iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063288

Ensembl Protein ID

ENSMUSP00000028997.7

UniProt Accession

P97477; O35624; Q8C3H8; Q91YU4; AURKA_MOUSE

Genbank Protein ID

AAB62982.1; AAB63205.1; AAC12682.1; BAC39557.1; AAH05425.1; AAH14711.1

Protein Name

Aurora kinase A; Aurora 2; Aurora family kinase 1; Aurora/IPL1-related kinase 1; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A

Genbank Nucleotide ID

U80932; AF007817; U69106; AK085861; BC005425; BC014711

Gene Name

Aurka; Aik; Airk; Ark1; Aura; Ayk1; Btak; Iak1; Stk15; Stk6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000027496.15	ENSMUST00000028997.7	ENSMUSP00000028997.7

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	82.18	0.00e+00	654.00	IUUC-Hsa-046968

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Protein Sequence
(Fasta)

MAVEGEPGCC KRIGKAVWRR GDMDRCKENC VSRPVKTTVP FGPKRVLVTE QIPSQNLGSA 60
SSGQAQRVLC PSNSQRVPSQ AQKLGAGQKP APKQLPAASV PRPVSRLNNP QKNEQPAASG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATTGTAAC GGCTGAGCTA CCGGGATCGC TTGGAGGCTT CGGTCGGGAG CAGGTTCCTG 60
CCTGTGAGTT GGAAAGGGAC ATGGCTGTTG AGGGCGAGCC TGGATGCTGC AAACGGATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0493--Microtubule
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR030616--Aur
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0043203--C:axon hillock
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0032133--C:chromosome passenger complex
GO:0005929--C:cilium
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005829--C:cytosol
GO:0042585--C:germinal vesicle
GO:0072687--C:meiotic spindle
GO:0015630--C:microtubule cytoskeleton
GO:0005815--C:microtubule organizing center
GO:0072686--C:mitotic spindle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0045120--C:pronucleus
GO:0005876--C:spindle microtubule
GO:0051233--C:spindle midzone
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0009948--P:anterior/posterior axis specification
GO:0051301--P:cell division
GO:0051642--P:centrosome localization
GO:0051297--P:centrosome organization
GO:0097421--P:liver regeneration
GO:0007126--P:meiotic nuclear division
GO:0000212--P:meiotic spindle organization
GO:0000226--P:microtubule cytoskeleton organization
GO:0000278--P:mitotic cell cycle
GO:0007100--P:mitotic centrosome separation
GO:0007067--P:mitotic nuclear division
GO:0007052--P:mitotic spindle organization
GO:0043066--P:negative regulation of apoptotic process
GO:0032091--P:negative regulation of protein binding
GO:1990138--P:neuron projection extension
GO:1900195--P:positive regulation of oocyte maturation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071539--P:protein localization to centrosome
GO:0006468--P:protein phosphorylation
GO:0032465--P:regulation of cytokinesis
GO:0031647--P:regulation of protein stability
GO:0009611--P:response to wounding
GO:0007057--P:spindle assembly involved in female meiosis I
GO:0007051--P:spindle organization

KEGG

mmu:20878

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000930	Aegilops tauschii	63.23	8.00e-107	379.00
IUUC-Aml-001426	Ailuropoda melanoleuca	84.83	0.00e+00	658.00
IUUC-Atr-002453	Amborella trichopoda	65.05	3.00e-110	391.00
IUUC-Apl-003626	Anas platyrhynchos	69.17	4.00e-149	521.00
IUUC-Aca-004602	Anolis carolinensis	65.91	8.00e-143	499.00
IUUC-Aly-005878	Arabidopsis lyrata	64.31	3.00e-107	380.00
IUUC-Ath-007117	Arabidopsis thaliana	62.67	5.00e-108	383.00
IUUC-Acl-008199	Aspergillus clavatus	56.83	6.00e-87	314.00
IUUC-Afl-008419	Aspergillus flavus	56.07	6.00e-86	311.00
IUUC-Afu-008751	Aspergillus fumigatus	54.05	1.00e-86	313.00
IUUC-Ani-009181	Aspergillus nidulans	52.61	1.00e-89	323.00
IUUC-Ang-009787	Aspergillus niger	59.61	2.00e-86	312.00
IUUC-Aor-009980	Aspergillus oryzae	56.07	6.00e-86	311.00
IUUC-Ate-010286	Aspergillus terreus	52.04	1.00e-86	313.00
IUUC-Ame-010849	Astyanax mexicanus	74.73	5.00e-128	451.00
IUUC-Bgr-012110	Blumeria graminis	49.35	8.00e-88	317.00
IUUC-Bta-013474	Bos taurus	82.22	0.00e+00	644.00
IUUC-Bci-013756	Botrytis cinerea	57.79	6.00e-94	337.00
IUUC-Bdi-014257	Brachypodium distachyon	63.23	1.00e-107	382.00
IUUC-Bol-016310	Brassica oleracea	65.68	2.00e-105	375.00
IUUC-Bra-017438	Brassica rapa	63.03	1.00e-106	379.00
IUUC-Cel-018157	Caenorhabditis elegans	61.83	7.00e-99	353.00
IUUC-Cja-019282	Callithrix jacchus	81.84	0.00e+00	636.00
IUUC-Cfa-020162	Canis familiaris	81.57	0.00e+00	653.00
IUUC-Cpo-021764	Cavia porcellus	81.14	0.00e+00	626.00
IUUC-Cre-022827	Chlamydomonas reinhardtii	69.17	2.00e-111	395.00
IUUC-Csa-023694	Chlorocebus sabaeus	78.71	1.00e-173	602.00
IUUC-Cho-024350	Choloepus hoffmanni	93.37	1.00e-107	382.00
IUUC-Cin-025542	Ciona intestinalis	69.40	6.00e-118	416.00
IUUC-Csv-025873	Ciona savignyi	70.40	1.00e-119	422.00
IUUC-Cgl-026632	Colletotrichum gloeosporioides	49.39	3.00e-82	298.00
IUUC-Cne-026928	Cryptococcus neoformans	60.85	3.00e-95	342.00
IUUC-Cme-027336	Cyanidioschyzon merolae	67.96	1.00e-117	416.00
IUUC-Dre-028198	Danio rerio	62.63	3.00e-134	471.00
IUUC-Dno-029928	Dasypus novemcinctus	81.40	9.00e-175	605.00
IUUC-Dor-030238	Dipodomys ordii	78.30	2.00e-177	614.00
IUUC-Dse-031266	Dothistroma septosporum	50.71	1.00e-95	342.00
IUUC-Dme-032007	Drosophila melanogaster	61.45	2.00e-100	359.00
IUUC-Ete-032911	Echinops telfairi	61.15	3.00e-121	428.00
IUUC-Eca-033749	Equus caballus	84.24	0.00e+00	647.00
IUUC-Eeu-035170	Erinaceus europaeus	79.61	3.00e-180	624.00
IUUC-Fca-035498	Felis catus	83.12	0.00e+00	649.00
IUUC-Fal-037397	Ficedula albicollis	66.10	3.00e-145	508.00
IUUC-Fox-037747	Fusarium oxysporum	51.45	3.00e-91	328.00
IUUC-Fso-038429	Fusarium solani	55.03	3.00e-89	322.00
IUUC-Gmo-039378	Gadus morhua	61.13	2.00e-125	442.00
IUUC-Ggr-039939	Gaeumannomyces graminis	61.45	1.00e-93	337.00
IUUC-Gga-040187	Gallus gallus	68.22	3.00e-148	518.00
IUUC-Gac-042223	Gasterosteus aculeatus	58.41	1.00e-133	469.00
IUUC-Gma-042870	Glycine max	66.67	3.00e-101	361.00
IUUC-Ggo-045617	Gorilla gorilla	82.43	0.00e+00	655.00
IUUC-Hsa-046968	Homo sapiens	82.18	0.00e+00	654.00
IUUC-Hvu-047072	Hordeum vulgare	54.10	5.00e-81	293.00
IUUC-Itr-048233	Ictidomys tridecemlineatus	74.19	4.00e-163	567.00
IUUC-Kpa-049093	Komagataella pastoris	54.79	4.00e-75	275.00
IUUC-Lch-050346	Latimeria chalumnae	70.84	4.00e-147	514.00
IUUC-Lpe-051466	Leersia perrieri	65.49	2.00e-108	384.00
IUUC-Lma-053006	Leptosphaeria maculans	58.78	1.00e-88	319.00
IUUC-Laf-053422	Loxodonta africana	80.74	0.00e+00	645.00
IUUC-Mcc-055245	Macaca mulatta	79.74	7.00e-172	596.00
IUUC-Mor-056952	Magnaporthe oryzae	59.16	4.00e-90	325.00
IUUC-Mpo-057605	Magnaporthe poae	58.61	3.00e-93	335.00
IUUC-Mtr-057726	Medicago truncatula	66.42	2.00e-107	381.00
IUUC-Mla-059174	Melampsora laricipopulina	61.39	6.00e-97	347.00
IUUC-Mga-059562	Meleagris gallopavo	60.71	9.00e-114	403.00
IUUC-Mvi-060305	Microbotryum violaceum	59.77	4.00e-92	332.00
IUUC-Mmr-061588	Microcebus murinus	81.39	0.00e+00	648.00
IUUC-Mdo-061914	Monodelphis domestica	75.71	5.00e-166	577.00
IUUC-Mac-064969	Musa acuminata	65.29	1.00e-109	389.00
IUUC-Mpu-066855	Mustela putorius furo	82.69	0.00e+00	641.00
IUUC-Mlu-068046	Myotis lucifugus	82.78	0.00e+00	637.00
IUUC-Nfi-068527	Neosartorya fischeri	60.00	5.00e-86	311.00
IUUC-Ncr-068678	Neurospora crassa	60.08	6.00e-91	327.00
IUUC-Nle-069848	Nomascus leucogenys	82.18	0.00e+00	654.00
IUUC-Opr-070589	Ochotona princeps	75.00	7.00e-168	583.00
IUUC-Ont-071733	Oreochromis niloticus	60.72	7.00e-125	440.00
IUUC-Oan-073399	Ornithorhynchus anatinus	82.26	4.00e-152	530.00
IUUC-Ocu-074063	Oryctolagus cuniculus	82.13	0.00e+00	650.00
IUUC-Oba-075264	Oryza barthii	64.26	3.00e-107	380.00
IUUC-Obr-076048	Oryza brachyantha	66.18	3.00e-106	377.00
IUUC-Ogl-077637	Oryza glaberrima	67.04	1.00e-106	379.00
IUUC-Ogu-078830	Oryza glumaepatula	64.26	3.00e-107	381.00
IUUC-Oin-079150	Oryza indica	64.26	2.00e-107	382.00
IUUC-Olo-080398	Oryza longistaminata	56.43	4.00e-81	294.00
IUUC-Ome-081544	Oryza meridionalis	53.82	1.00e-89	323.00
IUUC-Oni-082250	Oryza nivara	64.26	2.00e-107	382.00
IUUC-Opu-083638	Oryza punctata	64.26	1.00e-107	382.00
IUUC-Oru-084981	Oryza rufipogon	64.26	1.00e-107	382.00
IUUC-Osa-085961	Oryza sativa	64.26	1.00e-107	382.00
IUUC-Olu-087880	Ostreococcus lucimarinus	69.03	4.00e-113	401.00
IUUC-Oga-088891	Otolemur garnettii	82.43	0.00e+00	638.00
IUUC-Oar-090021	Ovis aries	79.61	0.00e+00	626.00
IUUC-Ptr-091458	Pan troglodytes	82.43	0.00e+00	655.00
IUUC-Pan-092546	Papio anubis	78.71	1.00e-173	602.00
IUUC-Psi-093280	Pelodiscus sinensis	75.07	5.00e-155	540.00
IUUC-Pma-094298	Petromyzon marinus	76.30	7.00e-121	426.00
IUUC-Pno-094847	Phaeosphaeria nodorum	60.31	4.00e-89	321.00
IUUC-Ppa-095855	Physcomitrella patens	62.28	1.00e-109	389.00
IUUC-Pfo-096428	Poecilia formosa	60.95	6.00e-128	450.00
IUUC-Pab-098696	Pongo abelii	81.98	0.00e+00	648.00
IUUC-Pop-099405	Populus trichocarpa	63.36	1.00e-108	386.00
IUUC-Pca-100740	Procavia capensis	77.78	5.00e-179	620.00
IUUC-Ppe-101854	Prunus persica	64.04	2.00e-109	388.00
IUUC-Pva-103212	Pteropus vampyrus	82.43	0.00e+00	629.00
IUUC-Pgr-103474	Puccinia graminis	62.12	2.00e-98	352.00
IUUC-Ptt-103933	Puccinia triticina	48.26	8.00e-62	230.00
IUUC-Pte-104089	Pyrenophora teres	51.23	3.00e-89	322.00
IUUC-Pyt-104555	Pyrenophora triticirepentis	51.23	3.00e-89	322.00
IUUC-Rno-105057	Rattus norvegicus	93.70	0.00e+00	768.00
IUUC-Sha-107137	Sarcophilus harrisii	77.38	4.00e-169	587.00
IUUC-Sja-107767	Schizosaccharomyces japonicus	59.11	1.00e-97	349.00
IUUC-Spo-108078	Schizosaccharomyces pombe	55.74	3.00e-100	358.00
IUUC-Smo-109288	Selaginella moellendorffii	66.91	4.00e-109	387.00
IUUC-Sit-110246	Setaria italica	62.54	7.00e-106	376.00
IUUC-Sly-111379	Solanum lycopersicum	65.71	2.00e-108	385.00
IUUC-Stu-112777	Solanum tuberosum	63.27	2.00e-107	381.00
IUUC-Sbi-114325	Sorghum bicolor	63.64	2.00e-106	378.00
IUUC-Sre-115203	Sporisorium reilianum	58.49	6.00e-81	295.00
IUUC-Ssc-115361	Sus scrofa	82.13	0.00e+00	646.00
IUUC-Tgu-116967	Taeniopygia guttata	70.43	2.00e-144	505.00
IUUC-Tru-117570	Takifugu rubripes	63.08	1.00e-134	472.00
IUUC-Tsy-119280	Tarsius syrichta	63.73	3.00e-131	461.00
IUUC-Tni-120721	Tetraodon nigroviridis	63.71	2.00e-135	475.00
IUUC-Tca-121494	Theobroma cacao	63.92	8.00e-108	383.00
IUUC-Tre-121869	Trichoderma reesei	56.35	1.00e-92	333.00
IUUC-Tvi-122510	Trichoderma virens	58.10	7.00e-91	327.00
IUUC-Tae-123071	Triticum aestivum	63.23	8.00e-107	379.00
IUUC-Tur-126240	Triticum urartu	63.23	2.00e-106	378.00
IUUC-Tme-126921	Tuber melanosporum	60.81	6.00e-97	347.00
IUUC-Tbe-127872	Tupaia belangeri	75.89	9.00e-162	562.00
IUUC-Ttr-129134	Tursiops truncatus	83.98	2.00e-179	621.00
IUUC-Uma-129412	Ustilago maydis	47.11	4.00e-79	288.00
IUUC-Vda-130003	Verticillium dahliae	49.00	2.00e-92	332.00
IUUC-Vvi-131272	Vitis vinifera	64.04	2.00e-108	385.00
IUUC-Xtr-132019	Xenopus tropicalis	66.91	4.00e-146	511.00
IUUC-Xma-134203	Xiphophorus maculatus	61.13	7.00e-133	466.00
IUUC-Yli-134503	Yarrowia lipolytica	53.67	8.00e-86	310.00
IUUC-Zma-135232	Zea mays	65.20	6.00e-106	376.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence