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Tag Content
UUCD2 ID IUUC-Xtr-132628
UUCD1 version UUC-XeT-00895
Ensembl Protein ID ENSXETP00000010793.2
UniProt Accession Q28E95; SH3R1_XENTR
Genbank Protein ID CAJ83039.1
Protein Name E3 ubiquitin-protein ligase SH3RF1; Plenty of SH3s; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1
Genbank Nucleotide ID CR848380
Gene Name sh3rf1; posh; TNeu006c09.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000004943.3 ENSXETT00000010793.2 ENSXETP00000010793.2
ENSXETG00000004943.3 ENSXETT00000010795.3 ENSXETP00000010795.3
ENSXETG00000004943.3 ENSXETT00000010794.3 ENSXETP00000010794.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 3.90e-08 33.9 12 53
UBD/SH3 3.10e-47 158.5 439 494
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle+++   +vlpC+H+f++ Cl  +     ss++e rCP Cr
   Q: 12   CPVCLERLDASAKVLPCQHTFCKRCLLGI----VSSRNELRCPECR 53
           **********9**************9777....89**********8 PP
   

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++ ++y+y + ++deL+l+kG++ lv  + +   gW kg++  + k G+fP n+v+ +
   Q: 439  VFVAIYPYIPRKEDELELRKGEMFLVF-ERC-QDGWFKGTSMHTSKIGVFPGNYVAPV 494
           6889**********************9.555.569********************988 PP
   
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as ube2d1 or ube2n and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination.
 Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as ube2d1 or ube2n and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination.
Protein Sequence
(Fasta)
MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VSSRNELRCP ECRTLVECGV 60
DELPSNILLV RLLDGIKQRP RKAGVGGSAG NSTNVLRAQG SLTTNCGLND AQNIHGGQQR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Xtr-132628|E3,RING;UBD,SH3|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGGAGTTCA TGGGAGAGAC CCAGGCACAC ACTCAGTGAT ATTGCCGCAG GGACAAAGGC 60
ACAGGAGACA CCGAGGGGCT CAGTGGATCC CCATAGTCTG TTCTTTGGAT TGTAGGTCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132628|E3,RING;UBD,SH3|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001452--SH3_domain
IPR028502--SH3RF1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00018--SH3_1
PF14604--SH3_9
PF00097--zf-C3HC4
PRINTS

PR00452--SH3DOMAIN
SMART

SM00184--RING
SM00326--SH3
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0030027--C:lamellipodium
GO:0048471--C:perinuclear region of cytoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0016567--P:protein ubiquitination
GO:0046328--P:regulation of JNK cascade
KEGG xtr:548727
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001528 Ailuropoda melanoleuca 71.17 0.00e+00 1051.00
IUUC-Apl-003961 Anas platyrhynchos 74.50 0.00e+00 897.00
IUUC-Aca-004386 Anolis carolinensis 71.23 0.00e+00 1056.00
IUUC-Ame-010659 Astyanax mexicanus 57.62 0.00e+00 833.00
IUUC-Bta-012563 Bos taurus 74.38 2.00e-164 572.00
IUUC-Cja-019730 Callithrix jacchus 75.53 0.00e+00 839.00
IUUC-Cfa-020992 Canis familiaris 71.09 0.00e+00 1069.00
IUUC-Cpo-021304 Cavia porcellus 72.18 0.00e+00 1098.00
IUUC-Csa-023925 Chlorocebus sabaeus 78.37 0.00e+00 849.00
IUUC-Cho-024630 Choloepus hoffmanni 68.14 7.00e-143 501.00
IUUC-Cin-025274 Ciona intestinalis 47.44 2.00e-72 265.00
IUUC-Csv-026136 Ciona savignyi 40.05 8.00e-72 263.00
IUUC-Cme-027278 Cyanidioschyzon merolae 40.43 1.00e-07 52.00
IUUC-Dre-028290 Danio rerio 58.99 0.00e+00 860.00
IUUC-Dno-029083 Dasypus novemcinctus 77.74 0.00e+00 864.00
IUUC-Dor-030388 Dipodomys ordii 83.43 2.00e-169 589.00
IUUC-Dme-032207 Drosophila melanogaster 45.09 9.00e-66 244.00
IUUC-Ete-032809 Echinops telfairi 61.22 0.00e+00 627.00
IUUC-Eca-034185 Equus caballus 68.81 0.00e+00 852.00
IUUC-Eeu-034816 Erinaceus europaeus 62.25 0.00e+00 830.00
IUUC-Fca-036439 Felis catus 68.84 0.00e+00 1067.00
IUUC-Fal-037074 Ficedula albicollis 71.96 0.00e+00 1068.00
IUUC-Gmo-039443 Gadus morhua 60.81 3.00e-120 426.00
IUUC-Ggr-040119 Gaeumannomyces graminis 42.37 4.00e-12 67.40
IUUC-Gga-040749 Gallus gallus 74.46 0.00e+00 874.00
IUUC-Gac-041420 Gasterosteus aculeatus 63.39 0.00e+00 665.00
IUUC-Ggo-045215 Gorilla gorilla 72.20 0.00e+00 1059.00
IUUC-Hsa-046315 Homo sapiens 70.52 0.00e+00 1053.00
IUUC-Lch-049453 Latimeria chalumnae 73.56 0.00e+00 671.00
IUUC-Loc-052248 Lepisosteus oculatus 39.38 2.00e-73 270.00
IUUC-Laf-053651 Loxodonta africana 70.71 0.00e+00 1038.00
IUUC-Mcc-054688 Macaca mulatta 78.12 0.00e+00 852.00
IUUC-Meu-056291 Macropus eugenii 62.79 0.00e+00 637.00
IUUC-Mor-056932 Magnaporthe oryzae 40.98 3.00e-12 68.20
IUUC-Mpo-057322 Magnaporthe poae 43.10 4.00e-12 67.40
IUUC-Mga-059944 Meleagris gallopavo 74.62 0.00e+00 881.00
IUUC-Mmr-061553 Microcebus murinus 75.53 0.00e+00 836.00
IUUC-Mdo-062313 Monodelphis domestica 67.76 0.00e+00 1015.00
IUUC-Mmu-063516 Mus musculus 76.13 0.00e+00 887.00
IUUC-Mpu-066064 Mustela putorius furo 70.80 0.00e+00 1044.00
IUUC-Mlu-067312 Myotis lucifugus 76.01 0.00e+00 835.00
IUUC-Nle-069035 Nomascus leucogenys 71.97 0.00e+00 1053.00
IUUC-Opr-070690 Ochotona princeps 61.79 2.00e-124 439.00
IUUC-Ont-071484 Oreochromis niloticus 63.65 0.00e+00 719.00
IUUC-Oan-073305 Ornithorhynchus anatinus 71.04 0.00e+00 1069.00
IUUC-Ocu-074936 Oryctolagus cuniculus 77.05 0.00e+00 872.00
IUUC-Ola-086675 Oryzias latipes 61.88 2.00e-179 622.00
IUUC-Oga-087933 Otolemur garnettii 71.69 3.00e-175 608.00
IUUC-Oar-090408 Ovis aries 72.08 7.00e-160 557.00
IUUC-Ptr-090865 Pan troglodytes 72.34 0.00e+00 1057.00
IUUC-Pan-092362 Papio anubis 78.54 0.00e+00 851.00
IUUC-Psi-093876 Pelodiscus sinensis 77.64 0.00e+00 894.00
IUUC-Pfo-097116 Poecilia formosa 65.72 0.00e+00 723.00
IUUC-Pab-098127 Pongo abelii 72.23 0.00e+00 1059.00
IUUC-Pca-100485 Procavia capensis 74.88 0.00e+00 838.00
IUUC-Pva-102661 Pteropus vampyrus 74.59 0.00e+00 814.00
IUUC-Rno-105728 Rattus norvegicus 72.14 0.00e+00 1058.00
IUUC-Sha-106515 Sarcophilus harrisii 74.79 0.00e+00 806.00
IUUC-Smo-109517 Selaginella moellendorffii 41.79 3.00e-09 52.80
IUUC-Sar-113161 Sorex araneus 83.99 7.00e-167 580.00
IUUC-Ssc-115314 Sus scrofa 73.73 0.00e+00 796.00
IUUC-Tgu-117012 Taeniopygia guttata 76.19 0.00e+00 914.00
IUUC-Tru-118467 Takifugu rubripes 62.72 2.00e-158 553.00
IUUC-Tsy-119566 Tarsius syrichta 76.55 9.00e-151 527.00
IUUC-Tni-120830 Tetraodon nigroviridis 57.44 1.00e-165 577.00
IUUC-Tbe-128070 Tupaia belangeri 73.83 0.00e+00 755.00
IUUC-Ttr-128161 Tursiops truncatus 84.71 6.00e-124 438.00
IUUC-Vpa-130075 Vicugna pacos 68.85 1.00e-50 194.00
Created Date 25-Jun-2017

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