iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-060203

Ensembl Protein ID

ENSMGAP00000004667.1

UniProt Accession

G1MZZ3; G1MZZ3_MELGA

Protein Name

Uncharacterized protein

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000004793.1	ENSMGAT00000005388.1	ENSMGAP00000004667.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	2.90e-22	78.1	435	494

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +ee+let+ vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k+ + l+d ++ s
   Q: 435  QEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLAVQLAYLLKEQQNLEDLGRSS 494
           79***************************************************9988765 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MSSKPQIRPA ENGEHCRSKM ENGMDSVAPP TLSTYTPEEM VQQMKELITE NNELKEAMKL 60
HNQAMKDRYE ELSIWREKQK EEREFYEAKF KEAKQCLLAK CIENEQLQQQ LQSLKEREEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGTCACTG CAGAGATGTC CAGCAAGCCA CAGATCCGTC CTGCTGAAAA TGGAGAGCAT 60
TGCAGGAGTA AAATGGAGAA TGGAATGGAC AGTGTGGCTC CCCCCACCCT CAGTACCTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	54.81	4.00e-138	484.00
IUUC-Apl-003812	Anas platyrhynchos	84.80	0.00e+00	889.00
IUUC-Aca-004625	Anolis carolinensis	63.12	4.00e-177	613.00
IUUC-Aly-005781	Arabidopsis lyrata	50.00	6.50e-02	31.60
IUUC-Ame-011116	Astyanax mexicanus	37.17	6.00e-63	234.00
IUUC-Bta-013240	Bos taurus	56.94	2.00e-157	548.00
IUUC-Bol-016499	Brassica oleracea	33.33	6.00e-01	28.90
IUUC-Cja-019911	Callithrix jacchus	57.79	6.00e-154	536.00
IUUC-Cfa-020330	Canis familiaris	56.15	6.00e-144	503.00
IUUC-Cpo-021753	Cavia porcellus	53.74	1.00e-143	502.00
IUUC-Csa-023662	Chlorocebus sabaeus	57.44	3.00e-152	531.00
IUUC-Cho-024574	Choloepus hoffmanni	48.26	5.00e-73	267.00
IUUC-Dre-027720	Danio rerio	43.10	1.00e-95	343.00
IUUC-Dno-029079	Dasypus novemcinctus	56.52	3.00e-133	468.00
IUUC-Dor-030890	Dipodomys ordii	55.61	3.00e-152	531.00
IUUC-Dme-032072	Drosophila melanogaster	30.34	9.00e-06	44.30
IUUC-Ete-032568	Echinops telfairi	56.95	2.00e-137	482.00
IUUC-Eca-033528	Equus caballus	56.20	3.00e-145	508.00
IUUC-Eeu-035219	Erinaceus europaeus	53.97	2.00e-139	489.00
IUUC-Fca-035852	Felis catus	55.35	3.00e-144	504.00
IUUC-Fal-036862	Ficedula albicollis	86.40	0.00e+00	856.00
IUUC-Gmo-038735	Gadus morhua	39.62	2.00e-73	269.00
IUUC-Gga-040939	Gallus gallus	95.70	0.00e+00	1004.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.58	4.00e-91	328.00
IUUC-Ggo-045034	Gorilla gorilla	53.16	2.00e-136	478.00
IUUC-Hsa-046624	Homo sapiens	59.78	6.00e-158	550.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	51.97	2.00e-138	485.00
IUUC-Lch-049720	Latimeria chalumnae	47.93	9.00e-77	280.00
IUUC-Loc-052185	Lepisosteus oculatus	43.27	7.00e-103	367.00
IUUC-Laf-054079	Loxodonta africana	54.31	1.00e-140	493.00
IUUC-Mcc-055674	Macaca mulatta	58.01	1.00e-151	529.00
IUUC-Meu-056769	Macropus eugenii	71.34	2.00e-62	233.00
IUUC-Mmr-061492	Microcebus murinus	56.67	1.00e-144	506.00
IUUC-Mdo-063051	Monodelphis domestica	57.00	6.00e-162	563.00
IUUC-Mmu-063409	Mus musculus	53.50	2.00e-151	528.00
IUUC-Mpu-065907	Mustela putorius furo	51.85	2.00e-140	492.00
IUUC-Mlu-066957	Myotis lucifugus	57.83	7.00e-141	493.00
IUUC-Nle-069973	Nomascus leucogenys	57.34	4.00e-153	534.00
IUUC-Opr-071049	Ochotona princeps	52.85	4.00e-131	461.00
IUUC-Ont-071915	Oreochromis niloticus	42.93	6.00e-98	350.00
IUUC-Oan-072965	Ornithorhynchus anatinus	56.72	1.00e-157	549.00
IUUC-Ocu-074029	Oryctolagus cuniculus	53.77	3.00e-124	438.00
IUUC-Ola-087019	Oryzias latipes	40.21	1.00e-83	303.00
IUUC-Oga-088613	Otolemur garnettii	56.70	4.00e-151	528.00
IUUC-Oar-090386	Ovis aries	57.12	1.00e-157	549.00
IUUC-Ptr-091619	Pan troglodytes	59.43	3.00e-156	544.00
IUUC-Pan-092178	Papio anubis	57.66	2.00e-152	532.00
IUUC-Psi-093214	Pelodiscus sinensis	66.43	0.00e+00	647.00
IUUC-Pfo-096901	Poecilia formosa	42.11	8.00e-88	317.00
IUUC-Pab-097560	Pongo abelii	52.59	1.00e-123	436.00
IUUC-Pca-100853	Procavia capensis	47.15	6.00e-59	221.00
IUUC-Pva-102255	Pteropus vampyrus	53.12	1.00e-128	452.00
IUUC-Rno-105812	Rattus norvegicus	53.07	3.00e-151	528.00
IUUC-Sha-107225	Sarcophilus harrisii	62.87	3.00e-120	424.00
IUUC-Sar-113736	Sorex araneus	56.83	3.00e-90	325.00
IUUC-Ssc-115422	Sus scrofa	56.15	1.00e-151	529.00
IUUC-Tgu-116924	Taeniopygia guttata	79.23	0.00e+00	760.00
IUUC-Tru-117695	Takifugu rubripes	41.51	3.00e-85	308.00
IUUC-Tsy-119090	Tarsius syrichta	51.92	6.00e-75	274.00
IUUC-Tni-120645	Tetraodon nigroviridis	40.58	8.00e-87	313.00
IUUC-Tbe-127970	Tupaia belangeri	65.26	3.00e-93	335.00
IUUC-Ttr-129244	Tursiops truncatus	57.17	3.00e-147	514.00
IUUC-Vpa-130313	Vicugna pacos	56.60	4.00e-144	504.00
IUUC-Xtr-132115	Xenopus tropicalis	44.06	4.00e-102	364.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence