iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-001806

Ensembl Protein ID

ENSAMEP00000007326.1

UniProt Accession

G1LK66; G1LK66_AILME

Genbank Protein ID

ENSAMEP00000007326

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

ACTA01168522

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000006918.1	ENSAMET00000007633.1	ENSAMEP00000007326.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.60e-28	97.2	1216	1267

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
            C++C++++ +e+ l++C++C++w+H++C +l  e+++++  +  + C +C+
   Q: 1216 TCPICHAPYMEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADegFDCVSCQ 1267
           6*******************************9888887776677******7 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MDSQKPPGED KDSEPAADGP AASEESGTTE PDLPNPHVGE VSVPSSGGPR LQEPPQDCSG 60
GPVRRCALCN CGEPSLHGQR ELRRFELPFD WPQGPVVSPG GNPGPSEAAL PSEDLSQIGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACAGCC AGAAGCCGCC TGGTGAGGAT AAAGATTCAG AACCGGCAGG TGAGGAGGGC 60
AAATTCTGGG TTTGCTGGCA GCCTTCTGTC CTTCCCAGGC AACCTTAGGT TTCTGGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	28.03	7.00e-13	69.30
IUUC-Aca-005364	Anolis carolinensis	53.01	0.00e+00	1221.00
IUUC-Ame-010612	Astyanax mexicanus	81.00	0.00e+00	1008.00
IUUC-Bta-013011	Bos taurus	92.89	0.00e+00	6098.00
IUUC-Cja-019841	Callithrix jacchus	91.60	0.00e+00	3852.00
IUUC-Cfa-021131	Canis familiaris	96.77	0.00e+00	3866.00
IUUC-Cpo-021957	Cavia porcellus	89.93	0.00e+00	3732.00
IUUC-Csa-023722	Chlorocebus sabaeus	93.40	0.00e+00	3783.00
IUUC-Dno-029932	Dasypus novemcinctus	87.96	0.00e+00	2347.00
IUUC-Dor-030192	Dipodomys ordii	87.73	0.00e+00	1729.00
IUUC-Ete-032572	Echinops telfairi	86.84	0.00e+00	1992.00
IUUC-Eca-034166	Equus caballus	95.76	0.00e+00	779.00
IUUC-Eeu-034848	Erinaceus europaeus	92.93	0.00e+00	1334.00
IUUC-Fca-035424	Felis catus	96.15	0.00e+00	3856.00
IUUC-Fal-037179	Ficedula albicollis	66.53	0.00e+00	1177.00
IUUC-Gmo-038719	Gadus morhua	82.02	0.00e+00	908.00
IUUC-Gga-040815	Gallus gallus	58.52	0.00e+00	1928.00
IUUC-Gac-042436	Gasterosteus aculeatus	79.68	0.00e+00	994.00
IUUC-Ggo-044711	Gorilla gorilla	94.16	0.00e+00	3707.00
IUUC-Hsa-046567	Homo sapiens	92.93	0.00e+00	3750.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	92.62	0.00e+00	3730.00
IUUC-Loc-051979	Lepisosteus oculatus	82.64	0.00e+00	1058.00
IUUC-Laf-054377	Loxodonta africana	92.76	0.00e+00	3709.00
IUUC-Mcc-055577	Macaca mulatta	92.58	0.00e+00	3742.00
IUUC-Meu-055992	Macropus eugenii	79.30	0.00e+00	1345.00
IUUC-Mmr-061772	Microcebus murinus	90.71	0.00e+00	3702.00
IUUC-Mdo-062876	Monodelphis domestica	78.33	0.00e+00	1170.00
IUUC-Mmu-063903	Mus musculus	88.55	0.00e+00	3534.00
IUUC-Mpu-066700	Mustela putorius furo	96.62	0.00e+00	3838.00
IUUC-Mlu-068180	Myotis lucifugus	92.65	0.00e+00	3940.00
IUUC-Nle-069362	Nomascus leucogenys	94.79	0.00e+00	3704.00
IUUC-Opr-070304	Ochotona princeps	85.78	0.00e+00	4385.00
IUUC-Ont-071881	Oreochromis niloticus	58.42	0.00e+00	1397.00
IUUC-Oan-073663	Ornithorhynchus anatinus	86.08	0.00e+00	906.00
IUUC-Ocu-074053	Oryctolagus cuniculus	86.66	0.00e+00	4757.00
IUUC-Ola-086384	Oryzias latipes	60.13	0.00e+00	1325.00
IUUC-Oga-088450	Otolemur garnettii	90.12	0.00e+00	3977.00
IUUC-Oar-089975	Ovis aries	95.11	0.00e+00	2065.00
IUUC-Ptr-091073	Pan troglodytes	94.16	0.00e+00	3705.00
IUUC-Pan-092871	Papio anubis	88.16	0.00e+00	3989.00
IUUC-Pfo-097525	Poecilia formosa	63.73	0.00e+00	1319.00
IUUC-Pab-097679	Pongo abelii	94.09	0.00e+00	3757.00
IUUC-Pca-100499	Procavia capensis	88.29	0.00e+00	2281.00
IUUC-Pva-102898	Pteropus vampyrus	94.37	0.00e+00	3673.00
IUUC-Rno-105660	Rattus norvegicus	88.65	0.00e+00	3576.00
IUUC-Sha-107431	Sarcophilus harrisii	79.71	0.00e+00	3156.00
IUUC-Sbi-113816	Sorghum bicolor	33.71	3.00e-13	70.90
IUUC-Ssc-115678	Sus scrofa	94.35	0.00e+00	3644.00
IUUC-Tru-117922	Takifugu rubripes	80.21	0.00e+00	1009.00
IUUC-Tsy-118905	Tarsius syrichta	87.08	0.00e+00	1673.00
IUUC-Tbe-127625	Tupaia belangeri	87.17	7.00e-159	556.00
IUUC-Ttr-129162	Tursiops truncatus	93.49	0.00e+00	2179.00
IUUC-Xtr-132455	Xenopus tropicalis	63.85	0.00e+00	1299.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence