iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sja-107841

Ensembl Protein ID

EEB05828

UniProt Accession

B6JWS7; B6JWS7_SCHJY

Genbank Protein ID

EEB05828.2

Protein Name

Ubiquitin activating enzyme E1

Genbank Nucleotide ID

KE651166

Gene Name

SJAG_00853

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SJAG_00853	EEB05828	EEB05828

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.00e-181	600.4	405	885

Active Site

Position(s)	Description	Evidence
588	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdv..nveahe 94
           YD+Qi ++G + q+kl++ k +lvGag++GcE+lKn +++Gv     g++ v+Dmd +e+snlnrqFLfr++dvgk K+e+aa a+  +n +   +++a++
   Q: 405  YDGQITVFGKKFQAKLENLKQFLVGAGAIGCEMLKNWAMMGVgagpnGHVFVTDMDSIEKSNLNRQFLFRPKDVGKHKSECAATAVGIMNASSigSITAYQ 505
           ***************************************************************************************9997643599**** PP
   S: 95   esiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.. 190
           e++ +++e+i+   Ff+++d+V +aldn++ar +++r+c+  ++pl+esgtlG++G+++v+++ lte+ys+s+dpp+k++P+ctlk++pn++ehti wa  
   Q: 506  ERVGQETENIFnddFFENLDIVTNALDNVDARQYMDRRCVFFQKPLLESGTLGTKGNTQVVLPFLTESYSSSQDPPEKSFPICTLKNFPNQIEHTIAWArd 606
           **********9****************************************************************************************** PP
   S: 191  ..........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv....... 274
                       +n +l+  ++ e++l+  +s++++e+++ +++ l++ ++ +fee+i + + +f+k+++++i+qll +f++d vt+s++pfw+       
   Q: 607  lfeglfkqpiDNVNLYLSSPNFLETTLK--TSNNPREVLESIRDHLVTDKPLSFEECIVWGRMQFEKYFNHNIQQLLFNFPKDSVTSSGQPFWSgpkrapt 705
           *******999999999999999999999..679******************************************************************** PP
   S: 275  ................................................sfcsnaealqvpekvekdeevvkasaplylllralerfekkkgrkpgelsfek 327
                                                             ++   ++qv+e+ e ++e+++++++l++ + +l   ++  g   + ++fek
   Q: 706  plvfdahnplhydfvinaanlyaynyglkgeaspdvvekvlssievpsFTPKSGVKIQVNETDEVPQETSADESELKTIVDSLPAPSSLAGYRLNPCEFEK 806
           ********************************************99965666778999***********999999************************** PP
   S: 328  ddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfda 403
           ddds  ++d++taa+nlra++++i+p +d++++k +ag+i+pa+ t +av +Gl+++E++Kvv+g    e + n f+++a
   Q: 807  DDDSnhHIDFITAASNLRATNYQIKP-VDRFKTKFVAGKIVPAMCTSTAVASGLVNLELYKVVDGkkNLEDYSNGFFNLA 885
           **************************.**************************************555566888888876 PP

Organism

Schizosaccharomyces japonicus

Protein Sequence
(Fasta)

MKIDTSDGET IDESLYSRQL YVLGHDAMKK MSHSNVLIIG CRGLGIEIAK NVCLAGVKSV 60
TIYDPQPTRM EDLSTQYFLH EDDIGKPRAE VSVPRLAELN EYVPVKAITD ISLETLKNFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAATCG ACACGTCTGA TGGCGAGACC ATTGACGAAA GCCTTTATTC GAGACAACTG 60
TAAGCAGATT GGGACACGTT CAGATCCGAA TTCCGTGAGC GATACAGCTA AATTGTGTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004839--F:ubiquitin activating enzyme activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	45.78	0.00e+00	852.00
IUUC-Aml-001311	Ailuropoda melanoleuca	55.45	0.00e+00	1124.00
IUUC-Atr-002684	Amborella trichopoda	44.46	0.00e+00	834.00
IUUC-Apl-004158	Anas platyrhynchos	42.76	0.00e+00	715.00
IUUC-Aca-004620	Anolis carolinensis	54.86	0.00e+00	1112.00
IUUC-Aly-005418	Arabidopsis lyrata	44.39	0.00e+00	862.00
IUUC-Ath-006992	Arabidopsis thaliana	44.32	0.00e+00	845.00
IUUC-Ago-007873	Ashbya gossypii	57.35	0.00e+00	1149.00
IUUC-Acl-008181	Aspergillus clavatus	60.30	0.00e+00	1229.00
IUUC-Afl-008455	Aspergillus flavus	60.77	0.00e+00	1208.00
IUUC-Afu-009065	Aspergillus fumigatus	60.53	0.00e+00	1254.00
IUUC-Ani-009371	Aspergillus nidulans	59.49	0.00e+00	1207.00
IUUC-Ang-009737	Aspergillus niger	60.73	0.00e+00	1238.00
IUUC-Aor-010007	Aspergillus oryzae	60.77	0.00e+00	1208.00
IUUC-Ate-010466	Aspergillus terreus	59.73	0.00e+00	1253.00
IUUC-Ame-010933	Astyanax mexicanus	55.19	0.00e+00	1046.00
IUUC-Bgr-012281	Blumeria graminis	58.57	0.00e+00	1201.00
IUUC-Bta-012767	Bos taurus	55.16	0.00e+00	1128.00
IUUC-Bci-013721	Botrytis cinerea	59.84	0.00e+00	1190.00
IUUC-Bdi-014009	Brachypodium distachyon	43.90	0.00e+00	815.00
IUUC-Bol-015665	Brassica oleracea	44.62	0.00e+00	843.00
IUUC-Bra-017707	Brassica rapa	44.72	0.00e+00	862.00
IUUC-Cel-018260	Caenorhabditis elegans	45.74	0.00e+00	828.00
IUUC-Cja-019152	Callithrix jacchus	55.43	0.00e+00	1128.00
IUUC-Cfa-020622	Canis familiaris	54.92	0.00e+00	1074.00
IUUC-Cpo-022526	Cavia porcellus	56.01	0.00e+00	1117.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	42.36	0.00e+00	751.00
IUUC-Csa-023780	Chlorocebus sabaeus	55.51	0.00e+00	1123.00
IUUC-Cho-024682	Choloepus hoffmanni	38.62	4.00e-89	320.00
IUUC-Cin-025790	Ciona intestinalis	52.64	0.00e+00	1076.00
IUUC-Csv-026084	Ciona savignyi	51.50	0.00e+00	1059.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	59.37	0.00e+00	1233.00
IUUC-Cne-026960	Cryptococcus neoformans	59.62	0.00e+00	1201.00
IUUC-Cme-027290	Cyanidioschyzon merolae	40.96	0.00e+00	768.00
IUUC-Dre-028149	Danio rerio	55.50	0.00e+00	1074.00
IUUC-Dno-028884	Dasypus novemcinctus	55.31	0.00e+00	1126.00
IUUC-Dor-030229	Dipodomys ordii	53.13	0.00e+00	1057.00
IUUC-Dse-031524	Dothistroma septosporum	58.72	0.00e+00	1195.00
IUUC-Dme-032045	Drosophila melanogaster	52.50	0.00e+00	1048.00
IUUC-Ete-033124	Echinops telfairi	38.54	1.00e-132	465.00
IUUC-Eca-033330	Equus caballus	55.61	0.00e+00	1127.00
IUUC-Eeu-035323	Erinaceus europaeus	39.50	2.00e-149	521.00
IUUC-Fca-036255	Felis catus	55.71	0.00e+00	1121.00
IUUC-Fal-036848	Ficedula albicollis	41.86	0.00e+00	717.00
IUUC-Fox-038007	Fusarium oxysporum	59.14	0.00e+00	641.00
IUUC-Fso-038339	Fusarium solani	58.86	0.00e+00	1167.00
IUUC-Gmo-039338	Gadus morhua	54.03	0.00e+00	1035.00
IUUC-Ggr-039823	Gaeumannomyces graminis	58.32	0.00e+00	1234.00
IUUC-Gga-040747	Gallus gallus	42.53	0.00e+00	719.00
IUUC-Gac-041773	Gasterosteus aculeatus	53.48	0.00e+00	1032.00
IUUC-Gma-043165	Glycine max	44.75	0.00e+00	854.00
IUUC-Ggo-045336	Gorilla gorilla	55.71	0.00e+00	1113.00
IUUC-Hsa-045982	Homo sapiens	55.61	0.00e+00	1110.00
IUUC-Hvu-047418	Hordeum vulgare	46.20	0.00e+00	835.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	55.61	0.00e+00	1125.00
IUUC-Kpa-049112	Komagataella pastoris	59.59	0.00e+00	1174.00
IUUC-Lch-050371	Latimeria chalumnae	55.36	0.00e+00	1096.00
IUUC-Lpe-051299	Leersia perrieri	44.17	0.00e+00	842.00
IUUC-Loc-052936	Lepisosteus oculatus	55.46	0.00e+00	1095.00
IUUC-Lma-053315	Leptosphaeria maculans	59.82	0.00e+00	1252.00
IUUC-Laf-053948	Loxodonta africana	54.82	0.00e+00	1095.00
IUUC-Mcc-055843	Macaca mulatta	55.61	0.00e+00	1127.00
IUUC-Meu-056258	Macropus eugenii	54.22	0.00e+00	1092.00
IUUC-Mor-057269	Magnaporthe oryzae	59.25	0.00e+00	1227.00
IUUC-Mpo-057435	Magnaporthe poae	57.92	0.00e+00	1205.00
IUUC-Mtr-058572	Medicago truncatula	45.44	0.00e+00	839.00
IUUC-Mla-059176	Melampsora laricipopulina	59.56	0.00e+00	1184.00
IUUC-Mga-059721	Meleagris gallopavo	42.70	0.00e+00	701.00
IUUC-Mvi-060437	Microbotryum violaceum	56.62	0.00e+00	1147.00
IUUC-Mmr-061405	Microcebus murinus	54.73	0.00e+00	1086.00
IUUC-Mdo-062032	Monodelphis domestica	52.76	0.00e+00	1058.00
IUUC-Mmu-063280	Mus musculus	55.61	0.00e+00	1110.00
IUUC-Mac-065505	Musa acuminata	44.63	0.00e+00	825.00
IUUC-Mpu-066409	Mustela putorius furo	55.71	0.00e+00	1130.00
IUUC-Mlu-067217	Myotis lucifugus	54.52	0.00e+00	1099.00
IUUC-Nfi-068407	Neosartorya fischeri	60.44	0.00e+00	1230.00
IUUC-Ncr-068698	Neurospora crassa	60.02	0.00e+00	1250.00
IUUC-Nle-070072	Nomascus leucogenys	53.52	0.00e+00	1036.00
IUUC-Opr-070715	Ochotona princeps	36.22	8.00e-176	608.00
IUUC-Ont-071671	Oreochromis niloticus	55.40	0.00e+00	1073.00
IUUC-Oan-073268	Ornithorhynchus anatinus	40.63	0.00e+00	660.00
IUUC-Ocu-074544	Oryctolagus cuniculus	55.71	0.00e+00	1129.00
IUUC-Oba-075120	Oryza barthii	45.15	0.00e+00	829.00
IUUC-Obr-076557	Oryza brachyantha	46.12	0.00e+00	829.00
IUUC-Ogl-077887	Oryza glaberrima	45.05	0.00e+00	828.00
IUUC-Ogu-078305	Oryza glumaepatula	43.88	0.00e+00	830.00
IUUC-Oin-079370	Oryza indica	44.19	0.00e+00	812.00
IUUC-Olo-081089	Oryza longistaminata	43.88	0.00e+00	832.00
IUUC-Ome-081942	Oryza meridionalis	45.15	0.00e+00	832.00
IUUC-Oni-082365	Oryza nivara	45.25	0.00e+00	831.00
IUUC-Opu-083977	Oryza punctata	45.35	0.00e+00	837.00
IUUC-Oru-084469	Oryza rufipogon	43.98	0.00e+00	832.00
IUUC-Osa-085949	Oryza sativa	45.35	0.00e+00	840.00
IUUC-Ola-087002	Oryzias latipes	55.80	0.00e+00	1081.00
IUUC-Olu-087687	Ostreococcus lucimarinus	43.66	0.00e+00	774.00
IUUC-Oga-088594	Otolemur garnettii	55.36	0.00e+00	1105.00
IUUC-Oar-090068	Ovis aries	54.91	0.00e+00	1120.00
IUUC-Ptr-090609	Pan troglodytes	41.84	0.00e+00	698.00
IUUC-Pan-092114	Papio anubis	55.41	0.00e+00	1123.00
IUUC-Psi-093489	Pelodiscus sinensis	41.46	0.00e+00	715.00
IUUC-Pma-094214	Petromyzon marinus	45.18	3.00e-36	142.00
IUUC-Pno-095154	Phaeosphaeria nodorum	59.60	0.00e+00	1247.00
IUUC-Ppa-095227	Physcomitrella patens	46.60	0.00e+00	854.00
IUUC-Pfo-097184	Poecilia formosa	54.22	0.00e+00	1060.00
IUUC-Pab-097861	Pongo abelii	55.41	0.00e+00	1098.00
IUUC-Pop-098934	Populus trichocarpa	44.46	0.00e+00	853.00
IUUC-Pca-100347	Procavia capensis	53.80	0.00e+00	945.00
IUUC-Ppe-102012	Prunus persica	43.50	0.00e+00	840.00
IUUC-Pva-102584	Pteropus vampyrus	55.51	0.00e+00	1144.00
IUUC-Pgr-103336	Puccinia graminis	56.84	0.00e+00	1125.00
IUUC-Ptt-103939	Puccinia triticina	56.84	0.00e+00	1122.00
IUUC-Pte-104200	Pyrenophora teres	59.82	0.00e+00	1249.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	58.70	0.00e+00	1242.00
IUUC-Rno-105462	Rattus norvegicus	55.51	0.00e+00	1107.00
IUUC-Sce-106245	Saccharomyces cerevisiae	57.81	0.00e+00	1174.00
IUUC-Sha-107142	Sarcophilus harrisii	53.43	0.00e+00	1085.00
IUUC-Spo-108034	Schizosaccharomyces pombe	73.51	0.00e+00	1536.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	59.22	0.00e+00	1210.00
IUUC-Smo-108912	Selaginella moellendorffii	46.26	0.00e+00	844.00
IUUC-Sit-110281	Setaria italica	46.39	0.00e+00	856.00
IUUC-Sly-110914	Solanum lycopersicum	44.28	0.00e+00	859.00
IUUC-Stu-112109	Solanum tuberosum	43.99	0.00e+00	861.00
IUUC-Sar-113737	Sorex araneus	55.31	0.00e+00	1117.00
IUUC-Sbi-114089	Sorghum bicolor	46.49	0.00e+00	859.00
IUUC-Sre-115148	Sporisorium reilianum	57.85	0.00e+00	1169.00
IUUC-Ssc-115777	Sus scrofa	55.11	0.00e+00	1118.00
IUUC-Tgu-116565	Taeniopygia guttata	41.63	0.00e+00	712.00
IUUC-Tru-118742	Takifugu rubripes	54.91	0.00e+00	1036.00
IUUC-Tsy-119436	Tarsius syrichta	38.12	2.00e-140	491.00
IUUC-Tni-120401	Tetraodon nigroviridis	55.70	0.00e+00	1053.00
IUUC-Tca-121672	Theobroma cacao	44.50	0.00e+00	850.00
IUUC-Tre-122009	Trichoderma reesei	58.19	0.00e+00	1150.00
IUUC-Tvi-122259	Trichoderma virens	58.02	0.00e+00	1142.00
IUUC-Tae-125676	Triticum aestivum	44.62	0.00e+00	847.00
IUUC-Tur-126330	Triticum urartu	46.03	0.00e+00	850.00
IUUC-Tme-127055	Tuber melanosporum	59.11	0.00e+00	1170.00
IUUC-Tbe-127487	Tupaia belangeri	55.65	7.00e-151	526.00
IUUC-Ttr-128331	Tursiops truncatus	55.07	0.00e+00	1118.00
IUUC-Uma-129387	Ustilago maydis	58.33	0.00e+00	1168.00
IUUC-Vda-129977	Verticillium dahliae	59.11	0.00e+00	1154.00
IUUC-Vpa-130716	Vicugna pacos	40.00	0.00e+00	657.00
IUUC-Vvi-130857	Vitis vinifera	44.79	0.00e+00	853.00
IUUC-Xtr-132947	Xenopus tropicalis	39.37	0.00e+00	650.00
IUUC-Xma-133805	Xiphophorus maculatus	54.32	0.00e+00	1049.00
IUUC-Yli-134547	Yarrowia lipolytica	58.46	0.00e+00	1221.00
IUUC-Zma-135052	Zea mays	46.35	0.00e+00	857.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence