iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000035203.16	ENSMUST00000098845.9	ENSMUSP00000096445.3
ENSMUSG00000035203.16	ENSMUST00000208634.1	ENSMUSP00000146638.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UIM	1.80e-08	34.6	183	201
UBD/Alpha-Helix/UIM	0.00024	12.9	208	226

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+++LqlAla+S++E+++
   Q: 183  EEELQLQLALAMSKEEADQ 201
           79**************987 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           ++d +LqlAl lS++E+++
   Q: 208  EDDVQLQLALSLSREEHDK 226
           699*************985 PP

Organism

Mus musculus

Functional Description
(View)

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.

Protein Sequence
(Fasta)

MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI 60
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCTGCCAC CTTCGGTTGC TTCCCGTCCG CTCGGCGGCT CCCCTCCCCC GCCCGGCTCT 60
CTGCGCCCCT CCCGGGCGCC GGGGCGGCGG GGCCGTCGCT GTGCGGCCCT CCGTGCGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR003903--UIM_dom

PROSITE

PS50942--ENTH
PS50330--UIM

Pfam

PF01417--ENTH
PF02809--UIM

SMART

SM00273--ENTH
SM00726--UIM

Gene Ontology

GO:0005905--C:clathrin-coated pit
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0008289--F:lipid binding
GO:0048568--P:embryonic organ development
GO:0006897--P:endocytosis
GO:0007565--P:female pregnancy
GO:0001701--P:in utero embryonic development
GO:0007219--P:Notch signaling pathway

KEGG

mmu:13854

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002304	Ailuropoda melanoleuca	93.82	0.00e+00	765.00
IUUC-Atr-002956	Amborella trichopoda	47.65	1.00e-41	164.00
IUUC-Aca-005208	Anolis carolinensis	64.82	9.00e-166	577.00
IUUC-Ame-011460	Astyanax mexicanus	78.36	5.00e-101	362.00
IUUC-Bta-013352	Bos taurus	92.71	0.00e+00	724.00
IUUC-Cel-018350	Caenorhabditis elegans	41.19	1.00e-74	273.00
IUUC-Cfa-020367	Canis familiaris	93.92	0.00e+00	757.00
IUUC-Csa-023208	Chlorocebus sabaeus	94.44	0.00e+00	743.00
IUUC-Dre-028015	Danio rerio	74.82	5.00e-104	372.00
IUUC-Dno-029947	Dasypus novemcinctus	91.30	4.00e-173	601.00
IUUC-Dor-030137	Dipodomys ordii	100.00	3.00e-120	425.00
IUUC-Dme-032149	Drosophila melanogaster	39.90	8.00e-85	308.00
IUUC-Eca-034189	Equus caballus	94.79	0.00e+00	783.00
IUUC-Fca-036270	Felis catus	93.75	0.00e+00	781.00
IUUC-Fso-038083	Fusarium solani	40.43	3.00e-41	162.00
IUUC-Gac-042085	Gasterosteus aculeatus	76.12	2.00e-97	349.00
IUUC-Hsa-046033	Homo sapiens	94.79	0.00e+00	726.00
IUUC-Itr-048041	Ictidomys tridecemlineatus	95.31	0.00e+00	773.00
IUUC-Kpa-049233	Komagataella pastoris	37.87	2.00e-35	144.00
IUUC-Laf-054571	Loxodonta africana	94.79	0.00e+00	778.00
IUUC-Mcc-055036	Macaca mulatta	94.97	0.00e+00	724.00
IUUC-Meu-056308	Macropus eugenii	82.72	2.00e-100	359.00
IUUC-Mtr-058328	Medicago truncatula	49.66	7.00e-43	169.00
IUUC-Mmr-060634	Microcebus murinus	93.58	0.00e+00	779.00
IUUC-Mdo-062555	Monodelphis domestica	99.12	4.00e-102	365.00
IUUC-Mac-064643	Musa acuminata	50.00	3.00e-43	170.00
IUUC-Mpu-066803	Mustela putorius furo	93.23	0.00e+00	776.00
IUUC-Mlu-067895	Myotis lucifugus	81.63	1.00e-96	347.00
IUUC-Nle-069810	Nomascus leucogenys	94.59	0.00e+00	704.00
IUUC-Opr-071138	Ochotona princeps	85.92	3.00e-130	458.00
IUUC-Ont-071888	Oreochromis niloticus	54.03	4.00e-111	395.00
IUUC-Ola-087447	Oryzias latipes	52.40	1.00e-111	397.00
IUUC-Oga-088369	Otolemur garnettii	92.71	0.00e+00	791.00
IUUC-Oar-090071	Ovis aries	84.97	2.00e-154	538.00
IUUC-Ptr-091336	Pan troglodytes	90.28	0.00e+00	627.00
IUUC-Pan-091921	Papio anubis	94.79	0.00e+00	723.00
IUUC-Ppa-095284	Physcomitrella patens	48.99	4.00e-44	173.00
IUUC-Pfo-097111	Poecilia formosa	56.11	1.00e-106	380.00
IUUC-Pab-098722	Pongo abelii	94.62	0.00e+00	773.00
IUUC-Pca-100297	Procavia capensis	85.76	0.00e+00	724.00
IUUC-Pva-102305	Pteropus vampyrus	83.40	5.00e-176	610.00
IUUC-Rno-104941	Rattus norvegicus	99.13	0.00e+00	788.00
IUUC-Spo-108319	Schizosaccharomyces pombe	51.85	6.00e-41	162.00
IUUC-Smo-109370	Selaginella moellendorffii	49.02	3.00e-40	158.00
IUUC-Tru-117791	Takifugu rubripes	60.49	1.00e-92	333.00
IUUC-Ttr-128384	Tursiops truncatus	92.80	0.00e+00	657.00
IUUC-Xtr-131804	Xenopus tropicalis	61.82	1.00e-159	556.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence