iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-25	88.6	107	143
UBD/Beta-Prp	2.60e-42	145.0	17	309

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gHt +v +l+  +  ++++sGs D+t+++WDlr+ ++
   Q: 107  GHTKKVISLCIsPVeDTFLSGSLDKTLRLWDLRSPNC 143
           8**********955689***************99877 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgse..Drtikvwdlstgkcvhtlkghedsvls 99
           +++ ++++ i++++f+p++++l++ s+d+ i ++d ++g+  r++ +++ +v  + f +  ++ + +s+  D+ti+  +l ++k+++ + gh+++v s
   Q: 17   KIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTkvDDTIRYLSLHDNKYLRYFPGHTKKVIS 114
           67788999***************************************************9997776665449************************** PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl....ktgkllrtltgghtdsvyslsfdsngk 193
           l +sp  d+++sGs d+t+r+wdl++  c       h +   +++++p+g ++++G + + ++l+dl    k  ++  +l ++++ + + l+f+++gk
   Q: 115  LCISPVEDTFLSGSLDKTLRLWDLRSPNCQG---LMHLSGRPIAAYDPEGLIFAAGVNSESIKLYDLrsfdKGPFVTFKLNQEKECDWTGLKFSRDGK 209
           *****************************97...4566666699***********************7665555666666555777777788****** PP
   S: 194  elvsgsldgtvklwdlqtgecvrtlnghtdn...vksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedsk 288
            ++   + + ++l+d  +g+ ++t++g+ +n   +    fsp+++++ sgs Dg + iW+ ++g+ +++l++ +    +v++++f+ ++++l+s+  +
   Q: 210  TILISTNGSVIRLVDAFHGTPLQTFTGYPNNkgiPIEASFSPDSQFIFSGSTDGRVHIWNADTGNKVSVLNGDH--PGPVQCVQFNPKYMMLASACTN 305
           ***************************87661114568888*******************************55..99****************9767 PP
   S: 289  vniw 292
             +w
   Q: 306  MAFW 309
           7666 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3.

Protein Sequence
(Fasta)

MKIKLIDSVV RSFKVAKIFR ENTDKINAID FAPNGEHLIS CSEDDQIVIY DCEKGTQSRT 60
VNSKKYGVDL IHFTHANNTA IHSSTKVDDT IRYLSLHDNK YLRYFPGHTK KVISLCISPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCACCGATA ACATTGTTTG CAACAATTGA GCATATTGAC AACAAAACGA AATTCGACAG 60
GCTAAAATGA AGATAAAACT AATAGATTCG GTGGTGCGCA GTTTTAAGGT GGCCAAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0048188--C:Set1C/COMPASS complex
GO:0003682--F:chromatin binding
GO:0051568--P:histone H3-K4 methylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0019233--P:sensory perception of pain

KEGG

dme:Dmel_CG17293

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000390	Aegilops tauschii	36.86	7.00e-62	229.00
IUUC-Aml-001221	Ailuropoda melanoleuca	69.01	6.00e-137	479.00
IUUC-Atr-002607	Amborella trichopoda	41.67	1.00e-72	265.00
IUUC-Apl-003817	Anas platyrhynchos	69.08	4.00e-132	464.00
IUUC-Aca-005383	Anolis carolinensis	69.01	1.00e-135	474.00
IUUC-Aly-005437	Arabidopsis lyrata	39.24	3.00e-70	258.00
IUUC-Ath-006793	Arabidopsis thaliana	39.24	5.00e-70	256.00
IUUC-Ago-007804	Ashbya gossypii	35.44	1.00e-50	192.00
IUUC-Acl-008217	Aspergillus clavatus	36.23	2.00e-56	211.00
IUUC-Afl-008539	Aspergillus flavus	36.71	8.00e-58	216.00
IUUC-Afu-009105	Aspergillus fumigatus	36.36	4.00e-57	214.00
IUUC-Ani-009474	Aspergillus nidulans	36.61	7.00e-56	210.00
IUUC-Ang-009858	Aspergillus niger	36.55	5.00e-58	217.00
IUUC-Aor-009955	Aspergillus oryzae	36.71	8.00e-58	216.00
IUUC-Ate-010364	Aspergillus terreus	37.54	1.00e-58	219.00
IUUC-Ame-010661	Astyanax mexicanus	68.09	8.00e-131	459.00
IUUC-Bgr-012008	Blumeria graminis	34.75	2.00e-55	208.00
IUUC-Bta-013022	Bos taurus	69.08	3.00e-132	464.00
IUUC-Bci-013966	Botrytis cinerea	38.15	6.00e-53	200.00
IUUC-Bdi-015066	Brachypodium distachyon	41.48	1.00e-72	265.00
IUUC-Bol-016019	Brassica oleracea	39.12	3.00e-70	257.00
IUUC-Bra-017871	Brassica rapa	38.92	4.00e-70	257.00
IUUC-Cel-018276	Caenorhabditis elegans	45.67	1.00e-76	279.00
IUUC-Cja-019309	Callithrix jacchus	69.01	6.00e-137	479.00
IUUC-Cfa-020345	Canis familiaris	69.01	6.00e-137	479.00
IUUC-Cpo-022227	Cavia porcellus	63.17	8.00e-120	422.00
IUUC-Csa-023267	Chlorocebus sabaeus	66.45	7.00e-135	472.00
IUUC-Cho-024409	Choloepus hoffmanni	61.02	8.00e-105	372.00
IUUC-Cin-025628	Ciona intestinalis	73.19	2.00e-146	510.00
IUUC-Csv-026164	Ciona savignyi	72.29	1.00e-144	504.00
IUUC-Cgl-026516	Colletotrichum gloeosporioides	34.94	2.00e-50	192.00
IUUC-Cne-026890	Cryptococcus neoformans	31.17	1.00e-41	162.00
IUUC-Cme-027288	Cyanidioschyzon merolae	37.20	4.00e-63	234.00
IUUC-Dre-028001	Danio rerio	68.69	9.00e-136	475.00
IUUC-Dno-029056	Dasypus novemcinctus	69.01	6.00e-137	479.00
IUUC-Dor-031078	Dipodomys ordii	68.63	1.00e-89	321.00
IUUC-Dse-031152	Dothistroma septosporum	35.84	5.00e-58	217.00
IUUC-Ete-033158	Echinops telfairi	66.45	6.00e-132	462.00
IUUC-Eca-033879	Equus caballus	70.16	4.00e-112	397.00
IUUC-Eeu-035229	Erinaceus europaeus	60.53	9.00e-111	392.00
IUUC-Fca-035896	Felis catus	69.01	6.00e-137	479.00
IUUC-Fal-036843	Ficedula albicollis	69.08	3.00e-132	464.00
IUUC-Fox-037858	Fusarium oxysporum	35.24	1.00e-54	206.00
IUUC-Fso-038386	Fusarium solani	33.72	3.00e-45	174.00
IUUC-Gmo-038506	Gadus morhua	67.87	3.00e-129	454.00
IUUC-Ggr-040090	Gaeumannomyces graminis	35.10	6.00e-53	200.00
IUUC-Gga-040192	Gallus gallus	69.01	2.00e-136	477.00
IUUC-Gac-042494	Gasterosteus aculeatus	66.34	1.00e-126	446.00
IUUC-Gma-044074	Glycine max	40.00	6.00e-71	259.00
IUUC-Ggo-045204	Gorilla gorilla	69.08	8.00e-133	466.00
IUUC-Hsa-045866	Homo sapiens	69.01	6.00e-137	479.00
IUUC-Hvu-047690	Hordeum vulgare	37.18	9.00e-63	233.00
IUUC-Itr-048338	Ictidomys tridecemlineatus	69.01	6.00e-137	479.00
IUUC-Kpa-049249	Komagataella pastoris	37.34	6.00e-54	203.00
IUUC-Lch-050431	Latimeria chalumnae	68.51	7.00e-133	466.00
IUUC-Lpe-050830	Leersia perrieri	40.19	1.00e-70	259.00
IUUC-Loc-052505	Lepisosteus oculatus	62.50	9.00e-27	111.00
IUUC-Lma-053026	Leptosphaeria maculans	35.28	6.00e-56	210.00
IUUC-Laf-054265	Loxodonta africana	55.34	1.00e-94	338.00
IUUC-Mcc-055583	Macaca mulatta	69.01	6.00e-137	479.00
IUUC-Meu-056113	Macropus eugenii	56.87	1.00e-105	375.00
IUUC-Mor-057267	Magnaporthe oryzae	33.92	1.00e-45	176.00
IUUC-Mpo-057502	Magnaporthe poae	34.22	1.00e-50	192.00
IUUC-Mtr-058200	Medicago truncatula	40.31	6.00e-71	260.00
IUUC-Mla-058815	Melampsora laricipopulina	40.00	2.00e-70	258.00
IUUC-Mga-059407	Meleagris gallopavo	70.43	3.00e-116	410.00
IUUC-Mvi-060411	Microbotryum violaceum	38.23	4.00e-66	244.00
IUUC-Mmr-061470	Microcebus murinus	69.01	6.00e-137	479.00
IUUC-Mdo-062860	Monodelphis domestica	68.37	2.00e-135	474.00
IUUC-Mmu-063105	Mus musculus	69.01	6.00e-137	479.00
IUUC-Mac-065314	Musa acuminata	41.19	2.00e-71	261.00
IUUC-Mpu-066472	Mustela putorius furo	70.04	2.00e-116	410.00
IUUC-Mlu-067073	Myotis lucifugus	69.06	1.00e-134	471.00
IUUC-Nfi-068284	Neosartorya fischeri	36.36	3.00e-57	214.00
IUUC-Ncr-068702	Neurospora crassa	35.84	3.00e-46	177.00
IUUC-Nle-069451	Nomascus leucogenys	69.01	6.00e-137	479.00
IUUC-Opr-071112	Ochotona princeps	70.04	2.00e-116	410.00
IUUC-Ont-071988	Oreochromis niloticus	67.43	9.00e-130	456.00
IUUC-Oan-072947	Ornithorhynchus anatinus	70.43	3.00e-116	409.00
IUUC-Ocu-074969	Oryctolagus cuniculus	69.01	6.00e-137	479.00
IUUC-Oba-075229	Oryza barthii	35.46	3.00e-57	215.00
IUUC-Obr-076456	Oryza brachyantha	40.51	4.00e-71	260.00
IUUC-Ogl-076973	Oryza glaberrima	40.51	4.00e-71	260.00
IUUC-Ogu-078068	Oryza glumaepatula	35.67	2.00e-57	215.00
IUUC-Oin-079656	Oryza indica	40.51	4.00e-71	260.00
IUUC-Olo-080893	Oryza longistaminata	33.76	9.00e-51	192.00
IUUC-Ome-081559	Oryza meridionalis	36.46	1.00e-32	132.00
IUUC-Oni-082990	Oryza nivara	35.14	5.00e-57	214.00
IUUC-Opu-083374	Oryza punctata	35.67	1.00e-57	215.00
IUUC-Oru-084354	Oryza rufipogon	35.14	6.00e-57	214.00
IUUC-Osa-086296	Oryza sativa	40.51	4.00e-71	260.00
IUUC-Ola-087095	Oryzias latipes	67.09	9.00e-134	468.00
IUUC-Olu-087603	Ostreococcus lucimarinus	36.70	6.00e-55	206.00
IUUC-Oga-088766	Otolemur garnettii	69.01	6.00e-137	479.00
IUUC-Oar-089565	Ovis aries	67.41	2.00e-132	464.00
IUUC-Ptr-091219	Pan troglodytes	64.54	2.00e-131	460.00
IUUC-Pan-091733	Papio anubis	69.01	6.00e-137	479.00
IUUC-Psi-092972	Pelodiscus sinensis	68.20	2.00e-130	458.00
IUUC-Pma-094332	Petromyzon marinus	70.93	4.00e-144	503.00
IUUC-Pno-094960	Phaeosphaeria nodorum	37.61	2.00e-58	218.00
IUUC-Ppa-095292	Physcomitrella patens	45.83	4.00e-82	296.00
IUUC-Pfo-096775	Poecilia formosa	67.11	2.00e-129	455.00
IUUC-Pab-098340	Pongo abelii	66.13	5.00e-134	469.00
IUUC-Pop-099608	Populus trichocarpa	43.08	5.00e-74	270.00
IUUC-Pca-100635	Procavia capensis	69.65	5.00e-113	399.00
IUUC-Ppe-101452	Prunus persica	41.72	6.00e-72	263.00
IUUC-Pva-102798	Pteropus vampyrus	68.37	8.00e-136	475.00
IUUC-Pgr-103395	Puccinia graminis	39.72	7.00e-75	273.00
IUUC-Ptt-103747	Puccinia triticina	39.71	8.00e-72	263.00
IUUC-Pte-104129	Pyrenophora teres	36.70	1.00e-53	204.00
IUUC-Pyt-104773	Pyrenophora triticirepentis	34.59	3.00e-56	211.00
IUUC-Rno-106127	Rattus norvegicus	67.20	2.00e-130	457.00
IUUC-Sce-106257	Saccharomyces cerevisiae	35.65	1.00e-46	179.00
IUUC-Sha-107529	Sarcophilus harrisii	62.94	2.00e-126	444.00
IUUC-Sja-107724	Schizosaccharomyces japonicus	33.86	5.00e-47	180.00
IUUC-Spo-108206	Schizosaccharomyces pombe	34.65	3.00e-50	191.00
IUUC-Smo-108979	Selaginella moellendorffii	44.19	4.00e-79	286.00
IUUC-Sit-109858	Setaria italica	40.38	1.00e-70	258.00
IUUC-Sly-111267	Solanum lycopersicum	42.99	6.00e-72	263.00
IUUC-Sar-113079	Sorex araneus	70.04	2.00e-116	410.00
IUUC-Sbi-114094	Sorghum bicolor	35.67	7.00e-60	223.00
IUUC-Sre-115157	Sporisorium reilianum	35.41	7.00e-56	210.00
IUUC-Ssc-116386	Sus scrofa	69.01	6.00e-137	479.00
IUUC-Tgu-116465	Taeniopygia guttata	70.28	8.00e-111	393.00
IUUC-Tru-117604	Takifugu rubripes	67.43	6.00e-131	460.00
IUUC-Tsy-119314	Tarsius syrichta	53.63	5.00e-77	279.00
IUUC-Tni-120237	Tetraodon nigroviridis	67.43	1.00e-129	455.00
IUUC-Tca-121853	Theobroma cacao	41.19	7.00e-72	263.00
IUUC-Tre-122205	Trichoderma reesei	34.19	1.00e-52	199.00
IUUC-Tvi-122471	Trichoderma virens	29.83	2.00e-38	152.00
IUUC-Tae-125200	Triticum aestivum	41.80	2.00e-73	268.00
IUUC-Tur-126512	Triticum urartu	39.49	6.00e-59	220.00
IUUC-Tme-126883	Tuber melanosporum	39.14	5.00e-58	217.00
IUUC-Tbe-127310	Tupaia belangeri	59.09	2.00e-47	181.00
IUUC-Ttr-128307	Tursiops truncatus	70.04	2.00e-116	410.00
IUUC-Uma-129579	Ustilago maydis	35.09	7.00e-55	206.00
IUUC-Vda-129826	Verticillium dahliae	34.67	8.00e-50	190.00
IUUC-Vpa-130091	Vicugna pacos	70.04	2.00e-116	410.00
IUUC-Vvi-131587	Vitis vinifera	39.94	5.00e-70	256.00
IUUC-Xtr-132660	Xenopus tropicalis	66.13	4.00e-129	454.00
IUUC-Xma-133496	Xiphophorus maculatus	67.09	5.00e-134	469.00
IUUC-Yli-134509	Yarrowia lipolytica	37.46	1.00e-60	225.00
IUUC-Zma-134685	Zea mays	40.51	1.00e-70	259.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence