iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012448

Ensembl Protein ID

ENSBTAP00000035991.3

UniProt Accession

Q148F0; URM1_BOVIN

Genbank Protein ID

AAI18392.1

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

BC118391

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000025612.3	ENSBTAT00000036128.3	ENSBTAP00000035991.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	41.41	8.00e-17	79.70	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPLSVEVE FGGGAELLFD GVKKHQVTLP GQEEPWDIRS LLVWIKKNLL KERPELFIQG 60
DSVRPGILVL VNDADWELLG ELDYQLQDQD SVLFISTLHG G 101

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Nucleotide Sequence
(Fasta)

AGGCCCTCTG CTCCCCAATT TCCACCTTCT CTTGGTGCTC CAGCATGTCC TACTACCCAG 60
AGTCTTTGCA CTTTCCGTTC TCGCTGGAAT GCTCCTAGCA GATTTTCTCT CCGCATATCC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

KEGG

bta:515890; bta:781062

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	98.02	2.00e-53	199.00
IUUC-Atr-003089	Amborella trichopoda	56.57	3.00e-30	122.00
IUUC-Apl-003382	Anas platyrhynchos	86.81	6.00e-43	164.00
IUUC-Aca-004981	Anolis carolinensis	82.18	9.00e-48	181.00
IUUC-Aly-005517	Arabidopsis lyrata	55.43	1.00e-27	113.00
IUUC-Ath-006718	Arabidopsis thaliana	55.95	3.00e-24	102.00
IUUC-Ago-007917	Ashbya gossypii	42.42	1.00e-19	87.80
IUUC-Acl-008054	Aspergillus clavatus	64.00	5.00e-15	72.00
IUUC-Afl-008704	Aspergillus flavus	53.93	1.00e-20	90.50
IUUC-Aor-009890	Aspergillus oryzae	56.44	4.00e-25	106.00
IUUC-Bci-013865	Botrytis cinerea	45.54	2.00e-21	94.00
IUUC-Bdi-014980	Brachypodium distachyon	62.34	4.00e-24	102.00
IUUC-Bol-016055	Brassica oleracea	55.00	9.00e-24	101.00
IUUC-Bra-016845	Brassica rapa	55.00	9.00e-24	101.00
IUUC-Cel-018485	Caenorhabditis elegans	33.01	2.00e-11	60.10
IUUC-Cja-019587	Callithrix jacchus	98.02	2.00e-53	199.00
IUUC-Cfa-020653	Canis familiaris	99.01	7.00e-54	201.00
IUUC-Cpo-021622	Cavia porcellus	98.02	2.00e-53	199.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	52.04	3.00e-25	105.00
IUUC-Csa-023756	Chlorocebus sabaeus	96.20	3.00e-40	157.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	44.55	7.00e-21	92.00
IUUC-Cne-026953	Cryptococcus neoformans	55.34	1.00e-27	115.00
IUUC-Cme-027314	Cyanidioschyzon merolae	42.71	7.00e-18	81.30
IUUC-Dre-027884	Danio rerio	77.23	1.00e-44	170.00
IUUC-Dno-029262	Dasypus novemcinctus	91.36	6.00e-39	152.00
IUUC-Dor-030601	Dipodomys ordii	65.35	2.00e-27	113.00
IUUC-Dme-031893	Drosophila melanogaster	61.76	4.00e-32	129.00
IUUC-Ete-032773	Echinops telfairi	92.08	1.00e-48	184.00
IUUC-Eca-034187	Equus caballus	97.03	3.00e-53	199.00
IUUC-Eeu-034808	Erinaceus europaeus	94.06	6.00e-52	194.00
IUUC-Fca-036107	Felis catus	96.04	6.00e-53	198.00
IUUC-Fal-036607	Ficedula albicollis	85.71	2.00e-42	163.00
IUUC-Fox-037698	Fusarium oxysporum	46.15	4.00e-23	99.40
IUUC-Gmo-039492	Gadus morhua	75.25	8.00e-44	167.00
IUUC-Ggr-039965	Gaeumannomyces graminis	47.12	1.00e-20	91.70
IUUC-Gga-041268	Gallus gallus	86.14	2.00e-48	182.00
IUUC-Gac-042111	Gasterosteus aculeatus	79.21	2.00e-46	176.00
IUUC-Gma-043240	Glycine max	54.76	5.00e-23	98.60
IUUC-Ggo-045176	Gorilla gorilla	93.67	4.00e-32	130.00
IUUC-Hsa-046077	Homo sapiens	95.05	4.00e-45	172.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	95.51	2.00e-38	149.00
IUUC-Kpa-049157	Komagataella pastoris	47.47	6.00e-20	88.20
IUUC-Lch-049889	Latimeria chalumnae	80.20	6.00e-46	174.00
IUUC-Lpe-050783	Leersia perrieri	56.63	9.00e-23	97.80
IUUC-Loc-052400	Lepisosteus oculatus	78.22	3.00e-45	172.00
IUUC-Lma-053259	Leptosphaeria maculans	44.55	7.00e-21	91.70
IUUC-Laf-053596	Loxodonta africana	95.15	1.00e-51	193.00
IUUC-Mcc-054845	Macaca mulatta	90.82	4.00e-47	178.00
IUUC-Meu-055968	Macropus eugenii	90.10	1.00e-50	190.00
IUUC-Mor-057126	Magnaporthe oryzae	45.19	1.00e-19	88.20
IUUC-Mpo-057311	Magnaporthe poae	48.51	1.00e-21	95.10
IUUC-Mtr-058266	Medicago truncatula	52.33	8.00e-23	97.80
IUUC-Mla-058847	Melampsora laricipopulina	41.75	2.00e-12	63.90
IUUC-Mga-059468	Meleagris gallopavo	86.81	5.00e-43	164.00
IUUC-Mvi-060235	Microbotryum violaceum	35.10	4.00e-19	87.00
IUUC-Mdo-061948	Monodelphis domestica	89.11	2.00e-50	190.00
IUUC-Mmu-063946	Mus musculus	94.06	6.00e-52	194.00
IUUC-Mac-064812	Musa acuminata	58.33	2.00e-24	103.00
IUUC-Mpu-066763	Mustela putorius furo	96.04	4.00e-52	195.00
IUUC-Mlu-066970	Myotis lucifugus	97.47	1.00e-40	156.00
IUUC-Ncr-068824	Neurospora crassa	43.56	1.00e-19	87.80
IUUC-Nle-069849	Nomascus leucogenys	94.94	9.00e-40	155.00
IUUC-Opr-070227	Ochotona princeps	98.02	2.00e-53	199.00
IUUC-Ont-072530	Oreochromis niloticus	80.20	3.00e-46	176.00
IUUC-Oan-073191	Ornithorhynchus anatinus	80.41	6.00e-42	161.00
IUUC-Ocu-074460	Oryctolagus cuniculus	96.94	4.00e-51	191.00
IUUC-Oba-075499	Oryza barthii	65.62	2.00e-22	98.20
IUUC-Obr-076896	Oryza brachyantha	56.25	1.00e-21	96.70
IUUC-Ogl-077834	Oryza glaberrima	65.62	5.00e-23	98.60
IUUC-Ogu-078622	Oryza glumaepatula	65.62	5.00e-23	98.60
IUUC-Oin-079358	Oryza indica	65.62	2.00e-22	98.60
IUUC-Olo-081035	Oryza longistaminata	51.49	2.00e-23	101.00
IUUC-Oni-082425	Oryza nivara	65.62	5.00e-23	98.60
IUUC-Opu-083461	Oryza punctata	65.08	3.00e-22	97.40
IUUC-Oru-084875	Oryza rufipogon	59.15	5.00e-21	91.70
IUUC-Oga-089128	Otolemur garnettii	96.04	5.00e-53	198.00
IUUC-Oar-089896	Ovis aries	100.00	5.00e-54	201.00
IUUC-Ptr-091618	Pan troglodytes	93.67	4.00e-32	130.00
IUUC-Pan-092238	Papio anubis	96.20	3.00e-40	156.00
IUUC-Psi-093879	Pelodiscus sinensis	84.16	1.00e-47	180.00
IUUC-Pma-094484	Petromyzon marinus	80.20	9.00e-36	140.00
IUUC-Ppa-095801	Physcomitrella patens	58.02	8.00e-23	97.80
IUUC-Pfo-097192	Poecilia formosa	79.21	5.00e-46	175.00
IUUC-Pab-098203	Pongo abelii	94.06	1.00e-44	171.00
IUUC-Pop-099614	Populus trichocarpa	58.33	5.00e-24	102.00
IUUC-Pca-100507	Procavia capensis	98.73	1.00e-40	157.00
IUUC-Ppe-101174	Prunus persica	56.57	9.00e-29	117.00
IUUC-Pva-102735	Pteropus vampyrus	96.04	1.00e-49	187.00
IUUC-Pgr-103510	Puccinia graminis	40.78	4.00e-12	63.20
IUUC-Ptt-103918	Puccinia triticina	36.89	2.00e-10	57.00
IUUC-Pte-104173	Pyrenophora teres	46.60	5.00e-23	99.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	46.60	5.00e-23	99.00
IUUC-Rno-105820	Rattus norvegicus	95.05	2.00e-52	196.00
IUUC-Sce-106366	Saccharomyces cerevisiae	41.41	3.00e-17	79.70
IUUC-Sja-107727	Schizosaccharomyces japonicus	42.71	1.00e-16	77.80
IUUC-Spo-108074	Schizosaccharomyces pombe	41.84	3.00e-10	56.20
IUUC-Smo-108944	Selaginella moellendorffii	60.67	2.00e-26	109.00
IUUC-Sit-110277	Setaria italica	55.95	9.00e-24	101.00
IUUC-Sly-111505	Solanum lycopersicum	54.76	4.00e-24	102.00
IUUC-Stu-112076	Solanum tuberosum	55.95	1.00e-24	103.00
IUUC-Sbi-114274	Sorghum bicolor	61.04	2.00e-24	103.00
IUUC-Sre-114953	Sporisorium reilianum	58.82	1.00e-27	114.00
IUUC-Ssc-115418	Sus scrofa	95.05	1.00e-52	197.00
IUUC-Tgu-117311	Taeniopygia guttata	85.71	2.00e-42	162.00
IUUC-Tru-118598	Takifugu rubripes	82.02	1.00e-40	157.00
IUUC-Tni-120109	Tetraodon nigroviridis	77.45	4.00e-43	165.00
IUUC-Tca-120942	Theobroma cacao	56.63	2.00e-23	100.00
IUUC-Tre-122099	Trichoderma reesei	47.31	9.00e-16	74.30
IUUC-Tvi-122285	Trichoderma virens	50.96	1.00e-20	91.70
IUUC-Tae-125193	Triticum aestivum	56.63	4.00e-23	99.00
IUUC-Tur-126677	Triticum urartu	49.47	1.00e-20	90.90
IUUC-Tme-127120	Tuber melanosporum	47.12	5.00e-24	102.00
IUUC-Tbe-128050	Tupaia belangeri	71.29	7.00e-34	134.00
IUUC-Ttr-129019	Tursiops truncatus	93.07	1.00e-49	187.00
IUUC-Uma-129483	Ustilago maydis	55.88	3.00e-25	106.00
IUUC-Vda-129690	Verticillium dahliae	40.18	3.00e-16	76.60
IUUC-Vvi-131174	Vitis vinifera	57.83	3.00e-24	102.00
IUUC-Xma-133862	Xiphophorus maculatus	79.21	5.00e-46	175.00
IUUC-Yli-134398	Yarrowia lipolytica	45.45	5.00e-19	85.10
IUUC-Zma-134964	Zea mays	58.54	1.00e-22	97.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence