iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-07	31.9	186	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt+ v+ ++   +  +ll+s+s+Dgt+++W++r+g++l+
   Q: 186  GHTEFVSRISVvpTQpGLLLSSSGDGTLRLWEYRSGRQLH 225
           67777777776853369*******************9986 PP

Organism

Homo sapiens

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Protein Sequence
(Fasta)

MAGSVGLALC GQTLVVRGGS RFLATSIASS DDDSLFIYDC SAAEKKSQEN KGEDAPLDQG 60
SGAILASTFS KSGSYFALTD DSKRLILFRT KPWQCLSVRT VARRCTALTF IASEEKVLVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTCACCGA CCGGTGCGGA CAGGAAGAGG CTCTGGGCTG GCACATGTGT ATGGCGGTGA 60
GGCGGGCGGG TACATGGCGG GCTCTGTGGG ACTGGCGTTG TGCGGGCAGA CGTTGGTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043527--C:tRNA methyltransferase complex
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0006400--P:tRNA modification

KEGG

hsa:10785

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000556	Aegilops tauschii	33.74	5.00e-11	62.40
IUUC-Apl-003975	Anas platyrhynchos	60.18	4.00e-121	428.00
IUUC-Aca-005170	Anolis carolinensis	53.93	1.00e-103	370.00
IUUC-Aly-005769	Arabidopsis lyrata	30.45	3.00e-24	106.00
IUUC-Ath-006733	Arabidopsis thaliana	35.38	2.00e-23	103.00
IUUC-Acl-008151	Aspergillus clavatus	35.62	4.00e-15	76.30
IUUC-Afl-008518	Aspergillus flavus	34.25	3.00e-17	82.80
IUUC-Afu-009102	Aspergillus fumigatus	35.06	5.00e-13	69.30
IUUC-Ani-009442	Aspergillus nidulans	25.66	2.00e-15	77.00
IUUC-Aor-010133	Aspergillus oryzae	27.70	2.00e-20	93.60
IUUC-Ate-010465	Aspergillus terreus	37.29	3.00e-14	73.60
IUUC-Ame-010613	Astyanax mexicanus	45.63	3.00e-87	315.00
IUUC-Bgr-012067	Blumeria graminis	33.56	2.00e-18	87.40
IUUC-Bta-012788	Bos taurus	77.24	1.00e-180	625.00
IUUC-Bdi-014458	Brachypodium distachyon	37.44	2.00e-19	90.50
IUUC-Bol-015373	Brassica oleracea	36.41	2.00e-23	105.00
IUUC-Bra-016644	Brassica rapa	38.12	2.00e-23	105.00
IUUC-Cpo-021963	Cavia porcellus	78.84	2.00e-169	588.00
IUUC-Csa-024148	Chlorocebus sabaeus	96.36	0.00e+00	688.00
IUUC-Cne-026834	Cryptococcus neoformans	35.10	3.00e-19	90.10
IUUC-Dre-028427	Danio rerio	47.65	7.00e-90	324.00
IUUC-Dno-028881	Dasypus novemcinctus	69.14	3.00e-156	544.00
IUUC-Dor-030522	Dipodomys ordii	75.06	3.00e-165	574.00
IUUC-Dme-032136	Drosophila melanogaster	33.01	4.00e-25	109.00
IUUC-Fca-035833	Felis catus	73.21	2.00e-165	575.00
IUUC-Fal-037497	Ficedula albicollis	57.29	6.00e-119	420.00
IUUC-Gga-040547	Gallus gallus	58.54	1.00e-123	436.00
IUUC-Gac-041761	Gasterosteus aculeatus	44.68	8.00e-83	300.00
IUUC-Gma-043941	Glycine max	35.94	4.00e-26	112.00
IUUC-Ggo-045340	Gorilla gorilla	97.82	0.00e+00	756.00
IUUC-Hvu-047643	Hordeum vulgare	39.89	2.00e-20	93.60
IUUC-Itr-048103	Ictidomys tridecemlineatus	80.15	4.00e-178	617.00
IUUC-Kpa-049283	Komagataella pastoris	33.96	2.00e-18	86.70
IUUC-Lch-050682	Latimeria chalumnae	48.89	2.00e-106	379.00
IUUC-Lpe-050712	Leersia perrieri	36.32	3.00e-23	102.00
IUUC-Loc-052599	Lepisosteus oculatus	51.84	4.00e-115	408.00
IUUC-Laf-054390	Loxodonta africana	77.97	6.00e-177	613.00
IUUC-Mcc-054747	Macaca mulatta	96.12	0.00e+00	719.00
IUUC-Mtr-058600	Medicago truncatula	39.33	2.00e-24	107.00
IUUC-Mla-059129	Melampsora laricipopulina	26.15	7.00e-13	67.80
IUUC-Mga-059876	Meleagris gallopavo	56.96	2.00e-122	432.00
IUUC-Mvi-060359	Microbotryum violaceum	29.35	5.00e-13	69.70
IUUC-Mmr-061518	Microcebus murinus	82.32	0.00e+00	648.00
IUUC-Mac-065625	Musa acuminata	34.04	2.00e-20	94.00
IUUC-Nfi-068402	Neosartorya fischeri	27.37	2.00e-14	73.60
IUUC-Nle-069914	Nomascus leucogenys	95.15	0.00e+00	707.00
IUUC-Ont-071555	Oreochromis niloticus	41.78	9.00e-78	283.00
IUUC-Oan-072951	Ornithorhynchus anatinus	67.35	2.00e-151	528.00
IUUC-Ocu-074679	Oryctolagus cuniculus	81.18	1.00e-169	589.00
IUUC-Oba-075355	Oryza barthii	27.86	4.00e-11	62.80
IUUC-Obr-076769	Oryza brachyantha	32.44	1.00e-24	107.00
IUUC-Ogl-077168	Oryza glaberrima	33.71	4.00e-25	108.00
IUUC-Ogu-078275	Oryza glumaepatula	27.20	2.00e-11	63.90
IUUC-Oin-079207	Oryza indica	33.71	4.00e-25	108.00
IUUC-Oni-082437	Oryza nivara	28.69	1.00e-11	65.10
IUUC-Opu-084031	Oryza punctata	33.82	3.00e-23	103.00
IUUC-Oru-084380	Oryza rufipogon	28.05	5.00e-11	62.80
IUUC-Osa-085327	Oryza sativa	34.26	6.00e-25	108.00
IUUC-Ola-086716	Oryzias latipes	44.21	8.00e-79	287.00
IUUC-Olu-087708	Ostreococcus lucimarinus	29.10	1.00e-13	70.90
IUUC-Oar-090239	Ovis aries	80.59	3.00e-172	597.00
IUUC-Ptr-090851	Pan troglodytes	98.30	0.00e+00	759.00
IUUC-Pan-092558	Papio anubis	96.14	0.00e+00	688.00
IUUC-Psi-093792	Pelodiscus sinensis	59.51	1.00e-129	456.00
IUUC-Ppa-095757	Physcomitrella patens	40.59	3.00e-21	96.30
IUUC-Pfo-096465	Poecilia formosa	41.86	1.00e-84	306.00
IUUC-Pab-097722	Pongo abelii	96.60	0.00e+00	740.00
IUUC-Pop-098979	Populus trichocarpa	35.68	3.00e-20	93.20
IUUC-Pca-100753	Procavia capensis	74.05	4.00e-116	411.00
IUUC-Ppe-101515	Prunus persica	35.52	8.00e-20	91.70
IUUC-Sja-107780	Schizosaccharomyces japonicus	26.77	6.00e-15	75.50
IUUC-Spo-108251	Schizosaccharomyces pombe	30.04	1.00e-13	71.20
IUUC-Smo-108938	Selaginella moellendorffii	37.82	1.00e-24	107.00
IUUC-Sit-110020	Setaria italica	36.08	8.00e-23	101.00
IUUC-Sly-111543	Solanum lycopersicum	34.24	2.00e-22	100.00
IUUC-Stu-111925	Solanum tuberosum	32.99	1.00e-22	100.00
IUUC-Sbi-114061	Sorghum bicolor	39.23	9.00e-23	101.00
IUUC-Tgu-117321	Taeniopygia guttata	58.72	2.00e-112	399.00
IUUC-Tru-118454	Takifugu rubripes	44.50	6.00e-81	294.00
IUUC-Tni-119894	Tetraodon nigroviridis	44.82	7.00e-78	284.00
IUUC-Tca-121746	Theobroma cacao	35.15	9.00e-22	98.20
IUUC-Tae-124114	Triticum aestivum	39.33	8.00e-20	91.70
IUUC-Tur-126254	Triticum urartu	33.53	1.00e-12	67.80
IUUC-Tbe-127683	Tupaia belangeri	52.08	1.00e-58	220.00
IUUC-Ttr-129056	Tursiops truncatus	73.12	6.00e-161	560.00
IUUC-Vvi-131428	Vitis vinifera	36.27	1.00e-21	97.80
IUUC-Xma-133605	Xiphophorus maculatus	42.16	2.00e-85	309.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence