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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063876
Ensembl Protein ID ENSMUSP00000043215.2
UniProt Accession A2AHZ2; A2AHZ2_MOUSE
Genbank Protein ID EDL40763.1
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID AL732294
Gene Name Siah1b; mCG_115797
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040749.11 ENSMUST00000037928.8 ENSMUSP00000043215.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
HINT
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 84.27 2.00e-125 445.00 IUUC-Dme-031700
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description



     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MSRQAATALS TGTSKCPPSQ RVPALTDTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL 60
VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY SASGCEITLP HTKKAEHEEL 120
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Protein Fasta Sequence



>IUUC-Mmu-063876|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
TAAGCGACGG ATGGAGGCGG GCTGGTGACA TGGGCGGAGC GCGAAAATCG GCCTGTGGTC 60
TTAGGCGCAA GGGTGATCGC ATGCCGCTGT TCGAGATCAA AGGCCTGGGC AAGTCACTTG 120
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Nucleotide Fasta Sequence



>IUUC-Mmu-063876|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG mmu:20438
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000061 Aegilops tauschii 37.82 2.00e-44 172.00
IUUC-Atr-002857 Amborella trichopoda 35.21 8.00e-45 174.00
IUUC-Bra-016910 Brassica rapa 36.82 3.00e-41 162.00
IUUC-Cel-018320 Caenorhabditis elegans 72.27 1.00e-114 406.00
IUUC-Cin-025674 Ciona intestinalis 78.72 2.00e-135 475.00
IUUC-Csv-026233 Ciona savignyi 84.65 1.00e-132 465.00
IUUC-Dme-031700 Drosophila melanogaster 84.27 2.00e-120 424.00
IUUC-Obr-076037 Oryza brachyantha 35.43 2.00e-40 159.00
IUUC-Tae-123647 Triticum aestivum 37.82 2.00e-44 172.00
IUUC-Tur-126049 Triticum urartu 35.04 7.00e-39 154.00
Created Date 25-Jun-2017

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