iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-37	126.4	50	86
UBD/Beta-Prp	2.80e-75	253.3	3	327

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H ++v+++af +  +l+vsG+dD +ikvW++++ +++
   Q: 50   HDGPVRGVAFhQQmPLFVSGGDDYKIKVWNYKQRRCI 86
           99********95559***************9988875 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
           t +++++++++ + f+p++++++++  +g i++wd+++ +ll+++ +h+++v+ v f+++ +++v+g++D+ ikvw+++++ c+ tl +h d+v++++
   Q: 3    TNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPLFVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVA 100
           557889999***************************************************************************************** PP
   S: 102  fspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..............................ktg 169
           f+ +  +++s+s+d+tir+w+++++ c+  +l+gh++ v+c+++hp+++ +vs+slD+tvr+Wd+                              + +
   Q: 101  FHHEYPWILSASDDQTIRIWNWQSRNCIC-VLTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDIsglrkknvapgpgglddhlkghpgatdlfgQAD 197
           *****************************.*****************************************************************666 PP
   S: 170  kllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhns 265
            ++++  +gh++ v++ sf+++ + +vsg++d+ vklw + + +   v+t++gh +nv+sv f+p++++++s ++D+sir+Wd++++++l t+ + n+
   Q: 198  AVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAweVDTCRGHYNNVSSVLFHPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNE 295
           666666556********************************766667*************************************************** PP
   S: 266  svisvavlsfgdnvlvlgsedskvniwklkknep 299
           +++  ++ +++ n +++g  d+   ++kl++++p
   Q: 296  RFWILTA-HPTLNLFAAG-HDGGMVVFKLERERP 327
           *******.7777666655.58999999*998775 PP

Organism

Drosophila melanogaster

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTNFESKSA RVKGLSFHPK RPWILVSLHS GVIQLWDYRM HTLLEKFDEH DGPVRGVAFH 60
QQMPLFVSGG DDYKIKVWNY KQRRCIFTLL AHLDYVRTVA FHHEYPWILS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAATTGACG TGTCACAATT TCGACGATTG GTTGGTGTTT TTCATAAAAT TAATTGTTGG 60
CAGTATATTA CGTGTTACTT GTAGCGTATC AATAAAATGG GTTTGTTCTA ACACCCACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0167--Capsid protein
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0813--Transport
KW-0946--Virion
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0019028--C:viral capsid
GO:0005198--F:structural molecule activity
GO:0000902--P:cell morphogenesis
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0007112--P:male meiosis cytokinesis
GO:0048812--P:neuron projection morphogenesis
GO:0006909--P:phagocytosis
GO:0010883--P:regulation of lipid storage
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
GO:0016192--P:vesicle-mediated transport

KEGG

dme:Dmel_CG7961

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000201	Aegilops tauschii	51.28	0.00e+00	1220.00
IUUC-Aml-001758	Ailuropoda melanoleuca	69.21	0.00e+00	1769.00
IUUC-Atr-002493	Amborella trichopoda	62.33	0.00e+00	1067.00
IUUC-Apl-003385	Anas platyrhynchos	65.62	0.00e+00	1449.00
IUUC-Aca-005154	Anolis carolinensis	78.10	4.00e-100	356.00
IUUC-Aly-006020	Arabidopsis lyrata	60.58	0.00e+00	1060.00
IUUC-Ath-007360	Arabidopsis thaliana	60.82	0.00e+00	1060.00
IUUC-Ago-007992	Ashbya gossypii	41.95	0.00e+00	967.00
IUUC-Acl-008027	Aspergillus clavatus	56.39	0.00e+00	986.00
IUUC-Afl-008644	Aspergillus flavus	56.24	0.00e+00	989.00
IUUC-Afu-008964	Aspergillus fumigatus	56.44	0.00e+00	998.00
IUUC-Ani-009379	Aspergillus nidulans	55.88	0.00e+00	987.00
IUUC-Ang-009756	Aspergillus niger	57.23	0.00e+00	1004.00
IUUC-Aor-010174	Aspergillus oryzae	56.24	0.00e+00	989.00
IUUC-Ate-010302	Aspergillus terreus	48.03	0.00e+00	1187.00
IUUC-Ame-011229	Astyanax mexicanus	75.15	0.00e+00	1323.00
IUUC-Bgr-012300	Blumeria graminis	46.44	0.00e+00	1092.00
IUUC-Bta-012524	Bos taurus	69.79	0.00e+00	1759.00
IUUC-Bci-013781	Botrytis cinerea	55.53	0.00e+00	981.00
IUUC-Bdi-014549	Brachypodium distachyon	59.74	0.00e+00	1054.00
IUUC-Bol-015925	Brassica oleracea	60.17	0.00e+00	1051.00
IUUC-Bra-016978	Brassica rapa	59.81	0.00e+00	1044.00
IUUC-Cel-018115	Caenorhabditis elegans	62.28	0.00e+00	1100.00
IUUC-Cja-019107	Callithrix jacchus	67.30	0.00e+00	1726.00
IUUC-Cfa-020675	Canis familiaris	69.11	0.00e+00	1739.00
IUUC-Cpo-021813	Cavia porcellus	76.17	0.00e+00	1366.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	62.19	0.00e+00	1065.00
IUUC-Csa-023523	Chlorocebus sabaeus	69.79	0.00e+00	1782.00
IUUC-Cho-024704	Choloepus hoffmanni	74.27	1.00e-142	500.00
IUUC-Cin-025572	Ciona intestinalis	69.48	0.00e+00	1248.00
IUUC-Csv-025864	Ciona savignyi	69.99	0.00e+00	1190.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	56.66	0.00e+00	1001.00
IUUC-Cne-027053	Cryptococcus neoformans	56.73	0.00e+00	1004.00
IUUC-Cme-027222	Cyanidioschyzon merolae	39.32	1.00e-136	481.00
IUUC-Dre-027421	Danio rerio	67.65	0.00e+00	1714.00
IUUC-Dno-029303	Dasypus novemcinctus	69.40	0.00e+00	1770.00
IUUC-Dor-030290	Dipodomys ordii	60.42	0.00e+00	674.00
IUUC-Dse-031543	Dothistroma septosporum	45.40	0.00e+00	1093.00
IUUC-Ete-032873	Echinops telfairi	73.12	0.00e+00	1295.00
IUUC-Eca-033773	Equus caballus	76.17	0.00e+00	1366.00
IUUC-Eeu-034874	Erinaceus europaeus	62.88	2.00e-121	429.00
IUUC-Fca-035739	Felis catus	76.00	0.00e+00	1347.00
IUUC-Fal-037263	Ficedula albicollis	70.42	0.00e+00	1192.00
IUUC-Fox-037738	Fusarium oxysporum	47.60	0.00e+00	1183.00
IUUC-Fso-038153	Fusarium solani	48.12	0.00e+00	1173.00
IUUC-Gmo-039602	Gadus morhua	74.22	0.00e+00	1300.00
IUUC-Ggr-039931	Gaeumannomyces graminis	55.81	0.00e+00	997.00
IUUC-Gga-040590	Gallus gallus	75.69	0.00e+00	1362.00
IUUC-Gac-041318	Gasterosteus aculeatus	67.46	0.00e+00	1731.00
IUUC-Gma-043894	Glycine max	61.25	0.00e+00	1065.00
IUUC-Ggo-045029	Gorilla gorilla	69.37	0.00e+00	1775.00
IUUC-Hsa-046078	Homo sapiens	69.37	0.00e+00	1775.00
IUUC-Hvu-047556	Hordeum vulgare	52.21	0.00e+00	1287.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	64.07	0.00e+00	1130.00
IUUC-Kpa-049256	Komagataella pastoris	52.27	0.00e+00	889.00
IUUC-Lch-049706	Latimeria chalumnae	68.58	0.00e+00	1741.00
IUUC-Lpe-051316	Leersia perrieri	60.94	0.00e+00	1065.00
IUUC-Loc-051867	Lepisosteus oculatus	59.13	0.00e+00	981.00
IUUC-Lma-053138	Leptosphaeria maculans	55.36	0.00e+00	998.00
IUUC-Laf-053510	Loxodonta africana	69.39	0.00e+00	1776.00
IUUC-Mcc-055836	Macaca mulatta	75.36	0.00e+00	1356.00
IUUC-Meu-056238	Macropus eugenii	68.06	0.00e+00	945.00
IUUC-Mor-057172	Magnaporthe oryzae	47.52	0.00e+00	1163.00
IUUC-Mtr-058248	Medicago truncatula	61.01	0.00e+00	1060.00
IUUC-Mla-059019	Melampsora laricipopulina	56.97	0.00e+00	1035.00
IUUC-Mga-059499	Meleagris gallopavo	75.51	0.00e+00	1355.00
IUUC-Mvi-060336	Microbotryum violaceum	56.60	0.00e+00	1030.00
IUUC-Mmr-061102	Microcebus murinus	76.11	0.00e+00	1352.00
IUUC-Mdo-062594	Monodelphis domestica	68.81	0.00e+00	1774.00
IUUC-Mmu-063736	Mus musculus	75.24	0.00e+00	1356.00
IUUC-Mac-065272	Musa acuminata	57.35	0.00e+00	965.00
IUUC-Mpu-066701	Mustela putorius furo	75.69	0.00e+00	1362.00
IUUC-Mlu-067392	Myotis lucifugus	62.88	5.00e-123	435.00
IUUC-Nfi-068270	Neosartorya fischeri	56.75	0.00e+00	994.00
IUUC-Ncr-068892	Neurospora crassa	56.41	0.00e+00	994.00
IUUC-Nle-069634	Nomascus leucogenys	76.92	0.00e+00	1098.00
IUUC-Opr-070952	Ochotona princeps	58.56	0.00e+00	981.00
IUUC-Ont-072488	Oreochromis niloticus	75.57	0.00e+00	1323.00
IUUC-Ocu-074211	Oryctolagus cuniculus	69.55	0.00e+00	1773.00
IUUC-Oba-075761	Oryza barthii	60.70	0.00e+00	1062.00
IUUC-Obr-076429	Oryza brachyantha	60.82	0.00e+00	1064.00
IUUC-Ogl-077364	Oryza glaberrima	60.70	0.00e+00	1063.00
IUUC-Ogu-078257	Oryza glumaepatula	60.89	0.00e+00	1062.00
IUUC-Oin-080029	Oryza indica	60.82	0.00e+00	1063.00
IUUC-Olo-080895	Oryza longistaminata	60.82	0.00e+00	1054.00
IUUC-Ome-081993	Oryza meridionalis	62.42	0.00e+00	991.00
IUUC-Oni-082608	Oryza nivara	61.06	0.00e+00	1063.00
IUUC-Opu-083370	Oryza punctata	61.18	0.00e+00	1067.00
IUUC-Oru-084274	Oryza rufipogon	60.70	0.00e+00	1063.00
IUUC-Osa-085841	Oryza sativa	61.06	0.00e+00	1065.00
IUUC-Ola-086921	Oryzias latipes	75.48	0.00e+00	1315.00
IUUC-Olu-087639	Ostreococcus lucimarinus	53.66	0.00e+00	1310.00
IUUC-Oga-087991	Otolemur garnettii	66.11	0.00e+00	1670.00
IUUC-Oar-089590	Ovis aries	69.71	0.00e+00	1776.00
IUUC-Ptr-090808	Pan troglodytes	69.37	0.00e+00	1775.00
IUUC-Pan-092475	Papio anubis	69.33	0.00e+00	1768.00
IUUC-Psi-093044	Pelodiscus sinensis	65.25	0.00e+00	1093.00
IUUC-Pno-094839	Phaeosphaeria nodorum	54.21	0.00e+00	928.00
IUUC-Ppa-095254	Physcomitrella patens	64.58	0.00e+00	1115.00
IUUC-Pfo-097493	Poecilia formosa	68.34	0.00e+00	1727.00
IUUC-Pab-098497	Pongo abelii	69.79	0.00e+00	1782.00
IUUC-Pop-099992	Populus trichocarpa	60.89	0.00e+00	1063.00
IUUC-Pca-100413	Procavia capensis	66.61	0.00e+00	769.00
IUUC-Ppe-101899	Prunus persica	62.21	0.00e+00	1087.00
IUUC-Pva-102126	Pteropus vampyrus	66.96	0.00e+00	1689.00
IUUC-Pgr-103376	Puccinia graminis	57.46	0.00e+00	1026.00
IUUC-Ptt-103978	Puccinia triticina	48.40	0.00e+00	802.00
IUUC-Pte-104126	Pyrenophora teres	54.65	0.00e+00	949.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	45.21	6.00e-174	603.00
IUUC-Rno-105428	Rattus norvegicus	76.17	0.00e+00	1365.00
IUUC-Sce-106464	Saccharomyces cerevisiae	49.34	0.00e+00	849.00
IUUC-Sha-107301	Sarcophilus harrisii	68.72	0.00e+00	1746.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	44.77	0.00e+00	1047.00
IUUC-Spo-108217	Schizosaccharomyces pombe	46.01	0.00e+00	1082.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	55.53	0.00e+00	980.00
IUUC-Smo-109582	Selaginella moellendorffii	62.95	0.00e+00	1097.00
IUUC-Sit-109697	Setaria italica	60.70	0.00e+00	1062.00
IUUC-Sly-111447	Solanum lycopersicum	62.58	0.00e+00	1097.00
IUUC-Stu-112564	Solanum tuberosum	62.94	0.00e+00	1093.00
IUUC-Sar-113313	Sorex araneus	58.83	0.00e+00	973.00
IUUC-Sbi-114388	Sorghum bicolor	60.94	0.00e+00	1065.00
IUUC-Sre-115209	Sporisorium reilianum	55.01	0.00e+00	992.00
IUUC-Ssc-115933	Sus scrofa	69.55	0.00e+00	1772.00
IUUC-Tgu-117109	Taeniopygia guttata	63.45	6.00e-144	503.00
IUUC-Tru-117772	Takifugu rubripes	61.04	1.00e-119	424.00
IUUC-Tsy-119105	Tarsius syrichta	69.19	0.00e+00	1217.00
IUUC-Tni-120556	Tetraodon nigroviridis	54.22	0.00e+00	748.00
IUUC-Tca-121545	Theobroma cacao	62.82	0.00e+00	1087.00
IUUC-Tre-121951	Trichoderma reesei	56.49	0.00e+00	997.00
IUUC-Tvi-122359	Trichoderma virens	56.65	0.00e+00	1003.00
IUUC-Tae-123688	Triticum aestivum	52.13	0.00e+00	1285.00
IUUC-Tur-126016	Triticum urartu	50.34	0.00e+00	1154.00
IUUC-Tme-127170	Tuber melanosporum	48.63	0.00e+00	1182.00
IUUC-Tbe-127882	Tupaia belangeri	54.75	6.00e-173	600.00
IUUC-Ttr-128217	Tursiops truncatus	67.28	0.00e+00	1698.00
IUUC-Uma-129337	Ustilago maydis	55.01	0.00e+00	989.00
IUUC-Vda-129828	Verticillium dahliae	55.19	0.00e+00	977.00
IUUC-Vpa-130537	Vicugna pacos	68.55	0.00e+00	1756.00
IUUC-Vvi-130958	Vitis vinifera	61.85	0.00e+00	1076.00
IUUC-Xtr-132857	Xenopus tropicalis	66.37	0.00e+00	1641.00
IUUC-Xma-133138	Xiphophorus maculatus	68.42	0.00e+00	1730.00
IUUC-Yli-134399	Yarrowia lipolytica	49.13	0.00e+00	841.00
IUUC-Zma-135612	Zea mays	58.64	0.00e+00	1039.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence