iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19723762; 21148181; 19364825; 19346490; 19285057; 11565033; 20176921
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	15182669; 21148181; 19364825; 19346490; 11565033

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.80e-57	187.4	1237	1271
E3 adaptor/Cullin RING/SCF/F-box	4.60e-05	23.5	889	935
UBD/Beta-Prp	3.70e-94	315.3	988	1268

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvll 36
           H + vtcl+f+++++v++sdDgt+k+WD++tg+ +
   Q: 1237 HHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFI 1271
           8889******559******************9865 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 100  aglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++ ++ lp e+ + +l++l++++llraa++cr+w+ l++++ lwk+ 
   Q: 889  RDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEK 935
           667889*****************************88888****975 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
           k+lkgh+++vitc++f  +++ +++gs+d+t+kvw++ +gk+lr+l gh+++v++ ++s +  i+++gs+Drt+kvwd+++g cvhtl+gh+++v+
   Q: 988  KVLKGHDDHVITCLQF--SGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGN--IIISGSTDRTLKVWDMDSGACVHTLQGHTSTVR 1079
           6799************..*****************************************99..********************************* PP
   S: 99   slsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngke 194
           +++++   +k+vsGs+d t+rvwd+e+g+cl+ +l gh ++v+cv++++  +l+vsG++D +v++W  +++++l+tl+g ht++vysl+fd    +
   Q: 1080 CMHLHG--SKVVSGSRDATLRVWDIEQGSCLH-VLVGHLAAVRCVQYDG--KLIVSGAYDYMVKIWHPERQECLHTLQG-HTNRVYSLQFDG--LH 1167
           *****9..************************.****************..***************************9.***********9..89 PP
   S: 195  lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvn 290
           +vsgsld+++++wd++tg+c +tl gh++ ++ +++   +++lvsg++D ++++Wd+++g++l+tl+++n++ ++v++l+f+ + +v+ s+d++v+
   Q: 1168 VVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELR--QNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVK 1261
           *************************************..********************************************************* PP
   S: 291  iwklkkn 297
           +w++k+ 
   Q: 1262 LWDVKTG 1268
           ***9876 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Involved in the degradation of cyclin E and dm/Myc. Required for endocycles, but not mitosis in follicle cell epithelium.

Protein Sequence
(Fasta)

MERGCPAASS ESVTSAGERT QSAVTSSTST WVKSQASTSR KTEASEESGL GAVDAEVGAG 60
REAFVSMSTL REDVEDVCVS SNSQHGFAVV LDDESSTFEI SSSNSLPTSA GAASTVGVVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGAGCGGT GGTCACACTG GATCCGCATT AGTTTTTTTT CGGGTCCAAA ATCTGTCCAA 60
ATCCGCAAAT TGCACGCATA TTCTAGTATC TGAAAACCAG AAATTTAGAT AGACTGGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030332--F:cyclin binding
GO:0007411--P:axon guidance
GO:0035147--P:branch fusion, open tracheal system
GO:0071456--P:cellular response to hypoxia
GO:0042023--P:DNA endoreduplication
GO:1900038--P:negative regulation of cellular response to hypoxia
GO:0060253--P:negative regulation of glial cell proliferation
GO:0045926--P:negative regulation of growth
GO:0016567--P:protein ubiquitination
GO:0007096--P:regulation of exit from mitosis
GO:1903146--P:regulation of mitophagy
GO:0007088--P:regulation of mitotic nuclear division
GO:0030162--P:regulation of proteolysis
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0060438--P:trachea development
GO:0007419--P:ventral cord development

KEGG

dme:Dmel_CG15010

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	78.08	0.00e+00	803.00
IUUC-Apl-003176	Anas platyrhynchos	74.90	0.00e+00	795.00
IUUC-Aca-005318	Anolis carolinensis	78.12	0.00e+00	802.00
IUUC-Ago-007888	Ashbya gossypii	29.27	1.00e-61	230.00
IUUC-Acl-008123	Aspergillus clavatus	34.02	6.00e-75	274.00
IUUC-Afl-008730	Aspergillus flavus	33.26	7.00e-78	284.00
IUUC-Afu-009014	Aspergillus fumigatus	32.58	5.00e-76	278.00
IUUC-Ani-009332	Aspergillus nidulans	33.20	3.00e-75	275.00
IUUC-Ang-009529	Aspergillus niger	36.31	5.00e-80	291.00
IUUC-Aor-010215	Aspergillus oryzae	37.39	7.00e-68	251.00
IUUC-Ate-010535	Aspergillus terreus	31.60	6.00e-74	271.00
IUUC-Ame-010898	Astyanax mexicanus	77.43	0.00e+00	795.00
IUUC-Bgr-012075	Blumeria graminis	34.26	1.00e-81	296.00
IUUC-Bta-012391	Bos taurus	78.12	0.00e+00	801.00
IUUC-Bci-013725	Botrytis cinerea	38.22	2.00e-73	269.00
IUUC-Cel-018495	Caenorhabditis elegans	49.90	2.00e-135	475.00
IUUC-Cja-018902	Callithrix jacchus	78.29	0.00e+00	805.00
IUUC-Cfa-020237	Canis familiaris	78.29	0.00e+00	804.00
IUUC-Cpo-022234	Cavia porcellus	78.12	0.00e+00	803.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.18	4.00e-45	174.00
IUUC-Csa-023532	Chlorocebus sabaeus	78.29	0.00e+00	804.00
IUUC-Cho-025026	Choloepus hoffmanni	72.62	4.00e-143	501.00
IUUC-Cin-025516	Ciona intestinalis	63.88	8.00e-130	455.00
IUUC-Csv-026312	Ciona savignyi	69.72	0.00e+00	724.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	36.20	2.00e-86	312.00
IUUC-Cne-027018	Cryptococcus neoformans	31.87	7.00e-74	271.00
IUUC-Cme-027168	Cyanidioschyzon merolae	32.58	1.00e-33	137.00
IUUC-Dre-028303	Danio rerio	77.92	0.00e+00	793.00
IUUC-Dno-029576	Dasypus novemcinctus	75.99	0.00e+00	783.00
IUUC-Dor-030196	Dipodomys ordii	77.66	0.00e+00	790.00
IUUC-Dse-031558	Dothistroma septosporum	39.66	7.00e-74	271.00
IUUC-Ete-032791	Echinops telfairi	78.92	0.00e+00	785.00
IUUC-Eca-033424	Equus caballus	78.12	0.00e+00	802.00
IUUC-Eeu-034996	Erinaceus europaeus	71.46	0.00e+00	791.00
IUUC-Fca-036422	Felis catus	78.29	0.00e+00	804.00
IUUC-Fal-037478	Ficedula albicollis	74.56	0.00e+00	795.00
IUUC-Fox-037800	Fusarium oxysporum	34.74	3.00e-84	305.00
IUUC-Fso-038258	Fusarium solani	34.55	3.00e-85	308.00
IUUC-Gmo-039478	Gadus morhua	67.96	0.00e+00	657.00
IUUC-Ggr-039781	Gaeumannomyces graminis	35.59	2.00e-87	316.00
IUUC-Gga-040170	Gallus gallus	74.51	0.00e+00	799.00
IUUC-Gac-042423	Gasterosteus aculeatus	71.67	0.00e+00	694.00
IUUC-Ggo-044422	Gorilla gorilla	78.29	0.00e+00	804.00
IUUC-Hsa-045898	Homo sapiens	78.29	0.00e+00	805.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	79.06	0.00e+00	786.00
IUUC-Kpa-049097	Komagataella pastoris	32.11	7.00e-81	294.00
IUUC-Lch-050414	Latimeria chalumnae	77.87	0.00e+00	800.00
IUUC-Loc-052348	Lepisosteus oculatus	77.92	0.00e+00	796.00
IUUC-Lma-053185	Leptosphaeria maculans	33.47	1.00e-77	283.00
IUUC-Laf-054054	Loxodonta africana	78.50	0.00e+00	805.00
IUUC-Mcc-055056	Macaca mulatta	78.29	0.00e+00	804.00
IUUC-Meu-056778	Macropus eugenii	72.13	2.00e-106	379.00
IUUC-Mor-057076	Magnaporthe oryzae	30.57	3.00e-64	239.00
IUUC-Mpo-057423	Magnaporthe poae	35.59	4.00e-85	308.00
IUUC-Mla-059081	Melampsora laricipopulina	36.46	2.00e-78	285.00
IUUC-Mga-060171	Meleagris gallopavo	74.75	0.00e+00	791.00
IUUC-Mvi-060490	Microbotryum violaceum	37.88	2.00e-68	254.00
IUUC-Mmr-061292	Microcebus murinus	78.29	0.00e+00	803.00
IUUC-Mdo-062304	Monodelphis domestica	77.92	0.00e+00	807.00
IUUC-Mmu-063610	Mus musculus	78.08	0.00e+00	803.00
IUUC-Mpu-065931	Mustela putorius furo	78.29	0.00e+00	804.00
IUUC-Mlu-066976	Myotis lucifugus	78.29	0.00e+00	806.00
IUUC-Nfi-068428	Neosartorya fischeri	32.47	5.00e-76	278.00
IUUC-Ncr-068688	Neurospora crassa	36.55	4.00e-88	318.00
IUUC-Nle-070174	Nomascus leucogenys	78.29	0.00e+00	805.00
IUUC-Opr-070851	Ochotona princeps	74.62	2.00e-119	421.00
IUUC-Ont-071997	Oreochromis niloticus	72.36	0.00e+00	791.00
IUUC-Oan-072936	Ornithorhynchus anatinus	78.12	0.00e+00	805.00
IUUC-Ocu-074742	Oryctolagus cuniculus	78.12	0.00e+00	805.00
IUUC-Ola-087098	Oryzias latipes	72.74	0.00e+00	792.00
IUUC-Olu-087837	Ostreococcus lucimarinus	33.58	4.00e-36	143.00
IUUC-Oga-088884	Otolemur garnettii	83.29	0.00e+00	641.00
IUUC-Oar-090220	Ovis aries	77.48	0.00e+00	799.00
IUUC-Ptr-090492	Pan troglodytes	78.29	0.00e+00	805.00
IUUC-Pan-091770	Papio anubis	78.29	0.00e+00	804.00
IUUC-Psi-093207	Pelodiscus sinensis	78.12	0.00e+00	803.00
IUUC-Pma-094749	Petromyzon marinus	78.71	0.00e+00	779.00
IUUC-Pno-095026	Phaeosphaeria nodorum	37.50	2.00e-73	270.00
IUUC-Pfo-096493	Poecilia formosa	78.17	0.00e+00	796.00
IUUC-Pab-098141	Pongo abelii	78.12	0.00e+00	802.00
IUUC-Pca-100571	Procavia capensis	74.30	8.00e-148	516.00
IUUC-Pva-102988	Pteropus vampyrus	78.29	0.00e+00	805.00
IUUC-Pgr-103612	Puccinia graminis	34.41	4.00e-61	228.00
IUUC-Pte-104275	Pyrenophora teres	32.76	1.00e-79	290.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	32.38	7.00e-79	287.00
IUUC-Rno-105706	Rattus norvegicus	78.29	0.00e+00	804.00
IUUC-Sce-106314	Saccharomyces cerevisiae	30.12	6.00e-66	244.00
IUUC-Sha-107653	Sarcophilus harrisii	78.08	0.00e+00	804.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	32.17	2.00e-77	283.00
IUUC-Spo-108063	Schizosaccharomyces pombe	28.97	2.00e-59	223.00
IUUC-Sar-113600	Sorex araneus	72.65	0.00e+00	734.00
IUUC-Sre-114901	Sporisorium reilianum	42.70	2.00e-64	240.00
IUUC-Ssc-115787	Sus scrofa	76.41	0.00e+00	778.00
IUUC-Tgu-117510	Taeniopygia guttata	78.08	0.00e+00	803.00
IUUC-Tru-117819	Takifugu rubripes	72.99	0.00e+00	798.00
IUUC-Tsy-118828	Tarsius syrichta	78.29	0.00e+00	804.00
IUUC-Tni-120468	Tetraodon nigroviridis	72.80	0.00e+00	795.00
IUUC-Tre-122193	Trichoderma reesei	37.31	3.00e-89	322.00
IUUC-Tvi-122615	Trichoderma virens	35.90	1.00e-85	310.00
IUUC-Tur-126271	Triticum urartu	32.59	2.00e-29	122.00
IUUC-Tme-127021	Tuber melanosporum	35.63	3.00e-89	321.00
IUUC-Tbe-127925	Tupaia belangeri	78.12	0.00e+00	803.00
IUUC-Ttr-128899	Tursiops truncatus	77.92	0.00e+00	802.00
IUUC-Uma-129449	Ustilago maydis	42.81	9.00e-65	241.00
IUUC-Vda-129936	Verticillium dahliae	37.60	6.00e-76	278.00
IUUC-Vpa-130082	Vicugna pacos	76.79	0.00e+00	644.00
IUUC-Xtr-132213	Xenopus tropicalis	77.66	0.00e+00	799.00
IUUC-Xma-133646	Xiphophorus maculatus	78.01	0.00e+00	792.00
IUUC-Yli-134429	Yarrowia lipolytica	34.17	2.00e-86	312.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence