl+  +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++ ++K+
   Q: 825  dvavIEDLLAKLQEYAKMlpPGFQMKPIQFEKDDDTnfHMDLISGLANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLALYKL 917
           5567788888888888754489************************************.******************************99988 PP
   S: 388  vsg.....kfeplknfflfda 403
           ++      + e ++n+f ++a
   Q: 918  YKViagehPVEDYRNTFANLA 938
           776555778888999998876 PP

Organism

Triticum urartu

Protein Sequence
(Fasta)

MGCLRRLLRR GLRAMLPSKR PSDAAAGDEN GRGGDAKRMR RLFASDVLVS GLNGLGAEIE 60
VILPKYGRDT DLKLLKVFNP PCWASKNLAL AGVKSVTIHD VKTVEMWDLS GNFFLSEDDI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTGCT TACGGCGGCT GCTGCGCAGG GGCCTGCGCG CCATGCTCCC GTCCAAGAGG 60
CCGTCCGACG CCGCGGCGGG GGACGAAAAC GGCCGCGGAG GGGACGCCAA GAGGATGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000144	Aegilops tauschii	95.39	0.00e+00	1974.00
IUUC-Bdi-014009	Brachypodium distachyon	83.02	0.00e+00	1727.00
IUUC-Hvu-047191	Hordeum vulgare	95.29	0.00e+00	1974.00
IUUC-Lpe-051299	Leersia perrieri	85.77	0.00e+00	1770.00
IUUC-Oba-075934	Oryza barthii	86.26	0.00e+00	1779.00
IUUC-Obr-076244	Oryza brachyantha	84.89	0.00e+00	1712.00
IUUC-Ogl-077762	Oryza glaberrima	86.26	0.00e+00	1778.00
IUUC-Ogu-078305	Oryza glumaepatula	86.06	0.00e+00	1779.00
IUUC-Oin-080154	Oryza indica	86.26	0.00e+00	1779.00
IUUC-Olo-081089	Oryza longistaminata	86.56	0.00e+00	1785.00
IUUC-Ome-081171	Oryza meridionalis	80.18	0.00e+00	1663.00
IUUC-Oni-082447	Oryza nivara	86.16	0.00e+00	1779.00
IUUC-Opu-083863	Oryza punctata	85.48	0.00e+00	1762.00
IUUC-Oru-084469	Oryza rufipogon	86.36	0.00e+00	1782.00
IUUC-Osa-085625	Oryza sativa	86.36	0.00e+00	1778.00
IUUC-Sit-110294	Setaria italica	85.08	0.00e+00	1800.00
IUUC-Sbi-114774	Sorghum bicolor	86.06	0.00e+00	1820.00
IUUC-Tae-122812	Triticum aestivum	93.43	0.00e+00	2028.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence