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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031721
UUCD1 version UUC-DrM-00030
Ensembl Protein ID FBpp0084614
UniProt Accession Q9VB08; O18380; RING1_DROME
Genbank Protein ID CAA04797.1; AAF56737.1; AAL13764.1
Protein Name E3 ubiquitin-protein ligase RING1; RING-type E3 ubiquitin transferase RING1; Sex comb extra protein; dRING protein; dRING1
Genbank Nucleotide ID AJ001514; AE014297; AY058535
Gene Name Sce; CG5595
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0003330 FBtr0085245 FBpp0084614
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18923078
Classification
Family E-value Score Start End
E3 activity/RING/RING 5.50e-07 30.0 46 86
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+   +  C H f+ dC+  ++       s++  CP+Cr
   Q: 46   CPICLDMLKKTMTTKECLHRFCSDCIvTAL------RSGNKECPTCR 86
           ********99555556**********7777......**********8 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG complexes act via modification of histones, such as methylation, deacetylation, ubiquitination rendering chromatin heritably changed in its expressibility. May play a role in meiotic sister chromatid cohesion.
 E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG complexes act via modification of histones, such as methylation, deacetylation, ubiquitination rendering chromatin heritably changed in its expressibility. May play a role in meiotic sister chromatid cohesion.
Protein Sequence
(Fasta)
MTSLDPAPNK TWELSLYELQ RKPQEVITDS TEIAVSPRSL HSELMCPICL DMLKKTMTTK 60
ECLHRFCSDC IVTALRSGNK ECPTCRKKLV SKRSLRADPN FDLLISKIYP SREEYEAIQE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031721|E3,RING|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
GATTTATTGA ACAACCAAAG TGCGGTCACA CTTCAAGCTA ATTTGGAAAA TCTTAGCGAA 60
AATTTCGTAA AAAGTGGTGT TTGTGTATTG AAAAGCCTCA GAATTGGTGT GAAAATGACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031721|E3,RING|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0008278--C:cohesin complex
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006342--P:chromatin silencing
GO:0030708--P:germarium-derived female germ-line cyst encapsulation
GO:0035518--P:histone H2A monoubiquitination
GO:0051321--P:meiotic cell cycle
GO:0007275--P:multicellular organism development
GO:0022008--P:neurogenesis
GO:0030713--P:ovarian follicle cell stalk formation
GO:0045498--P:sex comb development
GO:0007062--P:sister chromatid cohesion
GO:0006351--P:transcription, DNA-templated
GO:0007419--P:ventral cord development
KEGG dme:Dmel_CG5595
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000516 Aegilops tauschii 51.39 5.00e-18 84.70
IUUC-Aml-001250 Ailuropoda melanoleuca 78.91 2.00e-68 251.00
IUUC-Apl-003587 Anas platyrhynchos 78.23 1.00e-67 249.00
IUUC-Aca-005261 Anolis carolinensis 79.59 4.00e-68 250.00
IUUC-Aly-005911 Arabidopsis lyrata 48.89 3.00e-22 99.00
IUUC-Ath-006899 Arabidopsis thaliana 52.70 1.00e-21 96.70
IUUC-Ame-010622 Astyanax mexicanus 78.91 3.00e-68 251.00
IUUC-Bta-013553 Bos taurus 78.91 3.00e-68 251.00
IUUC-Bdi-014202 Brachypodium distachyon 53.01 8.00e-23 100.00
IUUC-Bol-015993 Brassica oleracea 47.06 2.00e-23 102.00
IUUC-Bra-017150 Brassica rapa 47.06 2.00e-23 102.00
IUUC-Cel-018573 Caenorhabditis elegans 37.50 2.00e-15 78.60
IUUC-Cja-019093 Callithrix jacchus 78.91 2.00e-68 251.00
IUUC-Cfa-020681 Canis familiaris 78.38 6.00e-67 246.00
IUUC-Cpo-021402 Cavia porcellus 80.28 2.00e-67 248.00
IUUC-Csa-024231 Chlorocebus sabaeus 78.91 2.00e-68 251.00
IUUC-Cho-024843 Choloepus hoffmanni 70.86 7.00e-58 216.00
IUUC-Csv-026314 Ciona savignyi 74.83 1.00e-63 235.00
IUUC-Dre-027685 Danio rerio 78.91 4.00e-68 250.00
IUUC-Dno-029993 Dasypus novemcinctus 78.91 3.00e-68 251.00
IUUC-Dor-030986 Dipodomys ordii 61.90 6.00e-48 183.00
IUUC-Dse-031151 Dothistroma septosporum 29.41 9.00e-06 45.10
IUUC-Ete-032564 Echinops telfairi 47.26 4.00e-31 127.00
IUUC-Eca-033251 Equus caballus 78.91 3.00e-68 251.00
IUUC-Eeu-034951 Erinaceus europaeus 78.91 3.00e-68 251.00
IUUC-Fca-036240 Felis catus 78.91 3.00e-68 251.00
IUUC-Fal-037376 Ficedula albicollis 78.23 2.00e-67 248.00
IUUC-Gmo-038879 Gadus morhua 75.68 7.00e-64 236.00
IUUC-Gga-041134 Gallus gallus 78.23 1.00e-67 249.00
IUUC-Gac-042589 Gasterosteus aculeatus 77.18 4.00e-66 243.00
IUUC-Gma-044107 Glycine max 44.83 1.00e-23 103.00
IUUC-Ggo-044529 Gorilla gorilla 78.91 2.00e-68 251.00
IUUC-Hsa-046100 Homo sapiens 78.91 2.00e-68 251.00
IUUC-Hvu-047152 Hordeum vulgare 53.01 1.00e-22 100.00
IUUC-Itr-047891 Ictidomys tridecemlineatus 78.91 3.00e-68 251.00
IUUC-Lch-049442 Latimeria chalumnae 79.05 8.00e-69 253.00
IUUC-Lpe-050923 Leersia perrieri 51.81 2.00e-23 102.00
IUUC-Loc-052544 Lepisosteus oculatus 80.00 1.00e-67 249.00
IUUC-Laf-054431 Loxodonta africana 78.23 1.00e-66 246.00
IUUC-Mcc-055685 Macaca mulatta 78.91 4.00e-68 250.00
IUUC-Meu-056000 Macropus eugenii 78.23 7.00e-67 246.00
IUUC-Mpo-057316 Magnaporthe poae 35.82 4.00e-06 45.40
IUUC-Mtr-058234 Medicago truncatula 50.60 2.00e-23 102.00
IUUC-Mga-059354 Meleagris gallopavo 78.23 1.00e-67 249.00
IUUC-Mmr-060809 Microcebus murinus 78.91 2.00e-68 251.00
IUUC-Mdo-062206 Monodelphis domestica 78.23 1.00e-67 249.00
IUUC-Mmu-063715 Mus musculus 78.91 2.00e-68 251.00
IUUC-Mac-064893 Musa acuminata 50.00 8.00e-23 100.00
IUUC-Mpu-066460 Mustela putorius furo 78.91 3.00e-68 251.00
IUUC-Mlu-067743 Myotis lucifugus 78.91 3.00e-68 251.00
IUUC-Nle-069512 Nomascus leucogenys 78.91 2.00e-68 251.00
IUUC-Opr-070456 Ochotona princeps 90.00 6.00e-34 137.00
IUUC-Ont-072541 Oreochromis niloticus 78.23 2.00e-67 248.00
IUUC-Oan-073454 Ornithorhynchus anatinus 78.23 1.00e-67 249.00
IUUC-Ocu-073981 Oryctolagus cuniculus 78.91 2.00e-68 251.00
IUUC-Oba-075605 Oryza barthii 51.81 2.00e-22 99.80
IUUC-Obr-076282 Oryza brachyantha 51.81 2.00e-23 102.00
IUUC-Ogl-077288 Oryza glaberrima 51.81 4.00e-23 101.00
IUUC-Ogu-078992 Oryza glumaepatula 51.81 2.00e-22 99.80
IUUC-Oin-079939 Oryza indica 51.81 3.00e-23 102.00
IUUC-Olo-081069 Oryza longistaminata 47.06 8.00e-24 104.00
IUUC-Ome-081418 Oryza meridionalis 51.81 2.00e-23 102.00
IUUC-Oni-083103 Oryza nivara 51.81 4.00e-23 101.00
IUUC-Opu-083314 Oryza punctata 51.81 2.00e-23 102.00
IUUC-Oru-084356 Oryza rufipogon 53.95 4.00e-22 99.00
IUUC-Osa-085727 Oryza sativa 51.81 3.00e-23 102.00
IUUC-Ola-086937 Oryzias latipes 78.23 2.00e-67 248.00
IUUC-Olu-087771 Ostreococcus lucimarinus 39.62 5.00e-06 44.70
IUUC-Oga-088881 Otolemur garnettii 78.23 1.00e-66 246.00
IUUC-Oar-089823 Ovis aries 78.91 4.00e-68 250.00
IUUC-Ptr-090557 Pan troglodytes 78.91 2.00e-68 251.00
IUUC-Pan-091950 Papio anubis 78.91 2.00e-68 251.00
IUUC-Psi-093349 Pelodiscus sinensis 78.23 1.00e-67 249.00
IUUC-Ppa-095164 Physcomitrella patens 58.21 9.00e-22 97.10
IUUC-Pfo-096803 Poecilia formosa 78.23 5.00e-67 247.00
IUUC-Pab-098392 Pongo abelii 78.08 2.00e-67 248.00
IUUC-Pop-100011 Populus trichocarpa 45.63 4.00e-24 105.00
IUUC-Pca-100649 Procavia capensis 76.87 1.00e-61 229.00
IUUC-Ppe-101894 Prunus persica 58.18 3.00e-16 78.20
IUUC-Pva-102498 Pteropus vampyrus 84.17 9.00e-58 216.00
IUUC-Rno-105492 Rattus norvegicus 78.91 2.00e-68 251.00
IUUC-Sha-106734 Sarcophilus harrisii 78.23 4.00e-67 247.00
IUUC-Smo-108741 Selaginella moellendorffii 53.25 4.00e-21 91.70
IUUC-Sit-109707 Setaria italica 43.12 3.00e-24 105.00
IUUC-Sly-111537 Solanum lycopersicum 40.00 2.00e-19 89.40
IUUC-Stu-112805 Solanum tuberosum 41.09 1.00e-20 93.60
IUUC-Sar-113064 Sorex araneus 78.57 7.00e-57 213.00
IUUC-Sbi-114112 Sorghum bicolor 45.05 2.00e-23 102.00
IUUC-Ssc-115830 Sus scrofa 78.91 3.00e-68 251.00
IUUC-Tgu-116694 Taeniopygia guttata 78.23 1.00e-67 249.00
IUUC-Tru-117837 Takifugu rubripes 78.23 2.00e-67 248.00
IUUC-Tsy-119174 Tarsius syrichta 78.91 3.00e-68 251.00
IUUC-Tni-120389 Tetraodon nigroviridis 78.23 2.00e-67 248.00
IUUC-Tca-121428 Theobroma cacao 41.74 3.00e-23 102.00
IUUC-Tae-123769 Triticum aestivum 53.95 6.00e-23 101.00
IUUC-Tur-126796 Triticum urartu 53.01 1.00e-22 100.00
IUUC-Tbe-127428 Tupaia belangeri 46.90 1.00e-24 105.00
IUUC-Ttr-128796 Tursiops truncatus 78.91 2.00e-68 251.00
IUUC-Vpa-130691 Vicugna pacos 78.91 3.00e-68 251.00
IUUC-Vvi-131143 Vitis vinifera 39.85 3.00e-24 105.00
IUUC-Xtr-131799 Xenopus tropicalis 79.59 2.00e-68 251.00
IUUC-Xma-133424 Xiphophorus maculatus 79.31 2.00e-67 248.00
IUUC-Yli-134480 Yarrowia lipolytica 48.15 5.00e-08 49.70
Created Date 25-Jun-2017

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