iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033796

UUCD1 version

UUC-EqC-00223

Ensembl Protein ID

ENSECAP00000006720.1

UniProt Accession

F6TGI2; F6TGI2_HORSE

Protein Name

Uncharacterized protein

Gene Name

TBL1XR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000008249.1	ENSECAT00000008912.1	ENSECAP00000006720.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-33	113.8	442	480
UBD/Beta-Prp	2.20e-43	148.7	373	513

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ tg l++s
   Q: 442  HQEPVYSVAFsPDgRYLASGSFDKCVHIWNTQTGALVHS 480
           9**********999*******************998875 PP

UBD/Beta-Prp

   S: 75   tikvwdlstgkcvhtlkghedsvlslsfsp........sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvs 154
            + +w++++  cvh l++h+++++++++sp        +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+s
   Q: 373  PLFIWSMKQDNCVHDLQAHNKEIYTIKWSPtgpgtnnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLAS 460
           35566666666666666666666666666644444333222356666666666666666666666.66666666666666666666666 PP
   S: 155  GslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           Gs D++v +W+ +tg l++  +g  t+ +  + ++  g  + + + dg+v + dl
   Q: 461  GSFDKCVHIWNTQTGALVHSYRG--TGGIFEVCWNAAGDKVGASASDGSVCVLDL 513
           66666666666666666666665..666666666666666666666666665555 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV 60
EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQAAA AAAAAAATNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGCATCAG CAACTTGTGA TTGGTGGTAC CGGATACTCA GTTGCACATC CCCACATCAA 60
TGCACTGCCA ATGGTAAGAA TGCCTCCTGC TCCGAATGCC AGTGTTTTAA TTGCTCTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0060613--P:fat pad development
GO:0016575--P:histone deacetylation
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0050872--P:white fat cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	61.15	5.00e-55	206.00
IUUC-Cho-024872	Choloepus hoffmanni	99.15	2.00e-112	399.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence