iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091395

UUCD1 version

UUC-PaT-01104

Ensembl Protein ID

ENSPTRP00000001399.3

UniProt Accession

H2PZ55; H2PZ55_PANTR

Genbank Protein ID

JAA04421.1; JAA04422.1; JAA27359.1; JAA35258.1

Protein Name

Ubiquitin specific peptidase 1

Genbank Nucleotide ID

AACZ03003347; GABC01006916; GABD01005741; GABE01009481

Gene Name

USP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000000810.4	ENSPTRT00000001537.3	ENSPTRP00000001399.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-87	294.1	81	784

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..........ellkslqklfeel.......w..... 61
           +Gl+NlgNtCY+NS+LQ+L+++p +++ +++      +kke+l++e+++++kg          el++slq+l+ ++       +     
   Q: 81   VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHlfniisRKKEALKDEANQKDKGnckedslasyELICSLQSLIISVeqlqasfLlnpek 169
           6************************************999999999999999999999*****99999999999995555555144555 PP
   S: 62   kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde.... 129
           ++++ a++pr+ll++l++++++++gy q+DaqE+l+++l +++e+++                  e  +pkee+++ ++ e++++    
   Q: 170  YTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLlkkeevknvaelptkveEIPHPKEEMSGINSMEMDSMrhse 258
           88888*****************************************556667788888888888777788888888887777777**** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 259  dfkeklpkgngkrksdtefgnmkkkvkvskehqsleenqrqtrskrkatsdtlesppkiipkyisenesprpsqkksrvkinwlksatk 347
           ***************************************************************************************** PP
   S: 130  .............................................................aeekkkkknk.....slisdlFqgqlks 152
                                                                        +e k+ +k++     +l+++lFqgql  
   Q: 348  qpsilskfcslgkittnqgvkgqskenecdpeedlgkcesdnttngcglespgntvtpvnvNEVKPINKGEeqigfELVEKLFQGQLVL 436
           ***********************************************************99555555555556666************* PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkke..............slqdcLesftkeeelegenkyycekckkkqeaekklklkklP 227
           +++clec++ ++r+e+f+d+s+pv+++e +k e              +l++++++f++ e++ ge+ky+ce+c++++eae++l ++k+P
   Q: 437  RTRCLECESLTERREDFQDISVPVQEDELSKVEesseispepktemkTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMP 525
           ****************************99998******************************************************** PP
   S: 228  evLilhLkRf.....sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn......... 301
           ev+++hLk+f     +f+++++  +kin+ + +pl+L+l+++ t+p+     +++Y L+avv+HsG ++ssGHY+a vk          
   Q: 526  EVITIHLKCFaasglEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPT-----NDSYGLFAVVMHSGiTISSGHYTASVKVtdlnsleld 609
           *********************************************99.....678********************************** PP
   S: 302  ......................................................................................... 301
                                                                                                    
   Q: 610  kgnfvvdqmceigkpeplneeeargvvenyndeevsirvggntqpskvlnkknveaigllggqkskadyelynkasnpdkvastafaen 698
           ***************************************************************************************** PP
   S: 302  ............................................ekgkWllfdDskVtevkeeevleetg......staYvlfYkr 337
                                                        +gkWllfdDs+V++++e+++l++ +      st+Y+lfYk+
   Q: 699  rnsetsdttgthesdrnkessdqtginisgfenkisyvvqslkeYEGKWLLFDDSEVKVTEEKDFLNSLSpstsptSTPYLLFYKK 784
           *********999999999999999999999988888888877766999*******************888**************97 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKAS EYRASEIDQV 60
VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKSGVK HLFNIISRKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGCGCGCA CGAATGGTTA AAAAAAGGGT GTGAGGCTCG AGCCCGCCAG CCAGGCCGCT 60
AGCACCTCGC GCGCGCCCTC AGCGAGGACC CGCACGAGCT GCCCGGCTCT GTGCCTGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0009411--P:response to UV
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ptr:456901

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001939	Ailuropoda melanoleuca	94.02	0.00e+00	1428.00
IUUC-Apl-004204	Anas platyrhynchos	73.01	0.00e+00	939.00
IUUC-Aca-004637	Anolis carolinensis	66.46	0.00e+00	935.00
IUUC-Ame-011718	Astyanax mexicanus	48.08	4.00e-173	601.00
IUUC-Bta-012552	Bos taurus	92.10	0.00e+00	1404.00
IUUC-Cja-019588	Callithrix jacchus	97.32	0.00e+00	1519.00
IUUC-Cfa-020211	Canis familiaris	94.52	0.00e+00	1442.00
IUUC-Cpo-021551	Cavia porcellus	84.46	0.00e+00	1270.00
IUUC-Csa-024186	Chlorocebus sabaeus	97.83	0.00e+00	1531.00
IUUC-Cho-024739	Choloepus hoffmanni	83.41	0.00e+00	752.00
IUUC-Dre-028184	Danio rerio	49.27	6.00e-177	614.00
IUUC-Dno-029669	Dasypus novemcinctus	90.61	0.00e+00	1398.00
IUUC-Dor-030168	Dipodomys ordii	86.80	0.00e+00	1260.00
IUUC-Dme-031732	Drosophila melanogaster	28.77	4.00e-18	87.40
IUUC-Ete-032825	Echinops telfairi	86.63	0.00e+00	955.00
IUUC-Eca-033595	Equus caballus	93.96	0.00e+00	1355.00
IUUC-Eeu-034877	Erinaceus europaeus	80.50	8.00e-162	563.00
IUUC-Fca-035381	Felis catus	93.90	0.00e+00	1013.00
IUUC-Fal-037592	Ficedula albicollis	69.38	0.00e+00	965.00
IUUC-Gmo-039680	Gadus morhua	44.72	4.00e-152	531.00
IUUC-Gga-041196	Gallus gallus	72.12	0.00e+00	1059.00
IUUC-Gac-042292	Gasterosteus aculeatus	57.25	1.00e-82	301.00
IUUC-Ggo-044671	Gorilla gorilla	99.62	0.00e+00	1564.00
IUUC-Hsa-047020	Homo sapiens	99.62	0.00e+00	1566.00
IUUC-Itr-048800	Ictidomys tridecemlineatus	85.50	0.00e+00	1269.00
IUUC-Lch-050543	Latimeria chalumnae	57.35	0.00e+00	705.00
IUUC-Loc-052338	Lepisosteus oculatus	52.96	0.00e+00	704.00
IUUC-Laf-053707	Loxodonta africana	90.87	0.00e+00	1414.00
IUUC-Mcc-055885	Macaca mulatta	97.83	0.00e+00	1533.00
IUUC-Meu-056573	Macropus eugenii	67.09	0.00e+00	951.00
IUUC-Mga-059346	Meleagris gallopavo	72.73	0.00e+00	1006.00
IUUC-Mmr-061612	Microcebus murinus	93.89	0.00e+00	1409.00
IUUC-Mdo-062887	Monodelphis domestica	73.85	0.00e+00	1058.00
IUUC-Mmu-064044	Mus musculus	88.30	0.00e+00	1366.00
IUUC-Mpu-066847	Mustela putorius furo	94.90	0.00e+00	1445.00
IUUC-Mlu-067684	Myotis lucifugus	91.49	0.00e+00	1425.00
IUUC-Nle-070057	Nomascus leucogenys	98.73	0.00e+00	1554.00
IUUC-Opr-070463	Ochotona princeps	84.18	0.00e+00	1258.00
IUUC-Ont-071975	Oreochromis niloticus	51.50	6.00e-143	501.00
IUUC-Oan-073062	Ornithorhynchus anatinus	85.71	9.00e-47	178.00
IUUC-Ocu-074840	Oryctolagus cuniculus	93.38	0.00e+00	1436.00
IUUC-Ola-087088	Oryzias latipes	46.75	2.00e-173	602.00
IUUC-Oga-088472	Otolemur garnettii	93.38	0.00e+00	1432.00
IUUC-Oar-089498	Ovis aries	92.36	0.00e+00	1411.00
IUUC-Pan-092462	Papio anubis	97.96	0.00e+00	1533.00
IUUC-Psi-093583	Pelodiscus sinensis	71.94	0.00e+00	911.00
IUUC-Pma-094644	Petromyzon marinus	36.78	1.00e-28	119.00
IUUC-Pfo-096314	Poecilia formosa	46.27	2.00e-168	586.00
IUUC-Pab-098568	Pongo abelii	99.36	0.00e+00	1561.00
IUUC-Pca-100948	Procavia capensis	81.70	0.00e+00	1240.00
IUUC-Pva-102853	Pteropus vampyrus	93.37	0.00e+00	1437.00
IUUC-Rno-105573	Rattus norvegicus	88.54	0.00e+00	1352.00
IUUC-Sha-107495	Sarcophilus harrisii	72.31	0.00e+00	893.00
IUUC-Sar-113545	Sorex araneus	77.55	0.00e+00	1108.00
IUUC-Ssc-115962	Sus scrofa	94.17	0.00e+00	1463.00
IUUC-Tgu-116731	Taeniopygia guttata	69.69	0.00e+00	979.00
IUUC-Tru-117893	Takifugu rubripes	46.14	2.00e-158	552.00
IUUC-Tsy-119644	Tarsius syrichta	84.69	0.00e+00	1258.00
IUUC-Tni-119819	Tetraodon nigroviridis	45.21	5.00e-169	588.00
IUUC-Tbe-127272	Tupaia belangeri	88.89	0.00e+00	1261.00
IUUC-Ttr-128404	Tursiops truncatus	93.88	0.00e+00	1451.00
IUUC-Vpa-130205	Vicugna pacos	93.24	0.00e+00	1438.00
IUUC-Xtr-132613	Xenopus tropicalis	56.12	0.00e+00	746.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence