iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107122

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

AEFK01133773

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000006960.1	ENSSHAT00000008088.1	ENSSHAP00000008024.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-42	140.6	257	293
UBD/Beta-Prp	9.50e-45	153.2	248	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH+d ++++ +sd + ++s+s+D+ti+vWD+ tg+l 
   Q: 257  GHNDAIFSVLWSDaGEICSASWDHTIRVWDVETGNLK 293
           8**********999*******************9875 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh+d + s+ +s     + s+s+d tirvwd+etg   + tl+g++ + nc++++p ++ l+sG  Dr +rlWd +t++ 
   Q: 248  TRTPIMTLSGHNDAIFSVLWSD-AGEICSASWDHTIRVWDVETGNLKS-TLTGNK-AFNCISYSPLCKRLASGNSDRHIRLWDPRTKDG 333
           6789*****************9.899*********************9.****98.779*************************88764 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ h++ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v++v+ + +  +l+sg++D+ ++ +
   Q: 334  SLVLlslTS-HNNWVTSVKWSPTHeQQLISGSLDNLVKLWDTRsCKAPLYDLAAHEDKVLCVDWT-EAGLLLSGGADNKLYSY 414
           444444387.************9889*****************54566****************9.999********998876 PP

Organism

Sarcophilus harrisii

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQTRFFT TNKKYAVDNV PFSIPAASEI SDLSNIINKL LEAKNEVHKY VEFDFLIKGH 60
FLRMPLIKHM ELENISTEEV VEIEYVEKYI APQPEECIVH DDWISSIEGT EEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCCTCAGC CCTATGGCCG CCGGGAGCCC TGCAGGGCAA CCAGGGAAGT CCGCTAAGCG 60
CCGGAGCCGA GGGGGAGAAA ATTCAAAACG AGTCTACTCA ACCTCGTCTT GGCTCCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	34.43	3.00e-61	229.00
IUUC-Aml-001997	Ailuropoda melanoleuca	84.31	0.00e+00	676.00
IUUC-Atr-002544	Amborella trichopoda	35.06	4.00e-57	215.00
IUUC-Apl-003981	Anas platyrhynchos	82.40	0.00e+00	628.00
IUUC-Aca-004370	Anolis carolinensis	81.60	0.00e+00	691.00
IUUC-Aly-006455	Arabidopsis lyrata	34.84	1.00e-57	216.00
IUUC-Ath-006669	Arabidopsis thaliana	36.14	5.00e-53	201.00
IUUC-Ago-007864	Ashbya gossypii	28.99	6.00e-36	144.00
IUUC-Acl-008177	Aspergillus clavatus	29.02	3.00e-32	132.00
IUUC-Afl-008617	Aspergillus flavus	28.23	3.00e-31	129.00
IUUC-Afu-008752	Aspergillus fumigatus	28.50	3.00e-28	119.00
IUUC-Ani-009136	Aspergillus nidulans	30.71	2.00e-31	130.00
IUUC-Ang-009701	Aspergillus niger	28.57	1.00e-29	124.00
IUUC-Aor-009884	Aspergillus oryzae	28.47	9.00e-31	127.00
IUUC-Ame-011432	Astyanax mexicanus	74.70	0.00e+00	639.00
IUUC-Bgr-012218	Blumeria graminis	28.54	3.00e-32	132.00
IUUC-Bta-012829	Bos taurus	85.51	0.00e+00	708.00
IUUC-Bci-013953	Botrytis cinerea	28.26	1.00e-31	130.00
IUUC-Bdi-014351	Brachypodium distachyon	36.79	2.00e-58	219.00
IUUC-Bol-016514	Brassica oleracea	35.24	4.00e-53	201.00
IUUC-Bra-016988	Brassica rapa	35.24	8.00e-53	201.00
IUUC-Cel-018569	Caenorhabditis elegans	31.88	1.00e-48	186.00
IUUC-Cja-019468	Callithrix jacchus	83.61	0.00e+00	679.00
IUUC-Cfa-020471	Canis familiaris	84.32	0.00e+00	677.00
IUUC-Cpo-022260	Cavia porcellus	84.32	0.00e+00	688.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	31.08	4.00e-39	155.00
IUUC-Csa-023989	Chlorocebus sabaeus	84.56	0.00e+00	684.00
IUUC-Cho-024426	Choloepus hoffmanni	81.39	5.00e-147	513.00
IUUC-Cin-025789	Ciona intestinalis	41.41	1.00e-94	339.00
IUUC-Cne-027063	Cryptococcus neoformans	24.42	2.00e-22	99.80
IUUC-Dre-027907	Danio rerio	76.36	0.00e+00	657.00
IUUC-Dno-029225	Dasypus novemcinctus	85.04	0.00e+00	705.00
IUUC-Dor-031082	Dipodomys ordii	68.88	8.00e-155	539.00
IUUC-Dse-031308	Dothistroma septosporum	26.55	2.00e-32	132.00
IUUC-Dme-032189	Drosophila melanogaster	39.90	8.00e-89	320.00
IUUC-Ete-032247	Echinops telfairi	79.57	0.00e+00	655.00
IUUC-Eca-034285	Equus caballus	85.04	0.00e+00	705.00
IUUC-Eeu-035322	Erinaceus europaeus	76.00	1.00e-173	602.00
IUUC-Fca-036114	Felis catus	84.32	0.00e+00	699.00
IUUC-Fal-036891	Ficedula albicollis	83.85	2.00e-171	594.00
IUUC-Fox-037965	Fusarium oxysporum	24.41	1.00e-31	130.00
IUUC-Fso-038244	Fusarium solani	25.05	9.00e-32	130.00
IUUC-Gmo-039040	Gadus morhua	74.00	0.00e+00	652.00
IUUC-Gga-040610	Gallus gallus	80.81	0.00e+00	695.00
IUUC-Gac-042117	Gasterosteus aculeatus	73.76	0.00e+00	630.00
IUUC-Gma-043425	Glycine max	37.05	3.00e-62	232.00
IUUC-Ggo-045179	Gorilla gorilla	83.85	0.00e+00	675.00
IUUC-Hsa-046114	Homo sapiens	84.56	0.00e+00	681.00
IUUC-Hvu-047331	Hordeum vulgare	35.04	2.00e-56	213.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	83.85	0.00e+00	696.00
IUUC-Kpa-049304	Komagataella pastoris	29.62	4.00e-39	155.00
IUUC-Lch-050655	Latimeria chalumnae	73.31	9.00e-142	496.00
IUUC-Lpe-051675	Leersia perrieri	36.08	9.00e-62	231.00
IUUC-Loc-052868	Lepisosteus oculatus	80.09	0.00e+00	666.00
IUUC-Lma-053258	Leptosphaeria maculans	27.21	1.00e-30	129.00
IUUC-Laf-053993	Loxodonta africana	83.37	0.00e+00	698.00
IUUC-Mcc-055128	Macaca mulatta	68.65	2.00e-153	535.00
IUUC-Meu-056501	Macropus eugenii	87.20	2.00e-180	624.00
IUUC-Mor-057114	Magnaporthe oryzae	26.00	2.00e-25	110.00
IUUC-Mtr-058367	Medicago truncatula	37.71	1.00e-60	227.00
IUUC-Mla-059107	Melampsora laricipopulina	27.21	6.00e-30	125.00
IUUC-Mga-059745	Meleagris gallopavo	78.77	0.00e+00	669.00
IUUC-Mvi-060362	Microbotryum violaceum	30.09	1.00e-34	140.00
IUUC-Mdo-062257	Monodelphis domestica	91.49	0.00e+00	777.00
IUUC-Mmu-063546	Mus musculus	82.66	0.00e+00	692.00
IUUC-Mac-065540	Musa acuminata	35.00	5.00e-57	214.00
IUUC-Mpu-066284	Mustela putorius furo	85.27	0.00e+00	705.00
IUUC-Mlu-067241	Myotis lucifugus	84.32	0.00e+00	701.00
IUUC-Nfi-068260	Neosartorya fischeri	28.50	6.00e-30	125.00
IUUC-Ncr-068719	Neurospora crassa	26.68	1.00e-27	117.00
IUUC-Nle-068981	Nomascus leucogenys	84.56	0.00e+00	665.00
IUUC-Opr-071218	Ochotona princeps	78.50	2.00e-179	621.00
IUUC-Ont-071646	Oreochromis niloticus	73.76	0.00e+00	657.00
IUUC-Oan-073453	Ornithorhynchus anatinus	84.36	0.00e+00	724.00
IUUC-Ocu-074008	Oryctolagus cuniculus	84.09	0.00e+00	700.00
IUUC-Oba-075712	Oryza barthii	31.44	4.00e-44	171.00
IUUC-Obr-076721	Oryza brachyantha	35.39	2.00e-61	229.00
IUUC-Ogl-077229	Oryza glaberrima	35.92	4.00e-61	228.00
IUUC-Ogu-078977	Oryza glumaepatula	31.44	3.00e-44	172.00
IUUC-Oin-079683	Oryza indica	35.92	2.00e-61	229.00
IUUC-Olo-080291	Oryza longistaminata	31.46	7.00e-30	124.00
IUUC-Ome-081834	Oryza meridionalis	36.15	4.00e-62	232.00
IUUC-Oni-082507	Oryza nivara	34.82	2.00e-57	216.00
IUUC-Opu-083396	Oryza punctata	36.17	1.00e-61	230.00
IUUC-Oru-085220	Oryza rufipogon	34.82	4.00e-57	215.00
IUUC-Osa-085767	Oryza sativa	35.92	2.00e-61	229.00
IUUC-Ola-087420	Oryzias latipes	76.12	0.00e+00	657.00
IUUC-Olu-087740	Ostreococcus lucimarinus	30.12	2.00e-40	159.00
IUUC-Oga-088264	Otolemur garnettii	83.61	0.00e+00	681.00
IUUC-Oar-089335	Ovis aries	85.04	0.00e+00	703.00
IUUC-Ptr-091320	Pan troglodytes	84.56	0.00e+00	681.00
IUUC-Pan-092833	Papio anubis	85.04	0.00e+00	684.00
IUUC-Psi-093504	Pelodiscus sinensis	83.89	0.00e+00	701.00
IUUC-Pma-094189	Petromyzon marinus	68.66	2.00e-169	588.00
IUUC-Pno-094929	Phaeosphaeria nodorum	27.93	2.00e-31	130.00
IUUC-Ppa-095429	Physcomitrella patens	34.91	1.00e-62	233.00
IUUC-Pfo-096337	Poecilia formosa	74.23	0.00e+00	661.00
IUUC-Pab-097571	Pongo abelii	84.09	0.00e+00	679.00
IUUC-Pop-099977	Populus trichocarpa	37.47	7.00e-67	247.00
IUUC-Pca-100394	Procavia capensis	79.36	6.00e-178	616.00
IUUC-Ppe-101848	Prunus persica	36.45	4.00e-62	231.00
IUUC-Pva-102921	Pteropus vampyrus	83.13	2.00e-106	378.00
IUUC-Pgr-103637	Puccinia graminis	28.60	3.00e-34	139.00
IUUC-Ptt-103781	Puccinia triticina	28.36	6.00e-34	138.00
IUUC-Pte-104135	Pyrenophora teres	26.67	2.00e-31	131.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.27	8.00e-31	127.00
IUUC-Rno-105114	Rattus norvegicus	82.19	0.00e+00	691.00
IUUC-Sce-106401	Saccharomyces cerevisiae	28.67	9.00e-37	147.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.09	8.00e-49	187.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.93	3.00e-40	159.00
IUUC-Smo-108720	Selaginella moellendorffii	33.33	6.00e-58	218.00
IUUC-Sit-110311	Setaria italica	37.24	3.00e-61	228.00
IUUC-Sly-111178	Solanum lycopersicum	34.24	1.00e-55	210.00
IUUC-Stu-112778	Solanum tuberosum	35.71	1.00e-59	223.00
IUUC-Sar-113596	Sorex araneus	71.26	2.00e-157	548.00
IUUC-Sbi-114193	Sorghum bicolor	36.13	1.00e-59	223.00
IUUC-Sre-115002	Sporisorium reilianum	25.53	1.00e-13	71.20
IUUC-Ssc-116066	Sus scrofa	85.27	0.00e+00	704.00
IUUC-Tgu-117048	Taeniopygia guttata	82.67	0.00e+00	629.00
IUUC-Tsy-119573	Tarsius syrichta	54.33	4.00e-114	404.00
IUUC-Tni-119820	Tetraodon nigroviridis	74.70	0.00e+00	661.00
IUUC-Tca-121605	Theobroma cacao	36.75	9.00e-61	227.00
IUUC-Tre-121947	Trichoderma reesei	25.34	2.00e-31	130.00
IUUC-Tvi-122481	Trichoderma virens	26.01	3.00e-33	135.00
IUUC-Tae-125861	Triticum aestivum	34.67	2.00e-61	229.00
IUUC-Tur-126586	Triticum urartu	35.29	6.00e-59	221.00
IUUC-Tme-126900	Tuber melanosporum	30.12	3.00e-46	179.00
IUUC-Tbe-127736	Tupaia belangeri	64.50	4.00e-135	474.00
IUUC-Ttr-129041	Tursiops truncatus	75.30	9.00e-175	605.00
IUUC-Vpa-130260	Vicugna pacos	85.04	0.00e+00	705.00
IUUC-Vvi-131009	Vitis vinifera	37.18	9.00e-61	227.00
IUUC-Xtr-132083	Xenopus tropicalis	77.49	0.00e+00	655.00
IUUC-Xma-133094	Xiphophorus maculatus	72.81	0.00e+00	649.00
IUUC-Yli-134531	Yarrowia lipolytica	23.66	2.00e-15	77.40
IUUC-Zma-135509	Zea mays	34.04	8.00e-61	227.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence