iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026031

UUCD1 version

UUC-CiS-00377

Ensembl Protein ID

ENSCSAVP00000011260.1

UniProt Accession

H2Z0Z8; H2Z0Z8_CIOSA

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000006589.1	ENSCSAVT00000011390.1	ENSCSAVP00000011258.1
ENSCSAVG00000006589.1	ENSCSAVT00000011391.1	ENSCSAVP00000011259.1
ENSCSAVG00000006589.1	ENSCSAVT00000011392.1	ENSCSAVP00000011260.1
ENSCSAVG00000006589.1	ENSCSAVT00000011393.1	ENSCSAVP00000011261.1
ENSCSAVG00000006589.1	ENSCSAVT00000011394.1	ENSCSAVP00000011262.1
ENSCSAVG00000006589.1	ENSCSAVT00000011395.1	ENSCSAVP00000011263.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.50e-92	308.4	2239	2677

Active Site

Position(s)	Description	Evidence
2646	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................e 66
           + k+ levef gEeg++l G+t+ef++l+++elq++dl ++l ++n ++  + + +s   ++                       e
   Q: 2239 EKKSILEVEFMGEEGTGL-GPTLEFYSLVAAELQRKDLAMWLVDDNFTHKPRDRVESVD-EKksdhyvqrpgglfpaplpqdnidE 2322
           5678899***********.**********************888885555444443332.22366677888*************** PP
   S: 67   hlklFeflGrllgkalqdgrlldlplsksfykll.................................................... 100
           +  lF flG+ll+k+lqd+rl+dlpls+sf+kl+                                                    
   Q: 2323 VVGLFGFLGTLLAKCLQDSRLIDLPLSTSFIKLIcrespicpqsqvgicltqlneaitifiscsiqysviktcnitvtssdtsqsn 2408
           **********************************6666666666666666666666666666555555555555554444443333 PP
   S: 101  .lgkklsledleevdpelykslkeikenaes...............................dieelgldltfsvseeilgetkee 154
             +  l l+dl ++dp ++ +l ++ ++ ++                               ++e+lgl+l+f +++++++ t+  
   Q: 2409 lATGVLGLSDLVSIDPARHTFLAKLVALSDErdeimnngslsdaekthkvegllldyngtkcKVEDLGLTLQFLPTSSVYKFTSYP 2494
           322259****************9999998445667777788888889999999999999999**************9999887766 PP
   S: 155  eLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe..eeidvedlkketkykgg 238
            L++gGe+++ t +N+++Yv+l++++ ++ g ++q++afr+Gfn+v+p++ l +Ft+ el l +cG+  ++++ +d+ + t+ k g
   Q: 2495 -LVEGGERVDLTLQNARQYVDLTINFYFELGLRKQMAAFRDGFNRVFPITNLLSFTKDELHLKLCGDqtPQWTRDDVIAYTEPKLG 2579
           .******************************************************************5566666777777777*** PP
   S: 239  ytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekL 323
           +t+ds ++  F++v++++s  erk fLqF+Tg+s+lP+gG+a+l+p l++++k d+ d ++Ps+nTC++yLkLP+Yss+ ilke+L
   Q: 2580 FTKDSTGFLHFVNVMCDLSGSERKSFLQFATGCSSLPPGGLANLSPHLTIVKKvDSGDGSYPSVNTCVHYLKLPDYSSEAILKERL 2665
           *****************************************************99999**************************** PP
   S: 324  lyAieetkgFels 336
           l+A++e kgF+l+
   Q: 2666 LAATRE-KGFHLN 2677
           ******.****86 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

MADVDPDTLL EWLQTGVGQE RDMQLIALEQ LCMLLLMSDN VDRCFEMCPP RSFLPALCKI 60
FLDETAPDNV VEVAARAMTY YLDVSAECTR RIVAVDGAVK AICNRLSLRL LDDRTNKDLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGACG TAGATCCGGA CACTTTATTG GAATGGCTTC AGACTGGGGT TGGTCAGGAG 60
CGAGACATGC AACTTATAGC ATTGGAACAA CTGTGTATGT TGTTGCTTAT GTCTGATAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	50.90	0.00e+00	1315.00
IUUC-Apl-003493	Anas platyrhynchos	51.18	0.00e+00	1315.00
IUUC-Aca-004521	Anolis carolinensis	51.11	0.00e+00	1304.00
IUUC-Ame-011258	Astyanax mexicanus	50.61	0.00e+00	1252.00
IUUC-Bta-012835	Bos taurus	51.04	0.00e+00	1315.00
IUUC-Cel-018153	Caenorhabditis elegans	42.15	2.00e-167	583.00
IUUC-Cja-019174	Callithrix jacchus	50.59	0.00e+00	1295.00
IUUC-Cfa-021115	Canis familiaris	50.42	0.00e+00	1284.00
IUUC-Cpo-022382	Cavia porcellus	47.21	0.00e+00	1160.00
IUUC-Csa-023230	Chlorocebus sabaeus	50.97	0.00e+00	1314.00
IUUC-Cho-024711	Choloepus hoffmanni	42.86	2.00e-144	506.00
IUUC-Cin-025342	Ciona intestinalis	72.17	0.00e+00	2238.00
IUUC-Dre-027435	Danio rerio	50.90	0.00e+00	1308.00
IUUC-Dno-029954	Dasypus novemcinctus	50.83	0.00e+00	1308.00
IUUC-Dor-030734	Dipodomys ordii	49.33	0.00e+00	715.00
IUUC-Dme-031739	Drosophila melanogaster	48.48	0.00e+00	1251.00
IUUC-Ete-033192	Echinops telfairi	46.67	3.00e-175	607.00
IUUC-Eca-033434	Equus caballus	50.69	0.00e+00	1304.00
IUUC-Eeu-035031	Erinaceus europaeus	41.82	2.00e-142	498.00
IUUC-Fca-035998	Felis catus	50.68	0.00e+00	1261.00
IUUC-Fal-037468	Ficedula albicollis	49.73	0.00e+00	1310.00
IUUC-Gmo-038495	Gadus morhua	53.21	0.00e+00	800.00
IUUC-Gga-040736	Gallus gallus	51.11	0.00e+00	1307.00
IUUC-Gac-041777	Gasterosteus aculeatus	51.13	0.00e+00	1286.00
IUUC-Ggo-044677	Gorilla gorilla	47.85	0.00e+00	1191.00
IUUC-Hsa-045879	Homo sapiens	50.97	0.00e+00	1314.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	51.04	0.00e+00	1315.00
IUUC-Lch-050444	Latimeria chalumnae	50.47	0.00e+00	1240.00
IUUC-Loc-051986	Lepisosteus oculatus	50.57	0.00e+00	1251.00
IUUC-Laf-054230	Loxodonta africana	50.55	0.00e+00	1293.00
IUUC-Mcc-054787	Macaca mulatta	50.97	0.00e+00	1314.00
IUUC-Meu-056502	Macropus eugenii	45.12	3.00e-129	456.00
IUUC-Mga-059409	Meleagris gallopavo	49.44	0.00e+00	974.00
IUUC-Mmr-061667	Microcebus murinus	50.72	0.00e+00	1308.00
IUUC-Mdo-061960	Monodelphis domestica	51.25	0.00e+00	1323.00
IUUC-Mmu-063941	Mus musculus	50.90	0.00e+00	1315.00
IUUC-Mpu-065939	Mustela putorius furo	50.90	0.00e+00	1312.00
IUUC-Mlu-068112	Myotis lucifugus	50.90	0.00e+00	1311.00
IUUC-Nle-069001	Nomascus leucogenys	50.97	0.00e+00	1314.00
IUUC-Opr-071222	Ochotona princeps	49.45	0.00e+00	1084.00
IUUC-Ont-072101	Oreochromis niloticus	51.10	0.00e+00	1301.00
IUUC-Oan-072814	Ornithorhynchus anatinus	50.90	0.00e+00	1314.00
IUUC-Ocu-074011	Oryctolagus cuniculus	50.97	0.00e+00	1313.00
IUUC-Ola-086412	Oryzias latipes	51.13	0.00e+00	1293.00
IUUC-Oar-089668	Ovis aries	51.04	0.00e+00	1315.00
IUUC-Ptr-090517	Pan troglodytes	50.76	0.00e+00	1304.00
IUUC-Pan-091849	Papio anubis	48.68	0.00e+00	1222.00
IUUC-Psi-093390	Pelodiscus sinensis	51.11	0.00e+00	1261.00
IUUC-Pma-094628	Petromyzon marinus	48.05	0.00e+00	800.00
IUUC-Pfo-097075	Poecilia formosa	51.83	0.00e+00	1306.00
IUUC-Pab-098176	Pongo abelii	50.97	0.00e+00	1314.00
IUUC-Pca-101123	Procavia capensis	57.03	2.00e-180	626.00
IUUC-Pva-103008	Pteropus vampyrus	52.14	0.00e+00	837.00
IUUC-Rno-105885	Rattus norvegicus	50.97	0.00e+00	1313.00
IUUC-Sha-107048	Sarcophilus harrisii	51.07	0.00e+00	1313.00
IUUC-Sar-113071	Sorex araneus	50.30	0.00e+00	684.00
IUUC-Ssc-115963	Sus scrofa	50.97	0.00e+00	1312.00
IUUC-Tgu-117488	Taeniopygia guttata	52.78	0.00e+00	754.00
IUUC-Tru-118626	Takifugu rubripes	50.69	0.00e+00	1307.00
IUUC-Tsy-119504	Tarsius syrichta	45.09	0.00e+00	909.00
IUUC-Tni-119877	Tetraodon nigroviridis	51.23	0.00e+00	1296.00
IUUC-Tbe-127602	Tupaia belangeri	59.07	0.00e+00	640.00
IUUC-Ttr-128394	Tursiops truncatus	49.70	5.00e-166	578.00
IUUC-Vpa-130280	Vicugna pacos	50.87	0.00e+00	1316.00
IUUC-Xtr-131787	Xenopus tropicalis	50.96	0.00e+00	1280.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence