iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000027711.5	ENSRNOT00000036814.5	ENSRNOP00000031281.4
ENSRNOG00000027711.5	ENSRNOT00000081649.1	ENSRNOP00000074862.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.20e-107	358.1	770	1603

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtC+mNS +Qc sn+++l++++ + ++  +ln++np ++kg+++k++ +l++elw++++k+v+p +l  +++k+a++f+g
   Q: 770  TGLSNLGNTCFMNSSIQCVSNTQPLTQYFISgRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNG 856
           7******************************9******************************************************* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           ++qqD+qE+laflld+l+e+l++ ++kp+ e++++d   ++d+     a++++ ++n+s+++dlF+gql+sq+kc++c+++s+r++p
   Q: 857  FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSD--GRPDWevaaeAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDP 941
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           f+ lslp+p+++ +++e                                                                      
   Q: 942  FNFLSLPLPMDSYMHLEitvikldgttpiryglrlnmdekytglkkqlsdlcglkseqilfaevhssniknfpqdnqkvrlsvsgfl 1028
           *************9999********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1029 cafeipipaspvsacspiqtdcssspstnglftvttngdlprpifipngmpntvvpcgteknatngivnghmpplpddpftgyiiav 1115
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1116 hrkmmrtelyflssqknrpslfgmplivpctvhtrkkdlydavwiqvsrlasplppqeasnhaqdcddsmgyqypftlrvvqkdgns 1202
           *************************************************************************************** PP
   S: 186  ...................................................................slqdcLesftkeeelegenk 205
                                                                              +l++cL++ft+eeel ++++
   Q: 1203 cawcpwyrfcrgckidcgedrafignaciavdwdptalhlryqtsqervveehesveqsrraqaepiNLDSCLRAFTSEEELGENEM 1289
           *************************************************************************************** PP
   S: 206  yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts........................ 267
           yyc+kck ++ a+kkl+l++lP++Li+hLkRf+f +   + +k +k v+fp+e +d s f++                         
   Q: 1290 YYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNG--RWIKSQKIVKFPREsFDPSAFLVPrdptlcqhkpltpqgddvselpip 1374
           ********************************99775..5569******************99999999999999999999999999 PP
   S: 268  ....................................................................................... 267
                                                                                                  
   Q: 1375 agdvkkvdvqnpageedvllskspsslsanitsspkgspsssrksgascpssknsspnssprtlgrnkgrlrlpqigsknklssske 1461
           999999999999999999999999999999999988888888888888888777777777777777777777777777776666666 PP
   S: 268  .....................................................................peekqke..........k 275
                                                                                +     +          k
   Q: 1462 nldasrengagqiceladtlnrghvlggsqpelvtpldheitlangflyehetcgngysngqlgnhseeD-----StddqredthsK 1543
           6666666666666666666666666666666666666666666666666666666666555555555550.....05555556666* PP
   S: 276  kkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
            +Y+L+a+ +HsG l++GHYv+y+kn + kW++++Ds+++e++ +e+ +   ++aY+lfY+++
   Q: 1544 PIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDT---DSAYILFYEQQ 1603
           *************************************************...********985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MCHRVSCGQK TAEEADSLPS PCEFWELNSG HQAEGVEARP LPAESSYQPF PWEFEVTDVE 60
LKRLKDAFKR TCGLSYYMSQ HCFIREVLGD GVPPKVAEVI YCSFGGTSKG LHFNNLIVGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACATTATT TATGAATTGT GTGTGCATTT TATGTGCAGG CATTCATGTG CCACAGGGTG 60
TCCTGTGGCC AGAAGACAGC TGAGGAAGCT GACTCTCTCC CTTCACCGTG TGAGTTCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF13202--EF-hand_5
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP
SM00054--EFh

Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005509--F:calcium ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001611	Ailuropoda melanoleuca	94.75	0.00e+00	2573.00
IUUC-Apl-003272	Anas platyrhynchos	83.30	0.00e+00	2637.00
IUUC-Aca-005057	Anolis carolinensis	83.67	0.00e+00	2291.00
IUUC-Ame-010781	Astyanax mexicanus	80.88	0.00e+00	2149.00
IUUC-Bta-013502	Bos taurus	91.06	0.00e+00	2768.00
IUUC-Cel-018710	Caenorhabditis elegans	30.11	2.00e-80	294.00
IUUC-Cja-018754	Callithrix jacchus	95.21	0.00e+00	3007.00
IUUC-Cfa-020526	Canis familiaris	95.08	0.00e+00	2989.00
IUUC-Cpo-021568	Cavia porcellus	90.56	0.00e+00	2734.00
IUUC-Csa-023143	Chlorocebus sabaeus	95.39	0.00e+00	2972.00
IUUC-Cho-024603	Choloepus hoffmanni	60.93	0.00e+00	665.00
IUUC-Cin-025583	Ciona intestinalis	54.49	0.00e+00	858.00
IUUC-Csv-026344	Ciona savignyi	46.72	0.00e+00	1132.00
IUUC-Dre-028121	Danio rerio	82.67	0.00e+00	2133.00
IUUC-Dno-029911	Dasypus novemcinctus	94.01	0.00e+00	2935.00
IUUC-Dor-030608	Dipodomys ordii	62.01	0.00e+00	1075.00
IUUC-Dme-032094	Drosophila melanogaster	45.40	2.00e-123	437.00
IUUC-Ete-032639	Echinops telfairi	91.55	0.00e+00	1542.00
IUUC-Eca-034253	Equus caballus	94.88	0.00e+00	2956.00
IUUC-Eeu-035084	Erinaceus europaeus	83.10	0.00e+00	1551.00
IUUC-Fca-035474	Felis catus	94.06	0.00e+00	2430.00
IUUC-Fal-036985	Ficedula albicollis	82.91	0.00e+00	2593.00
IUUC-Gmo-039568	Gadus morhua	80.25	0.00e+00	2073.00
IUUC-Gga-040509	Gallus gallus	83.18	0.00e+00	2692.00
IUUC-Gac-041757	Gasterosteus aculeatus	80.20	0.00e+00	2125.00
IUUC-Ggo-044956	Gorilla gorilla	87.48	0.00e+00	1793.00
IUUC-Hsa-046107	Homo sapiens	95.71	0.00e+00	3008.00
IUUC-Itr-048865	Ictidomys tridecemlineatus	93.67	0.00e+00	1162.00
IUUC-Lch-050681	Latimeria chalumnae	77.72	0.00e+00	2369.00
IUUC-Loc-052474	Lepisosteus oculatus	77.49	0.00e+00	2429.00
IUUC-Laf-054273	Loxodonta africana	94.26	0.00e+00	2961.00
IUUC-Mcc-054718	Macaca mulatta	95.39	0.00e+00	2996.00
IUUC-Meu-056558	Macropus eugenii	72.08	0.00e+00	1373.00
IUUC-Mga-059892	Meleagris gallopavo	84.66	0.00e+00	2641.00
IUUC-Mmr-060866	Microcebus murinus	94.61	0.00e+00	3024.00
IUUC-Mdo-062607	Monodelphis domestica	91.18	0.00e+00	2879.00
IUUC-Mmu-063797	Mus musculus	98.68	0.00e+00	3152.00
IUUC-Mpu-066121	Mustela putorius furo	95.52	0.00e+00	3018.00
IUUC-Mlu-067581	Myotis lucifugus	93.40	0.00e+00	2994.00
IUUC-Nle-069916	Nomascus leucogenys	93.06	0.00e+00	2899.00
IUUC-Opr-071073	Ochotona princeps	84.70	0.00e+00	1191.00
IUUC-Ont-071310	Oreochromis niloticus	78.96	0.00e+00	2114.00
IUUC-Oan-073356	Ornithorhynchus anatinus	89.61	0.00e+00	2831.00
IUUC-Ocu-074216	Oryctolagus cuniculus	95.21	0.00e+00	2992.00
IUUC-Ola-087434	Oryzias latipes	79.12	0.00e+00	2078.00
IUUC-Oga-089034	Otolemur garnettii	93.67	0.00e+00	2913.00
IUUC-Oar-090369	Ovis aries	95.08	0.00e+00	2987.00
IUUC-Ptr-090605	Pan troglodytes	95.65	0.00e+00	3005.00
IUUC-Pan-092381	Papio anubis	95.34	0.00e+00	2957.00
IUUC-Psi-093819	Pelodiscus sinensis	86.31	0.00e+00	2722.00
IUUC-Pma-094480	Petromyzon marinus	63.71	0.00e+00	1467.00
IUUC-Pfo-096561	Poecilia formosa	79.97	0.00e+00	2079.00
IUUC-Pab-097643	Pongo abelii	95.33	0.00e+00	2905.00
IUUC-Pca-100944	Procavia capensis	76.01	0.00e+00	999.00
IUUC-Pva-102732	Pteropus vampyrus	84.79	0.00e+00	2606.00
IUUC-Sha-107608	Sarcophilus harrisii	82.86	2.00e-166	578.00
IUUC-Sar-113201	Sorex araneus	82.40	0.00e+00	1661.00
IUUC-Ssc-115469	Sus scrofa	91.52	0.00e+00	631.00
IUUC-Tgu-117322	Taeniopygia guttata	84.32	0.00e+00	2708.00
IUUC-Tru-118705	Takifugu rubripes	59.57	0.00e+00	881.00
IUUC-Tsy-119433	Tarsius syrichta	80.53	0.00e+00	2085.00
IUUC-Tni-120631	Tetraodon nigroviridis	78.42	0.00e+00	2072.00
IUUC-Tbe-127553	Tupaia belangeri	88.55	0.00e+00	690.00
IUUC-Ttr-128260	Tursiops truncatus	93.50	0.00e+00	2981.00
IUUC-Vpa-130479	Vicugna pacos	90.03	0.00e+00	2798.00
IUUC-Xtr-132686	Xenopus tropicalis	83.14	0.00e+00	2576.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence