iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17962185

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	3.2	8.4	106	141

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpC..gHvfhadClqkwpglknssskefrCPlCr 46
           C++C+  ++  p+ ++C  gH+++ +C           sk  +CP+Cr
   Q: 106  CPVCFGYIMP-PI-MQCprGHLICSTC----------RSKLTICPVCR 141
           ********98.55.55655********..........9999******8 PP

Organism

Drosophila melanogaster

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. The adapter phyl is required to direct the degradation of the two isoforms of the transcriptional repressor Tramtrack (Ttk). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. A phyl-independent mechanism of degradation exists for isoform beta of ttk that involves motifs in the C-terminus of ttk.

Protein Sequence
(Fasta)

MSVRNSRPQL SWPERVSPQR TIDTPTASGE MLTRRQSAPA LVVPPEETTH VVVVKRQSPD 60
AAAAGELVPS RRKDSVAVQS GIVATGPLDT TRSGARDDFL MALLECPVCF GYIMPPIMQC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTAGCTT CGTTGTATTG TGGTACAGAT TGTATTTTCG AATTCTTTTA AGCAAAATTT 60
CAGTGTTCAG AAAAAGTAAA AAAAAAGTAA AACCATCGGC ACTCTCATTC TTCAGAATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0010498--P:proteasomal protein catabolic process
GO:0045676--P:regulation of R7 cell differentiation
GO:0007423--P:sensory organ development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG13030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003118	Amborella trichopoda	35.64	5.00e-41	160.00
IUUC-Aly-006207	Arabidopsis lyrata	36.10	3.00e-39	154.00
IUUC-Ath-007049	Arabidopsis thaliana	36.51	2.00e-39	155.00
IUUC-Bol-015523	Brassica oleracea	36.51	2.00e-39	155.00
IUUC-Bra-016847	Brassica rapa	35.43	7.00e-39	153.00
IUUC-Mtr-057852	Medicago truncatula	31.23	3.00e-40	157.00
IUUC-Mac-065670	Musa acuminata	35.69	2.00e-37	148.00
IUUC-Ppa-095212	Physcomitrella patens	35.06	4.00e-39	154.00
IUUC-Pgr-103457	Puccinia graminis	35.00	6.90e-01	28.90
IUUC-Smo-109412	Selaginella moellendorffii	34.43	2.00e-41	161.00
IUUC-Sly-111117	Solanum lycopersicum	36.32	6.00e-42	163.00
IUUC-Stu-112714	Solanum tuberosum	35.89	6.00e-43	167.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence