iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115710

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Cell division cycle protein 20 homolog; p55CDC

Genbank Nucleotide ID

AB192873

Gene Name

CDC20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000003949.2	ENSSSCT00000004368.2	ENSSSCP00000004268.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	1.30e-147	491.3	172	478
E3 adaptor/Cullin RING/DCX/DWD	2.40e-28	97.3	307	336

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+++ldape+r+d+ylnL+dWss nvlavaL++svylwsa++gd+ +l ++ +++d+v+sv+wi+eg++lavGt+++ev+++Dv+++k+
   Q: 172  PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMeQPGDYVSSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 260
           689************************************************899*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse....Plk 173
           +r++t+hsarvg+L Wn+++lssGsr+g+i+h+dvrv+e++++tl++h+qevCGl+w+ d+++LasGGnDn v+vw ++  e    Pl+
   Q: 261  LRNMTSHSARVGSLCWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQ 349
           ********************************************************************************9999***** PP
   S: 174  kfkehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvae 262
           +f++h++avka+aw+Pwq+++La+GGGt+Dr+i++wn+++ga+l+++d++sqvcs+lws+++kel+s+hGfa+n++++wkyp+++kvae
   Q: 350  TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438
           ***************************************************************************************** PP
   S: 263  lkgheaRvlslalspdgeaivtaagDetlrfwklfdkkka 302
           lkgh+aRvlsl++spdg+++++aa+Detlr+w++f+ ++a
   Q: 439  LKGHTARVLSLTMSPDGATVASAAADETLRLWRCFELDPA 478
           ***********************************99876 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW 28
           gH+ +v++l++ +d ++l+sG++D+ + vW
   Q: 307  GHSQEVCGLRWaPDgRHLASGGNDNLVNVW 336
           8***********999*************** PP

Organism

Sus scrofa

Functional Description
(View)

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity).

Protein Sequence
(Fasta)

MAQFVFESDL HSLLQLDAPI PNAPPARWQR KAKEAAGPAP SPMRAANRSH SAGRTPGRTP 60
GKSNSKMQTT PSKPGGDRYI PHRSASQMEV ASFLLSKENQ PDNSQTPTKK EHQKAWALNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACGGTCGC GTCTNCCTGG GNCTCGCGGG CGGCCGCCTC AAGCACCCCT CNCCTTCCAG 60
CCGCTCNCAT GGCCCAGTTC GTGTTCGAGA GCGACCTGCA CTCCCTGCTG CAGCTGGATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033187--CDC20
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0000922--C:spindle pole
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007064--P:mitotic sister chromatid cohesion
GO:0090307--P:mitotic spindle assembly
GO:1904146--P:positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination
GO:0040020--P:regulation of meiotic nuclear division

KEGG

ssc:397379

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000638	Aegilops tauschii	46.10	2.00e-110	392.00
IUUC-Aml-001545	Ailuropoda melanoleuca	98.20	0.00e+00	952.00
IUUC-Atr-003103	Amborella trichopoda	46.21	3.00e-108	385.00
IUUC-Apl-003255	Anas platyrhynchos	80.68	0.00e+00	753.00
IUUC-Aca-004920	Anolis carolinensis	76.23	0.00e+00	780.00
IUUC-Aly-006012	Arabidopsis lyrata	48.34	5.00e-109	387.00
IUUC-Ath-006795	Arabidopsis thaliana	45.33	9.00e-108	383.00
IUUC-Ate-010479	Aspergillus terreus	50.47	8.00e-92	330.00
IUUC-Ame-010850	Astyanax mexicanus	60.35	2.00e-90	325.00
IUUC-Bgr-012059	Blumeria graminis	49.51	5.00e-95	341.00
IUUC-Bta-012625	Bos taurus	98.40	0.00e+00	960.00
IUUC-Bci-013607	Botrytis cinerea	48.25	1.00e-98	353.00
IUUC-Bdi-014344	Brachypodium distachyon	48.42	1.00e-109	389.00
IUUC-Bol-015368	Brassica oleracea	46.12	2.00e-106	380.00
IUUC-Bra-016738	Brassica rapa	46.60	2.00e-105	376.00
IUUC-Cja-019132	Callithrix jacchus	97.39	0.00e+00	952.00
IUUC-Cfa-020780	Canis familiaris	97.60	0.00e+00	949.00
IUUC-Cpo-022223	Cavia porcellus	97.80	0.00e+00	905.00
IUUC-Cre-022701	Chlamydomonas reinhardtii	50.00	2.00e-116	412.00
IUUC-Csa-023666	Chlorocebus sabaeus	98.20	0.00e+00	955.00
IUUC-Cho-024920	Choloepus hoffmanni	97.16	6.00e-162	563.00
IUUC-Cin-025675	Ciona intestinalis	51.00	4.00e-134	471.00
IUUC-Csv-026019	Ciona savignyi	50.75	2.00e-130	459.00
IUUC-Cgl-026465	Colletotrichum gloeosporioides	41.21	2.00e-97	349.00
IUUC-Cme-027234	Cyanidioschyzon merolae	52.73	2.00e-106	379.00
IUUC-Dre-028026	Danio rerio	59.76	0.00e+00	628.00
IUUC-Dno-028865	Dasypus novemcinctus	97.00	0.00e+00	938.00
IUUC-Dor-030958	Dipodomys ordii	96.99	0.00e+00	949.00
IUUC-Dse-031391	Dothistroma septosporum	39.37	1.00e-96	347.00
IUUC-Dme-031905	Drosophila melanogaster	49.15	2.00e-143	502.00
IUUC-Ete-032387	Echinops telfairi	91.98	0.00e+00	906.00
IUUC-Eca-033522	Equus caballus	88.18	0.00e+00	858.00
IUUC-Eeu-035059	Erinaceus europaeus	84.80	0.00e+00	795.00
IUUC-Fca-036346	Felis catus	98.41	0.00e+00	873.00
IUUC-Fal-037558	Ficedula albicollis	80.16	0.00e+00	796.00
IUUC-Fox-037850	Fusarium oxysporum	45.69	2.00e-98	352.00
IUUC-Fso-038375	Fusarium solani	45.60	3.00e-99	355.00
IUUC-Gmo-039284	Gadus morhua	62.10	0.00e+00	628.00
IUUC-Ggr-039864	Gaeumannomyces graminis	48.55	1.00e-98	353.00
IUUC-Gga-040790	Gallus gallus	79.92	0.00e+00	815.00
IUUC-Gac-041431	Gasterosteus aculeatus	61.63	3.00e-179	621.00
IUUC-Gma-043489	Glycine max	46.86	2.00e-106	379.00
IUUC-Ggo-045052	Gorilla gorilla	98.20	0.00e+00	955.00
IUUC-Hsa-046305	Homo sapiens	98.20	0.00e+00	955.00
IUUC-Hvu-047476	Hordeum vulgare	45.35	7.00e-110	390.00
IUUC-Itr-048461	Ictidomys tridecemlineatus	98.20	0.00e+00	909.00
IUUC-Lch-050174	Latimeria chalumnae	60.81	2.00e-172	598.00
IUUC-Lpe-050954	Leersia perrieri	47.80	4.00e-101	361.00
IUUC-Loc-052638	Lepisosteus oculatus	62.92	0.00e+00	630.00
IUUC-Lma-052998	Leptosphaeria maculans	43.50	8.00e-101	360.00
IUUC-Laf-053742	Loxodonta africana	98.20	0.00e+00	952.00
IUUC-Mcc-054948	Macaca mulatta	98.20	0.00e+00	955.00
IUUC-Meu-056013	Macropus eugenii	87.63	1.00e-143	502.00
IUUC-Mor-057277	Magnaporthe oryzae	52.15	4.00e-96	345.00
IUUC-Mpo-057624	Magnaporthe poae	51.47	1.00e-96	347.00
IUUC-Mtr-057725	Medicago truncatula	45.12	1.00e-99	356.00
IUUC-Mga-060102	Meleagris gallopavo	80.16	0.00e+00	816.00
IUUC-Mmr-061615	Microcebus murinus	98.33	0.00e+00	949.00
IUUC-Mdo-061982	Monodelphis domestica	89.57	0.00e+00	778.00
IUUC-Mmu-063864	Mus musculus	94.59	0.00e+00	933.00
IUUC-Mac-064861	Musa acuminata	47.70	3.00e-110	391.00
IUUC-Mpu-066502	Mustela putorius furo	98.00	0.00e+00	945.00
IUUC-Mlu-067277	Myotis lucifugus	90.42	0.00e+00	890.00
IUUC-Ncr-068951	Neurospora crassa	45.87	3.00e-95	342.00
IUUC-Nle-070149	Nomascus leucogenys	98.20	0.00e+00	949.00
IUUC-Opr-070778	Ochotona princeps	96.38	0.00e+00	692.00
IUUC-Ont-071660	Oreochromis niloticus	60.96	2.00e-177	615.00
IUUC-Oan-073677	Ornithorhynchus anatinus	77.69	0.00e+00	708.00
IUUC-Ocu-073797	Oryctolagus cuniculus	98.19	0.00e+00	951.00
IUUC-Oba-075946	Oryza barthii	48.40	3.00e-108	385.00
IUUC-Obr-076018	Oryza brachyantha	47.69	2.00e-108	385.00
IUUC-Ogl-077254	Oryza glaberrima	48.03	3.00e-101	362.00
IUUC-Ogu-078521	Oryza glumaepatula	48.40	2.00e-108	386.00
IUUC-Oin-079145	Oryza indica	48.18	3.00e-108	385.00
IUUC-Olo-080798	Oryza longistaminata	48.16	3.00e-108	385.00
IUUC-Ome-081186	Oryza meridionalis	48.16	2.00e-108	386.00
IUUC-Oni-082243	Oryza nivara	48.03	3.00e-101	362.00
IUUC-Opu-084007	Oryza punctata	48.03	4.00e-101	361.00
IUUC-Oru-084562	Oryza rufipogon	48.40	2.00e-108	386.00
IUUC-Osa-086094	Oryza sativa	48.03	3.00e-101	361.00
IUUC-Ola-086907	Oryzias latipes	60.63	3.00e-165	574.00
IUUC-Olu-087647	Ostreococcus lucimarinus	49.31	2.00e-119	422.00
IUUC-Oga-088184	Otolemur garnettii	96.80	0.00e+00	938.00
IUUC-Oar-090023	Ovis aries	92.87	0.00e+00	852.00
IUUC-Ptr-090935	Pan troglodytes	97.25	0.00e+00	888.00
IUUC-Pan-091845	Papio anubis	98.20	0.00e+00	955.00
IUUC-Psi-093188	Pelodiscus sinensis	80.93	0.00e+00	843.00
IUUC-Pma-094187	Petromyzon marinus	54.56	5.00e-149	520.00
IUUC-Pno-094809	Phaeosphaeria nodorum	41.31	2.00e-101	362.00
IUUC-Ppa-095457	Physcomitrella patens	46.77	6.00e-110	390.00
IUUC-Pfo-097429	Poecilia formosa	58.37	9.00e-160	556.00
IUUC-Pab-098603	Pongo abelii	98.40	0.00e+00	955.00
IUUC-Pop-099654	Populus trichocarpa	46.39	1.00e-102	366.00
IUUC-Pca-101062	Procavia capensis	97.19	0.00e+00	930.00
IUUC-Ppe-101865	Prunus persica	46.76	1.00e-96	346.00
IUUC-Pva-102925	Pteropus vampyrus	96.59	0.00e+00	974.00
IUUC-Pte-104142	Pyrenophora teres	42.64	5.00e-99	354.00
IUUC-Pyt-104693	Pyrenophora triticirepentis	42.48	5.00e-99	354.00
IUUC-Rno-106005	Rattus norvegicus	95.19	0.00e+00	936.00
IUUC-Sha-107472	Sarcophilus harrisii	90.60	0.00e+00	898.00
IUUC-Sja-107919	Schizosaccharomyces japonicus	43.06	9.00e-94	337.00
IUUC-Spo-108075	Schizosaccharomyces pombe	44.72	2.00e-96	345.00
IUUC-Ssl-108507	Sclerotinia sclerotiorum	49.56	6.00e-98	351.00
IUUC-Smo-108922	Selaginella moellendorffii	49.25	5.00e-123	434.00
IUUC-Sit-110732	Setaria italica	46.92	1.00e-109	389.00
IUUC-Sly-111202	Solanum lycopersicum	44.65	2.00e-105	375.00
IUUC-Stu-112676	Solanum tuberosum	45.32	4.00e-97	347.00
IUUC-Sar-113092	Sorex araneus	91.78	0.00e+00	887.00
IUUC-Sbi-114558	Sorghum bicolor	45.80	1.00e-109	389.00
IUUC-Tgu-117100	Taeniopygia guttata	79.17	0.00e+00	795.00
IUUC-Tru-118184	Takifugu rubripes	57.58	8.00e-139	486.00
IUUC-Tsy-118892	Tarsius syrichta	97.16	3.00e-163	566.00
IUUC-Tni-120474	Tetraodon nigroviridis	59.21	9.00e-168	583.00
IUUC-Tca-120949	Theobroma cacao	46.51	2.00e-106	379.00
IUUC-Tre-122211	Trichoderma reesei	41.16	6.00e-98	350.00
IUUC-Tvi-122531	Trichoderma virens	40.53	5.00e-97	348.00
IUUC-Tae-123017	Triticum aestivum	45.43	3.00e-110	391.00
IUUC-Tur-126193	Triticum urartu	45.58	6.00e-110	390.00
IUUC-Tbe-127384	Tupaia belangeri	99.33	2.00e-177	615.00
IUUC-Ttr-128511	Tursiops truncatus	98.00	0.00e+00	950.00
IUUC-Vda-129993	Verticillium dahliae	40.60	1.00e-97	350.00
IUUC-Vvi-131245	Vitis vinifera	47.17	3.00e-94	338.00
IUUC-Xtr-131993	Xenopus tropicalis	73.29	0.00e+00	755.00
IUUC-Xma-133332	Xiphophorus maculatus	61.54	3.00e-176	611.00
IUUC-Zma-135135	Zea mays	48.08	7.00e-108	383.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence