iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.70e-10	38.7	227	261

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgv 34
           gH + v++la+ ++ +++s+s+D+t++vW++ +g+
   Q: 227  GHREFVSGLALlTEQHIASASGDKTLRVWNYIQGK 261
           79999*****98889***************87766 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis.

Protein Sequence
(Fasta)

MCTTISFAEP EIVLGHGRRV LFVNPDDLQI FKEIELPPDL GLKGHTSQSQ ESCTAAAAAS 60
TATAASGQAP GGKEQQLANQ PEEGGTSASA SGLGCATSTS VQNVAYSPDG QLLAVTTSGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTAGTCAG TAGTTGTGCA AACCTATCGG TGGCTATCGA ATCGAGTCGC AAGAATGTGC 60
ACAACAATTT CGTTCGCGGA ACCCGAAATC GTGCTCGGCC ATGGCCGCAG GGTGCTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0539--Nucleus
KW-0896--Oogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0001674--C:female germ cell nucleus
GO:0001673--C:male germ cell nucleus
GO:0043527--C:tRNA methyltransferase complex
GO:0007275--P:multicellular organism development
GO:0048477--P:oogenesis
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0007283--P:spermatogenesis
GO:0008033--P:tRNA processing

KEGG

dme:Dmel_CG15897

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003975	Anas platyrhynchos	41.07	2.00e-29	122.00
IUUC-Aca-005170	Anolis carolinensis	34.62	1.00e-23	103.00
IUUC-Aly-005769	Arabidopsis lyrata	31.32	2.00e-15	76.30
IUUC-Ath-006733	Arabidopsis thaliana	30.22	2.00e-15	75.90
IUUC-Acl-008151	Aspergillus clavatus	24.24	4.00e-11	62.00
IUUC-Afl-008518	Aspergillus flavus	35.79	5.00e-12	64.70
IUUC-Afu-009102	Aspergillus fumigatus	30.18	1.00e-09	57.40
IUUC-Ani-009442	Aspergillus nidulans	24.06	2.00e-14	73.20
IUUC-Aor-010133	Aspergillus oryzae	23.74	9.00e-13	67.40
IUUC-Ate-010465	Aspergillus terreus	32.67	2.00e-10	60.10
IUUC-Ame-010613	Astyanax mexicanus	36.99	8.00e-26	110.00
IUUC-Bgr-012067	Blumeria graminis	33.06	1.00e-11	63.90
IUUC-Bta-012788	Bos taurus	34.47	1.00e-27	117.00
IUUC-Bdi-014458	Brachypodium distachyon	29.78	1.00e-12	66.60
IUUC-Bol-016398	Brassica oleracea	30.46	3.00e-16	79.00
IUUC-Bra-016644	Brassica rapa	30.10	7.00e-16	79.00
IUUC-Cpo-021963	Cavia porcellus	37.50	8.00e-27	113.00
IUUC-Csa-024148	Chlorocebus sabaeus	36.36	4.00e-24	105.00
IUUC-Cne-026834	Cryptococcus neoformans	33.50	2.00e-19	90.10
IUUC-Dre-028427	Danio rerio	35.79	6.00e-26	110.00
IUUC-Dno-028881	Dasypus novemcinctus	29.89	2.00e-14	72.80
IUUC-Dor-030522	Dipodomys ordii	29.48	7.00e-27	114.00
IUUC-Fca-035833	Felis catus	39.88	6.00e-29	120.00
IUUC-Fal-037497	Ficedula albicollis	39.88	2.00e-29	122.00
IUUC-Gga-040547	Gallus gallus	40.48	3.00e-29	122.00
IUUC-Gac-041761	Gasterosteus aculeatus	34.60	4.00e-26	111.00
IUUC-Gma-043722	Glycine max	39.80	1.00e-13	70.10
IUUC-Ggo-045340	Gorilla gorilla	36.87	1.00e-24	106.00
IUUC-Hsa-046403	Homo sapiens	36.41	3.00e-25	108.00
IUUC-Hvu-047643	Hordeum vulgare	29.91	3.00e-15	75.50
IUUC-Itr-048103	Ictidomys tridecemlineatus	40.37	2.00e-27	115.00
IUUC-Kpa-049283	Komagataella pastoris	32.16	2.00e-22	99.80
IUUC-Lch-050682	Latimeria chalumnae	30.58	3.00e-34	138.00
IUUC-Lpe-050712	Leersia perrieri	28.81	1.00e-14	73.20
IUUC-Loc-052599	Lepisosteus oculatus	28.77	2.00e-34	139.00
IUUC-Laf-054390	Loxodonta africana	36.84	1.00e-28	119.00
IUUC-Mcc-054747	Macaca mulatta	36.36	9.00e-24	103.00
IUUC-Mtr-058600	Medicago truncatula	30.11	3.00e-17	82.40
IUUC-Mla-059129	Melampsora laricipopulina	25.53	1.00e-11	62.80
IUUC-Mga-059876	Meleagris gallopavo	38.86	2.00e-28	119.00
IUUC-Mvi-060359	Microbotryum violaceum	27.67	2.00e-10	59.70
IUUC-Mmr-061518	Microcebus murinus	34.95	2.00e-27	115.00
IUUC-Mac-065625	Musa acuminata	25.81	3.00e-13	68.60
IUUC-Nfi-068402	Neosartorya fischeri	30.18	5.00e-10	58.20
IUUC-Nle-069914	Nomascus leucogenys	33.98	1.00e-21	97.10
IUUC-Ont-071555	Oreochromis niloticus	42.24	3.00e-28	118.00
IUUC-Oan-072951	Ornithorhynchus anatinus	28.65	2.00e-32	132.00
IUUC-Ocu-074679	Oryctolagus cuniculus	38.69	6.00e-22	97.80
IUUC-Obr-076769	Oryza brachyantha	28.16	9.00e-16	77.40
IUUC-Ogl-077168	Oryza glaberrima	27.18	1.00e-14	73.60
IUUC-Oin-079207	Oryza indica	27.18	1.00e-14	73.60
IUUC-Opu-084031	Oryza punctata	27.18	8.00e-14	71.20
IUUC-Osa-085327	Oryza sativa	27.18	1.00e-14	73.60
IUUC-Ola-086716	Oryzias latipes	38.82	4.00e-27	114.00
IUUC-Olu-087708	Ostreococcus lucimarinus	25.52	6.00e-09	54.30
IUUC-Oar-090239	Ovis aries	39.88	3.00e-28	118.00
IUUC-Ptr-090851	Pan troglodytes	35.92	1.00e-24	106.00
IUUC-Pan-092558	Papio anubis	36.36	3.00e-24	105.00
IUUC-Psi-093792	Pelodiscus sinensis	42.60	6.00e-30	124.00
IUUC-Ppa-095757	Physcomitrella patens	32.95	1.00e-16	80.10
IUUC-Pfo-096465	Poecilia formosa	28.02	2.00e-28	119.00
IUUC-Pab-097722	Pongo abelii	30.97	2.00e-26	112.00
IUUC-Pop-098979	Populus trichocarpa	27.80	1.00e-14	73.60
IUUC-Pca-100753	Procavia capensis	37.59	5.00e-19	87.80
IUUC-Ppe-101515	Prunus persica	28.86	4.00e-14	71.60
IUUC-Sja-107780	Schizosaccharomyces japonicus	27.32	4.00e-16	78.20
IUUC-Spo-108251	Schizosaccharomyces pombe	27.41	9.00e-15	73.90
IUUC-Smo-108938	Selaginella moellendorffii	30.11	2.00e-15	76.30
IUUC-Sit-110020	Setaria italica	28.80	6.00e-15	74.70
IUUC-Sly-111543	Solanum lycopersicum	28.65	6.00e-15	74.70
IUUC-Stu-111925	Solanum tuberosum	29.19	2.00e-15	75.90
IUUC-Sbi-114061	Sorghum bicolor	28.80	8.00e-16	77.40
IUUC-Tgu-117321	Taeniopygia guttata	39.88	1.00e-25	109.00
IUUC-Tru-118454	Takifugu rubripes	35.50	4.00e-28	118.00
IUUC-Tni-119894	Tetraodon nigroviridis	35.82	2.00e-28	119.00
IUUC-Tca-121746	Theobroma cacao	31.08	2.00e-19	89.70
IUUC-Tae-124114	Triticum aestivum	29.46	6.00e-15	74.30
IUUC-Tur-126254	Triticum urartu	26.11	2.00e-07	49.30
IUUC-Tbe-127683	Tupaia belangeri	45.78	2.00e-12	65.90
IUUC-Ttr-129056	Tursiops truncatus	38.86	7.00e-30	124.00
IUUC-Vvi-131428	Vitis vinifera	28.27	2.00e-13	69.30
IUUC-Xma-133605	Xiphophorus maculatus	29.20	1.00e-27	116.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence