iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026932

Ensembl Protein ID

AAW43174

UniProt Accession

P0CQ08; Q55UG2; Q5KHY2; PAN2_CRYNJ

Genbank Protein ID

AAW43174.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AE017344

Gene Name

PAN2; CND04900

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CND04900	AAW43174	AAW43174

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.60e-12	43.4	520	849

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 11   YmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.......gyeqqDa......qEflaf 98
           Y NS+LQ+L+ + +lr     +   ++      +++ +ll++   lf+ l + k ++ + +++ +a++++++ +        ++++  a      q f ++
   Q: 520  YTNSLLQALHYTLPLRAIATAHICVDC------KKEHCLLCEAGFLFRMLEDAKGRNCQASNFSRAFSATSQAYAlglmdenTNSKSTApygsliQNFNRW 614
           9****************9999444444......5678**************99*****************9998886666554444443444444677777 PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeee 199
           ll+++++e     ++   + + +++s      +    + ++s i++++++++k++ +c +c+ vssr+++   + l  p+k +   +s++d+L+s   +++
   Q: 615  LLSTFSTESIVDGETFHLRPFPQKTSG----LDGLSMNDGPSAIDQVLGVKIKTTNTCRHCGFVSSRDSTLHVVDLVYPKKMNP-RLSFSDILRSSLIRDS 710
           777777776222222222233333333....3344677888*****************************99999999988865.789*****99999999 PP
   S: 200  legenkyycekckkkqe.....aekklklkklPevLilhLkRfsfseeqksrekinkkve......fpleLdlspfctspeekqkekkkYeLiavvvHsG. 288
            ++     c++ck+        +    + + lP+vL+++ +  + + ++  + k + k +      +p++++++++    e++q+e +kY++ ++vv    
   Q: 711  TTK---AICSSCKAFAPldsrrSLSPSSGHPLPPVLSVNAMVTNSDVYGFWKDKKDVKEKdgvrrfLPKRVTIREVGKL-ENGQEEGVKYSIRSMVVQIQe 807
           985...8999999665521111333444567*********999555554444444444444444559*******98887.456668**********99998 PP
   S: 289  slss.GHYvayvknekgk....WllfdDskVtevkeeevlee 325
           s++   H v++vk  +++    W+ f+D  V++v+e+evl++
   Q: 808  SPDAvAHLVSFVKMPSKDgssaWIMFNDFLVRPVSEDEVLSF 849
           876438********66666789*****************996 PP

Organism

Cryptococcus neoformans

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MNYNPLHLLP LPPTALDPKP IPTSLTLDPF SDVLWVGASS GIVSALCSPL TLARNVHFPA 60
HGCKIGGGGF SAQGVSAVRE VRVTDRDVWT LTEGGIGGRK RGGAPKWIVS DVTRSLRTMS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCATCCTT GTTGCCTCGA AAGCAGTTCA TCGCGACGCA GGCAACACGC ATACTTCCCT 60
CGCCCATGCC CTCCGGGATA CGCAGCGATG AACTATAACC CTCTCCATCT CCTGCCCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII
SM00320--WD40

Gene Ontology

GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

cne:CND04900

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	33.21	7.00e-140	489.00
IUUC-Apl-003500	Anas platyrhynchos	46.59	1.00e-62	233.00
IUUC-Aca-004930	Anolis carolinensis	44.38	1.00e-72	266.00
IUUC-Acl-008214	Aspergillus clavatus	34.49	5.00e-171	593.00
IUUC-Afu-009112	Aspergillus fumigatus	33.85	4.00e-157	546.00
IUUC-Ang-009531	Aspergillus niger	34.17	3.00e-162	564.00
IUUC-Ame-011259	Astyanax mexicanus	44.97	1.00e-75	276.00
IUUC-Bta-012371	Bos taurus	32.03	1.00e-141	495.00
IUUC-Bci-013684	Botrytis cinerea	31.75	3.00e-152	531.00
IUUC-Cja-019297	Callithrix jacchus	31.24	2.00e-141	494.00
IUUC-Cfa-020489	Canis familiaris	33.24	1.00e-140	492.00
IUUC-Cpo-022392	Cavia porcellus	33.46	3.00e-140	491.00
IUUC-Csa-023220	Chlorocebus sabaeus	33.49	3.00e-141	494.00
IUUC-Csv-025841	Ciona savignyi	41.55	4.00e-66	244.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	34.32	2.00e-174	604.00
IUUC-Dre-028482	Danio rerio	44.01	2.00e-75	275.00
IUUC-Dno-029398	Dasypus novemcinctus	33.56	5.00e-143	500.00
IUUC-Dor-030307	Dipodomys ordii	33.00	3.00e-99	355.00
IUUC-Dme-032111	Drosophila melanogaster	40.45	1.00e-69	256.00
IUUC-Eca-033985	Equus caballus	33.24	2.00e-140	491.00
IUUC-Eeu-034928	Erinaceus europaeus	30.30	2.00e-22	99.80
IUUC-Fca-035587	Felis catus	31.76	2.00e-141	494.00
IUUC-Fal-037587	Ficedula albicollis	45.40	3.00e-72	265.00
IUUC-Fso-038133	Fusarium solani	36.59	6.00e-109	387.00
IUUC-Gmo-039076	Gadus morhua	45.03	1.00e-70	259.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.93	5.00e-155	540.00
IUUC-Gga-040948	Gallus gallus	43.45	7.00e-72	263.00
IUUC-Gac-042396	Gasterosteus aculeatus	42.86	5.00e-71	261.00
IUUC-Ggo-045412	Gorilla gorilla	33.40	3.00e-140	491.00
IUUC-Hsa-046076	Homo sapiens	33.30	4.00e-141	493.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.77	7.00e-68	250.00
IUUC-Kpa-049178	Komagataella pastoris	30.50	3.00e-145	507.00
IUUC-Lch-050279	Latimeria chalumnae	43.52	8.00e-72	263.00
IUUC-Loc-052872	Lepisosteus oculatus	43.33	3.00e-71	262.00
IUUC-Lma-052986	Leptosphaeria maculans	34.43	3.00e-167	580.00
IUUC-Laf-054181	Loxodonta africana	43.52	3.00e-76	278.00
IUUC-Mcc-054812	Macaca mulatta	33.75	1.00e-141	495.00
IUUC-Meu-056325	Macropus eugenii	32.82	1.00e-137	482.00
IUUC-Mor-057246	Magnaporthe oryzae	31.19	4.00e-134	470.00
IUUC-Mpo-057464	Magnaporthe poae	33.02	3.00e-158	551.00
IUUC-Mla-058911	Melampsora laricipopulina	38.41	0.00e+00	691.00
IUUC-Mga-059335	Meleagris gallopavo	45.69	1.00e-72	266.00
IUUC-Mvi-060461	Microbotryum violaceum	45.85	0.00e+00	807.00
IUUC-Mmr-060636	Microcebus murinus	32.95	1.00e-139	489.00
IUUC-Mmu-063503	Mus musculus	43.86	7.00e-72	264.00
IUUC-Mpu-066670	Mustela putorius furo	33.24	1.00e-140	492.00
IUUC-Mlu-068119	Myotis lucifugus	31.53	2.00e-142	498.00
IUUC-Nfi-068398	Neosartorya fischeri	34.86	2.00e-167	581.00
IUUC-Ncr-068927	Neurospora crassa	32.19	7.00e-140	489.00
IUUC-Nle-069651	Nomascus leucogenys	32.05	9.00e-134	469.00
IUUC-Opr-070614	Ochotona princeps	33.21	1.00e-139	489.00
IUUC-Ont-072433	Oreochromis niloticus	44.83	2.00e-73	269.00
IUUC-Oan-073283	Ornithorhynchus anatinus	41.76	3.00e-67	248.00
IUUC-Ocu-074401	Oryctolagus cuniculus	43.52	6.00e-73	267.00
IUUC-Ola-087522	Oryzias latipes	44.38	7.00e-76	277.00
IUUC-Oga-088226	Otolemur garnettii	43.52	8.00e-73	267.00
IUUC-Oar-089241	Ovis aries	31.93	3.00e-144	504.00
IUUC-Pan-092297	Papio anubis	33.62	4.00e-142	497.00
IUUC-Psi-094043	Pelodiscus sinensis	32.49	6.00e-122	430.00
IUUC-Pma-094394	Petromyzon marinus	45.76	1.00e-73	270.00
IUUC-Pno-095053	Phaeosphaeria nodorum	36.16	2.00e-164	571.00
IUUC-Ppa-095188	Physcomitrella patens	27.91	3.00e-58	218.00
IUUC-Pfo-097517	Poecilia formosa	43.60	1.00e-74	273.00
IUUC-Pca-100471	Procavia capensis	32.98	2.00e-144	504.00
IUUC-Pva-102805	Pteropus vampyrus	30.97	3.00e-118	418.00
IUUC-Pte-104021	Pyrenophora teres	34.49	3.00e-169	587.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	34.44	4.00e-169	587.00
IUUC-Rno-105471	Rattus norvegicus	32.39	4.00e-144	504.00
IUUC-Sce-106235	Saccharomyces cerevisiae	28.99	3.00e-112	398.00
IUUC-Sha-106883	Sarcophilus harrisii	42.74	8.00e-73	266.00
IUUC-Spo-108169	Schizosaccharomyces pombe	34.43	2.00e-167	581.00
IUUC-Sar-113323	Sorex araneus	34.57	2.00e-129	455.00
IUUC-Sbi-114848	Sorghum bicolor	30.43	4.00e-03	34.70
IUUC-Sre-115075	Sporisorium reilianum	62.44	2.00e-78	286.00
IUUC-Ssc-116363	Sus scrofa	43.52	3.00e-76	278.00
IUUC-Tru-118427	Takifugu rubripes	43.03	8.00e-73	267.00
IUUC-Tni-120218	Tetraodon nigroviridis	43.49	4.00e-74	271.00
IUUC-Tre-122177	Trichoderma reesei	33.13	5.00e-169	586.00
IUUC-Tme-127176	Tuber melanosporum	36.22	1.00e-171	595.00
IUUC-Tbe-127641	Tupaia belangeri	30.16	3.00e-20	92.40
IUUC-Ttr-128888	Tursiops truncatus	43.06	2.00e-68	252.00
IUUC-Uma-129361	Ustilago maydis	43.26	3.00e-79	288.00
IUUC-Xtr-132811	Xenopus tropicalis	43.82	2.00e-72	265.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence