iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091518

Ensembl Protein ID

ENSPTRP00000025003.5

UniProt Accession

H2QLW3; H2QLW3_PANTR

Genbank Protein ID

JAA33590.1

Protein Name

Peroxisome proliferator-activated receptor alpha

Genbank Nucleotide ID

AACZ03126592

Gene Name

PPARA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014505.5	ENSPTRT00000027121.5	ENSPTRP00000025003.5

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.79	0.00e+00	921.00	IUUC-Hsa-046893

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG FTEYQYLGSC 60
PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI ECRICGDKAS GYHYGVHACE 120

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Nucleotide Sequence
(Fasta)

GTCGCGATGG TGGACACGGA AAGCCCACTC TGCCCCCTCT CCCCACTGGA GGCTGGCGAT 60
CTAGAGAGCC CGTTATCTGA AGAGTTCCTG CAAGAAATGG GAAACATCCA AGAGATTTCG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003076--1Cnucl_rcpt_A
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01289--PROXISOMPAAR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0008144--F:drug binding
GO:0008289--F:lipid binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0032922--P:circadian regulation of gene expression
GO:0070166--P:enamel mineralization
GO:0008544--P:epidermis development
GO:0006631--P:fatty acid metabolic process
GO:0032099--P:negative regulation of appetite
GO:0010887--P:negative regulation of cholesterol storage
GO:0050728--P:negative regulation of inflammatory response
GO:1903038--P:negative regulation of leukocyte cell-cell adhesion
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0072366--P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752--P:regulation of circadian rhythm
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369--P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0042060--P:wound healing

KEGG

ptr:458910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002222	Ailuropoda melanoleuca	93.83	0.00e+00	914.00
IUUC-Apl-003330	Anas platyrhynchos	88.35	0.00e+00	840.00
IUUC-Aca-004598	Anolis carolinensis	85.26	0.00e+00	811.00
IUUC-Acl-008339	Aspergillus clavatus	48.48	7.00e-02	30.40
IUUC-Ame-011508	Astyanax mexicanus	73.13	0.00e+00	697.00
IUUC-Bta-012621	Bos taurus	94.66	0.00e+00	884.00
IUUC-Cja-019688	Callithrix jacchus	97.44	0.00e+00	900.00
IUUC-Cfa-020859	Canis familiaris	94.44	0.00e+00	917.00
IUUC-Cpo-021607	Cavia porcellus	88.87	0.00e+00	837.00
IUUC-Csa-023313	Chlorocebus sabaeus	99.15	0.00e+00	913.00
IUUC-Cho-024741	Choloepus hoffmanni	83.33	0.00e+00	743.00
IUUC-Cgl-026615	Colletotrichum gloeosporioides	32.20	2.40e-01	28.10
IUUC-Dre-027446	Danio rerio	72.34	0.00e+00	682.00
IUUC-Dno-029173	Dasypus novemcinctus	92.52	0.00e+00	863.00
IUUC-Dor-030581	Dipodomys ordii	90.58	0.00e+00	808.00
IUUC-Dme-031794	Drosophila melanogaster	34.40	1.00e-56	215.00
IUUC-Ete-032330	Echinops telfairi	90.81	0.00e+00	870.00
IUUC-Eca-033712	Equus caballus	95.09	0.00e+00	874.00
IUUC-Fca-036555	Felis catus	95.11	0.00e+00	920.00
IUUC-Fal-036677	Ficedula albicollis	88.03	0.00e+00	838.00
IUUC-Gmo-039240	Gadus morhua	81.23	0.00e+00	643.00
IUUC-Gga-040473	Gallus gallus	88.89	0.00e+00	846.00
IUUC-Gac-041872	Gasterosteus aculeatus	71.61	0.00e+00	702.00
IUUC-Ggo-045226	Gorilla gorilla	99.79	0.00e+00	921.00
IUUC-Hsa-046893	Homo sapiens	99.79	0.00e+00	921.00
IUUC-Itr-048952	Ictidomys tridecemlineatus	92.74	0.00e+00	864.00
IUUC-Lch-050116	Latimeria chalumnae	79.70	0.00e+00	766.00
IUUC-Loc-052131	Lepisosteus oculatus	82.96	0.00e+00	689.00
IUUC-Laf-054323	Loxodonta africana	94.87	0.00e+00	884.00
IUUC-Mcc-054841	Macaca mulatta	99.57	0.00e+00	923.00
IUUC-Meu-056833	Macropus eugenii	82.91	0.00e+00	749.00
IUUC-Mtr-058471	Medicago truncatula	29.82	1.70e-01	30.00
IUUC-Mga-059995	Meleagris gallopavo	80.08	0.00e+00	748.00
IUUC-Mdo-061954	Monodelphis domestica	88.36	0.00e+00	783.00
IUUC-Mmu-064295	Mus musculus	92.09	0.00e+00	833.00
IUUC-Mpu-066216	Mustela putorius furo	94.87	0.00e+00	920.00
IUUC-Nle-069970	Nomascus leucogenys	99.57	0.00e+00	919.00
IUUC-Ont-071594	Oreochromis niloticus	72.67	0.00e+00	697.00
IUUC-Oan-073501	Ornithorhynchus anatinus	91.42	0.00e+00	762.00
IUUC-Ocu-074634	Oryctolagus cuniculus	85.69	0.00e+00	834.00
IUUC-Oni-082926	Oryza nivara	29.41	1.20e-02	30.80
IUUC-Ola-086585	Oryzias latipes	79.05	0.00e+00	635.00
IUUC-Oga-088738	Otolemur garnettii	97.01	0.00e+00	889.00
IUUC-Oar-090453	Ovis aries	94.23	0.00e+00	880.00
IUUC-Pan-092006	Papio anubis	99.79	0.00e+00	924.00
IUUC-Psi-093352	Pelodiscus sinensis	86.65	0.00e+00	834.00
IUUC-Pfo-096060	Poecilia formosa	71.40	0.00e+00	684.00
IUUC-Pab-098602	Pongo abelii	93.04	0.00e+00	819.00
IUUC-Pva-102175	Pteropus vampyrus	89.32	0.00e+00	856.00
IUUC-Rno-105283	Rattus norvegicus	91.88	0.00e+00	835.00
IUUC-Sce-106436	Saccharomyces cerevisiae	29.03	8.00e-03	32.00
IUUC-Sha-106560	Sarcophilus harrisii	92.31	0.00e+00	864.00
IUUC-Smo-109075	Selaginella moellendorffii	30.00	1.10e-01	29.60
IUUC-Ssc-115266	Sus scrofa	94.23	0.00e+00	923.00
IUUC-Tgu-116778	Taeniopygia guttata	88.03	0.00e+00	838.00
IUUC-Tru-118436	Takifugu rubripes	71.40	0.00e+00	692.00
IUUC-Tsy-119642	Tarsius syrichta	83.33	0.00e+00	743.00
IUUC-Tni-119859	Tetraodon nigroviridis	71.40	0.00e+00	687.00
IUUC-Tvi-122624	Trichoderma virens	30.91	8.40e-02	29.60
IUUC-Tbe-127464	Tupaia belangeri	93.38	0.00e+00	905.00
IUUC-Ttr-129307	Tursiops truncatus	90.83	0.00e+00	832.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence