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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046026
UUCD1 version UUC-HoS-01065
Ensembl Protein ID ENSP00000253023.2
UniProt Accession P61081; O76069; Q8VC50; UBC12_HUMAN
Genbank Protein ID BAA33145.1; AAC26141.1; AAP35400.1; AAH58924.1
Protein Name NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M
Genbank Nucleotide ID AB012191; AF075599; BT006754; BC058924
Gene Name UBE2M; UBC12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130725.7 ENST00000253023.7 ENSP00000253023.2
ENSG00000130725.7 ENST00000596985.1 ENSP00000469855.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 19940261; 20498703; 19617556; 17132228
Classification
Family E-value Score Start End
E2/UBC 7.20e-39 134.4 33 165
Active Site
Position(s) Description Evidence
111 Glycyl thioester intermediate N/A
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++k+++el  + p+++ ++++d +dl +++++i+ p++  Y+ g+F +++++ + YP +PPkvk++t ++hPn++ +G+vCl+il+  e+W
   Q: 33   RIQKDINEL--NLPKTCDISFSDPDDLLNFKLVIC-PDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILR--EDW 119
           89******9..89999********9*********9.**************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +p+l+++s+++++q l+ epnpe+pln+eaae l++nr+ ++++v+
   Q: 120  KPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQ 165
           ********************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
 Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Protein Sequence
(Fasta)
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS FSDPDDLLNF 60
KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046026|E2,E2/UBC|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGGCGGGA AGAGCCAAAG CGGGCAGGCG GCGGAAATAT CCGAAGCGGC GGGGCGCCCG 60
AGGCCGTTGC CGACCTCCGC GCTAAAGCCG CTGCTGCCGC GGAAGACGAT CCTCCAGTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046026|E2,E2/UBC|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005524--F:ATP binding
GO:0019788--F:NEDD8 transferase activity
GO:0018169--F:ribosomal S6-glutamic acid ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0038061--P:NIK/NF-kappaB signaling
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0007179--P:transforming growth factor beta receptor signaling pathway
KEGG hsa:9040
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000196 Aegilops tauschii 56.82 2.00e-54 204.00
IUUC-Aml-002007 Ailuropoda melanoleuca 100.00 6.00e-86 308.00
IUUC-Atr-003170 Amborella trichopoda 60.11 3.00e-65 240.00
IUUC-Aca-005037 Anolis carolinensis 97.81 3.00e-104 370.00
IUUC-Aly-006219 Arabidopsis lyrata 61.62 7.00e-66 243.00
IUUC-Ath-006846 Arabidopsis thaliana 62.16 2.00e-65 241.00
IUUC-Ago-007910 Ashbya gossypii 44.59 5.00e-36 144.00
IUUC-Acl-008364 Aspergillus clavatus 59.87 1.00e-54 205.00
IUUC-Afl-008463 Aspergillus flavus 62.50 2.00e-56 211.00
IUUC-Afu-008803 Aspergillus fumigatus 59.87 1.00e-54 206.00
IUUC-Ani-009422 Aspergillus nidulans 62.50 3.00e-57 214.00
IUUC-Ang-009728 Aspergillus niger 62.96 1.00e-50 191.00
IUUC-Aor-009962 Aspergillus oryzae 62.50 2.00e-56 211.00
IUUC-Ate-010430 Aspergillus terreus 59.01 4.00e-51 194.00
IUUC-Ame-011382 Astyanax mexicanus 90.27 9.00e-97 345.00
IUUC-Bgr-012306 Blumeria graminis 55.98 3.00e-60 224.00
IUUC-Bta-012818 Bos taurus 100.00 7.00e-107 379.00
IUUC-Bci-013626 Botrytis cinerea 56.52 7.00e-60 223.00
IUUC-Bdi-014528 Brachypodium distachyon 63.74 3.00e-63 234.00
IUUC-Bol-016135 Brassica oleracea 60.75 1.00e-65 242.00
IUUC-Bra-016704 Brassica rapa 60.54 2.00e-65 241.00
IUUC-Cja-019213 Callithrix jacchus 97.34 1.00e-104 371.00
IUUC-Cfa-020242 Canis familiaris 98.92 3.00e-105 373.00
IUUC-Cpo-022405 Cavia porcellus 95.63 2.00e-100 357.00
IUUC-Cre-022865 Chlamydomonas reinhardtii 60.57 9.00e-55 206.00
IUUC-Csa-023269 Chlorocebus sabaeus 100.00 7.00e-107 379.00
IUUC-Cin-025333 Ciona intestinalis 74.86 1.00e-81 295.00
IUUC-Csv-025898 Ciona savignyi 61.57 4.00e-74 270.00
IUUC-Cgl-026477 Colletotrichum gloeosporioides 56.28 4.00e-57 213.00
IUUC-Cne-027097 Cryptococcus neoformans 60.99 5.00e-62 229.00
IUUC-Cme-027287 Cyanidioschyzon merolae 48.05 1.00e-18 86.30
IUUC-Dre-028514 Danio rerio 87.03 6.00e-89 319.00
IUUC-Dno-029678 Dasypus novemcinctus 92.35 2.00e-97 347.00
IUUC-Dor-030851 Dipodomys ordii 67.66 6.00e-57 213.00
IUUC-Dse-031265 Dothistroma septosporum 56.83 2.00e-62 231.00
IUUC-Dme-032076 Drosophila melanogaster 75.27 3.00e-80 290.00
IUUC-Ete-032350 Echinops telfairi 73.04 9.00e-44 168.00
IUUC-Eca-034075 Equus caballus 98.91 2.00e-105 374.00
IUUC-Fca-035654 Felis catus 100.00 6.00e-86 308.00
IUUC-Fal-037283 Ficedula albicollis 87.95 6.00e-41 157.00
IUUC-Fox-037877 Fusarium oxysporum 57.30 2.00e-57 214.00
IUUC-Fso-038428 Fusarium solani 57.30 6.00e-63 233.00
IUUC-Gmo-039402 Gadus morhua 89.19 2.00e-96 343.00
IUUC-Ggr-039731 Gaeumannomyces graminis 59.24 9.00e-57 212.00
IUUC-Gga-041122 Gallus gallus 89.83 3.00e-92 331.00
IUUC-Gma-043805 Glycine max 60.54 1.00e-63 235.00
IUUC-Ggo-044436 Gorilla gorilla 100.00 7.00e-107 379.00
IUUC-Hvu-047056 Hordeum vulgare 60.99 3.00e-62 230.00
IUUC-Itr-047889 Ictidomys tridecemlineatus 100.00 7.00e-107 379.00
IUUC-Kpa-049315 Komagataella pastoris 49.16 8.00e-49 186.00
IUUC-Lch-050360 Latimeria chalumnae 75.61 3.00e-59 221.00
IUUC-Lpe-050743 Leersia perrieri 61.02 8.00e-63 233.00
IUUC-Lma-053001 Leptosphaeria maculans 57.92 5.00e-58 216.00
IUUC-Laf-053463 Loxodonta africana 99.32 2.00e-85 307.00
IUUC-Mcc-054966 Macaca mulatta 100.00 8.00e-44 167.00
IUUC-Meu-056085 Macropus eugenii 97.26 4.00e-83 299.00
IUUC-Mor-057250 Magnaporthe oryzae 61.84 2.00e-55 208.00
IUUC-Mpo-057481 Magnaporthe poae 63.16 3.00e-55 207.00
IUUC-Mtr-058251 Medicago truncatula 59.56 1.00e-64 238.00
IUUC-Mla-059119 Melampsora laricipopulina 59.02 8.00e-60 222.00
IUUC-Mga-059881 Meleagris gallopavo 90.57 3.00e-55 206.00
IUUC-Mvi-060449 Microbotryum violaceum 58.10 1.00e-58 219.00
IUUC-Mmr-061511 Microcebus murinus 100.00 5.00e-44 168.00
IUUC-Mmu-063962 Mus musculus 100.00 7.00e-107 379.00
IUUC-Mac-064967 Musa acuminata 62.84 8.00e-68 249.00
IUUC-Mlu-066955 Myotis lucifugus 98.01 2.00e-86 310.00
IUUC-Nfi-068300 Neosartorya fischeri 59.87 1.00e-54 206.00
IUUC-Ncr-068944 Neurospora crassa 56.76 7.00e-57 213.00
IUUC-Nle-069051 Nomascus leucogenys 100.00 6.00e-86 308.00
IUUC-Opr-070635 Ochotona princeps 100.00 2.00e-85 306.00
IUUC-Ont-072348 Oreochromis niloticus 89.19 5.00e-96 343.00
IUUC-Ocu-074905 Oryctolagus cuniculus 100.00 7.00e-107 379.00
IUUC-Oba-075825 Oryza barthii 61.54 7.00e-67 246.00
IUUC-Obr-076067 Oryza brachyantha 60.99 2.00e-66 244.00
IUUC-Ogl-077594 Oryza glaberrima 61.54 7.00e-67 246.00
IUUC-Ogu-078073 Oryza glumaepatula 61.54 7.00e-67 246.00
IUUC-Oin-080060 Oryza indica 61.20 1.00e-63 236.00
IUUC-Olo-080314 Oryza longistaminata 61.54 4.00e-67 247.00
IUUC-Ome-081713 Oryza meridionalis 61.54 8.00e-67 246.00
IUUC-Oni-082426 Oryza nivara 61.54 7.00e-67 246.00
IUUC-Opu-083942 Oryza punctata 61.85 4.00e-63 233.00
IUUC-Oru-085104 Oryza rufipogon 61.54 7.00e-67 246.00
IUUC-Osa-086168 Oryza sativa 61.54 6.00e-67 246.00
IUUC-Olu-087854 Ostreococcus lucimarinus 56.76 9.00e-58 216.00
IUUC-Oga-088580 Otolemur garnettii 100.00 7.00e-107 379.00
IUUC-Oar-089623 Ovis aries 93.24 4.00e-78 283.00
IUUC-Ptr-091161 Pan troglodytes 90.71 3.00e-93 333.00
IUUC-Pan-092119 Papio anubis 100.00 6.00e-86 308.00
IUUC-Psi-093494 Pelodiscus sinensis 97.28 2.00e-83 300.00
IUUC-Pno-094972 Phaeosphaeria nodorum 56.02 7.00e-56 209.00
IUUC-Ppa-095187 Physcomitrella patens 67.76 3.00e-70 257.00
IUUC-Pfo-097205 Poecilia formosa 85.56 2.00e-87 314.00
IUUC-Pab-098434 Pongo abelii 100.00 7.00e-107 379.00
IUUC-Pop-099789 Populus trichocarpa 61.20 2.00e-65 241.00
IUUC-Pca-100300 Procavia capensis 99.32 7.00e-85 305.00
IUUC-Ppe-101143 Prunus persica 60.66 2.00e-65 241.00
IUUC-Pva-102143 Pteropus vampyrus 100.00 7.00e-107 379.00
IUUC-Pgr-103675 Puccinia graminis 59.78 1.00e-58 219.00
IUUC-Ptt-103997 Puccinia triticina 61.24 7.00e-60 223.00
IUUC-Pte-104042 Pyrenophora teres 57.92 1.00e-57 215.00
IUUC-Pyt-104616 Pyrenophora triticirepentis 61.90 8.00e-53 199.00
IUUC-Rno-105107 Rattus norvegicus 100.00 7.00e-107 379.00
IUUC-Sce-106385 Saccharomyces cerevisiae 44.10 3.00e-37 148.00
IUUC-Sha-106899 Sarcophilus harrisii 90.18 1.00e-84 305.00
IUUC-Sja-107789 Schizosaccharomyces japonicus 51.10 4.00e-51 194.00
IUUC-Spo-108143 Schizosaccharomyces pombe 49.45 7.00e-50 189.00
IUUC-Ssl-108427 Sclerotinia sclerotiorum 56.28 2.00e-58 218.00
IUUC-Smo-108673 Selaginella moellendorffii 64.67 4.00e-68 250.00
IUUC-Sit-109702 Setaria italica 64.29 3.00e-62 230.00
IUUC-Sly-111650 Solanum lycopersicum 63.39 5.00e-67 246.00
IUUC-Stu-112655 Solanum tuberosum 62.84 2.00e-67 248.00
IUUC-Sar-113632 Sorex araneus 99.45 9.00e-106 375.00
IUUC-Sbi-114357 Sorghum bicolor 64.84 4.00e-63 233.00
IUUC-Sre-114912 Sporisorium reilianum 63.82 5.00e-58 216.00
IUUC-Tsy-119639 Tarsius syrichta 77.18 2.00e-60 224.00
IUUC-Tni-119674 Tetraodon nigroviridis 77.30 3.00e-77 280.00
IUUC-Tca-121359 Theobroma cacao 62.84 1.00e-66 245.00
IUUC-Tre-122115 Trichoderma reesei 59.75 1.00e-56 212.00
IUUC-Tvi-122656 Trichoderma virens 59.75 4.00e-56 210.00
IUUC-Tae-124489 Triticum aestivum 60.99 3.00e-62 230.00
IUUC-Tur-126125 Triticum urartu 60.99 3.00e-62 231.00
IUUC-Tme-126950 Tuber melanosporum 62.42 1.00e-57 215.00
IUUC-Tbe-127874 Tupaia belangeri 71.58 3.00e-66 244.00
IUUC-Ttr-128213 Tursiops truncatus 98.76 4.00e-91 326.00
IUUC-Uma-129329 Ustilago maydis 64.29 8.00e-58 216.00
IUUC-Vda-129754 Verticillium dahliae 61.78 4.00e-57 214.00
IUUC-Vvi-131182 Vitis vinifera 62.30 1.00e-65 242.00
IUUC-Xtr-132742 Xenopus tropicalis 97.81 2.00e-104 370.00
IUUC-Xma-133558 Xiphophorus maculatus 86.49 1.00e-88 318.00
IUUC-Yli-134467 Yarrowia lipolytica 55.49 3.00e-58 217.00
IUUC-Zma-135527 Zea mays 64.84 1.00e-62 232.00
Created Date 25-Jun-2017

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