iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-23	82.0	269	300
E3 adaptor/Cullin RING/APC_C/CDC20	1.20e-126	422.1	133	436

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW.D 29
           gH+ +v++l++ ++ ++l+sG+ D+ + vW D
   Q: 269  GHKLEVCGLQWsPSnRYLASGGSDNRLLVWtD 300
           79999*******555***************55 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltghsa 97
           p+k+ldapel+ddfylnL+dWsskn+lav+Lg+svylwsa +g+v++l+d+ +e++l+t+vsw  eg ++a+Gt++g v+i+D+e++k++  l++hsa
   Q: 133  PYKILDAPELQDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFnNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSA 230
           79*************************************************888999***************************************** PP
   S: 98   rvgaLsWnaevlssGsrdgeilhrdvrvkelkl.stlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavkaiawsPwqksl 194
           rv+aL+W  + l+sGsrd++il+rd+r + +++ + l++h+ evCGl+w+ ++++LasGG Dn + vw     eP++ f+ehka vka++wsP++++l
   Q: 231  RVTALAWCGNRLASGSRDRSILQRDIRNPPTHItRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGL 328
           ****************************99988899************************************************************** PP
   S: 195  LasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaagDetlr 292
           LasGGG+aDrc++fwn+ltg+l+++i+tg+q+++l+w++ s+elv+thG+a+ +++ w+ypsl+++a+l+gh++Rvl+l++spd e+ivt+++Detlr
   Q: 329  LASGGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETLR 426
           ************************************************************************************************** PP
   S: 293  fwklfdkkka 302
           fw +f k+k 
   Q: 427  FWTVFTKQKI 436
           *****99875 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MFQSEYQQRL LPGVAVGKKE DIDLRCIPTR AGNHWNRNFV NAPGDSNVYE SSVYSCLLRN 60
EFLDENITSL ENCEQTAQVH AQTDDFRDRH NRIFGFASGS SSPVRTPFAN ISESSQRLLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGGCATC ACACTACGAA CAAATATTGG AATTCGGAGA TGTTTCAATC AGAGTATCAG 60
CAACGATTGC TTCCGGGCGT CGCCGTCGGC AAAAAGGAGG ACATCGATCT GCGCTGCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0007140--P:male meiosis
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

KEGG

dme:Dmel_CG16783

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence