iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133094

Ensembl Protein ID

ENSXMAP00000013727.1

UniProt Accession

M4AGY3; M4AGY3_XIPMA

Genbank Protein ID

ENSXMAP00000013727

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

AGAJ01023863

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000013685.1	ENSXMAT00000013743.1	ENSXMAP00000013727.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-40	134.5	341	376
UBD/Beta-Prp	3.00e-46	158.0	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  s  + l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTAVKWapSHeHQLISGSLDNLVKLWDTRSCK 376
           ***********754688**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh++ v s+ ++  ++ + s+s+d tir+wd+e g     tlsg + v nc++++p ++ l+s+s+Dr +rlWd +t + 
   Q: 246  TRTPLMTLSGHSEAVSSVLWCD-SEEVCSASWDHTIRLWDVEAGVMKT-TLSGSK-VFNCISYSPLCRRLASASTDRHIRLWDPRTTDG 331
           57899*****************.8999*****************9998.999987.99**************************88765 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v+ +++ ++   +l+sgsld+ vklwd +  +  ++ l +h+d v +v+ + ++ +++sg+sD+ ++ +
   Q: 332  TLVLlslTS-HTGWVTAVKWAPSHeHQLISGSLDNLVKLWDTRsCKAPLYDLAAHEDKVFCVDWT-DSGLMLSGGSDNKLYTY 412
           444445487.**********9988788****************54566****************9.************99876 PP

Organism

Xiphophorus maculatus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQLQARFFT EDQRYIVDDV PFSIPAASEV LDLSNVINKL LEAKHASHSR VEFDFLVKGQ 60
FLRTQLATHM ETEGISTEDV VEIEYVQRLT APEPEECIMH DDWISSVEAD SEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCGACTCGA AAGTCTTCCC ACGCAGCACA TGGCGACACT GCATGAGAAT TTGACATGTG 60
ATGAAGTGGA GCGGAATAGT TTTATTACCG TTTGCTAATT TCTGGAATAT ATATATATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

KEGG

xma:102231706

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	32.30	7.00e-61	228.00
IUUC-Aml-001997	Ailuropoda melanoleuca	75.43	7.00e-178	616.00
IUUC-Atr-002544	Amborella trichopoda	33.33	2.00e-59	222.00
IUUC-Apl-003981	Anas platyrhynchos	75.93	2.00e-170	591.00
IUUC-Aca-004370	Anolis carolinensis	74.59	0.00e+00	664.00
IUUC-Aly-006455	Arabidopsis lyrata	33.33	2.00e-60	226.00
IUUC-Ath-006669	Arabidopsis thaliana	33.33	1.00e-55	210.00
IUUC-Ago-007864	Ashbya gossypii	30.23	2.00e-44	173.00
IUUC-Acl-008177	Aspergillus clavatus	29.16	4.00e-38	152.00
IUUC-Afl-008617	Aspergillus flavus	27.97	8.00e-41	161.00
IUUC-Afu-008752	Aspergillus fumigatus	26.55	4.00e-35	142.00
IUUC-Ani-009136	Aspergillus nidulans	28.83	6.00e-38	152.00
IUUC-Ang-009701	Aspergillus niger	27.31	2.00e-37	150.00
IUUC-Aor-009884	Aspergillus oryzae	27.53	8.00e-40	157.00
IUUC-Ame-011432	Astyanax mexicanus	82.51	0.00e+00	704.00
IUUC-Bgr-012218	Blumeria graminis	27.88	3.00e-38	152.00
IUUC-Bta-012829	Bos taurus	74.94	0.00e+00	638.00
IUUC-Bci-013953	Botrytis cinerea	28.57	1.00e-37	150.00
IUUC-Bdi-014351	Brachypodium distachyon	34.44	4.00e-58	218.00
IUUC-Bol-016190	Brassica oleracea	32.30	2.00e-57	216.00
IUUC-Bra-018095	Brassica rapa	33.07	1.00e-58	220.00
IUUC-Cel-018569	Caenorhabditis elegans	31.58	3.00e-51	196.00
IUUC-Cja-019468	Callithrix jacchus	74.23	2.00e-178	618.00
IUUC-Cfa-020471	Canis familiaris	75.18	2.00e-179	621.00
IUUC-Cpo-022260	Cavia porcellus	74.23	2.00e-180	624.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	31.90	3.00e-43	169.00
IUUC-Csa-023989	Chlorocebus sabaeus	74.47	3.00e-179	621.00
IUUC-Cho-024426	Choloepus hoffmanni	73.97	6.00e-134	470.00
IUUC-Cin-025789	Ciona intestinalis	42.82	2.00e-103	369.00
IUUC-Cne-027063	Cryptococcus neoformans	26.16	9.00e-16	78.20
IUUC-Dre-027907	Danio rerio	82.98	0.00e+00	717.00
IUUC-Dno-029225	Dasypus novemcinctus	74.47	0.00e+00	634.00
IUUC-Dor-031082	Dipodomys ordii	61.47	8.00e-135	473.00
IUUC-Dse-031308	Dothistroma septosporum	27.07	8.00e-39	154.00
IUUC-Dme-032189	Drosophila melanogaster	41.45	2.00e-97	349.00
IUUC-Ete-032247	Echinops telfairi	70.69	2.00e-168	585.00
IUUC-Eca-034285	Equus caballus	74.94	0.00e+00	637.00
IUUC-Eeu-035322	Erinaceus europaeus	68.84	7.00e-156	543.00
IUUC-Fca-036114	Felis catus	75.18	0.00e+00	640.00
IUUC-Fal-036891	Ficedula albicollis	76.55	8.00e-160	556.00
IUUC-Fox-037965	Fusarium oxysporum	25.80	2.00e-37	150.00
IUUC-Fso-038244	Fusarium solani	25.37	9.00e-36	144.00
IUUC-Gmo-039040	Gadus morhua	84.16	0.00e+00	739.00
IUUC-Ggr-040093	Gaeumannomyces graminis	26.48	1.00e-14	74.70
IUUC-Gga-040610	Gallus gallus	74.94	0.00e+00	656.00
IUUC-Gac-042117	Gasterosteus aculeatus	88.65	0.00e+00	757.00
IUUC-Gma-043146	Glycine max	35.73	6.00e-67	248.00
IUUC-Ggo-045179	Gorilla gorilla	74.00	1.00e-177	615.00
IUUC-Hsa-046114	Homo sapiens	74.47	3.00e-178	617.00
IUUC-Hvu-047331	Hordeum vulgare	32.65	3.00e-57	215.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	74.00	0.00e+00	634.00
IUUC-Kpa-049304	Komagataella pastoris	30.22	4.00e-46	178.00
IUUC-Lch-050655	Latimeria chalumnae	69.03	5.00e-132	463.00
IUUC-Lpe-051675	Leersia perrieri	33.81	3.00e-62	232.00
IUUC-Loc-052868	Lepisosteus oculatus	79.20	0.00e+00	680.00
IUUC-Lma-053258	Leptosphaeria maculans	26.12	1.00e-36	149.00
IUUC-Laf-053993	Loxodonta africana	74.94	0.00e+00	635.00
IUUC-Mcc-055128	Macaca mulatta	60.52	5.00e-137	480.00
IUUC-Meu-056501	Macropus eugenii	65.15	8.00e-140	489.00
IUUC-Mor-057114	Magnaporthe oryzae	26.00	1.00e-30	127.00
IUUC-Mtr-058367	Medicago truncatula	35.65	6.00e-62	231.00
IUUC-Mla-059107	Melampsora laricipopulina	26.08	1.00e-33	137.00
IUUC-Mga-059745	Meleagris gallopavo	74.16	0.00e+00	633.00
IUUC-Mvi-060362	Microbotryum violaceum	28.08	3.00e-36	146.00
IUUC-Mdo-062257	Monodelphis domestica	72.68	0.00e+00	650.00
IUUC-Mmu-063546	Mus musculus	74.94	0.00e+00	635.00
IUUC-Mac-065540	Musa acuminata	33.00	2.00e-61	229.00
IUUC-Mpu-066284	Mustela putorius furo	74.94	0.00e+00	638.00
IUUC-Mlu-067241	Myotis lucifugus	74.94	0.00e+00	635.00
IUUC-Nfi-068260	Neosartorya fischeri	28.93	2.00e-37	149.00
IUUC-Ncr-068719	Neurospora crassa	25.58	3.00e-29	122.00
IUUC-Nle-068981	Nomascus leucogenys	74.23	3.00e-174	604.00
IUUC-Opr-071218	Ochotona princeps	68.59	2.00e-161	561.00
IUUC-Ont-071646	Oreochromis niloticus	87.65	0.00e+00	743.00
IUUC-Oan-073453	Ornithorhynchus anatinus	76.36	0.00e+00	702.00
IUUC-Ocu-074008	Oryctolagus cuniculus	74.70	0.00e+00	636.00
IUUC-Oba-075712	Oryza barthii	30.40	2.00e-46	180.00
IUUC-Obr-076721	Oryza brachyantha	33.73	5.00e-63	234.00
IUUC-Ogl-077229	Oryza glaberrima	33.81	4.00e-62	232.00
IUUC-Ogu-078977	Oryza glumaepatula	30.36	1.00e-46	180.00
IUUC-Oin-079683	Oryza indica	34.05	6.00e-63	234.00
IUUC-Olo-080291	Oryza longistaminata	30.94	8.00e-32	130.00
IUUC-Ome-081834	Oryza meridionalis	34.29	1.00e-63	237.00
IUUC-Oni-082507	Oryza nivara	32.45	9.00e-58	217.00
IUUC-Opu-083396	Oryza punctata	33.57	2.00e-62	233.00
IUUC-Oru-085220	Oryza rufipogon	32.69	1.00e-57	216.00
IUUC-Osa-085767	Oryza sativa	34.05	6.00e-63	234.00
IUUC-Ola-087420	Oryzias latipes	87.94	0.00e+00	747.00
IUUC-Olu-087740	Ostreococcus lucimarinus	27.98	1.00e-41	164.00
IUUC-Oga-088264	Otolemur garnettii	73.76	6.00e-178	616.00
IUUC-Oar-089335	Ovis aries	74.47	0.00e+00	634.00
IUUC-Ptr-091320	Pan troglodytes	74.47	3.00e-178	617.00
IUUC-Pan-092833	Papio anubis	73.76	2.00e-177	615.00
IUUC-Psi-093504	Pelodiscus sinensis	75.89	0.00e+00	666.00
IUUC-Pma-094189	Petromyzon marinus	63.92	5.00e-163	567.00
IUUC-Pno-094929	Phaeosphaeria nodorum	25.85	1.00e-36	147.00
IUUC-Ppa-095429	Physcomitrella patens	35.68	4.00e-68	252.00
IUUC-Pfo-096337	Poecilia formosa	97.40	0.00e+00	832.00
IUUC-Pab-097571	Pongo abelii	74.23	5.00e-178	617.00
IUUC-Pop-099977	Populus trichocarpa	34.93	2.00e-64	239.00
IUUC-Pca-100394	Procavia capensis	73.11	5.00e-163	566.00
IUUC-Ppe-101848	Prunus persica	35.10	1.00e-64	240.00
IUUC-Pva-102921	Pteropus vampyrus	72.47	7.00e-90	323.00
IUUC-Pgr-103637	Puccinia graminis	28.33	3.00e-41	162.00
IUUC-Ptt-103781	Puccinia triticina	28.39	3.00e-41	162.00
IUUC-Pte-104135	Pyrenophora teres	27.25	5.00e-36	147.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.93	4.00e-35	142.00
IUUC-Rno-105114	Rattus norvegicus	74.70	0.00e+00	635.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.07	6.00e-44	171.00
IUUC-Sha-107122	Sarcophilus harrisii	72.81	6.00e-178	616.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.01	4.00e-52	198.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.41	9.00e-44	171.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	29.72	9.00e-41	161.00
IUUC-Smo-108720	Selaginella moellendorffii	33.02	1.00e-60	226.00
IUUC-Sit-110311	Setaria italica	34.02	1.00e-60	226.00
IUUC-Sly-111178	Solanum lycopersicum	33.83	2.00e-62	233.00
IUUC-Stu-112778	Solanum tuberosum	34.37	8.00e-66	244.00
IUUC-Sar-113596	Sorex araneus	61.47	5.00e-141	494.00
IUUC-Sbi-114193	Sorghum bicolor	34.87	4.00e-63	235.00
IUUC-Sre-115002	Sporisorium reilianum	25.64	3.00e-17	83.20
IUUC-Ssc-116066	Sus scrofa	74.00	0.00e+00	630.00
IUUC-Tgu-117048	Taeniopygia guttata	75.93	3.00e-170	591.00
IUUC-Tsy-119573	Tarsius syrichta	48.33	8.00e-104	370.00
IUUC-Tni-119820	Tetraodon nigroviridis	85.11	0.00e+00	730.00
IUUC-Tca-121605	Theobroma cacao	34.38	8.00e-63	234.00
IUUC-Tre-121947	Trichoderma reesei	26.28	1.00e-36	147.00
IUUC-Tvi-122481	Trichoderma virens	26.50	2.00e-38	153.00
IUUC-Tae-125861	Triticum aestivum	33.02	3.00e-61	229.00
IUUC-Tur-126586	Triticum urartu	33.42	9.00e-60	224.00
IUUC-Tme-126900	Tuber melanosporum	30.50	3.00e-49	189.00
IUUC-Tbe-127736	Tupaia belangeri	55.53	2.00e-119	422.00
IUUC-Ttr-129041	Tursiops truncatus	64.07	3.00e-153	534.00
IUUC-Uma-129628	Ustilago maydis	28.89	9.00e-11	62.00
IUUC-Vpa-130260	Vicugna pacos	74.94	0.00e+00	637.00
IUUC-Vvi-131009	Vitis vinifera	33.97	3.00e-62	232.00
IUUC-Xtr-132083	Xenopus tropicalis	73.52	0.00e+00	635.00
IUUC-Yli-134531	Yarrowia lipolytica	23.55	2.00e-24	107.00
IUUC-Zma-135509	Zea mays	33.17	1.00e-62	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence