iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	12766473
E3 adaptor/Cullin RING/SCF/F-box	F-box	12766473

Classification

Family	E-value	Score	Start	End
E2/UBC	1.70e-40	138.0	343	476
E3 adaptor/Cullin RING/SCF/F-box	0.00021	21.4	222	275

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 3    kkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsves 100
           + e++ l++ ++egisa p d+ + + w+++ilGp+++pYegg+F l i+fpe+YP++PP+v+fltki+hPnv+++G+v ++i++ +++Ws al+v++
   Q: 343  RGEANLLNSYESEGISAIPLDR-QNNYWQATILGPPGSPYEGGKFFLFIYFPERYPMTPPTVRFLTKILHPNVSRHGDVGIDIFQ-QHNWSLALNVAK 438
           5689999***************.699**********************************************************6.9*********** PP
   S: 101  vllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           vlls+qsll++p++e +++ e   +++++re++++ vr
   Q: 439  VLLSVQSLLTDPYTEVCMEPELGYIYEHERERFEQLVR 476
           ***********************************997 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 94   peegpdaglldrlpeeilveilklldkeellraarvcrrwqelas...qkalwk 144
              g+ +++++ +p e++++i+ +ld  +l +a++vc++w+ +      +++wk
   Q: 222  GASGSSRNIVNIIPVEVMLKIFAYLDDMSLWMASEVCKQWHDIVGkntAQSMWK 275
           567888999999*****************************5554233366666 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MTSCVPAHQQ KDQEQLLKEL ASSGDEMDDP DDPDQEHHQL VEPTFSFSNS NTCWVCNGYY 60
GPNFGEPLCG ACHAFLYNAQ RAEELLTELS DDEDSGNDEP PFKDKQEDEE TENDVDIMGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACACTTTTA GATGGTCTAT CGTTTGTCGA TTATTTATTT GTTTTAGCAC CAGTTTCTCG 60
GGAGTTCTGT AAAATGACTA GCTGCGTGCC AGCGCATCAG CAAAAGGACC AGGAGCAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001810--F-box_dom
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50181--FBOX
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF12937--F-box-like
PF00179--UQ_con

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0036435--F:K48-linked polyubiquitin binding
GO:1901694--P:positive regulation of compound eye retinal cell apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0046668--P:regulation of retinal cell programmed cell death
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG15437

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence