iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088094

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03086400

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000017094.2	ENSOGAT00000017099.2	ENSOGAP00000015309.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-40	139.8	341	648

Active Site

Position(s)	Description	Evidence
619	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v+E+   g + +G++ efl+ll+++l+n+   lf  + + +++l+ n ++      +++l++ +G++l+++l++g + + ++
   Q: 341  YAIEVAYVNENdnfGRERPGSKHEFLSLLLQHLENSP--LF--EGSLSKNLSLNTQAL-----KENLYYEAGKMLAISLVHGGPSPGFF 420
           57899999998888*********************99..56..566666667777664.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e+++ + +++ ++ + +i  +   ++ +  +dl++      ++e++++   +g+ +   t ++k++ vk+++ y
   Q: 421  SKTLFNCLVYGP---ENTQPILDDVSDFdVAKIIIRI--NTATNMADLNSV-----INECYNYLEFTGCVRLITTLNDKYMLVKDLLIY 499
           ***********8...9999999999999988888774..333334677765.....88899999999********************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++ + e  +++l+++  +++++ l++   ++ ++ +d +++  Fw+ + +++++ + ++ ++  
   Q: 500  HVIKRVQAPFESFKQGLKTLGVLEKIQTYPEAFCSILCHKPGNLSAKILSD--LFTVHTLPDVQTL-GFWNSYiQDVEDGKSATTIEdi 585
           *************************************************99..888899******8.9999988999999998877777 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
             F+Tg+s++P++Gf++ + ++ ++r      ++P  n+C n+L +P  s++++++e++ +A ++t  +
   Q: 586  liFATGCSSIPPAGFKPTP-SIECLRT-----DFPVGNKCNNCLAIPVTSTYKEFQENMDFALKNTPKL 648
           77****************9.9999999.....********************************98655 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MSSGIWQRGK EEEGLYGFLV EDIKKEVNRA SKLKCCICKK TGASIGCVAP RCKRSYHFPC 60
GLERECIFQF TGNFASFCWH HRPVQSIAAN SYRDSLPCTI CLEFVEPIPT YNILRSPCCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCCTAGTA AAATGAATGA AAATGAAAAT AAACCTGGTG ACTCACAGGA ACTTGGTAAG 60
TAAATGTATT TAAAATGTTT TTATAATAGT AAGCCTTTTA CAATCCTACC TAAACAATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	87.58	0.00e+00	1238.00
IUUC-Apl-003763	Anas platyrhynchos	58.82	0.00e+00	834.00
IUUC-Aca-004328	Anolis carolinensis	59.40	0.00e+00	808.00
IUUC-Ame-011288	Astyanax mexicanus	39.43	4.00e-148	518.00
IUUC-Bta-012496	Bos taurus	83.87	0.00e+00	1185.00
IUUC-Cja-019756	Callithrix jacchus	86.47	0.00e+00	1206.00
IUUC-Cfa-020806	Canis familiaris	86.36	0.00e+00	1219.00
IUUC-Cpo-022519	Cavia porcellus	83.79	0.00e+00	1155.00
IUUC-Csa-023957	Chlorocebus sabaeus	88.48	0.00e+00	1238.00
IUUC-Cho-024375	Choloepus hoffmanni	80.91	0.00e+00	1097.00
IUUC-Cin-025325	Ciona intestinalis	44.44	2.00e-55	209.00
IUUC-Csv-026262	Ciona savignyi	41.56	2.00e-57	216.00
IUUC-Dre-027829	Danio rerio	40.33	3.00e-143	502.00
IUUC-Dno-029362	Dasypus novemcinctus	86.54	0.00e+00	1192.00
IUUC-Dor-030710	Dipodomys ordii	82.42	0.00e+00	1157.00
IUUC-Dse-031248	Dothistroma septosporum	37.78	4.00e-03	37.40
IUUC-Dme-031692	Drosophila melanogaster	32.89	2.00e-34	140.00
IUUC-Ete-032282	Echinops telfairi	76.90	0.00e+00	1040.00
IUUC-Eca-033963	Equus caballus	86.52	0.00e+00	1225.00
IUUC-Eeu-035029	Erinaceus europaeus	83.74	0.00e+00	1176.00
IUUC-Fca-036229	Felis catus	87.42	0.00e+00	1236.00
IUUC-Fal-037015	Ficedula albicollis	56.96	0.00e+00	801.00
IUUC-Gmo-039715	Gadus morhua	39.57	3.00e-78	285.00
IUUC-Gga-040298	Gallus gallus	57.83	0.00e+00	840.00
IUUC-Gac-041444	Gasterosteus aculeatus	38.00	4.00e-129	455.00
IUUC-Ggo-045456	Gorilla gorilla	87.58	0.00e+00	1228.00
IUUC-Hsa-046297	Homo sapiens	88.18	0.00e+00	1238.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	87.28	0.00e+00	920.00
IUUC-Lch-050287	Latimeria chalumnae	67.12	6.00e-90	325.00
IUUC-Loc-052839	Lepisosteus oculatus	56.25	1.00e-18	84.70
IUUC-Laf-053581	Loxodonta africana	85.91	0.00e+00	1210.00
IUUC-Mcc-055615	Macaca mulatta	88.64	0.00e+00	1241.00
IUUC-Meu-056753	Macropus eugenii	48.07	1.00e-122	433.00
IUUC-Mga-059902	Meleagris gallopavo	57.83	0.00e+00	842.00
IUUC-Mmr-061522	Microcebus murinus	90.90	0.00e+00	1277.00
IUUC-Mdo-063022	Monodelphis domestica	64.47	0.00e+00	829.00
IUUC-Mmu-063609	Mus musculus	73.86	0.00e+00	1054.00
IUUC-Mpu-066656	Mustela putorius furo	86.52	0.00e+00	1229.00
IUUC-Mlu-067011	Myotis lucifugus	85.15	0.00e+00	1201.00
IUUC-Nle-069949	Nomascus leucogenys	87.88	0.00e+00	1234.00
IUUC-Opr-071224	Ochotona princeps	84.21	2.00e-134	473.00
IUUC-Ont-072174	Oreochromis niloticus	37.00	7.00e-126	444.00
IUUC-Oan-072712	Ornithorhynchus anatinus	66.09	0.00e+00	952.00
IUUC-Ocu-073776	Oryctolagus cuniculus	87.58	0.00e+00	1221.00
IUUC-Ola-087247	Oryzias latipes	36.07	3.00e-117	416.00
IUUC-Oar-090248	Ovis aries	83.41	0.00e+00	1180.00
IUUC-Ptr-090634	Pan troglodytes	87.88	0.00e+00	1234.00
IUUC-Pan-092876	Papio anubis	88.33	0.00e+00	1238.00
IUUC-Psi-093580	Pelodiscus sinensis	60.83	0.00e+00	868.00
IUUC-Pma-094295	Petromyzon marinus	52.21	7.00e-71	259.00
IUUC-Pfo-096351	Poecilia formosa	38.26	1.00e-133	470.00
IUUC-Pab-097596	Pongo abelii	88.33	0.00e+00	1240.00
IUUC-Pca-100309	Procavia capensis	79.39	0.00e+00	1103.00
IUUC-Pva-102526	Pteropus vampyrus	88.15	0.00e+00	761.00
IUUC-Rno-105432	Rattus norvegicus	79.18	0.00e+00	1107.00
IUUC-Sha-107089	Sarcophilus harrisii	64.95	0.00e+00	944.00
IUUC-Sar-113667	Sorex araneus	63.88	0.00e+00	856.00
IUUC-Ssc-116200	Sus scrofa	87.10	0.00e+00	1231.00
IUUC-Tgu-116467	Taeniopygia guttata	56.48	0.00e+00	792.00
IUUC-Tru-117690	Takifugu rubripes	38.88	7.00e-144	504.00
IUUC-Tsy-119481	Tarsius syrichta	84.14	0.00e+00	801.00
IUUC-Tni-119669	Tetraodon nigroviridis	36.70	4.00e-123	435.00
IUUC-Tbe-127241	Tupaia belangeri	82.65	0.00e+00	1120.00
IUUC-Ttr-129057	Tursiops truncatus	87.65	0.00e+00	939.00
IUUC-Vpa-130685	Vicugna pacos	85.52	0.00e+00	1169.00
IUUC-Xtr-132555	Xenopus tropicalis	52.94	0.00e+00	696.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence