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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105274
UUCD1 version UUC-RaN-00525
Ensembl Protein ID ENSRNOP00000063581.2
UniProt Accession B2RYN2; FBX31_RAT
Genbank Protein ID AAI66840.1
Protein Name F-box only protein 31
Genbank Nucleotide ID BC166840
Gene Name Fbxo31
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000042274.4 ENSRNOT00000074005.3 ENSRNOP00000067191.1
ENSRNOG00000042274.4 ENSRNOT00000068764.3 ENSRNOP00000063581.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 2.80e-06 27.8 11 95
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 65   gpsaaakpkaglrseaaaapapapaptp....tpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwkt 145
           gp+  ++ +   r  a +a a + a t       e gp + +l +lp e+lvei+  l++++l ++a+vc r++++ +++++w++
   Q: 11   GPARGCRRRQQRRGPAETAAADSEADTDpeeeRIEAGPARCSLLELPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIWRR 95
           55555555556666555555666665540011345699************************************99999999986 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).
 Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).
Protein Sequence
(Fasta)
MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR CSLLELPPEL 60
LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE YGVCENLRKL EITGVSCRDV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105274|E3,F-box|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGACGGGCAT GGCGGTGTGT GCTCGGCTCT GCGGCGTGGG CCCCGCGCGT GGGTGCCGCC 60
GCCGCCAGCA GCGCCGCGGC CCGGCCGAGA CTGCGGCGGC GGACAGTGAG GCGGACACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105274|E3,F-box|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR026941--FBXO31
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
Gene Ontology

GO:0005813--C:centrosome
GO:0043025--C:neuronal cell body
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:2001224--P:positive regulation of neuron migration
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG rno:498959
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000641 Aegilops tauschii 32.26 1.00e-03 37.40
IUUC-Aml-001283 Ailuropoda melanoleuca 79.63 0.00e+00 738.00
IUUC-Atr-003100 Amborella trichopoda 29.67 8.00e-05 42.40
IUUC-Apl-003209 Anas platyrhynchos 73.60 0.00e+00 651.00
IUUC-Aca-004894 Anolis carolinensis 76.04 0.00e+00 708.00
IUUC-Aly-005512 Arabidopsis lyrata 32.89 5.00e-04 39.70
IUUC-Ath-007284 Arabidopsis thaliana 30.63 6.00e-06 46.20
IUUC-Ame-011867 Astyanax mexicanus 65.29 0.00e+00 657.00
IUUC-Bta-012497 Bos taurus 78.91 0.00e+00 719.00
IUUC-Bdi-014535 Brachypodium distachyon 36.54 4.00e-03 36.20
IUUC-Cja-019896 Callithrix jacchus 81.62 0.00e+00 830.00
IUUC-Cfa-020183 Canis familiaris 84.62 0.00e+00 700.00
IUUC-Cpo-022420 Cavia porcellus 87.91 0.00e+00 857.00
IUUC-Cre-022968 Chlamydomonas reinhardtii 35.00 2.00e-04 41.60
IUUC-Csa-023606 Chlorocebus sabaeus 77.27 0.00e+00 816.00
IUUC-Dre-028579 Danio rerio 70.63 0.00e+00 652.00
IUUC-Dno-030013 Dasypus novemcinctus 84.24 2.00e-149 522.00
IUUC-Dor-030865 Dipodomys ordii 85.17 0.00e+00 797.00
IUUC-Eca-033625 Equus caballus 87.14 0.00e+00 714.00
IUUC-Eeu-034639 Erinaceus europaeus 70.95 0.00e+00 642.00
IUUC-Fca-036551 Felis catus 76.33 0.00e+00 707.00
IUUC-Fal-037031 Ficedula albicollis 82.73 0.00e+00 741.00
IUUC-Gmo-039215 Gadus morhua 65.37 3.00e-170 591.00
IUUC-Gga-040962 Gallus gallus 79.91 0.00e+00 741.00
IUUC-Gac-041683 Gasterosteus aculeatus 65.08 0.00e+00 634.00
IUUC-Ggo-044776 Gorilla gorilla 83.68 0.00e+00 828.00
IUUC-Hsa-046605 Homo sapiens 84.60 0.00e+00 829.00
IUUC-Hvu-047259 Hordeum vulgare 30.65 1.40e-02 34.70
IUUC-Itr-048607 Ictidomys tridecemlineatus 90.02 0.00e+00 712.00
IUUC-Lch-050047 Latimeria chalumnae 66.37 0.00e+00 694.00
IUUC-Lpe-051286 Leersia perrieri 32.65 6.00e-03 36.20
IUUC-Loc-052230 Lepisosteus oculatus 71.08 2.00e-179 622.00
IUUC-Laf-053797 Loxodonta africana 83.58 0.00e+00 823.00
IUUC-Mcc-055189 Macaca mulatta 82.29 7.00e-169 586.00
IUUC-Meu-055993 Macropus eugenii 73.48 4.00e-155 541.00
IUUC-Mga-059198 Meleagris gallopavo 74.72 0.00e+00 660.00
IUUC-Mvi-060509 Microbotryum violaceum 34.92 7.40e-02 32.70
IUUC-Mmr-061738 Microcebus murinus 88.08 0.00e+00 787.00
IUUC-Mdo-062753 Monodelphis domestica 86.98 4.00e-178 617.00
IUUC-Mmu-063936 Mus musculus 97.04 0.00e+00 836.00
IUUC-Mpu-066236 Mustela putorius furo 83.92 0.00e+00 700.00
IUUC-Mlu-068199 Myotis lucifugus 82.63 0.00e+00 812.00
IUUC-Nle-069835 Nomascus leucogenys 85.45 0.00e+00 704.00
IUUC-Opr-071142 Ochotona princeps 85.77 0.00e+00 791.00
IUUC-Ont-071669 Oreochromis niloticus 69.09 0.00e+00 648.00
IUUC-Oan-072716 Ornithorhynchus anatinus 82.44 0.00e+00 693.00
IUUC-Ocu-074345 Oryctolagus cuniculus 86.10 0.00e+00 711.00
IUUC-Oba-075322 Oryza barthii 31.91 1.10e-02 35.00
IUUC-Obr-076323 Oryza brachyantha 27.14 3.00e-03 35.40
IUUC-Ogu-078551 Oryza glumaepatula 31.91 1.10e-02 35.00
IUUC-Oin-079844 Oryza indica 39.58 2.10e-02 33.90
IUUC-Olo-080388 Oryza longistaminata 30.00 5.00e-03 34.70
IUUC-Oni-082615 Oryza nivara 39.58 2.30e-02 33.90
IUUC-Opu-083870 Oryza punctata 32.61 1.20e-02 35.00
IUUC-Osa-086248 Oryza sativa 39.58 2.30e-02 33.90
IUUC-Ola-087311 Oryzias latipes 73.70 1.00e-167 582.00
IUUC-Oga-089001 Otolemur garnettii 78.69 0.00e+00 810.00
IUUC-Oar-089350 Ovis aries 78.98 0.00e+00 672.00
IUUC-Ptr-090976 Pan troglodytes 81.77 0.00e+00 825.00
IUUC-Pan-092129 Papio anubis 81.40 0.00e+00 829.00
IUUC-Psi-093747 Pelodiscus sinensis 76.36 9.00e-138 483.00
IUUC-Pma-094219 Petromyzon marinus 72.76 3.00e-98 351.00
IUUC-Pfo-096548 Poecilia formosa 70.00 0.00e+00 644.00
IUUC-Pab-098720 Pongo abelii 81.77 0.00e+00 841.00
IUUC-Pop-099194 Populus trichocarpa 22.78 2.00e-03 37.70
IUUC-Pca-101114 Procavia capensis 71.47 3.00e-111 395.00
IUUC-Pva-102268 Pteropus vampyrus 90.94 5.00e-167 580.00
IUUC-Pgr-103461 Puccinia graminis 45.45 4.00e-05 43.10
IUUC-Ptt-103780 Puccinia triticina 41.30 7.00e-04 38.90
IUUC-Sha-107258 Sarcophilus harrisii 80.41 0.00e+00 676.00
IUUC-Sit-110285 Setaria italica 34.69 1.60e-02 34.30
IUUC-Stu-112846 Solanum tuberosum 26.32 3.40e-02 33.50
IUUC-Ssc-115393 Sus scrofa 78.98 0.00e+00 799.00
IUUC-Tgu-116622 Taeniopygia guttata 79.22 0.00e+00 763.00
IUUC-Tru-118647 Takifugu rubripes 66.46 0.00e+00 636.00
IUUC-Tni-120516 Tetraodon nigroviridis 70.04 0.00e+00 649.00
IUUC-Tae-122758 Triticum aestivum 32.26 1.00e-03 38.10
IUUC-Tur-126040 Triticum urartu 32.26 1.00e-03 37.00
IUUC-Tme-127118 Tuber melanosporum 41.30 9.00e-05 41.60
IUUC-Tbe-127269 Tupaia belangeri 83.26 0.00e+00 665.00
IUUC-Ttr-129258 Tursiops truncatus 86.15 0.00e+00 701.00
IUUC-Vpa-130056 Vicugna pacos 71.43 1.00e-39 157.00
IUUC-Xtr-132268 Xenopus tropicalis 68.60 0.00e+00 689.00
IUUC-Xma-134200 Xiphophorus maculatus 69.56 0.00e+00 642.00
Created Date 25-Jun-2017

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