iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037263

Ensembl Protein ID

ENSFALP00000007706.1

UniProt Accession

U3JY52; U3JY52_FICAL

Genbank Protein ID

ENSFALP00000007706

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

AGTO01002042

Gene Name

COPA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000007347.1	ENSFALT00000007738.1	ENSFALP00000007706.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-20	72.4	133	163
UBD/Beta-Prp	7.30e-54	182.6	12	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+  v c +f +  +l+vs+s D t++vWD
   Q: 133  GHNHYVMCAQFhPAeDLVVSASLDQTVRVWD 163
           8**********96669*************** PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
             + f+p++++++t+  +g i++wd+++ +l+ ++ +h++++  ++f +++k     ++   i vw+++ + c+ tl gh d+++++ f
   Q: 12   PGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGGIFGMDFRSHKK-NPDLGSAFKIEVWNYKLRRCLFTLLGHLDYIRTTFF 99
           55889*********************************************85.555555699*************************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl........................ 166
           + +  +++s+s+d+tirvw++++++c+   +l+gh++ v+c+++hp ++l+vs+slD+tvr+Wd+                        
   Q: 100  HHEYPWILSASDDQTIRVWNWQSRTCVWLsVLTGHNHYVMCAQFHPAEDLVVSASLDQTVRVWDIsglrkknlspgavesdvrgitgvd 188
           *************************98656*********************************************************** PP
   S: 167  ...ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
               t+ ++++  +gh++ v++    ++++ + s       k w l +++   v+t++gh +nv++  f+p++e+++s s+D+sir+Wd
   Q: 189  lfgTTDAVVKHVLEGHDREVNWAFHPHSRPLFFSPFFPPESKAWKLNKSKAweVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
           ***888888888777*******98888889*****************888888************************************ PP
   S: 251  lrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           + +++ ++t+ + +++++  a+ +++ n +++g  d+   ++kl++++p
   Q: 278  MSKRTGVQTFRRDHDRFWVLAA-HPNLNLFAAG-HDGGMLVFKLERERP 324
           **********************.5544444433.589999999988765 PP

Organism

Ficedula albicollis

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

FFSLFSHFSC VPGLSFHPKR PWILTSLHNG VIQLWDYRMC TLIDKFDEHD GGIFGMDFRS 60
HKKNPDLGSA FKIEVWNYKL RRCLFTLLGH LDYIRTTFFH HEYPWILSAS DDQTIRVWNW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTCTCCC TTTTTTCCCA CTTTTCCTGT GTGCCAGGGC TGTCCTTCCA CCCCAAGAGG 60
CCCTGGATCC TGACCAGCCT GCACAACGGG GTGATCCAGC TCTGGGACTA TCGCATGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030157--P:pancreatic juice secretion
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	57.69	0.00e+00	968.00
IUUC-Aml-001758	Ailuropoda melanoleuca	87.63	0.00e+00	2165.00
IUUC-Atr-002493	Amborella trichopoda	51.29	0.00e+00	1179.00
IUUC-Apl-003385	Anas platyrhynchos	90.42	0.00e+00	1914.00
IUUC-Aca-005154	Anolis carolinensis	88.21	1.00e-99	355.00
IUUC-Aly-006020	Arabidopsis lyrata	49.76	0.00e+00	1164.00
IUUC-Ath-007058	Arabidopsis thaliana	57.33	0.00e+00	950.00
IUUC-Ago-007992	Ashbya gossypii	40.93	0.00e+00	890.00
IUUC-Acl-008027	Aspergillus clavatus	52.15	0.00e+00	874.00
IUUC-Afl-008644	Aspergillus flavus	52.37	0.00e+00	874.00
IUUC-Afu-008964	Aspergillus fumigatus	52.08	0.00e+00	881.00
IUUC-Ani-009379	Aspergillus nidulans	51.83	0.00e+00	881.00
IUUC-Ang-009756	Aspergillus niger	53.10	0.00e+00	892.00
IUUC-Aor-010174	Aspergillus oryzae	52.37	0.00e+00	874.00
IUUC-Ate-010302	Aspergillus terreus	46.10	0.00e+00	1086.00
IUUC-Ame-011229	Astyanax mexicanus	80.66	0.00e+00	2000.00
IUUC-Bgr-012300	Blumeria graminis	45.41	0.00e+00	1013.00
IUUC-Bta-012524	Bos taurus	88.20	0.00e+00	2152.00
IUUC-Bci-013781	Botrytis cinerea	46.04	0.00e+00	1065.00
IUUC-Bdi-014549	Brachypodium distachyon	51.46	0.00e+00	1202.00
IUUC-Bol-015925	Brassica oleracea	57.21	0.00e+00	943.00
IUUC-Bra-016978	Brassica rapa	49.35	0.00e+00	1141.00
IUUC-Cel-018115	Caenorhabditis elegans	59.95	0.00e+00	1002.00
IUUC-Cja-019107	Callithrix jacchus	85.27	0.00e+00	2093.00
IUUC-Cfa-020675	Canis familiaris	88.00	0.00e+00	2158.00
IUUC-Cpo-021813	Cavia porcellus	88.28	0.00e+00	2170.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	60.57	0.00e+00	983.00
IUUC-Csa-023523	Chlorocebus sabaeus	88.28	0.00e+00	2176.00
IUUC-Cho-024704	Choloepus hoffmanni	81.08	0.00e+00	1235.00
IUUC-Cin-025572	Ciona intestinalis	69.11	0.00e+00	1716.00
IUUC-Csv-025864	Ciona savignyi	69.81	0.00e+00	1150.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	53.31	0.00e+00	896.00
IUUC-Cne-027053	Cryptococcus neoformans	49.27	0.00e+00	1119.00
IUUC-Cme-027222	Cyanidioschyzon merolae	38.06	5.00e-127	449.00
IUUC-Dre-027421	Danio rerio	80.34	0.00e+00	1993.00
IUUC-Dno-029303	Dasypus novemcinctus	88.32	0.00e+00	2171.00
IUUC-Dor-030290	Dipodomys ordii	88.89	0.00e+00	996.00
IUUC-Dse-031543	Dothistroma septosporum	43.66	0.00e+00	1000.00
IUUC-Dme-031945	Drosophila melanogaster	70.28	0.00e+00	1139.00
IUUC-Ete-032873	Echinops telfairi	82.18	0.00e+00	1843.00
IUUC-Eca-033773	Equus caballus	86.33	0.00e+00	2103.00
IUUC-Eeu-034874	Erinaceus europaeus	79.91	0.00e+00	1407.00
IUUC-Fca-035739	Felis catus	87.31	0.00e+00	2095.00
IUUC-Fox-037738	Fusarium oxysporum	46.24	0.00e+00	1089.00
IUUC-Fso-038153	Fusarium solani	46.20	0.00e+00	1069.00
IUUC-Gmo-039602	Gadus morhua	76.29	0.00e+00	1861.00
IUUC-Ggr-039931	Gaeumannomyces graminis	51.97	0.00e+00	884.00
IUUC-Gga-040590	Gallus gallus	90.33	0.00e+00	2201.00
IUUC-Gac-041318	Gasterosteus aculeatus	80.08	0.00e+00	2012.00
IUUC-Gma-043567	Glycine max	51.91	0.00e+00	1204.00
IUUC-Ggo-045029	Gorilla gorilla	87.63	0.00e+00	2165.00
IUUC-Hsa-046078	Homo sapiens	87.47	0.00e+00	2163.00
IUUC-Hvu-047556	Hordeum vulgare	52.07	0.00e+00	1219.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	87.85	0.00e+00	1548.00
IUUC-Kpa-049256	Komagataella pastoris	43.01	0.00e+00	971.00
IUUC-Lch-049706	Latimeria chalumnae	86.07	0.00e+00	2096.00
IUUC-Lpe-051316	Leersia perrieri	58.41	0.00e+00	974.00
IUUC-Loc-051867	Lepisosteus oculatus	65.14	0.00e+00	1065.00
IUUC-Lma-053138	Leptosphaeria maculans	51.90	0.00e+00	896.00
IUUC-Laf-053510	Loxodonta africana	87.79	0.00e+00	2201.00
IUUC-Mcc-055836	Macaca mulatta	87.14	0.00e+00	2159.00
IUUC-Meu-056238	Macropus eugenii	81.13	0.00e+00	997.00
IUUC-Mor-057172	Magnaporthe oryzae	45.93	0.00e+00	1064.00
IUUC-Mpo-057300	Magnaporthe poae	46.00	0.00e+00	1055.00
IUUC-Mtr-058248	Medicago truncatula	51.99	0.00e+00	1222.00
IUUC-Mla-059019	Melampsora laricipopulina	49.31	0.00e+00	1162.00
IUUC-Mga-059499	Meleagris gallopavo	90.10	0.00e+00	2196.00
IUUC-Mvi-060336	Microbotryum violaceum	49.59	0.00e+00	1144.00
IUUC-Mmr-061102	Microcebus murinus	87.79	0.00e+00	2129.00
IUUC-Mdo-062594	Monodelphis domestica	88.69	0.00e+00	2202.00
IUUC-Mmu-063736	Mus musculus	87.47	0.00e+00	2159.00
IUUC-Mac-065398	Musa acuminata	48.83	0.00e+00	1102.00
IUUC-Mpu-066701	Mustela putorius furo	88.24	0.00e+00	2167.00
IUUC-Mlu-067392	Myotis lucifugus	87.97	0.00e+00	2163.00
IUUC-Nfi-068270	Neosartorya fischeri	52.45	0.00e+00	879.00
IUUC-Ncr-068892	Neurospora crassa	46.74	0.00e+00	1066.00
IUUC-Nle-069634	Nomascus leucogenys	87.61	0.00e+00	1174.00
IUUC-Opr-070952	Ochotona princeps	76.92	0.00e+00	1574.00
IUUC-Ont-072488	Oreochromis niloticus	81.97	0.00e+00	2029.00
IUUC-Ocu-074211	Oryctolagus cuniculus	88.44	0.00e+00	2174.00
IUUC-Oba-075761	Oryza barthii	58.53	0.00e+00	976.00
IUUC-Obr-076429	Oryza brachyantha	58.17	0.00e+00	972.00
IUUC-Ogl-077364	Oryza glaberrima	58.53	0.00e+00	976.00
IUUC-Ogu-078257	Oryza glumaepatula	58.53	0.00e+00	975.00
IUUC-Oin-079274	Oryza indica	58.41	0.00e+00	974.00
IUUC-Olo-080466	Oryza longistaminata	58.39	0.00e+00	961.00
IUUC-Ome-081993	Oryza meridionalis	59.51	0.00e+00	900.00
IUUC-Oni-082874	Oryza nivara	58.53	0.00e+00	975.00
IUUC-Opu-083370	Oryza punctata	50.93	0.00e+00	1195.00
IUUC-Oru-084274	Oryza rufipogon	58.53	0.00e+00	976.00
IUUC-Osa-085565	Oryza sativa	58.53	0.00e+00	976.00
IUUC-Ola-086921	Oryzias latipes	80.02	0.00e+00	1970.00
IUUC-Olu-087639	Ostreococcus lucimarinus	53.02	0.00e+00	1230.00
IUUC-Oga-087991	Otolemur garnettii	83.33	0.00e+00	2033.00
IUUC-Oar-089590	Ovis aries	88.36	0.00e+00	2175.00
IUUC-Ptr-090808	Pan troglodytes	87.63	0.00e+00	2166.00
IUUC-Pan-092475	Papio anubis	87.92	0.00e+00	2162.00
IUUC-Psi-093044	Pelodiscus sinensis	74.91	0.00e+00	1521.00
IUUC-Pno-094839	Phaeosphaeria nodorum	50.83	0.00e+00	842.00
IUUC-Ppa-095254	Physcomitrella patens	53.31	0.00e+00	1262.00
IUUC-Pfo-097493	Poecilia formosa	81.31	0.00e+00	1989.00
IUUC-Pab-098497	Pongo abelii	88.20	0.00e+00	2175.00
IUUC-Pop-099992	Populus trichocarpa	52.34	0.00e+00	1201.00
IUUC-Pca-100413	Procavia capensis	79.28	0.00e+00	880.00
IUUC-Ppe-101899	Prunus persica	51.25	0.00e+00	1191.00
IUUC-Pva-102126	Pteropus vampyrus	84.13	0.00e+00	2055.00
IUUC-Pgr-103376	Puccinia graminis	49.35	0.00e+00	1170.00
IUUC-Ptt-103978	Puccinia triticina	46.85	0.00e+00	1006.00
IUUC-Pte-104126	Pyrenophora teres	52.28	0.00e+00	870.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	44.38	8.00e-173	600.00
IUUC-Rno-105428	Rattus norvegicus	88.11	0.00e+00	2166.00
IUUC-Sce-106464	Saccharomyces cerevisiae	40.59	0.00e+00	876.00
IUUC-Sha-107301	Sarcophilus harrisii	88.51	0.00e+00	2172.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	43.27	0.00e+00	974.00
IUUC-Spo-108217	Schizosaccharomyces pombe	51.31	0.00e+00	837.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	52.33	0.00e+00	886.00
IUUC-Smo-109582	Selaginella moellendorffii	60.74	0.00e+00	1013.00
IUUC-Sit-109697	Setaria italica	58.02	0.00e+00	967.00
IUUC-Sly-111759	Solanum lycopersicum	51.78	0.00e+00	1228.00
IUUC-Stu-112564	Solanum tuberosum	51.70	0.00e+00	1227.00
IUUC-Sar-113313	Sorex araneus	81.79	0.00e+00	1330.00
IUUC-Sbi-114388	Sorghum bicolor	58.41	0.00e+00	972.00
IUUC-Sre-115209	Sporisorium reilianum	54.03	0.00e+00	924.00
IUUC-Ssc-115933	Sus scrofa	88.28	0.00e+00	2174.00
IUUC-Tgu-117109	Taeniopygia guttata	87.02	0.00e+00	774.00
IUUC-Tru-117772	Takifugu rubripes	80.89	0.00e+00	1982.00
IUUC-Tsy-119105	Tarsius syrichta	75.10	0.00e+00	1840.00
IUUC-Tni-120556	Tetraodon nigroviridis	66.95	0.00e+00	1432.00
IUUC-Tca-120918	Theobroma cacao	60.48	0.00e+00	992.00
IUUC-Tre-121951	Trichoderma reesei	52.77	0.00e+00	894.00
IUUC-Tvi-122359	Trichoderma virens	53.00	0.00e+00	899.00
IUUC-Tae-123688	Triticum aestivum	52.15	0.00e+00	1217.00
IUUC-Tur-126754	Triticum urartu	57.45	0.00e+00	964.00
IUUC-Tme-127170	Tuber melanosporum	46.62	0.00e+00	1086.00
IUUC-Tbe-127882	Tupaia belangeri	87.61	0.00e+00	739.00
IUUC-Ttr-128217	Tursiops truncatus	85.52	0.00e+00	2098.00
IUUC-Uma-129337	Ustilago maydis	53.33	0.00e+00	924.00
IUUC-Vda-129828	Verticillium dahliae	45.53	0.00e+00	1054.00
IUUC-Vpa-130537	Vicugna pacos	87.23	0.00e+00	2123.00
IUUC-Vvi-130958	Vitis vinifera	58.49	0.00e+00	972.00
IUUC-Xtr-132857	Xenopus tropicalis	83.27	0.00e+00	2036.00
IUUC-Xma-133138	Xiphophorus maculatus	81.31	0.00e+00	1993.00
IUUC-Yli-134399	Yarrowia lipolytica	46.74	0.00e+00	749.00
IUUC-Zma-135612	Zea mays	51.14	0.00e+00	1198.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence